etv5b

Summary

Gene Symbol: etv5b
Description: ets variant 5b
Alias: cb805, erm, erm1, wu:fe05h04, wu:fj66a04, ets variant 5b, ets related protein erm
Species: zebrafish

Top Publications

  1. doi Expression and function of the Ets transcription factor pea3 during formation of zebrafish pronephros
    Qiuxia Chen
    Department of Nephrology, Nanjing Children s Hospital, Nanjing Medical University, Nanjing, 210008, People s Republic of China
    Pediatr Nephrol 26:391-400. 2011
  2. ncbi Endocytosis controls spreading and effective signaling range of Fgf8 protein
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics and Department of Genetics, Dresden University of Technology, D 01307 Dresden, Germany
    Curr Biol 14:1834-41. 2004
  3. doi Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b
    Adriana Bosco
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR3294, Institute of Neurobiology Albert Fessard, 1 Avenue de Terrasse, 91198 Gif sur Yvette, France
    Development 140:372-84. 2013
  4. pmc A spatial and temporal gradient of Fgf differentially regulates distinct stages of neural development in the zebrafish inner ear
    Shruti Vemaraju
    Biology Department, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 8:e1003068. 2012
  5. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
  6. ncbi sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth
    Steven A Harvey
    Division of Developmental Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Development 133:1165-73. 2006
  7. pmc Conditions that influence the response to Fgf during otic placode induction
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 364:1-10. 2012
  8. ncbi Retinoic acid activates myogenesis in vivo through Fgf8 signalling
    Aline Hamade
    UMR866 Différenciation Cellulaire et Croissance, INRA, Montpellier, France
    Dev Biol 289:127-40. 2006
  9. ncbi HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development
    William H J Norton
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 132:4963-73. 2005
  10. ncbi Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish
    Julie A Groves
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Development 132:4211-22. 2005

Scientific Experts

  • Yona Goldshmit
  • Marion Coolen
  • Donghun Shin
  • BRUCE RILEY
  • H Roehl
  • Stefan Hans
  • Isabelle Manfroid
  • Lisa Maves
  • B Frank Eames
  • Sabine Fischer
  • Steffen Scholpp
  • Kenneth D Poss
  • Michael J Jurynec
  • Laure Bally-Cuif
  • Michael Brand
  • Yukiko Nakayama
  • Mahesh S Padanad
  • Alexei Nechiporuk
  • Rosa Gonzalez-Quevedo
  • Carl J Neumann
  • Julia Ganz
  • Yoonsung Lee
  • Jan Kaslin
  • Zoltan Spiro
  • Mingyu Li
  • Wei Shi
  • Jingyun Li
  • Charanya Rengarajan
  • Xuemei Chen
  • Peter Koch
  • Lola Bajard
  • Adriana Bosco
  • Cheng Yung Lin
  • Joshua A Clanton
  • Xiuning Le
  • Wei Hao Liao
  • Qingshun Zhao
  • Mai E Nguyen-Chi
  • Christoph Winkler
  • Goo Young Kim
  • Shruti Vemaraju
  • Javier Terriente
  • Kyo Yamasu
  • Akinori Kawamura
  • Sizhou Huang
  • Airon A Wills
  • Mollie R Johnson Sorrell
  • Elewys G Lightman
  • Aurélie Clément
  • Neha Bhat
  • Aaron W Aday
  • Qiuxia Chen
  • David G Wilkinson
  • Benjamin L Martin
  • Satoshi Ota
  • Jing Zhang
  • Troy Camarata
  • Wade A Znosko
  • Virginie Esain
  • Hye Joo Kwon
  • Robert Esterberg
  • Junhao Mao
  • Carrie McMahon
  • Judith M Neugebauer
  • David Jonah Grunwald
  • Saradavey Vinothkumar
  • Daniel Liedtke
  • Johan Ledin
  • Stefanie Topp
  • Burcu Guner
  • Heiner Grandel
  • Rolf O Karlstrom
  • Stephen W Wilson
  • Steven A Harvey
  • Isabelle Foucher
  • Tor Linbo
  • Anandita Seth
  • David W Raible
  • Chris Hall
  • Myriam Roussigne
  • Aline Hamade
  • Nadia Mercader
  • Marlene J Rau
  • Julie A Groves
  • William H J Norton
  • Bryan T Phillips
  • Martin Paukert
  • Yao Yao
  • Xueran Chen
  • Fen Wang

Detail Information

Publications76

  1. doi Expression and function of the Ets transcription factor pea3 during formation of zebrafish pronephros
    Qiuxia Chen
    Department of Nephrology, Nanjing Children s Hospital, Nanjing Medical University, Nanjing, 210008, People s Republic of China
    Pediatr Nephrol 26:391-400. 2011
    ..in zebrafish embryos after pea3 messenger RNA (mRNA) overexpression and inhibition of double-target genes (pea3 and erm, another member of the PEA3 subfamily) by antisense morpholino-oligonucleotides (MO)...
