dlx2a

Summary

Gene Symbol: dlx2a
Description: distal-less homeobox 2a
Alias: dlx-2, dlx2, zgc:110518, homeobox protein Dlx2a, distal-less homeobox gene 2a
Species: zebrafish

Top Publications

  1. pmc Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation
    Shingo Kajimura
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:1240-5. 2005
  2. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
  3. ncbi A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
  4. pmc Genetic ablation of neural crest cell diversification
    Brigitte L Arduini
    Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, USA
    Development 136:1987-94. 2009
  5. ncbi Fgf signalling is required for formation of cartilage in the head
    Jennifer Walshe
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London, UK SE1 1UL
    Dev Biol 264:522-36. 2003
  6. ncbi A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish
    Maria Vega Flores
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Dev Dyn 235:3166-76. 2006
  7. ncbi Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl
    Jae Yeon Jeong
    Program in Developmental Biology, Department of Biopharmaceutical Sciences, University of California San Francisco, CA 94143 2811, USA
    Development 134:127-36. 2007
  8. ncbi Regulatory gene expression patterns reveal transverse and longitudinal subdivisions of the embryonic zebrafish forebrain
    G Hauptmann
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 91:105-18. 2000
  9. ncbi The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation
    Sabine Fischer
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 130:3515-24. 2003
  10. ncbi belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain
    Anandita Seth
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Development 133:725-35. 2006

Research Grants

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. pmc Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation
    Shingo Kajimura
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:1240-5. 2005
    ..The induction of IGFBP-1 expression may be a conserved physiological mechanism to restrict the IGF-stimulated growth and developmental process under hypoxic stress...
  2. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
    Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
  3. ncbi A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
    ..By contrast, subfunction partitioning between zebrafish co-orthologs of tetrapod genes, such as sox9a and sox9b, can relax pleiotropy and reveal both early and late developmental gene functions...
  4. pmc Genetic ablation of neural crest cell diversification
    Brigitte L Arduini
    Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, USA
    Development 136:1987-94. 2009
    ..Our results identify a genetic regulatory pathway functionally discrete from the process of neural crest induction that is required for the initiation of neural crest cell diversification during embryonic development...
  5. ncbi Fgf signalling is required for formation of cartilage in the head
    Jennifer Walshe
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London, UK SE1 1UL
    Dev Biol 264:522-36. 2003
    ..These data implicate Fgf3 and Fgf8 as key regulators of cartilage formation in the vertebrate head...
  6. ncbi A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish
    Maria Vega Flores
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Dev Dyn 235:3166-76. 2006
    ..We also show that, in contrast to data from mouse studies, zebrafish Runx1 is not required in the initial steps of chondrogenesis leading to endochondral bone formation...
  7. ncbi Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl
    Jae Yeon Jeong
    Program in Developmental Biology, Department of Biopharmaceutical Sciences, University of California San Francisco, CA 94143 2811, USA
    Development 134:127-36. 2007
    ..Our findings reveal that Fezl is crucial for establishing regional subdivisions within the diencephalon and may also play a role in the development of the telencephalon and hypothalamus...
  8. ncbi Regulatory gene expression patterns reveal transverse and longitudinal subdivisions of the embryonic zebrafish forebrain
    G Hauptmann
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 91:105-18. 2000
    ..Our data suggest a strong conservation of early forebrain organization between lower and higher vertebrates...
  9. ncbi The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation
    Sabine Fischer
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 130:3515-24. 2003
    ..We also show that fgf24 activity is necessary for the migration of tbx5-expressing cells to the fin bud, and for the activation of shh, but not hand2, expression in the posterior fin bud...
  10. ncbi belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain
    Anandita Seth
    Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
    Development 133:725-35. 2006
    ..Our analysis reveals new roles for Ihx2 in midline axon guidance, forebrain patterning and eye morphogenesis...
  11. ncbi Distribution of corticotropin-releasing hormone in the developing zebrafish brain
    Gayathri Chandrasekar
    School of Life Sciences, Södertörns University College, Huddinge, Sweden
    J Comp Neurol 505:337-51. 2007
    ..The widespread distribution of CRH-synthesizing cells outside the preoptic region suggests additional functions of CRH in the embryonic zebrafish brain...
