Genomes and Genes
Gene Symbol: foxa3
Description: forkhead box A3
Alias: Zffkh1, fa11c04, fkd2, forkhead-2, wu:fa11c04, wu:fc37a08, zf-FKH1, hepatocyte nuclear factor 3-gamma, fc37a08, fork head domain protein 2
Publications109 found, 100 shown here
- The subcellular localization of TRPP2 modulates its functionXiao Fu
Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
J Am Soc Nephrol 19:1342-51. 2008..Taken together, these findings support the hypothesis that TRPP2 assumes distinct subcellular localizations to exert tissue-specific functions...
- Mutations affecting development of the midline and general body shape during zebrafish embryogenesisM Brand
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
Development 123:129-42. 1996..As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues...
- Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerioM Hammerschmidt
Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
Development 123:143-51. 1996..Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac...
- fork head domain genes in zebrafishJ Odenthal
MPI für Entwicklungsbiologie, Spemannstrasse 35 III, D 72076 Tubingen, Germany
Dev Genes Evol 208:245-58. 1998..Members of class I (fkd1/axial, fkd2/Zffkh1, fkd4 and fkd7) are differentially transcribed in unsegmented dorsal axial structures such as the floor plate, the ..
- Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGFA Rodaway
Developmental Biology Research Centre, Randall Institute, King s College London, London, WC2B 5RL, UK
Development 126:3067-78. 1999....
- casanova plays an early and essential role in endoderm formation in zebrafishJ Alexander
Programs in Developmental Biology and Human Genetics, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 0448, USA
Dev Biol 215:343-57. 1999..The early endodermal expression of genes such as axial, gata5, and fkd2 does not initiate in casanova mutants, indicating that the endoderm is defective from the onset of gastrulation...
- Unified nomenclature for the winged helix/forkhead transcription factorsK H Kaestner
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Genes Dev 14:142-6. 2000
- Nil per os encodes a conserved RNA recognition motif protein required for morphogenesis and cytodifferentiation of digestive organs in zebrafishAlan N Mayer
Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Development 130:3917-28. 2003..Antisense-mediated knockdown of npo results in organ hypoplasia, and overexpression of npo causes an overgrowth of gastrointestinal organs. Thus, npo is a gene essential for a key step in the gut morphogenetic sequence...
- Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish developmentTakaaki Matsui
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 19:164-75. 2005..Overall, our results uncover a late, previously unexpected role of noncanonical Wnt signaling in the control of midline assembly of organ precursors during vertebrate embryo development...
- Inositol polyphosphates regulate zebrafish left-right asymmetryBhaskarjyoti Sarmah
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U 3209 MRBIII, 465 21 st Avenue South, Nashville, Tennessee 37232, USA
Dev Cell 9:133-45. 2005..Our data suggest that the pathway for inositol hexakisphosphate production is a key regulator of asymmetric Ca(2+) flux during LR specification...
- Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axisBrent W Bisgrove
Huntsman Cancer Institute Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
Dev Biol 287:274-88. 2005..Our data suggest that the functions of polaris and pkd2 in LR patterning are conserved between zebrafish and mice and that Kupffer's vesicle functions as a ciliated organ of asymmetry...
- Polycystin-2 immunolocalization and function in zebrafishTomoko Obara
Nephrology Division, Massachusetts General Hospital 149 8000 and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
J Am Soc Nephrol 17:2706-18. 2006....
- Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during developmentKunal Rai
Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
Mol Cell Biol 26:7077-85. 2006..Our results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues...
- Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafishKunal Rai
Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
Genes Dev 21:261-6. 2007..Furthermore, zebrafish Dnmt2 methylates an RNA species of approximately 80 bases, consistent with tRNA methylation. Thus, Dnmt2 promotes zebrafish development, likely through cytoplasmic RNA methylation...
- Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpawJodi Schottenfeld
Department of Molecular Biology, Princeton University, Princeton, NJ 08550, USA
Development 134:1605-15. 2007..pkd2 also appears to play a role in the propagation of Nodal signals in the LPM. Based on morpholino studies, we propose an additional role for maternal pkd2 in general mesendoderm patterning...
- Bmp and Fgf signaling are essential for liver specification in zebrafishDonghun Shin
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
Development 134:2041-50. 2007....
- Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetriesMatthias Carl
Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
Neuron 55:393-405. 2007..We identify a second role for the Wnt pathway in the left/right regulation of LPM Nodal pathway gene expression, and finally, we show that at later stages Axin1 is required for the elaboration of concordant neuroanatomical asymmetries...
- Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver developmentZhen Li
Department of Biological Sciences, National University of Singapore, Singapore
BMC Dev Biol 7:117. 2007....
- Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafishRui Monteiro
Hubrecht Institute, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
Dev Biol 315:55-71. 2008..We propose a mechanism whereby this differential interpretation of BMP signalling through bmpr2a and bmpr2b is essential for the establishment of LR asymmetry in the zebrafish embryo...
- Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafishMuhammad Farooq
Department of Biological Sciences, National University of Singapore, 117543, Singapore
Dev Biol 317:336-53. 2008..These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 and hdac3 in zebrafish embryonic development...
- Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulationTakamasa Mizoguchi
Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima, Japan
Development 135:2521-9. 2008....
- APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver developmentWolfram Goessling
Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 320:161-74. 2008..These studies reveal an important and time-dependent role for wnt signaling during liver development and regeneration...
- Genetic steps to organ laterality in zebrafishJ N Chen
Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Comp Funct Genomics 2:60-8. 2001..That laterality decisions of organs may be independently perturbed, as in the Class 3 mutation, indicates that there are distinctive pathways for reception and organotypic interpretation of the global signals...
- Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesisHonghui Huang
Laboratory of Functional Genomics, Institute of Molecular and Cell Biology, Proteos, Singapore
Development 135:3209-18. 2008....
- FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1Sung Kook Hong
Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:2230-5. 2009..We conclude that Ier2 and Fibp1 mediate FGF signaling in ciliogenesis in Kupffer's Vesicle and in the establishment of laterality in the zebrafish embryo...
- Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryosChristopher J Wilkinson
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
BMC Cell Biol 10:17. 2009..In a number of human diseases, such Bardet-Biedl syndrome, centrosome/cilium proteins are mutated, leading to polycystic kidney disease, situs inversus, and neurological problems, amongst other symptoms...
- Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterningFabrizio C Serluca
Massachusetts General Hospital, Charlestown, MA 02129, USA
Development 136:1621-31. 2009..Combined with recently published results, our alleles suggest that the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes...
- Fgf4 is required for left-right patterning of visceral organs in zebrafishHajime Yamauchi
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
Dev Biol 332:177-85. 2009..The present findings indicate that Fgf4 plays a unique role in the LR patterning of visceral organs in zebrafish...
- FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract developmentCarsten Stuckenholz
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Gastroenterology 137:1321-32. 2009..To identify differentially regulated genes important in gastrointestinal organogenesis, we profiled the transcriptome of the zebrafish developing gastrointestinal tract...
- Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesisChunlei Gao
State University of New York Upstate Medical University, Department of Cell and Developmental Biology, Syracuse, New York 13210, USA
Dev Dyn 239:2190-7. 2010..Analysis of cilium ultrastructure revealed loss of outer dynein arms in morphant embryos. These results support a remarkable level of functional conservation for Oda16/Wdr69...
- The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetryLudmila Francescatto
Department of Biology, Virginia Commonwealth University, Richmond, VA 23284 2012, USA
Development 137:2753-62. 2010....
- Notch signalling regulates left-right asymmetry through ciliary length controlSusana S Lopes
Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisboa, Portugal
Development 137:3625-32. 2010..Notch signalling brings together ciliary length control and fluid flow hydrodynamics with transcriptional activation of laterality genes. In addition, our deltaD mutant analysis discloses an uncoupling between gut and heart laterality...
- BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelinYann Gibert
Division of Hematology Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e14553. 2011..Taken together, these data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hjv...
- Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish developmentNan Li
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Development 138:1817-26. 2011....
- CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein armsJennifer R Panizzi
Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Nat Genet 44:714-9. 2012..Chlamydomonas Ccdc103/Pr46b functions as a tightly bound, axoneme-associated protein. These results identify Ccdc103 as a dynein arm attachment factor that causes primary ciliary dyskinesia when mutated...
- Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic developmentGang Zhai
Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Science, Wuhan, Hubei, People s Republic of China
Mol Cell Biol 34:1310-21. 2014..Our study reveals a novel role of sept6 in ciliogenesis during early embryonic development in zebrafish. ..
- Origin and development of the zebrafish endodermR M Warga
Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, Germany
Development 126:827-38. 1999..This suggests that a common pathway initially specifies germ layers together before a progressive sequence of determinative events segregate endoderm and mesoderm into morphologically distinct germ layers...
- Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time pointsSonja Chocron
Cardiac Development and Genetics Group, Hubrecht Laboratory, Uppsalalaan 8, Utrecht, The Netherlands
Dev Biol 305:577-88. 2007..The identification of these two distinct and opposing activities of BMP signaling provides new insight into how BMP signaling can regulate LR patterning...
- A cellular framework for gut-looping morphogenesis in zebrafishSally Horne-Badovinac
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, CA 94143, USA
Science 302:662-5. 2003..Finally, reducing left-sided Nodal activity randomizes the pattern of LPM migration and gut looping. These results reveal a cellular framework for the regulation of organ laterality by asymmetrically expressed genes...
- FoxA transcription factors are essential for the development of dorsal axial structuresSophie Dal-Pra
Department of Cell Biology, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
Dev Biol 350:484-95. 2011..In agreement with this hypothesis, we found that simultaneous knockdown of FoxA2 and FoxA3 abolish the formation of all axial derivatives, while overexpression of these transcription factors strongly ..
- Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryoXin Lou
Program in Development and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada
Development 138:3113-23. 2011..Our results reveal an evolutionarily conserved role for cBAF activity in cardiac differentiation. Importantly, they demonstrate that Smarcd3b and Gata5 can induce a primitive, CPC-like state...
- Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafishKelly A Smith
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
PLoS Genet 7:e1002289. 2011..When nodal flow has been established and Nodal activity is apparent, both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning...
- NPHP4 variants are associated with pleiotropic heart malformationsVanessa M French
Department of Clinical Genetics, Erasmus MC Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
Circ Res 110:1564-74. 2012..Failure to establish normal left-right (L-R) asymmetry often results in cardiovascular malformations and other laterality defects of visceral organs...
- Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowthSahar Nissim
Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Genetics Division, Brigham and Women s Hospital, Boston, MA 02115, USA Dana Farber Cancer Institute, Boston, MA 02115, USA
Dev Cell 28:423-37. 2014..PGE2 remains important for adult organ growth, as it modulates liver regeneration. This work provides in vivo evidence that PGE2 may act as a morphogen to regulate cell-fate decisions and outgrowth of the embryonic endodermal anlagen. ..
- Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreasMinho Won
Section on Developmental Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892 2790
Proc Natl Acad Sci U S A 112:12426-31. 2015..Further, the complex relationships among genotype, phenotype, and morpholino effect in this case may be instructive in the ongoing consideration of morpholino use. ..
- A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ FunctionEmily S Noël
Hubrecht Institute KNAW and Medical Physiology, Division Heart and Lungs, University Medical Centre, Utrecht, The Netherlands
Hum Mutat 37:194-200. 2016....
- Cannabinoid receptor signaling regulates liver development and metabolismLeah Y Liu
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Development 143:609-22. 2016..Our work describes a novel developmental role for EC signaling, whereby Cnr-mediated regulation of Srebfs and methionine metabolism impacts liver development and function. ..
- c21orf59/kurly Controls Both Cilia Motility and PolarizationKimberly M Jaffe
Molecular Biology Department, Princeton University, Princeton, NJ 08544, USA
Cell Rep 14:1841-9. 2016..Kur also makes interactions with other PCP components, including Disheveled. This supports a model wherein Kur plays a dual role in cilia motility and polarization. ..
- Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizerJunfeng Zhang
State Key Laboratory of Membrane Biology, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
Development 143:2603-15. 2016..Therefore, our data uncover an important role of Eph/ephrin signaling in maintaining DFC cluster boundary and KV boundary for normal left-right asymmetrical development. ..
- Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesisAndrew G Cox
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 113:E5562-71. 2016..Overall, our findings establish that seph regulates redox homeostasis and suppresses DNA damage. We hypothesize that SepH deficiency may contribute to the increased cancer risk observed in cohorts with low selenium levels. ..
- RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flowBrent W Bisgrove
Department of Neurobiology and Anatomy, University of Utah School of Medicine, USA
Dev Biol 363:166-78. 2012....
- Augmenter of liver regeneration (alr) promotes liver outgrowth during zebrafish hepatogenesisYan Li
Department of Biological Sciences, National University of Singapore, Singapore, Singapore
PLoS ONE 7:e30835. 2012..The dose-dependent and partial suppression of alr expression through MO-mediated knockdown allows the identification of its late developmental role in vertebrate liver organogenesis...
- DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafishShunya Hozumi
Department of Biological Science, Graduate School of Science, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan
PLoS ONE 7:e33675. 2012..Therefore, our results suggest a model in which zebrafish Ddx46 is required for the development of the digestive organs and brain, possibly through the control of pre-mRNA splicing...
- Fast homozygosity mapping and identification of a zebrafish ENU-induced mutation by whole-genome sequencingMarianne L Voz
Laboratoire de Biologie Moléculaire et de Génie Génétique, Universite de Liege, Sart Tilman, Belgium
PLoS ONE 7:e34671. 2012..In conclusion, this study constitutes a proof-of-concept that whole-genome sequencing is a fast and effective alternative to the classical positional cloning strategies in zebrafish...
- β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryosMin Zhang
State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
Development 139:2009-19. 2012..Taken together, our findings suggest that ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms...
- Zebrafish bcl2l is a survival factor in thyroid developmentImmacolata Porreca
IRGS, BIOGEM, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy
Dev Biol 366:142-52. 2012..This is the first demonstration of an active mechanism to ensure survival of the thyroid primordium during morphogenesis...
- Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesisAurélie Clément
Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Dev Dyn 241:1911-21. 2012..However, the question of whether CDC14 paralogs can functionally compensate for each other has yet to be addressed...
- The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and functionGayathri Chandrasekar
Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
PLoS ONE 8:e63123. 2013..Considering all these results, we propose an essential role for dyx1c1 in cilia growth and function...
- Laminin β1a controls distinct steps during the establishment of digestive organ lateralityTatiana Hochgreb-Hägele
Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Liver Center and Diabetes Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
Development 140:2734-45. 2013..Loss of Lamb1a function also results in aberrant protrusion of LPM cells into the gut. Collectively, our results provide cellular and molecular mechanisms by which extracellular matrix proteins regulate left-right organ morphogenesis...
- spadetail-dependent cell compaction of the dorsal zebrafish blastulaR M Warga
Abteilung für Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35, Tubingen, 72706, Germany
Dev Biol 203:116-21. 1998..This early process may be necessary for the correct location of the boundary separating axial and paraxial cells...
- Endothelial signaling in kidney morphogenesis: a role for hemodynamic forcesFabrizio C Serluca
Cardiovascular Research Center and Developmental Biology Laboratory, Boston, MA 02119, USA
Curr Biol 12:492-7. 2002..Thus, vascular flow is required for glomerular assembly, most probably acting via a stretch-responsive signaling system in the vessel wall...
- Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesisAnnie N Y Ng
Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Dev Biol 286:114-35. 2005..At 126 hpf, the posterior intestine remains an unfolded monolayer of simple columnar epithelium...
- FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulationIban Seiliez
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France
Dev Biol 290:152-63. 2006..Here, we show that, in zebrafish embryos, two transcription factors, FoxA3 and Goosecoid, coexpressed at the dorsal blastula margin, are required for the definition of anterior neural fate...
- Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cellsDavid Stafford
The Committee on Developmental Biology, The University of Chicago, 1027 East 57th Street, IL 60637, USA
Development 133:949-56. 2006..These findings suggest that RA will have important applications in the quest to induce islets from stem cells for therapeutic uses...
- Expression of the protein related to Dan and Cerberus gene--prdc--During eye, pharyngeal arch, somite, and swim bladder development in zebrafishIris I Müller
Vanderbilt University Medical Center, Division of Genetic Medicine, Nashville, Tennessee, USA
Dev Dyn 235:2881-8. 2006..Moreover, the complexity of the prdc expression pattern suggests possible roles in eye development, pharyngeal arch remodeling, somitogenesis, and swim bladder organogenesis...
- Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafishJianbo Song
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, CA 90095, USA
Dev Biol 303:561-75. 2007..Taken together, our data establish that vhnf1 acts downstream of the signaling pathways of RA, Bmp, and Fgf to regulate pancreas development in zebrafish...
- A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and developmentGang Lu
Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
Genes Dev 21:784-96. 2007..These data suggest that PP2Cm is a novel mitochondrial protein phosphatase that has a critical function in cell death and survival, and may play a role in regulating the MPTP opening...
- Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulatorsSergey Yaklichkin
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1110 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
BMC Genomics 8:201. 2007..Defining conserved functional domains that mediate the transcriptional activity of Fox proteins will contribute to a comprehensive understanding of the biological function of Fox family genes...
- Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determinationCamila V Esguerra
Center for Transgene Technology and Gene Therapy, VIB, Herestraat 49, B 3000 Leuven, Belgium
Development 134:4381-93. 2007....
- Regulation and function of foxe3 during early zebrafish developmentEric C Swindell
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genesis 46:177-83. 2008....
- Chemokine signaling controls endodermal migration during zebrafish gastrulationSreelaja Nair
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
Science 322:89-92. 2008..This process may have relevance to human gastrointestinal bifurcations and other organ defects...
- The orphan G protein-coupled receptor 161 is required for left-right patterningTinchung Leung
Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA
Dev Biol 323:31-40. 2008..Taken together, these data support a model in which gpr161 plays an essential role in left-right (L-R) patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer's vesicle...
- Hgf/c-met expression and functional analysis during zebrafish embryogenesisAndrew J Latimer
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Dev Dyn 237:3904-15. 2008..Similar to mouse, knockdown of zebrafish Met reduces liver size. Our results suggest a role for Met during endoderm specification and indicate that mechanisms of liver development are conserved between mammals and bony fish...
- Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxyZhen Zhang
Laboratory of Developmental Biology, National Heart Lung and Blood Institute, Bethesda, MD 20892 1583, USA
Proc Natl Acad Sci U S A 106:3219-24. 2009..Overall, through the recovery of an ENU-induced mutation, we uncovered Megf8 as an essential regulator of left-right patterning...
- Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryoCammon B Arrington
Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT 84112, USA
Development 136:3143-52. 2009....
- Fish-specific duplicated dmrt2b contributes to a divergent function through Hedgehog pathway and maintains left-right asymmetry establishment functionSha Liu
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Wuhan, China
PLoS ONE 4:e7261. 2009..Together, these data indicate that fish-specific duplicated dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway and maintains the common function for left-right asymmetry establishment...
- Dnmt3 and G9a cooperate for tissue-specific development in zebrafishKunal Rai
Department of Oncological Sciences, oward Hughes Medical Institute, and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
J Biol Chem 285:4110-21. 2010..We propose a model wherein specific DNMT-histone methyltransferase networks are utilized to silence critical regulators of cell fate in a tissue-specific manner...
- Pbx1 is essential for growth of zebrafish swim bladderPick Har Teoh
School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
Dev Dyn 239:865-74. 2010..The knockdown of pbx1 did not perturb the expression of prdc and foxA3, with both early swim bladder markers appearing normally at 36 and 48 hpf, respectively...
- The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafishCatherine T Nguyen
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Dev Biol 341:167-75. 2010..Taken together, these results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations...
- Nephrocystin-3 is required for ciliary function in zebrafish embryosWeibin Zhou
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
Am J Physiol Renal Physiol 299:F55-62. 2010..Thus nphp3, cooperating with nphp2/inversin, plays an essential role related to ciliary function, and the knockdown provides an animal model that may be used for studies of the pathogenesis and therapy for this disease...
- Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafishChunyue Yin
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Liver Center, University of California, San Francisco, San Francisco, CA 94158, USA
Dev Cell 18:973-84. 2010..Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis...
- Seson, a novel zinc finger protein, controls cilia integrity for the LR patterning during zebrafish embryogenesisNami Kang
Department of Biology, Chungnam National University, Daejeon 305 764, Republic of Korea
Biochem Biophys Res Commun 401:169-74. 2010..Seson function was also required for ciliogenesis in other tissues such as the pronephros and olfactory organs. Collectively, our data suggest that Seson has critical roles in ciliogenesis and LR body axis patterning...
- Restriction of hepatic competence by Fgf signalingDonghun Shin
Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
Development 138:1339-48. 2011..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
- The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypesBen Fogelgren
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS Genet 7:e1001361. 2011..Our work supports a model in which the exocyst is required for the ciliary localization of polycystin-2, thus allowing for polycystin-2 function in cellular processes...
- The zebrafish transcriptome during early developmentLiselotte Vesterlund
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
BMC Dev Biol 11:30. 2011..In this study RNA-Seq is used to compare the transcription profiles of four early developmental stages in zebrafish (Danio rerio) on a global scale...
- Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafishWei Gao
Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Beijing, People s Republic of China
PLoS ONE 6:e23386. 2011..Thus, we reveal a new and essential role for WD-repeat proteins in the determination and regulation of L-R asymmetry and propose a potential mechanism for wdr18 in the regulation of DFC clustering and migration and KV formation...
- G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesisIoannis Serafimidis
Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou 4, Athens 11527, Greece
Mol Cell Biol 31:4442-53. 2011..Finally, we identified sphingosine-1-phosphate (S1P) as a ligand mediating islet cell aggregation in both species acting through distinct but closely related receptors...
- Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreasGokhan Dalgin
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
Development 138:4597-608. 2011..In Mnx1-deficient embryos, precursor cells that are normally destined to differentiate as beta cells instead take on an alpha cell fate. Our findings suggest that Mnx1 functions to promote beta and suppress alpha cell fates...
- One-eyed pinhead regulates cell motility independent of Squint/Cyclops signalingRachel M Warga
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Dev Biol 261:391-411. 2003..We conclude that, in addition to a role in Nodal signaling, One-eyed pinhead is required for aspects of cell movement, possibly by regulating cell adhesion...
- Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascadeKaren Lunde
Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104, Freiburg, Germany
Curr Biol 14:48-55. 2004..We propose that pou5f1 plays an activating role in zebrafish endodermal development, where it maintains sox32 expression during gastrulation and acts with sox32 to induce sox17 expression in endodermal precursor cells...
- Perp is required for tissue-specific cell survival during zebrafish developmentM Nowak
Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
Cell Death Differ 12:52-64. 2005..We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival...
- Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signalingCarolyn A Zilinski
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genesis 41:33-40. 2005..In mutants with impaired hedgehog signaling, the lens placode frequently extends into more anterior ventral regions of the embryo...
- fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responsesK Anukampa Barth
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Curr Biol 15:844-50. 2005..Revealing a link between visceral and brain asymmetry and lateralized behavior, our studies help to explain the complexity of the relationship between the lateralities of visceral and neural asymmetries...
- Relationships among characiform fishes inferred from analysis of nuclear and mitochondrial gene sequencesDaniela Calcagnotto
Division of Vertebrate Zoology, American Museum of Natural History, Central Park West at 79th St, New York, NY 10024 5192, USA
Mol Phylogenet Evol 36:135-53. 2005....
- Endoderm development in vertebrates: fate mapping, induction and regional specificationKimiko Fukuda
Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minamiohsawa, Hachioji, Tokyo 192 0397, Japan
Dev Growth Differ 47:343-55. 2005..We discuss the classical fate mapping of the endoderm and the more recent progress in characterizing its induction, segregation and regional specification...
- Wnt5 signaling in vertebrate pancreas developmentHyon J Kim
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
BMC Biol 3:23. 2005..Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development...
- lessen encodes a zebrafish trap100 required for enteric nervous system developmentJacy Pietsch
Department of Biology, Emory University, Rollins Research Center, Atlanta, GA 30322, USA
Development 133:395-406. 2006..These studies demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of ENS precursors in the intestine...
- Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specificationDaniel Kopinke
University of Utah, Department of Neurobiology and Anatomy, Salt Lake City, Utah, USA
Dev Dyn 235:2695-709. 2006..These results demonstrate that the developmental processes underlying pharyngeal arch defects differ depending on when RA signaling is disturbed during development...
- Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterningXiaodong Shu
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Development 134:1921-30. 2007....
- Calcium fluxes in dorsal forerunner cells antagonize beta-catenin and alter left-right patterningIgor Schneider
Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
Development 135:75-84. 2008..As in zebrafish, manipulation of Ca(2+) release results in ectopic nuclear beta-catenin and altered laterality. Overall, our data support a conserved early Ca(2+) requirement in DFC-like cell function in zebrafish and Xenopus...
- A zebrafish model for the Shwachman-Diamond syndrome (SDS)Narayanan Venkatasubramani
Department of Pediatrics and Children s Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Pediatr Res 63:348-52. 2008..These data provide novel insight into the role of the sbds gene and support using zebrafish as a model system to study sbds gene function and for evaluation of novel therapies...