  2. ncbi Endocytosis controls spreading and effective signaling range of Fgf8 protein
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics and Department of Genetics, Dresden University of Technology, D 01307 Dresden, Germany
    Curr Biol 14:1834-41. 2004
    ....
  3. doi Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b
    Adriana Bosco
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR3294, Institute of Neurobiology Albert Fessard, 1 Avenue de Terrasse, 91198 Gif sur Yvette, France
    Development 140:372-84. 2013
    ..overexpression experiments, we demonstrate that Fgf signalling acts via another ETS-domain transcription factor, Etv5b (Erm), to induce hypothalamic 5-HT neurons...
  4. pmc A spatial and temporal gradient of Fgf differentially regulates distinct stages of neural development in the zebrafish inner ear
    Shruti Vemaraju
    Biology Department, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 8:e1003068. 2012
    ..Thus Fgf signaling renders SAG development self-regulating, ensuring steady production of an appropriate number of neurons as the larva grows...
  5. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
    ..We previously suggested that Foxi1 and Dlx3b may provide competence to form the ear because loss of both foxi1 and dlx3b results in ablation of all otic tissue even in the presence of a fully functional Fgf signaling pathway...
  6. ncbi sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth
    Steven A Harvey
    Division of Developmental Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Development 133:1165-73. 2006
    ..Our studies of Sall gene family redundancy and tbx5 offer explanations for the similarity of individuals with OS and HOS limb defects...
  7. pmc Conditions that influence the response to Fgf during otic placode induction
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 364:1-10. 2012
    ..These findings document the variables critically affecting the response to Fgf and clarify the roles of foxi1 and pax2/8 in the otic response...
  8. ncbi Retinoic acid activates myogenesis in vivo through Fgf8 signalling
    Aline Hamade
    UMR866 Différenciation Cellulaire et Croissance, INRA, Montpellier, France
    Dev Biol 289:127-40. 2006
    ..We propose that, in the developing embryo, localised synthesis of RA by Raldh2 in the anterior psm and in somites activates fgf8 expression which in turn induces the expression of myogenic genes and fast muscle differentiation...
  9. ncbi HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development
    William H J Norton
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 132:4963-73. 2005
    ..This reveals an unexpected specificity of HSPGs in regulating distinct vertebrate Fgfs...
  10. ncbi Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish
    Julie A Groves
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Development 132:4211-22. 2005
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  11. pmc Brachyury establishes the embryonic mesodermal progenitor niche
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 24:2778-83. 2010
    ..Thus, the embryonic mesodermal progenitors uniquely establish their own niche--with Brachyury being essential for creating a domain of high Wnt and low RA signaling--rather than having a niche created by separate support cells...
  12. pmc Identification of early requirements for preplacodal ectoderm and sensory organ development
    Hye Joo Kwon
    Biology Department, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 6:e1001133. 2010
    ....
  13. ncbi Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics, Department of Genetics, University of Technology TU, 01307, Dresden, Germany
    Dev Genes Evol 214:285-95. 2004
    ..The expression patterns of fgfr1 and fgf8 are strikingly similar and knock-down of fgfr1 phenocopies many aspects observed in the fgf8 mutant acerebellar, suggesting that Fgf8 exerts its function mainly by binding to FgfR1...
  14. pmc FGF-receptor signalling controls neural cell diversity in the zebrafish hindbrain by regulating olig2 and sox9
    Virginie Esain
    INSERM, U784, Laboratoire de Génétique Moléculaire du Développement, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 137:33-42. 2010
    ..Overall, for the first time in vivo, our results reveal a mechanism of FGF in the control of neural cell diversity...
  15. ncbi A direct role for Fgf but not Wnt in otic placode induction
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 131:923-31. 2004
    ..We propose that Wnt8 serves to regulate timely expression of Fgf3 and Fgf8 in the hindbrain, and that Fgf from the hindbrain then acts directly on preplacodal cells to induce otic differentiation...
  16. pmc FGF signalling during embryo development regulates cilia length in diverse epithelia
    Judith M Neugebauer
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 458:651-4. 2009
    ..We propose that a subset of developmental defects and diseases ascribed to FGF signalling are due in part to loss of cilia function...
  17. ncbi The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation
    Sabine Fischer
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 130:3515-24. 2003
    ..We also show that fgf24 activity is necessary for the migration of tbx5-expressing cells to the fin bud, and for the activation of shh, but not hand2, expression in the posterior fin bud...
  18. ncbi Expression of the Ets transcription factors erm and pea3 in early zebrafish development
    S R Münchberg
    Department of Cell Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076, Tubingen, Germany
    Mech Dev 88:233-6. 1999
    Here we report the cloning of zebrafish erm and pea3 cDNAs, which are members of the PEA3 subgroup of Ets transcription factors. The expression patterns of these two genes were examined during zebrafish embryogenesis...
  19. ncbi Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development
    F Raible
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Mech Dev 107:105-17. 2001
    ..Here we study Erm and Pea3, two ETS domain transcription factors, and show that their expression correlates closely with the domains ..
  20. ncbi Zebrafish pea3 and erm are general targets of FGF8 signaling
    H Roehl
    Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35 III, D 72076, Tubingen, Germany
    Curr Biol 11:503-7. 2001
    ..Here, we propose that two zebrafish ETS genes, pea3 and erm, are general targets of FGF8 signaling, based upon the following observations: both genes are expressed around all ..
  21. pmc dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity
    Robert Esterberg
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Dev Biol 325:189-99. 2009
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction...
  22. doi Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner
    Yukiko Nakayama
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama City, Saitama 338 8570, Japan
    Mech Dev 130:532-52. 2013
    ....
  23. pmc Normal function of Myf5 during gastrulation is required for pharyngeal arch cartilage development in zebrafish embryos
    Cheng Yung Lin
    Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    Zebrafish 10:486-99. 2013
    ..Together, the loss of Myf5 function results in a cascade effect that begins with abnormal formation of the dorsal organizer during gastrulation, causing, in turn, defects in the CNC and cranial cartilage of myf5-knockdown embryos...
  24. pmc Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling
    Charanya Rengarajan
    Karlsruhe Institute of Technology KIT, Institute of Toxicology and Genetic ITG, Karlsruhe, Germany
    PLoS ONE 9:e86373. 2014
    ..Therefore, we hypothesize that Fgf8 receiving cells control both, the propagation width and the signal strength of the morphogen. ..
  25. pmc Wnt-regulated dynamics of positional information in zebrafish somitogenesis
    Lola Bajard
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Development 141:1381-91. 2014
    ..The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information. ..
  26. pmc Characterization of zebrafish Pax1b and Pax9 in fin bud development
    Xuemei Chen
    Faculty of Basic Medical Sciences, Chongqing Medical University, Medical College Road 1, Chongqing 400016, China Emergency Department, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing 400042, China
    Biomed Res Int 2014:309385. 2014
    ..Together, this evidence for cell death caused by pax1b knockdown provides new insight into the role of the Pax protein family in cell fate determination and tissue specification. ..
  27. pmc A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons
    Peter Koch
    Developmental Biology, Institute Biology I, Faculty of Biology University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    PLoS ONE 9:e113829. 2014
    ..Our data indicate that attenuation of Cnot8 activity differentially affects mRNA levels of developmental control genes. ..
  28. pmc Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly
    Jingyun Li
    From the MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, China and the Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Care Hospital Affiliated with Nanjing Medical University, Nanjing 210004, China
    J Biol Chem 290:10216-28. 2015
    ..Taken together, our results demonstrate that foxc1a plays an essential role in early somitogenesis by controlling Fgf and Notch signaling through restricting the expression of aldh1a2 in paraxial mesoderm directly. ..
  29. pmc FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation
    Mingyu Li
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN
    Diabetes 65:96-109. 2016
    ..Thus, the recently discovered antidiabetes function of FGF1 may act partially through increasing β-cell differentiation...
  30. doi ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon
    Wei Shi
    Key Laboratory of the Ministry of Education for Experimental Teratology Shandong Provincial Key Laboratory of Mental Disorders, Department of Histology and Embryology, Shandong University School of Medicine, No 44, Wenhua Xi Road, Jinan, Shandong, 250012, PR China
    Dev Neurobiol 76:1014-28. 2016
    ..2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1014-1028, 2016. ..
  31. pmc Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish
    Zoltan Spiro
    Department of Biological Sciences, National University of Singapore, Singapore
    Sci Rep 6:27470. 2016
    ..In addition, we identified the ETS family transcription factor Etv5b to be responsible for increased smn transcription in motoneurons...
  32. ncbi FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain
    Lisa Maves
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Development 129:3825-37. 2002
    ..Taken together, our findings demonstrate a crucial role for FGF-mediated inter-rhombomere signaling in promoting early hindbrain patterning and underscore the significance of organizing centers in patterning the vertebrate neural plate...
  33. pmc Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Diabetes Center and Liver Center, University of California, San Francisco, CA 94158, USA
    Mech Dev 128:525-35. 2012
    ..Altogether, these studies reveal that there is more than one way to form a liver, and provide molecular insights into the phenomenon of tissue plasticity...
  34. pmc Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling
    Sabine Fischer
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    BMC Dev Biol 11:53. 2011
    ..However, potential roles for HS biosynthesis in regulating the function of paracrine signaling molecules that bind to HS are incompletely understood...
  35. doi miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors
    Marion Coolen
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR 3294, Institute of Neurobiology Alfred Fessard, 91198 Gif sur Yvette Cedex, France
    Dev Cell 22:1052-64. 2012
    ....
  36. doi Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish
    Yona Goldshmit
    Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia
    J Neurosci 32:7477-92. 2012
    ..This suggests that differential Fgf regulation, rather than intrinsic cell differences, underlie the distinct responses of mammalian and zebrafish glia to injury...
  37. pmc Signalling from hindbrain boundaries regulates neuronal clustering that patterns neurogenesis
    Javier Terriente
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 139:2978-87. 2012
    ..Sema3 signalling from boundaries thus links hindbrain segmentation to the positioning of fgf20a-expressing neurons that regulates neurogenesis...
  38. pmc HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8
    Goo Young Kim
    Department of Medical Life Sciences, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
    Mol Cell Biol 32:4482-92. 2012
    ..Furthermore, this study offers insight into new strategies to control human diseases associated with HtrA1 and FGF signaling...
  39. pmc Morphogenesis and cell fate determination within the adaxial cell equivalence group of the zebrafish myotome
    Mai E Nguyen-Chi
    Australian Regenerative Medicine Institute, Monash University, Clayton, Australia
    PLoS Genet 8:e1003014. 2012
    ..Thus our results reveal that the synergistic actions of HH, FGF, and BMP signaling independently create a three-dimensional (3D) signaling milieu that coordinates cell fate within the adaxial cell equivalence group...
  40. pmc Fgf signaling governs cell fate in the zebrafish pineal complex
    Joshua A Clanton
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37205, USA
    Development 140:323-32. 2013
    ..We conclude that this subset of anterior pineal complex precursors, which normally become parapineal cells, are bipotential and require Fgf8a to maintain parapineal identity and/or prevent cone identity...
  41. pmc Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling
    Wei Hao Liao
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 104, Taiwan
    Cell Mol Life Sci 70:2367-81. 2013
    ..Therefore, our findings demonstrate that Ptpro activity is required for patterning the zebrafish embryonic brain. Specifically, Ptpro regulates cerebellar formation during zebrafish development through modulating Fgf signaling...
  42. pmc A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development
    Xiuning Le
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 140:2354-64. 2013
    ..Our work demonstrates that the activated pathways in RAS induction during embryogenesis are also important in oncogenesis and that inhibition of these pathways suppresses tumor growth...
  43. pmc UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton
    B Frank Eames
    Institute of Neuroscience, 1254 University of Oregon, Eugene OR 97403 1254, USA
    Dev Biol 341:400-15. 2010
    ....
  44. ncbi Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction
    Nadia Mercader
    European Molecular Biology Laboratory EMBL Heidelberg, Germany
    Development 133:2805-15. 2006
    ..tbx5 is required for Fgf signaling in the limb bud leading to activation of prdm1 expression, which in turn is required for downstream activation of fgf10 expression...
  45. ncbi Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development
    Marlene J Rau
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 296:83-93. 2006
    ..Mediator is a coactivator complex transducing the interaction of DNA-binding transcription factors with RNA polymerase II, and our results reveal a critical function of the Trap230 subunit as a coactivator for Sox9...
  46. ncbi Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants
    Isabelle Foucher
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 9RT, UK
    Development 133:1891-900. 2006
    ..This maintenance is enough to allow cerebellar differentiation...
  47. ncbi An essential role for zebrafish Fgfrl1 during gill cartilage development
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, P O 92019, Auckland, New Zealand
    Mech Dev 123:925-40. 2006
    ..A duplicate zebrafish gene, fgfrl1b, has now been identified. We show that Fgfrl1b is also required for proper formation of all ventral cartilage elements and acts cooperatively with Fgfrl1a during gill cartilage formation...
  48. ncbi Specification of epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 134:611-23. 2007
    ..The coordinated interplay between craniofacial tissues would thus assure proper spatial and temporal interactions in the shaping of the vertebrate head...
  49. ncbi Divergence in regulation of the PEA3 family of ETS transcription factors
    Myriam Roussigne
    Centre de Biologie du Développement UMR5547, Universite Paul Sabatier, Bat 4R3, 118, route de Narbonne, 31062 Toulouse, France
    Gene Expr Patterns 6:777-82. 2006
    ..In keeping with this observation, while pea3, erm and XER81 require FGF activity for their expression, er81 does not require FGF signalling...
  50. ncbi belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain
    Anandita Seth
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Development 133:725-35. 2006
    ..Our analysis reveals new roles for Ihx2 in midline axon guidance, forebrain patterning and eye morphogenesis...
  51. ncbi Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 132:3717-30. 2005
    ..Based on these findings, we propose a model for epibranchial placode development in which Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis...
  52. ncbi Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain
    Bruce B Riley
    Biology Department, Texas A and M University, College Station, Texas 77843 3258, USA
    Dev Dyn 231:278-91. 2004
    ..Similar feedback mechanisms operate in the Drosophila wing disc and vertebrate limb bud, suggesting coaptation of a conserved signaling module that spatially organizes cells in complex organ systems...
  53. ncbi A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication
    Martin Paukert
    Department of Physiology II and Max Planck Institute of Developmental Biology, 72076 Tubingen, Germany
    J Biol Chem 279:18783-91. 2004
    ..This pattern suggests a predominant role for zASICs in neuronal communication. Our results suggest a conserved function for receptors of extracellular H(+) in the central nervous system of vertebrates...
  54. ncbi Fgf signalling is required for formation of cartilage in the head
    Jennifer Walshe
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London, UK SE1 1UL
    Dev Biol 264:522-36. 2003
    ..These data implicate Fgf3 and Fgf8 as key regulators of cartilage formation in the vertebrate head...
  55. ncbi Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development
    Isabelle Manfroid
    GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
    Development 134:4011-21. 2007
    ....
  56. doi Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis
    Elewys G Lightman
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Int J Dev Biol 55:597-602. 2011
    ..In the zebrafish hindbrain, Fgf20a promotes transcription of the gene encoding the ETS-domain transcription factor Erm in the non-neurogenic centres of rhombomeres...
  57. pmc SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo
    Michael J Jurynec
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Dis Model Mech 3:733-42. 2010
    ..We suggest that modulation of FGF signaling may be a principal function of SHIP2 in mammals...
  58. doi Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation
    Stefanie Topp
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Department Zebrafish Neurogenetics, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    J Comp Neurol 510:422-39. 2008
    ..We report expression of Fgf signals (fgf3,4,8a,8b,17b), receptors (fgfr1-4), and targets (erm, pea3, dusp6, spry1,2,4, and P-ERK) and document that genes of the embryonic fgf8 synexpression group acquire ..
  59. pmc Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb
    Junhao Mao
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Cell 16:600-6. 2009
    ..This study identifies another level of genetic interaction between the orthogonal axes during limb development...
  60. doi Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche
    Jan Kaslin
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany
    J Neurosci 29:6142-53. 2009
    ..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates...
  61. pmc Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 331:270-80. 2009
    ..Thus, the fin wound epidermis spatially confines Hh signaling through the activity of Fgf and Wnt pathways, impacting blastemal proliferation during regenerative outgrowth...
  62. pmc Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish
    Carrie McMahon
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Dev Biol 332:287-98. 2009
    ..Overall, we propose zebrafish lmx1b.1 and lmx1b.2 promote the survival of periocular mesenchymal cells that influence multiple signaling events required for proper ocular development...
  63. pmc Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis
    Burcu Guner
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:4435-51. 2008
    ..These data suggest that there are distinct origins and signaling requirements for the PD and PI...
  64. pmc Neuronal regulation of the spatial patterning of neurogenesis
    Rosa Gonzalez-Quevedo
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Dev Cell 18:136-47. 2010
    ..at segment centers comprises a distinct progenitor population that expresses fibroblast growth factor (fgfr) 2, erm, sox9b, and the retinoic acid degrading enzyme, cyp26b1...
  65. pmc Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development
    Wade A Znosko
    Department of Microbiology and Molecular Genetics, 3501 Fifth Avenue, BST3 5062, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Dev Biol 342:11-25. 2010
    ..In zebrafish, the simultaneous knock-down of three Pea3 ETS proteins, Etv5, Erm, and Pea3, produced phenotypes reminiscent of embryos deficient in FGF signaling...
  66. doi Loss of fish actinotrichia proteins and the fin-to-limb transition
    Jing Zhang
    CAREG, Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Nature 466:234-7. 2010
    ..We propose that the loss of both actinodins and actinotrichia during evolution may have led to the loss of lepidotrichia and may have contributed to the fin-to-limb transition...
  67. doi Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
    Glia 58:1345-63. 2010
    ....
  68. pmc Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle
    Michael J Jurynec
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 105:12485-90. 2008
    ....
  69. doi Sequential and cooperative action of Fgfs and Shh in the zebrafish retina
    Saradavey Vinothkumar
    Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe, Germany
    Dev Biol 314:200-14. 2008
    ..This sequence contains binding sites for the transcription factors Erm and Pea3 that are known transducers of Fgf signaling...
  70. pmc Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, Chicago, IL 60614, USA
    BMC Dev Biol 10:104. 2010
    ..This Tbx5 regulation is critical in heart formation, but the coexpression of both proteins in other developing tissues suggests a broader functional role...
  71. doi FGF receptor gene expression and its regulation by FGF signaling during early zebrafish development
    Satoshi Ota
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama, Japan
    Genesis 48:707-16. 2010
    ..1/fgf8a mutants, we found that fgfr expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis, revealing the presence of an autoregulatory mechanism...
  72. ncbi Midkine-b regulates cell specification at the neural plate border in zebrafish
    Daniel Liedtke
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
    Dev Dyn 237:62-74. 2008
    ..Our results imply that Mdkb is required for the earliest steps of cell specification at the neural plate border in zebrafish...
  73. pmc The Cdc14B phosphatase contributes to ciliogenesis in zebrafish
    Aurélie Clément
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 138:291-302. 2011
    ..This first study of a loss of function of a Cdc14 family member in a vertebrate organism reveals a new role for Cdc14B in ciliogenesis and consequently in a number of developmental processes...
  74. pmc Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites
    Aaron W Aday
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01602, USA
    Dev Biol 357:450-62. 2011
    ....
  75. pmc Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish
    Sizhou Huang
    Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, School of Life Sciences, Southwest University, Beibei, 400715 Chongqing, China
    J Biol Chem 286:28533-43. 2011
    ....
  76. pmc Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation
    Mollie R Johnson Sorrell
    Molecular Cardiovascular Biology Division and The Heart Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 358:44-55. 2011
    ....