  12. doi Ontogeny of vasotocin-expressing cells in zebrafish: selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area
    Jennifer L Eaton
    Department of Biology, The University of Akron, Akron, Ohio, USA
    Dev Dyn 237:995-1005. 2008
    ..In contrast, otp and sim1 are not required for avt expression in the ventral hypothalamus. Thus, the development of these two avt expression domains is influenced by separate gene regulatory networks...
  13. doi Short- and long-range functions of Goosecoid in zebrafish axis formation are independent of Chordin, Noggin 1 and Follistatin-like 1b
    Monica Dixon Fox
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada
    Development 136:1675-85. 2009
    ..Our findings suggest that Gsc has dose dependent effects on axis induction and provide new insights into molecularly distinct short- and long-range signaling activities of the organizer...
  14. pmc Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice
    Ryan B MacDonald
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, K1N 6N5, Canada
    BMC Evol Biol 10:157. 2010
    ..We first identified the elephant shark sequence orthologous to the URE2 cis -regulatory element of the mouse Dlx1/Dlx2 locus (herein named CmURE2)...
  15. ncbi Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype
    D Alexandre
    Developmental Biology Research Centre, Randall Institute, King s College, London, UK
    Development 122:735-46. 1996
    ..These results are discussed in terms of the role of Hoxa-1 in controlling anterior hindbrain patterning and the relationship between expression of Hoxa-1 and retinoic acid...
  16. pmc The evolution of the vertebrate Dlx gene family
    D W Stock
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Proc Natl Acad Sci U S A 93:10858-63. 1996
    ..Determination of the linkage relationship of these additional zebrafish Dlx genes to Hox clusters should help resolve this issue...
  17. ncbi The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development
    D Yelon
    Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA, USA
    Development 127:2573-82. 2000
    ..Thus, these studies reveal early functions for Hand2 in several cellular processes and highlight a genetic parallel between heart and forelimb development...
  18. ncbi Requirement for endoderm and FGF3 in ventral head skeleton formation
    Nicolas B David
    U 368 INSERM, Ecole Normale Superieure, 46 rue d Ulm, F 75230 Paris cedex 05, France
    Development 129:4457-68. 2002
    ..Together, our results reveal for the first time that the endoderm provides differential cues along the anteroposterior axis to control ventral head skeleton development and demonstrate that this function is mediated in part by Fgf3...
  19. ncbi Developmental expression of zebrafish emx1 during early embryogenesis
    Atsuo Kawahara
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Gene Expr Patterns 2:201-6. 2002
    ..Thus, emx1 displays a unique expression pattern that is distinct from the patterns of emx2 and emx3...
  20. ncbi Induction and prepatterning of the zebrafish pectoral fin bud requires axial retinoic acid signaling
    Yann Gibert
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Konstanz, Germany
    Development 133:2649-59. 2006
    ..Thus, RA signaling from flanking somites plays a dual early role in the condensing limb bud mesenchyme...
  21. ncbi Blimp-1 is an essential component of the genetic program controlling development of the pectoral limb bud
    Ban Chuan Lee
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 117688, Singapore
    Dev Biol 300:623-34. 2006
    ..Taken together, these results identify an additional layer of control in the genetic pathway that operates in the developing limb and provides novel insights into regulatory mechanisms that organize its pattern...
  22. ncbi valentino: a zebrafish gene required for normal hindbrain segmentation
    C B Moens
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Development 122:3981-90. 1996
    ..These results provide genetic evidence for a two-segment periodicity in the hindbrain and suggest that this periodicity arises sequentially, through the specification and later subdivision of a two-rhombomere unit, or 'protosegment'...
  23. ncbi Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos
    D L Ellies
    Department of Anatomy and Neurobiology, University of Ottawa, Ontario, Canada
    Mech Dev 61:23-36. 1997
    ....
  24. ncbi Zebrafish hox clusters and vertebrate genome evolution
    A Amores
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Science 282:1711-4. 1998
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis...
  25. pmc Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neurons
    K B Artinger
    Cardiovascular Research Center, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Development 126:3969-79. 1999
    ..We discuss the implications of these findings for the possibility that RB sensory neurons and neural crest cells share a common evolutionary origin...
  26. ncbi Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches
    G Hauptmann
    Biozentrum der Universitat Basel, Switzerland
    Dev Dyn 218:345-58. 2000
    ..We propose that coordinate expression of particular combinations of class III POU genes contribute to pattern formation or cell fate determination in the developing CNS and other structures...
  27. ncbi sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development
    C T Miller
    Institute of Neuroscience, Eugene, OR 97403 1254, USA
    Development 127:3815-28. 2000
    ..chondrogenesis, suc/et-1 mutant embryos have severe defects in ventral arch neural crest expression of dHAND, dlx2, msxE, gsc, dlx3 and EphA3 in the anterior arches. Dorsal expression patterns are unaffected...
  28. ncbi The early embryonic zebrafish forebrain is subdivided into molecularly distinct transverse and longitudinal domains
    Giselbert Hauptmann
    Biozentrum der Universitat Basel, Basel, Switzerland
    Brain Res Bull 57:371-5. 2002
    ..Furthermore, we identified a series of eight transverse diencephalic domains which may indicate a prosomeric organization of the rostral zebrafish brain...
  29. ncbi The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome
    Deborah M Garrity
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 129:4635-45. 2002
    ..However, the syndromic deficiencies of tbx5 mutation are remarkably well retained between fish and mammals...
  30. ncbi Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint
    Craig T Miller
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Development 130:1353-65. 2003
    ..Together our results reveal two critical edn1 effectors that pattern the vertebrate jaw: hand2 specifies ventral pharyngeal cartilage of the lower jaw and bapx1 specifies the jaw joint...
  31. ncbi Genetic analysis of the roles of Hh, FGF8, and nodal signaling during catecholaminergic system development in the zebrafish brain
    Jochen Holzschuh
    Developmental Biology, Institute Biology 1, University of Freiburg, D 79104 Freiburg, Germany
    J Neurosci 23:5507-19. 2003
    ..In summary, our results do not support the previously suggested dominant roles for sonic hedgehog and Fgf8 in specification of the first catecholaminergic neurons, but instead indicate a novel role for Nodal signaling in this process...
  32. ncbi Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development
    Jennifer Walshe
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Development 130:4337-49. 2003
    ..Analysis of embryos treated with an FGFR inhibitor suggests that continuous FGF signalling is required from gastrulation stages for normal forebrain patterning, and identifies additional requirements for FGFR activity...
  33. ncbi Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish
    Erin K O'Brien
    Department of Otolaryngology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Dev Biol 265:246-61. 2004
    ..These results reveal that Ap-2alpha regulates multiple steps of melanophore development, and is required for development of other neuronal and non-neuronal neural crest derivatives...
  34. ncbi Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, California, USA
    Dev Dyn 229:87-98. 2004
    ..Developmental Dynamics 229:87-98, 2004...
  35. ncbi Reiterated Wnt signaling during zebrafish neural crest development
    Jessica L Lewis
    Molecular and Cellular Biology Program, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 131:1299-308. 2004
    ..Taken together, these results demonstrate that Wnt signals are critical for the initial induction of zebrafish neural crest and suggest that this signaling pathway plays reiterated roles in its development...
  36. ncbi Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis
    Wiebke Herzog
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 131:3681-92. 2004
    ..This early specification seems to be essential for the subsequent survival of pituitary cells, but not for pituitary morphogenesis or pituitary cell proliferation...
  37. ncbi Fgf signaling is required for zebrafish tooth development
    William R Jackman
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309 0334, USA
    Dev Biol 274:139-57. 2004
    ..expression of lhx6 and lhx7 eliminated as expected from mouse studies, but the epithelial expression of dlx2a, dlx2b, fgf3, and fgf4 was as well...
  38. ncbi An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning
    Justin Gage Crump
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Development 131:5703-16. 2004
    ..Moreover, we argue that the Fgf-dependent morphogenesis of the pharyngeal endoderm into pouches is critical for the later patterning of pharyngeal cartilages...
  39. ncbi Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction
    Jared W Ragland
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 276:16-30. 2004
    ....
  40. ncbi Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Dev Biol 276:508-22. 2004
    ..This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies...
  41. ncbi HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development
    William H J Norton
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 132:4963-73. 2005
    ..This reveals an unexpected specificity of HSPGs in regulating distinct vertebrate Fgfs...
  42. ncbi Fgf19 regulated by Hh signaling is required for zebrafish forebrain development
    Ayumi Miyake
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 288:259-75. 2005
    ..The present findings indicate that Fgf19 signaling is crucial for forebrain development by interacting with Hh and provide new insights into the roles of Fgf signaling in brain development...
  43. ncbi Zebrafish Foxd3 is required for development of a subset of neural crest derivatives
    James A Lister
    Department of Biological Structure and Center for Developmental Biology, University of Washington, HSB G514, Box 357420, Seattle, 98195 7420, USA
    Dev Biol 290:92-104. 2006
    ....
  44. ncbi Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 133:855-64. 2006
    ..Furthermore, acquisition of correct prethalamic and thalamic gene expression is dependent on direct Hh signalling. We conclude that proper maturation of the diencephalon requires ZLI-derived Hh signalling...
  45. ncbi Zebrafish foxd3 is selectively required for neural crest specification, migration and survival
    Rodney A Stewart
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:174-88. 2006
    ....
  46. ncbi Expression of Dlx genes during the development of the zebrafish pharyngeal dentition: evolutionary implications
    V Borday-Birraux
    PGE UPR 9034, CNRS, Gif sur Yvette, France
    Evol Dev 8:130-41. 2006
    ....
  47. ncbi Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development
    Marlene J Rau
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 296:83-93. 2006
    ..Mediator is a coactivator complex transducing the interaction of DNA-binding transcription factors with RNA polymerase II, and our results reveal a critical function of the Trap230 subunit as a coactivator for Sox9...
  48. ncbi Fgf16 is essential for pectoral fin bud formation in zebrafish
    Ryohei Nomura
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto, Japan
    Biochem Biophys Res Commun 347:340-6. 2006
    ..These findings have revealed that Fgf16, a newly identified AER factor, plays a crucial role in pectoral fin bud outgrowth by mediating the interactions of AER-mesenchyme and AER-ZPA...
  49. ncbi Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes
    David W Stock
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309 0334, USA
    Development 133:3127-37. 2006
    ..The most significant difference we found was an absence in zebrafish oral epithelium of expression of dlx2a and dlx2b, transcription factors that are expressed in early Astyanax odontogenic epithelium...
  50. ncbi Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish
    Binnur Eroglu
    Center for Molecular Chaperone Radiobiology and Cancer Virology, Medical College of Georgia, Augusta, Georgia, USA
    Dev Dyn 235:2722-35. 2006
    ..This is exhibited by the aberrant brain patterning, a reduction in the sensory neurons, and craniofacial defects. These results further elucidate the critical role for Brg1 in neurogenesis, neural crest induction, and differentiation...
  51. pmc Transcriptional repressor foxl1 regulates central nervous system development by suppressing shh expression in zebra fish
    Chisako Nakada
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 26:7246-57. 2006
    ..In view of all of our data taken together, we propose zfoxl1 to be a novel regulator of neural development that acts by suppressing shh expression...
  52. ncbi The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish
    Mercedes Montero-Balaguer
    Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Dev Dyn 235:3199-212. 2006
    ..Further analysis of mosm188 mutants and foxd3 morphants revealed that NC cells are initially formed, suggesting that foxd3 function is required to maintain the pool of NC progenitors...
  53. ncbi Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome
    Ben Tucker
    ARC Special Research Center for the Molecular Genetics of Development and Discipline of Genetics, School of Molecular and Biomedical Science, The University of Adelaide, South Australia, Australia
    Hum Mol Genet 15:3446-58. 2006
    ..These abnormalities may be related to a role for fmr1 in neural crest cell specification and possibly in migration...
  54. pmc Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish
    Christina L Hammond
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Dev Biol 302:504-21. 2007
    ..Our data show that the relationship between Pax3/7 genes and myogenesis is evolutionarily ancient, but that changes in the MRF targets for particular signals contribute to myogenic differences between species...
  55. ncbi Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish
    Sreelaja Nair
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 134:335-45. 2007
    ..Collectively, our results indicate that Edn1 from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest...
  56. ncbi Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution
    Trevor L Hoffman
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2305, USA
    J Exp Zool B Mol Dev Evol 308:679-91. 2007
    ....
  57. ncbi Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements
    Steven M Sperber
    Department of Cellular and Molecular Medicine, University of Ottawa, and Ottawa Health Research Institute, Canada
    Dev Biol 314:59-70. 2008
    ..In zebrafish, dlx2a is expressed in the migrating cranial neural crest that contributes to the pharyngeal arches...
  58. doi Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression
    Thomas Mueller
    Department of Biopharmaceutical Sciences and Programs in Human Genetics, University of California, San Francisco, California 94143 2811, USA
    J Comp Neurol 507:1245-57. 2008
    We examined the brain expression patterns of zebrafish genes Lhx6, Lhx7, Dlx2a, GAD67, and Tbr2/eomesa; except for GAD67, expression domains are restricted to the forebrain...
  59. doi Cadmium inhibits neurogenesis in zebrafish embryonic brain development
    Elly Suk Hen Chow
    Division of Biology, California Institute of Technology, 1200 California Boulevard, Pasadena, CA 91125, USA
    Aquat Toxicol 87:157-69. 2008
    ..Our data suggest that cadmium-induced neurotoxicity can be caused by impaired neurogenesis, resulting in markedly reduced neuronal differentiation and axonogenesis...
  60. pmc Loss of unc45a precipitates arteriovenous shunting in the aortic arches
    Matthew J Anderson
    Tumor Biology Training Program, Georgetown University Medical Center, Washington, DC 20057, USA
    Dev Biol 318:258-67. 2008
    ..Our results are the first to ascribe a role for Unc45a, a putative myosin chaperone, in vertebrate development, and identify a novel mechanism by which an AVM can form...
  61. pmc barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches
    Steven M Sperber
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Dev Biol 321:101-10. 2008
    ..Together, these results indicate an essential role for barx1 at early stages of chondrogenesis within the developing zebrafish viscerocranium...
  62. doi Low divergence in Dlx gene expression between dentitions of the medaka (Oryzias latipes) versus high level of expression shuffling in osteichtyans
    M Debiais-Thibaud
    Laboratoire Evolution, Génome et Spéciation, UPR9034 CNRS, Gif sur Yvette, and Université Paris Sud, Orsay, France
    Evol Dev 10:464-76. 2008
    ..Our results demonstrate a low constraint on dlx gene expression shuffling in the odontogenic cascade within osteichtyans but the non-individualization of oral and pharyngeal dentitions in the medaka...
  63. doi Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish
    Heike Diekmann
    Summit Cambridge Ltd, Cambridge CB25 9TN, United Kingdom
    J Neurosci 29:1343-9. 2009
    ..Increasing BDNF expression may represent a useful strategy for Huntington's disease treatment...
  64. pmc Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation
    Catherine M Drerup
    Program in Human Molecular Genetics, Department of Pediatrics, Feinberg School of Medicine, Children s Memorial Research Center, Northwestern University, 2300 Children s Plaza, Chicago, IL 60614, USA
    Development 136:2623-32. 2009
    ..Based on our data, we propose a model in which Disc1 functions in the transcriptional repression of foxd3 and sox10, thus mediating CNC cell migration and differentiation...
  65. pmc A role for chemokine signaling in neural crest cell migration and craniofacial development
    EUGENIA C OLESNICKY KILLIAN
    Department of Craniofacial Biology, University of Colorado Denver School of Dental Medicine, Aurora, CO 80045, USA
    Dev Biol 333:161-72. 2009
    ....
  66. pmc Prdm1a is necessary for posterior pharyngeal arch development in zebrafish
    DENISE A BIRKHOLZ
    Department of Biomedical and Pharmaceutical Sciences, University of Montana, Center for Structural and Functional Neuroscience, Missoula, Montana, USA
    Dev Dyn 238:2575-87. 2009
    ..Together, these results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton...
  67. pmc Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression
    Nicholas A Sanek
    Department of Zoology and Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 136:3791-800. 2009
    ..These data uncover a novel, essential role for Zic2a as a modulator of Hh-activated gene expression in the developing forebrain and advance our understanding of a key gene regulatory network that, when disrupted, causes HPE...
  68. pmc Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development
    Tyler Schwend
    Integrated Graduate Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    BMC Dev Biol 9:59. 2009
    ..Here we study chameleon mutants, lacking a functional disp1(con/disp1)...
  69. doi Tgfbeta3 regulation of chondrogenesis and osteogenesis in zebrafish is mediated through formation and survival of a subpopulation of the cranial neural crest
    Felicia S H Cheah
    Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Mech Dev 127:329-44. 2010
    ..Therefore, proper cranial neural crest formation and survival, and ultimately craniofacial chondrogenesis and osteogenesis, are dependent on tight regulation of Tgfbeta3 protein levels in zebrafish...
  70. pmc Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face
    Elizabeth Zuniga
    Eli and Edythe Broad Institute for Regenerative Medicine and Stem Cell Research, Department of Cell and Neurobiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:1843-52. 2010
    ..Together, these results indicate a novel function of Jagged-Notch signaling in ensuring dorsal identity within broad fields of facial skeletal precursors...
  71. pmc Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration
    Sarah Piloto
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 137:1981-90. 2010
    ..Similar processes probably occur in other cell types in which Wnt signaling promotes migration...
  72. pmc hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches
    Jared Coffin Talbot
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 137:2507-17. 2010
    ..Knockdown of the broadly expressed genes dlx1a and dlx2a results in both dorsal and intermediate defects, whereas knockdown of three intermediate-domain restricted genes ..
  73. pmc The relationship between dlx and gad1 expression indicates highly conserved genetic pathways in the zebrafish forebrain
    Ryan B MacDonald
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
    Dev Dyn 239:2298-306. 2010
    ..Our results indicate the dlx genes are regulated by an evolutionarily conserved genetic pathway and may play a role in GABAergic interneuron differentiation in the zebrafish forebrain...
  74. pmc Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion
    Dongling Zheng
    Mineral Metabolism Group, Nutritional Sciences Division, King s College London, London SE1 9NH, UK
    BMC Genomics 11:548. 2010
    ....
  75. pmc Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation
    Dongling Zheng
    Mineral Metabolism Group, Nutritional Sciences Division, King s College London, London SE1 9NH, UK
    BMC Genomics 11:553. 2010
    ..This organ forms a conduit for zinc uptake whilst exhibiting conservation of zinc trafficking components...
  76. doi Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 409:705-10. 2011
    ..Fgfr1 knockdown embryos also showed dysplastic neurocranial and pharyngeal cartilages. The present findings indicate that Fgf20b is required for ectomesenchymal fate establishment via the activation of Fgfr1 in zebrafish...
  77. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
    ....
  78. pmc Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
    Elizabeth Zuniga
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 138:5147-56. 2011
    ....
  79. pmc Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors
    Bartosz Balczerski
    Eli and Edythe Broad Institute for Regenerative Medicine and Stem Cell Research, Department of Cell and Neurobiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 362:230-41. 2012
    ..Hence, we propose that the S1P-dependent anterior foregut endoderm functions primarily through Shh to regulate the growth but not DV patterning of zebrafish jaw precursors...
  80. pmc Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest
    Ankita Das
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 8:e1002710. 2012
    ..Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest...
  81. pmc Wnt-dependent epithelial transitions drive pharyngeal pouch formation
    Chong Pyo Choe
    Broad California Institute of Regenerative Medicine Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Dev Cell 24:296-309. 2013
    ..We propose that this dynamic control of epithelial morphology by Wnt signaling may be a common theme for the budding of organ anlagen from the endoderm...
  82. ncbi The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives
    R N Kelsh
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 127:515-25. 2000
    ..The combination of pigmentation and enteric nervous system defects makes colourless mutations a model for two human neurocristopathies, Waardenburg-Shah syndrome and Hirschsprung's disease...
  83. pmc The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney
    Sung Kook Hong
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:18473-8. 2005
    ..These results suggest that critical targets of TRAP230 function may include proteins important for cell mobility, cell sorting, and tissue assembly...
  84. ncbi Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): differential involvement in the visceral skeleton and braincase
    L Verreijdt
    Ghent University, Biology Department, Ghent, Belgium
    Dev Dyn 235:1371-89. 2006
    ..Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification...
  85. ncbi Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function
    Alejandro Barrallo-Gimeno
    GSF, Institute for Mammalian Genetics, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Development 131:1463-77. 2004
    ..craniofacial primordia in pharyngeal arches two to seven fail to express their typical set of genes (sox9a, wnt5a, dlx2, hoxa2/b2)...
  86. ncbi Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton
    R Craig Albertson
    Department of Cytokine Biology, The Forsyth Institute, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Dev Biol 283:310-21. 2005
    ..These data provide new insights into vertebrate laterality and offer the zebrafish ace/fgf8 mutant as a novel molecular tool to investigate tissue-specific molecular laterality mechanisms...
  87. ncbi p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1
    N Plaster
    Georges Köhler Laboratory, Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Death Differ 13:223-35. 2006
    ..This indicates that under replication-compromised conditions, the p53 branch of the S-phase checkpoint is responsible for eliminating stalled cells that, given more time, would have otherwise finished their normal developmental program...
  88. ncbi Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning
    Macie B Walker
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Dev Biol 295:194-205. 2006
    ....
  89. ncbi Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain
    Jason D Berndt
    Department of Zoology and Anatomy and Neuroscience Training Program, University of Wisconsin, Madison, WI 53706, USA
    Development 133:3983-92. 2006
    ..Finally, Sema3d overexpression rescues reduced proliferation caused by DeltaTCF expression, suggesting that Sema3d lies downstream of Wnt/TCF signaling in the molecular pathway thought to control cell cycle in NCC precursors...
  90. ncbi Zebrafish orthopedia (otp) is required for isotocin cell development
    Jennifer L Eaton
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, 232 Building D, 4000 Reservoir Rd, NW Washington, DC 20057, USA
    Dev Genes Evol 217:149-58. 2007
    ..Overall, these studies support the hypothesis that the role of otp in zebrafish neuroendocrine cell development is evolutionarily conserved with that of mammals...
  91. pmc Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway
    Marco J Koudijs
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
    BMC Dev Biol 8:15. 2008
    ..We attempted to fully activate the Hh pathway by removing both receptors for the Hh proteins, called Patched1 and 2, which are functioning as negative regulators in this pathway...
  92. pmc Cloning and spatiotemporal expression of zebrafish neuronal nicotinic acetylcholine receptor alpha 6 and alpha 4 subunit RNAs
    Kristin M Ackerman
    Department of Neuroscience, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Dev Dyn 238:980-92. 2009
    ..The most notable chrna4 expression was in neural crest cells at 24 hpf and reticulospinal neurons in hindbrain at 48 hpf. chrna4 RNA exhibited a widespread and robust expression pattern in the midbrain in 72 hpf and 96 hpf zebrafish...
  93. pmc The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish
    Catherine T Nguyen
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 341:167-75. 2010
    ..Taken together, these results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations...
  94. pmc Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output
    Sunit Dutta
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3013-8. 2010
    ..We propose that Kctd15 inhibits NC formation by attenuating the output of the canonical Wnt pathway, thereby restricting expansion of the NC domain beyond its normal range...
  95. pmc Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish
    Sadie A Bergeron
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 138:75-85. 2011
    ..This study reveals a role for Boc in ventral CNS cells that receive high levels of Hh and uncovers previously unknown roles for Boc in vertebrate embryogenesis...
  96. pmc FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish
    Michella Ghassibe-Sabbagh
    Laboratory of Human Molecular Genetics, de Duve Institute, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Am J Hum Genet 88:150-61. 2011
    ..Administration of faf1 mRNA rescues this phenotype. Our findings therefore identify FAF1 as a regulator of CNC differentiation and show that it predisposes humans to cleft palate and is necessary for lower jaw development in zebrafish...
  97. doi Deciphering the cellular and molecular roles of cellular nucleic acid binding protein during cranial neural crest development
    Andrea M J Weiner
    Molecular and Cellular Biology Institute IBR, National Council of Scientific and Technological Research CONICET Biology Area, Department of Biological Sciences, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Suipacha 531, Rosario, S2002LRK, Argentina
    Dev Growth Differ 53:934-47. 2011
    ....
  98. ncbi lockjaw encodes a zebrafish tfap2a required for early neural crest development
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 130:5755-68. 2003
    ..the mandibular arch is unaffected in low mutants, in contrast to the hyoid arch, which shows severe reductions in dlx2 and hoxa2 expression...
  99. ncbi Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation
    Yun Li
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:3613-20. 2005
    ..These findings suggest that IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish...
  100. ncbi Semaphorin signaling guides cranial neural crest cell migration in zebrafish
    Hung Hsiang Yu
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 280:373-85. 2005
    ....
  101. ncbi AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 132:3127-38. 2005
    ....

Research Grants5

  1. Transgenic Zebrafish as Models for Tooth Morphogenesis
    William Jackman; Fiscal Year: 2005
    ..These studies will reveal cell behavior during normal and experimentally perturbed tooth morphogenesis at a level of detail never before described. ..
  2. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  3. Site-specific transgenesis in zebrafish
    JAMES LISTER; Fiscal Year: 2008
    ..These tools will advance the usefulness of this model organism as a model for human development and disease. [unreadable] [unreadable] [unreadable]..
  4. Understanding Head Development: A Segmental Groundplan of Vertebrates
    Thomas Schilling; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ....