fgfr1a

Summary

Gene Symbol: fgfr1a
Description: fibroblast growth factor receptor 1a
Alias: FGFR-1-A, bFGF-R-1-A, cb231, fgfr1, sb:cb231, fibroblast growth factor receptor 1-A, basic fibroblast growth factor receptor 1-A, fibroblast growth factor receptor 1
Species: zebrafish

Top Publications

  1. doi Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression
    Andy Aman
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, 401 MREB, 20N Medical Drive, Salt Lake City, UT 84132, USA
    Dev Cell 15:749-61. 2008
  2. doi Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish
    Shunji Jia
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Biol 333:273-84. 2009
  3. ncbi Roles for Fgf signaling during zebrafish fin regeneration
    K D Poss
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, 15N 2030E, Salt Lake City, Utah, 84112, USA
    Dev Biol 222:347-58. 2000
  4. doi Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 409:705-10. 2011
  5. pmc Fgf signaling is required for photoreceptor maintenance in the adult zebrafish retina
    Sarah Hochmann
    DFG Center for Regenerative Therapies Dresden, Cluster of Excellence CRTD, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 7:e30365. 2012
  6. doi Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b
    Adriana Bosco
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR3294, Institute of Neurobiology Albert Fessard, 1 Avenue de Terrasse, 91198 Gif sur Yvette, France
    Development 140:372-84. 2013
  7. pmc Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3477-87. 2010
  8. doi Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
    Glia 58:1345-63. 2010
  9. doi Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules
    Shuizi Rachel Yu
    Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
    Nature 461:533-6. 2009
  10. doi Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication
    Nicolas Rohner
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Curr Biol 19:1642-7. 2009

Research Grants

Scientific Experts

  • Matthew P Harris
  • KATHLEEN WHITLOCK
  • Alex Nechiporuk
  • William Norton
  • Ryan Thummel
  • Nicolas Rohner
  • Michael Brand
  • Kenneth D Poss
  • Marie A Breau
  • Jan Kaslin
  • Yingzi He
  • Dongmei Tang
  • Renjie Chai
  • Huawei Li
  • Airon A Wills
  • Damian Dalle Nogare
  • Su Mei Tsai
  • Da Wei Liu
  • Tatjana Piotrowski
  • Ajay B Chitnis
  • Sarah Hochmann
  • Miho Matsuda
  • Julia Ganz
  • Laure Bally-Cuif
  • Virginie Lecaudey
  • Jonas Ries
  • Shuizi Rachel Yu
  • Wei Shi
  • Jacob M Daane
  • Junsu Kang
  • Marina Venero Galanternik
  • Sevi Durdu
  • Lola Bajard
  • Peter Koch
  • Di Yao
  • Hao Wei Han
  • Mark E Lush
  • Dong Liu
  • Mariana G Simões
  • Esther C Maier
  • Qing Sang
  • Steffen Scholpp
  • Chang Jen Huang
  • Chia Hsiung Cheng
  • Pung Pung Hwang
  • Sara Sousa
  • Wei Hao Liao
  • Patricia Rohs
  • Wei Chang Huang
  • Antonio Jacinto
  • Giulia Garaffo
  • Adriana Bosco
  • M Priyadarshini
  • Wen Pin Wang
  • Robert J Duszynski
  • David G Wilkinson
  • Qiling Xu
  • Molly J Harding
  • P K Umasankar
  • Ankita Das
  • Sandra Ernst
  • Noriko Tonou-Fujimori
  • Ana Sofia Azevedo
  • Aaron W Aday
  • Hajime Yamauchi
  • Darren Gilmour
  • Avinash Persaud
  • Stefan Hans
  • Michaela Geffarth
  • Troy Camarata
  • Satoshi Ota
  • Nobuyuki Itoh
  • Ayumi Miyake
  • Judith M Neugebauer
  • Markus Burkhardt
  • Natalia G Kan
  • Petra Schwille
  • Robert Esterberg
  • Shunji Jia
  • Yoshiaki Nakayama
  • Christian Stigloher
  • Stefanie Topp
  • A Smith
  • Andy Aman
  • Christoph Leucht
  • Akinori Kawamura
  • Hayato Yokoi
  • Donghun Shin
  • Yoshikazu Hirate
  • Chris Hall

Detail Information

Publications75

  1. doi Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression
    Andy Aman
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, 401 MREB, 20N Medical Drive, Salt Lake City, UT 84132, USA
    Dev Cell 15:749-61. 2008
    ..Although the Fgf, Wnt/beta-catenin, and chemokine signaling pathways are well known to be involved in cancer progression, these studies provide in vivo evidence that these pathways are functionally linked...
  2. doi Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish
    Shunji Jia
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Biol 333:273-84. 2009
    ..Thus, Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis...
  3. ncbi Roles for Fgf signaling during zebrafish fin regeneration
    K D Poss
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, 15N 2030E, Salt Lake City, Utah, 84112, USA
    Dev Biol 222:347-58. 2000
    ..We find that fibroblast growth factor receptor 1 (fgfr1) is expressed in mesenchymal cells underlying the wound epidermis during blastema formation ..
  4. doi Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 409:705-10. 2011
    ..However, the proliferation and apoptosis of cranial neural crest cells were essentially unchanged. Fgfr1 knockdown embryos also showed dysplastic neurocranial and pharyngeal cartilages...
  5. pmc Fgf signaling is required for photoreceptor maintenance in the adult zebrafish retina
    Sarah Hochmann
    DFG Center for Regenerative Therapies Dresden, Cluster of Excellence CRTD, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 7:e30365. 2012
    ..Ultimately, rod and cone photoreceptors are regenerated completely. Our study reveals the requirement of Fgf signaling to maintain photoreceptors and for proliferation during regeneration in the adult zebrafish retina...
  6. doi Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b
    Adriana Bosco
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR3294, Institute of Neurobiology Albert Fessard, 1 Avenue de Terrasse, 91198 Gif sur Yvette, France
    Development 140:372-84. 2013
    ..Our results highlight a novel role for Etv5b in neuronal development and provide support for the existence of a developmental heterogeneity among 5-HT neurons in their requirement for ETS-domain transcription factors...
  7. pmc Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3477-87. 2010
    ..in the central cell, it drives expression of fgf10 and of the Notch ligand deltaD, while it inhibits expression of fgfr1. As a source of Fgf10, the central cell activates the FGF pathway in neighboring cells, ensuring that they form ..
  8. doi Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
    Glia 58:1345-63. 2010
    ....
  9. doi Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules
    Shuizi Rachel Yu
    Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
    Nature 461:533-6. 2009
    ..Our results demonstrate that a freely diffusing morphogen can set up concentration gradients in a complex multicellular tissue by a simple source-sink mechanism...
  10. doi Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication
    Nicolas Rohner
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Curr Biol 19:1642-7. 2009
    ..The affected gene is fibroblast growth factor receptor 1 (fgfr1), which is known to have an essential embryonic function in vertebrate development...
  11. pmc Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy
    Natalia G Kan
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    FASEB J 23:3516-25. 2009
    ....
  12. doi Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium
    Virginie Lecaudey
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Development 135:2695-705. 2008
    ..Furthermore, this work uncovers a surprising link between internal tissue organization and collective migration...
  13. doi FGF-dependent mechanosensory organ patterning in zebrafish
    Alex Nechiporuk
    University of Washington, School of Medicine, Department of Biological Structure, Seattle, WA 98195 7420, USA
    Science 320:1774-7. 2008
    ..This previously unrecognized mechanism may be applicable to understanding segmentation and morphogenesis in other organ systems...
  14. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  15. ncbi Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Danio rerio
    Noriko Tonou-Fujimori
    Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo okubo, Saitama City, Saitama 338 8570, Japan
    Mech Dev 119:S173-8. 2002
    ..We compared the expression of the four fgfr genes (fgfr1-4) in the CNS of zebrafish embryos and show that fgfr1 is the only fgfr gene that is expressed in the dorsal ..
  16. ncbi Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics, Department of Genetics, University of Technology TU, 01307, Dresden, Germany
    Dev Genes Evol 214:285-95. 2004
    ..Here, we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1)...
  17. ncbi Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites
    A Sawada
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Development 127:1691-702. 2000
    ..a reduction in expression of the posterior genes, myoD and notch5, with uniform expression of the anterior genes, FGFR1, papc and notch6...
  18. ncbi Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 132:3717-30. 2005
    ..Based on these findings, we propose a model for epibranchial placode development in which Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis...
  19. ncbi Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish
    Julie A Groves
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Development 132:4211-22. 2005
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  20. ncbi Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:5173-83. 2005
    ..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage...
  21. ncbi Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb
    Ryan Thummel
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Dev Dyn 235:336-46. 2006
    ..Morpholino oligonucleotides against fgfr1 and msxb were utilized and knock-down of both proteins resulted in reduced fin outgrowth...
  22. ncbi Fgf19 is required for zebrafish lens and retina development
    Yoshiaki Nakayama
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 313:752-66. 2008
    ..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish...
  23. pmc ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/β-catenin
    Mark E Lush
    Stowers Institute for Medical Research, Kansas City, United States
    elife 3:e01832. 2014
    ..DOI: http://dx.doi.org/10.7554/eLife.01832.001. ..
  24. pmc Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways
    Dongmei Tang
    Department of Otorhinolaryngology, Affiliated Eye and ENT Hospital of Fudan University Shanghai, China
    Front Mol Neurosci 9:39. 2016
    ..Thus H3K9me2 plays a critical role in HC regeneration. ..
  25. doi Neuronal expression of fibroblast growth factor receptors in zebrafish
    Patricia Rohs
    Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Canada
    Gene Expr Patterns 13:354-61. 2013
    ..through a family of four fibroblast growth factor receptors (FGFR 1-4), one of which is duplicated in zebrafish (FGFR1)...
  26. pmc A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling
    Marie A Breau
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 110:16892-7. 2013
    ....
  27. pmc Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome
    Giulia Garaffo
    Department of Molecular Biotechnology and Health Science, University of Torino, Torino, Italy
    Front Endocrinol (Lausanne) 4:203. 2013
    ..A number of candidate will be discussed, that should be tested in future mutation screens. ..
  28. pmc The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor
    Hao Wei Han
    Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    PLoS ONE 9:e86345. 2014
    ..We thus suggest that a novel Nogo-C2 complex, consisting of Nogo-C2, NgRH1a, p75, and TROY, regulates Fgf signaling and dkk1b expression, thereby ensuring stable organization of the PLL primordium. ..
  29. pmc Wnt-regulated dynamics of positional information in zebrafish somitogenesis
    Lola Bajard
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Development 141:1381-91. 2014
    ..The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information. ..
  30. pmc Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration
    Marina Venero Galanternik
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84112, USA
    Cell Rep . 2015
    ..The HSPGs themselves are regulated by the Wnt/β-catenin and Fgf pathways and thus are integral components of the regulatory network that coordinates collective cell migration with organ specification and morphogenesis...
  31. pmc Modulation of tissue repair by regeneration enhancer elements
    Junsu Kang
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 532:201-6. 2016
    ..Our findings provide evidence for 'tissue regeneration enhancer elements' (TREEs) that trigger gene expression in injury sites and can be engineered to modulate the regenerative potential of vertebrate organs. ..
  32. doi Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42
    Qing Sang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200032, PR China, Institutes of Biomedical Sciences, Fudan University, No 138 Yixueyuan Road, Shanghai 200032, PR China
    Hum Mol Genet 23:6201-11. 2014
    ..We concluded that Ildr1b is crucial for the development of the inner ear and the lateral line system. This study provides the first evidence for the mechanism of Ildr1b on hearing in vivo and sheds light on the pathology of DFNB42. ..
  33. doi Dissecting the differentiation process of the preplacodal ectoderm in zebrafish
    Di Yao
    The Education Ministry Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio membrane and Membrane Bio engineering, School of Life Sciences, Peking University, Beijing, China
    Dev Dyn 243:1338-51. 2014
    ..The preplacodal region (PPR) is a region of specialized ectoderm at the border of neural and nonneural ectoderm (NNE). Coordinated Bmp, Fgf, and Wnt signals are known to drive PPR development; however, the underlying mechanism is unknown...
  34. doi ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon
    Wei Shi
    Key Laboratory of the Ministry of Education for Experimental Teratology Shandong Provincial Key Laboratory of Mental Disorders, Department of Histology and Embryology, Shandong University School of Medicine, No 44, Wenhua Xi Road, Jinan, Shandong, 250012, PR China
    Dev Neurobiol 76:1014-28. 2016
    ..2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1014-1028, 2016. ..
  35. pmc Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies
    Jacob M Daane
    Department of Genetics, Harvard Medical School, Boston, MA Department of Orthopaedic Research, Boston Children s Hospital, Boston, MA
    Mol Biol Evol 33:162-73. 2016
    ..Using our analysis pipeline, we show that duplication and divergence of fgfr1a is correlated with the reduction of scales within fishes of the genus Phoxinellus...
  36. pmc Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium
    Damian Dalle Nogare
    Section on Neural Developmental Dynamics, Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2790, USA
    Development 141:3188-96. 2014
    ....
  37. doi Luminal signalling links cell communication to tissue architecture during organogenesis
    Sevi Durdu
    European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 515:120-4. 2014
    ....
  38. pmc RA and FGF signalling are required in the zebrafish otic vesicle to pattern and maintain ventral otic identities
    Esther C Maier
    MRC Centre for Developmental and Biomedical Genetics, Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    PLoS Genet 10:e1004858. 2014
    ..In addition, our results indicate that FGF and RA signalling act in a feedback loop in the anterior OV, crucial for pattern refinement. ..
  39. doi HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish
    Yingzi He
    Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People s Republic of China
    Mol Neurobiol 53:5103-17. 2016
    ..Our results indicate that HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development. ..
  40. pmc A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons
    Peter Koch
    Developmental Biology, Institute Biology I, Faculty of Biology University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    PLoS ONE 9:e113829. 2014
    ..Our data indicate that attenuation of Cnot8 activity differentially affects mRNA levels of developmental control genes. ..
  41. pmc Denervation impairs regeneration of amputated zebrafish fins
    Mariana G Simões
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649 028, Lisboa, Portugal
    BMC Dev Biol 14:49. 2014
    ..Although some candidate factors have been proposed to mediate the nerve dependency of regeneration, the molecular mechanisms involved in this process remain unclear...
  42. pmc Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
    Avinash Persaud
    Programs in Cell Biology and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    EMBO J 30:3259-73. 2011
    b>Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis...
  43. pmc Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning
    P K Umasankar
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Nat Cell Biol 14:488-501. 2012
    ..Still, the fcho1 morphant phenotype is distinct from severe embryonic defects apparent when AP-2 is depleted. Our data thus challenge the primacy of FCHO1/2 in coat initiation...
  44. pmc Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest
    Ankita Das
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 8:e1002710. 2012
    ..Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest...
  45. pmc Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium
    Marie A Breau
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London NW7 1AA, UK
    Development 139:2246-53. 2012
    ..These findings reveal a novel chemotactic role for Fgf signalling in which it enables the coalescence of the lateral line primordium from an initial fuzzy pattern into a compact group of migrating cells...
  46. doi Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish
    Su Mei Tsai
    Institute of Medical Sciences, Tzu Chi University, No 701, Section 3, Chung Yang Road, Hualien, 970, Taiwan
    Transgenic Res 22:301-14. 2013
    ..Disruption of the Fgf signal-mediated metabolism might indirectly affect hepatocyte proliferation...
  47. pmc Fgfr-Ras-MAPK signaling is required for apical constriction via apical positioning of Rho-associated kinase during mechanosensory organ formation
    Molly J Harding
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Development 139:3130-5. 2012
    ..This mechanism presents a novel cellular strategy for driving cell shape changes...
  48. pmc An amputation resets positional information to a proximal identity in the regenerating zebrafish caudal fin
    Ana Sofia Azevedo
    Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisbon, 1649 028, Portugal
    BMC Dev Biol 12:24. 2012
    ..We investigated the existence of positional information for bifurcation formation by performing repeated amputations at different proximal-distal places along the fin...
  49. doi Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish
    Sandra Ernst
    Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, D 79104 Freiburg, Germany
    Development 139:4571-81. 2012
    ..In conclusion, we uncovered the first mechanistic link between patterning and morphogenesis during LL sensory organ formation...
  50. pmc Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration
    Robert J Duszynski
    Department of Biological Sciences, DePaul University, Chicago, IL 60614, USA
    Dev Growth Differ 55:282-300. 2013
    ..Multiple FGF ligands (fgf20a, fgf24), receptors (fgfr1-4) and downstream targets (pea3, il17d) are expressed in normal and regenerating barbel tissue, confirming FGF ..
  51. pmc Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling
    Wei Hao Liao
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 104, Taiwan
    Cell Mol Life Sci 70:2367-81. 2013
    ..Moreover, Ptpro physically interacted with the Fgf receptor 1a (Fgfr1a) and dephosphorylated Fgfr1a in a dose-dependant manner...
  52. doi A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling
    M Priyadarshini
    Neuroscience center and Institute of Biomedicine Anatomy, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    Neurobiol Dis 54:127-38. 2013
    ..Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway...
  53. pmc Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafish
    Da Wei Liu
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    PLoS ONE 8:e58310. 2013
    ..Although fibroblast growth factor (Fgf) signaling is important for cell proliferation and differentiation in various tissues, its role in intestinal differentiation is less well understood...
  54. pmc Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish
    Wei Chang Huang
    Department of Medical Science and Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan
    PLoS ONE 8:e66613. 2013
    ..Our findings may help to clarify the initiation of cardiac repair, which could be used to develop a therapeutic intervention that may enhance cardiac repair in humans to compensate for the loss of cardiomyocytes after an MI. ..
  55. ncbi An essential role for zebrafish Fgfrl1 during gill cartilage development
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, P O 92019, Auckland, New Zealand
    Mech Dev 123:925-40. 2006
    ..A duplicate zebrafish gene, fgfrl1b, has now been identified. We show that Fgfrl1b is also required for proper formation of all ventral cartilage elements and acts cooperatively with Fgfrl1a during gill cartilage formation...
  56. doi Gene expression analysis on sections of zebrafish regenerating fins reveals limitations in the whole-mount in situ hybridization method
    A Smith
    Ottawa Health Research Institute, Ottawa, ON, Canada
    Dev Dyn 237:417-25. 2008
    ....
  57. ncbi Specification of epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 134:611-23. 2007
    ..The coordinated interplay between craniofacial tissues would thus assure proper spatial and temporal interactions in the shaping of the vertebrate head...
  58. ncbi Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships
    Hayato Yokoi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Biol 304:326-37. 2007
    ..Positional-candidate cloning revealed that the hdf mutation causes a functionally null form of Fgfr1. The fgfr1hdf is thus the first fgf receptor mutant in fish...
  59. ncbi Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:183-92. 2008
    ..Our results demonstrate that the adult zebrafish ventricle grows and is maintained by cardiomyocyte hyperplasia, and that epicardial cells are added to the ventricle in an Fgf-dependent fashion to support homeostasis...
  60. doi Modular scanning FCS quantifies receptor-ligand interactions in living multicellular organisms
    Jonas Ries
    Biotechnology Center, Technical University of Dresden, Dresden, Germany
    Nat Methods 6:643-5. 2009
    ..We quantified the mobility of fibroblast growth factor receptors Fgfr1 and Fgfr4 in cell membranes of living zebrafish embryos and determined their in vivo binding affinities to their ..
  61. ncbi Development of GnRH cells: Setting the stage for puberty
    K E Whitlock
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, United States
    Mol Cell Endocrinol 254:39-50. 2006
    ..Thus the signaling of the GnRH neuronal circuitry is set up early in development laying the foundation for the GnRH network that is activated at puberty leading to reproductive function in the mature animal...
  62. ncbi Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling
    Morgane Poulain
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Development 133:2189-200. 2006
    ..These results identify a molecular mechanism whereby FGF attenuates Nodal-induced endodermal transcription factors and highlight a potential mechanism whereby mesoderm and endoderm fates could segregate from each other...
  63. pmc Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish
    Peter E Bayliss
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Chem Biol 2:265-73. 2006
    ..This study illustrates the utility of the adult zebrafish as a new model system for receptor signaling and chemical biology...
  64. ncbi Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish
    Yoshikazu Hirate
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    Curr Biol 16:421-7. 2006
    ..Cnpy1 is localized in the endoplasmic reticulum and interacts with FGFR1. This study highlights a positive-feedback loop between the FGFR pathway and Cnpy1 that may ensure the strength of ..
  65. ncbi Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signaling
    Yuta Komoike
    Department of Biology, School of Education and in Integrated Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University, 1 6 1 Nishi Waseda, Shinjuku, Tokyo 169 8050, Japan
    Biochem Biophys Res Commun 328:858-66. 2005
    ..Treatment with SU5402, an inhibitor of Fgfrs, or injection of dominant-negative Fgfr1 DNA markedly reduced ph2alpha expression in the tailbud...
  66. doi MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary
    Christoph Leucht
    Department of Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Nat Neurosci 11:641-8. 2008
    ..Together, these findings highlight a previously unknown mechanism by which a single microRNA fine-tunes late MHB coherence via its co-regulation of patterning activities and neurogenesis...
  67. doi Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation
    Stefanie Topp
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Department Zebrafish Neurogenetics, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    J Comp Neurol 510:422-39. 2008
    ..We report expression of Fgf signals (fgf3,4,8a,8b,17b), receptors (fgfr1-4), and targets (erm, pea3, dusp6, spry1,2,4, and P-ERK) and document that genes of the embryonic fgf8 ..
  68. pmc Fgfs control homeostatic regeneration in adult zebrafish fins
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:3063-70. 2008
    ..Our experiments reveal that the facultative machinery that regenerates amputated teleost fins also has a surprisingly vigorous role in homeostatic regeneration...
  69. pmc dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity
    Robert Esterberg
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Dev Biol 325:189-99. 2009
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction...
  70. pmc FGF signalling during embryo development regulates cilia length in diverse epithelia
    Judith M Neugebauer
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 458:651-4. 2009
    ..Morpholino knockdown of FGF receptor 1 (Fgfr1) in zebrafish cell-autonomously reduces cilia length in Kupffer's vesicle and perturbs directional fluid flow ..
  71. doi Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche
    Jan Kaslin
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany
    J Neurosci 29:6142-53. 2009
    ..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates...
  72. pmc Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, Chicago, IL 60614, USA
    BMC Dev Biol 10:104. 2010
    ..This Tbx5 regulation is critical in heart formation, but the coexpression of both proteins in other developing tissues suggests a broader functional role...
  73. doi FGF receptor gene expression and its regulation by FGF signaling during early zebrafish development
    Satoshi Ota
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama, Japan
    Genesis 48:707-16. 2010
    ..b>fgfr1 alone was expressed maternally throughout the blastoderm, and then zygotically in the anterior neural plate and ..
  74. pmc Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites
    Aaron W Aday
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01602, USA
    Dev Biol 357:450-62. 2011
    ....
  75. doi Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome
    William H J Norton
    Zebrafish Neurogenetics, Laboratory of Neurobiology and Development, Institut de Neurobiologie Alfred Fessard, Unité Propre de Recherche 3294, CNRS, Avenue de la Terrasse, Gif sur Yvette, 91190, France
    J Neurosci 31:13796-807. 2011
    ..Here we show that mutation of the gene encoding fibroblast growth factor receptor 1a (fgfr1a) simultaneously increases aggression, boldness, and exploration in adult zebrafish...

Research Grants3

  1. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  2. Development of Epibranchial Placodes and Ganglia in Zebrafish
    Alex Nechiporuk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ....