crx

Summary

Gene Symbol: crx
Description: cone-rod homeobox
Alias: cone-rod homeobox protein
Species: zebrafish

Top Publications

  1. ncbi Evolutionarily conserved and divergent regulatory sequences in the fish rod opsin promoter
    Shoji Kawamura
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277 8652, Japan
    Comp Biochem Physiol B Biochem Mol Biol 141:391-9. 2005
  2. pmc Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish
    Steve M Nelson
    Department of Biological Sciences, Moscow, Idaho 83844 3051, USA
    Dev Biol 328:24-39. 2009
  3. ncbi Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis
    Yu chi Shen
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0616, USA
    Dev Biol 269:237-51. 2004
  4. pmc The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper retinal development and lamination
    Yuqing Zhang
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e36145. 2012
  5. doi Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa
    Bastian Linder
    Department of Biochemistry, University of Wurzburg, Wurzburg, Germany
    Hum Mol Genet 20:368-77. 2011
  6. pmc Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors
    Sachihiro C Suzuki
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420
    Proc Natl Acad Sci U S A 110:15109-14. 2013
  7. ncbi Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function
    Hsan Jan Yen
    Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 15:667-77. 2006
  8. pmc Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform
    Pamela R Pretorius
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 6:e1000884. 2010
  9. pmc The developmental sequence of gene expression within the rod photoreceptor lineage in embryonic zebrafish
    Steve M Nelson
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844 3051, USA
    Dev Dyn 237:2903-17. 2008
  10. ncbi Dynamic expression of the basic helix-loop-helix transcription factor neuroD in the rod and cone photoreceptor lineages in the retina of the embryonic and larval zebrafish
    Malgorzata J Ochocinska
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan 48105, USA
    J Comp Neurol 501:1-12. 2007

Scientific Experts

  • Qin Liu
  • DEBORAH STENKAMP
  • Kelly E O'Quin
  • S Kawamura
  • Deborah C Otteson
  • Reiko Toyama
  • Joseph W Eichenbaum
  • Christoph Winkler
  • Xiaomei Wei
  • Yan Qiong Zhang
  • Brian Perkins
  • Marta Vitorino
  • Sachihiro C Suzuki
  • Kunal Rai
  • Pamela R Pretorius
  • David A Jones
  • Steve M Nelson
  • James A Marrs
  • Imelda T Sandoval
  • Diane C Slusarski
  • Val C Sheffield
  • Elizabeth J Manos
  • Stephanie Chidester
  • Madelyn Mullally
  • Leonardo E Valdivia
  • Mailin Sotolongo-Lopez
  • Iliana Serifi
  • Karen Alvarez-Delfin
  • James M Fadool
  • Carole J Saade
  • Scott M Taylor
  • Wen Hua Li
  • Susov Dhakal
  • Xin Zhang
  • Pooja Muralidharan
  • Alexandra D Almeida
  • I A Viringipurampeer
  • Shu Yu Wu
  • Yoichi Asaoka
  • Ashley A George
  • S Rey
  • Liyun Zhang
  • Hongxing Yang
  • Yun Chen
  • Marina Riera
  • Marie A Forbes-Osborne
  • Ying Li
  • Fanwei Meng
  • Hsin Yu Chung
  • Gaelle Boisset
  • Ruth A Frey
  • Jiangfei Chen
  • Utz Fischer
  • John H Postlethwait
  • Jun Yin
  • Bastian Linder
  • Jan Brocher
  • Peter F Hitchcock
  • Rosa A Uribe
  • Chris M Ireland
  • Hayato Yokoi
  • Smitha R James
  • Adam R Karpf
  • Bradley R Cairns
  • Robert F Mullins
  • Edwin M Stone
  • Rebecca L Bernardos
  • Malgorzata J Ochocinska
  • Bhavani Kashyap
  • Lincoln D Nadauld
  • Hsan Jan Yen
  • Pamela A Raymond
  • Sherry G Babb
  • Yu chi Shen
  • Terra S Vleeshouwer-Neumann
  • Stephen W Wilson
  • Caitlin Albrecht
  • Amanuel Tafessu
  • Wilson Horner
  • Florencia Cavodeassi
  • Andrea K Wester
  • Audrey M Williams
  • Rebecca Chowdhury
  • Anna M Krasnow
  • Lauren A Laboissonniere
  • Zoe Karetsou
  • Mary Horton
  • Quenten P Schwarz
  • Kara L Cerveny
  • Claudia Wierzbicki

Detail Information

Publications58

  1. ncbi Evolutionarily conserved and divergent regulatory sequences in the fish rod opsin promoter
    Shoji Kawamura
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277 8652, Japan
    Comp Biochem Physiol B Biochem Mol Biol 141:391-9. 2005
    ..conserved OTX (GATTA) and OTX-like (TATTA) sequences that can be recognized by the mammalian cone-rod homeobox (CRX) protein. However, binding of zebrafish crx to the OTX sequence has remained elusive...
  2. pmc Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish
    Steve M Nelson
    Department of Biological Sciences, Moscow, Idaho 83844 3051, USA
    Dev Biol 328:24-39. 2009
    ....
  3. ncbi Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis
    Yu chi Shen
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0616, USA
    Dev Biol 269:237-51. 2004
    The mammalian Cone-rod homeobox (Crx) gene is a divergent member of the Otx gene family known to be involved in differentiation and survival of retinal photoreceptors and photoentrainment of circadian rhythms...
  4. pmc The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper retinal development and lamination
    Yuqing Zhang
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e36145. 2012
    ..Since the expression of known TFs that can specify specific retinal cell type was also altered in Irx7-deficient retinas, thus the irx7 gene network is possibly a novel regulatory circuit for retinal development and lamination...
  5. doi Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa
    Bastian Linder
    Department of Biochemistry, University of Wurzburg, Wurzburg, Germany
    Hum Mol Genet 20:368-77. 2011
    ..Hence, various routes affecting the tri-snRNP can elicit tissue-specific gene expression defects and lead to the RP phenotype...
  6. pmc Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors
    Sachihiro C Suzuki
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420
    Proc Natl Acad Sci U S A 110:15109-14. 2013
    ..Ectopic expression of trβ2 after cone differentiation produces cones with mixed opsins. Temporal differences in the onset of trβ2 expression could explain why some species have mixed, and others have pure, cone types. ..
  7. ncbi Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function
    Hsan Jan Yen
    Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 15:667-77. 2006
    ..These studies are the first to comprehensively compare the diverse group of BBS genes in parallel and demonstrate a common role in intracellular trafficking, indicating that BBS proteins are involved in general organelle trafficking...
  8. pmc Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform
    Pamela R Pretorius
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 6:e1000884. 2010
    ..Bbs3L-null mice lack key features of previously published Bbs-null mice, including obesity. These data demonstrate that the BBS3L transcript is required for proper retinal function and organization...
  9. pmc The developmental sequence of gene expression within the rod photoreceptor lineage in embryonic zebrafish
    Steve M Nelson
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844 3051, USA
    Dev Dyn 237:2903-17. 2008
    ..expression was accompanied by sporadic upregulation of expression of the transcription factors NeuroD/nrd, rx1, crx, and Nr2e3/pnr...
  10. ncbi Dynamic expression of the basic helix-loop-helix transcription factor neuroD in the rod and cone photoreceptor lineages in the retina of the embryonic and larval zebrafish
    Malgorzata J Ochocinska
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan 48105, USA
    J Comp Neurol 501:1-12. 2007
    ..Furthermore, neuroD is coexpressed with the cone-rod-homeobox transcription factor (Crx) in putative cone progenitors and nascent cone photoreceptors, suggesting that, in the zebrafish retina, as in ..
  11. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007
    ..Furthermore, zebrafish Dnmt2 methylates an RNA species of approximately 80 bases, consistent with tRNA methylation. Thus, Dnmt2 promotes zebrafish development, likely through cytoplasmic RNA methylation...
  12. ncbi Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells
    Rebecca L Bernardos
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Neurosci 27:7028-40. 2007
    ..Müller glia-derived progenitors express Crx (cone rod homeobox) and are late retinal progenitors that generate the rod photoreceptor lineage in the ..
  13. pmc Vsx2 in the zebrafish retina: restricted lineages through derepression
    Marta Vitorino
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Neural Dev 4:14. 2009
    ..The neurons in the vertebrate retina arise from multipotent retinal progenitor cells (RPCs). It is not clear, however, which progenitors are multipotent or why they are multipotent...
  14. doi Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development
    Shu Yu Wu
    Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA
    Dev Biol 385:13-22. 2014
    ..We propose that the Mediator complex is responsible for subtle but significant changes in transcriptional timing and amplitude that are essential for coordinating the development of neurons in the epithalamus. ..
  15. pmc Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish
    I A Viringipurampeer
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z 3N9, Canada
    Cell Death Differ 21:665-75. 2014
    ..As bystander cell death is an important feature of many retinal diseases, combinatorial approaches targeting different cell death pathways may evolve as an important general principle in treatment. ..
  16. pmc Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments
    Ashley A George
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 9:e84394. 2014
    ..This last pathway also appears exacerbated by darkness. Taken altogether, these findings show that SynJ1 is required in cones for normal endolysosomal trafficking of synaptic proteins. ..
  17. pmc Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish
    Fanwei Meng
    Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Biol Evol 30:1527-43. 2013
    ..factors shown to have direct roles in retinal development and maintenance, including cone-rod homeobox (crx) and Wnt pathway members...
  18. doi Combining animal personalities with transcriptomics resolves individual variation within a wild-type zebrafish population and identifies underpinning molecular differences in brain function
    S Rey
    Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Barcelona, 08193, Bellaterra, Spain
    Mol Ecol 22:6100-15. 2013
    ..These differences can be mapped to distinct regions of the brain and provide a foundation towards understanding the coordination of underpinning adaptive molecular events within populations. ..
  19. doi Zebrafish hmx1 promotes retinogenesis
    Gaelle Boisset
    IRO, Institute for Research in Ophthalmology, Av Grand Champsec 64, 1950 Sion, Switzerland
    Exp Eye Res 105:34-42. 2012
    ..However, the key patterning genes tested so far were not regulated by hmx1. Altogether, these results suggest an important role for hmx1 in retinogenesis...
  20. pmc The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish
    Yoichi Asaoka
    Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 9:e97365. 2014
    ..yap (5SA)-expressing zebrafish embryos displayed decreased expression of transcription factors such as otx5 and crx, which orchestrate photoreceptor cell differentiation by activating the expression of rhodopsin and other ..
  21. ncbi The zebrafish homologs of SET/I2PP2A oncoprotein: expression patterns and insights into their physiological roles during development
    Iliana Serifi
    Laboratory of Biological Chemistry, Medical School, University of Ioannina, Ioannina, Greece
    Biochem J 473:4609-4627. 2016
    ..Collectively, our results suggest that seta and setb are required during embryogenesis and play roles in the zebrafish sensory system development...
  22. pmc Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish
    Mailin Sotolongo-Lopez
    Department of Biological Science, The Florida State University, Tallahassee, Florida, United States of America
    PLoS Genet 12:e1005968. 2016
    ....
  23. doi Expression Profiling of Developing Zebrafish Retinal Cells
    Madelyn Mullally
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa
    Zebrafish 13:272-80. 2016
    ..Further analysis of these profiles will reveal genes that can be mutated using genome editing techniques. Together these studies increase our knowledge of the genes driving development of different cell types in the zebrafish retina. ..
  24. pmc Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
    Leonardo E Valdivia
    Department of Cell and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Development 143:1087-98. 2016
    ..Together, our results support a model in which dorsally expressed gdf6a limits RA pathway activity to control the transition from proliferation to differentiation in the growing eye...
  25. pmc The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling
    Scott M Taylor
    Department of Ophthalmology and Visual Sciences University of Michigan, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
    Invest Ophthalmol Vis Sci 56:7496-515. 2015
    ..The purpose of this study was to identify these pathways, and during photoreceptor genesis, Notch signaling was investigated as the putative mediator of NeuroD function...
  26. pmc Abnormal retinal development in Cloche mutant zebrafish
    Susov Dhakal
    Department of Biological Sciences, University of Idaho, Moscow, Idaho
    Dev Dyn 244:1439-55. 2015
    ..These studies are possible in zebrafish embryos, which do not yet rely upon the vasculature for tissue oxygenation...
  27. pmc Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation
    Wen Hua Li
    1 State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, 2 Graduate University of the Chinese Academy of Sciences, Wuhan 430072, China
    Int J Biol Sci 11:688-700. 2015
    ..Furthermore, knockdown of lbh-like increases the activity of Notch pathway and perturbs the balance among proliferation, differentiation and survival of photoreceptor precursors. ..
  28. doi PCB1254 exposure contributes to the abnormalities of optomotor responses and influence of the photoreceptor cell development in zebrafish larvae
    Xin Zhang
    Department of Pediatrics, Nanjing Medical University, No 140, Hanzhong Road, Nanjing 210029, China Department of Pediatrics, Nanjing Maternity and Child Health Care Hospital of Nanjing Medical University, No 123, Tianfei Road, Mochou Street, Nanjing 210004, China
    Ecotoxicol Environ Saf 118:133-8. 2015
    ..01% methanol were also prepared. OMR test was used to detect the visual behavior. The mRNA expression of the CRX, RHO, SWS1, and SWS2 was assessed by the Quantitative Real-Time PCR...
  29. pmc Zebrafish retinal defects induced by ethanol exposure are rescued by retinoic acid and folic acid supplement
    Pooja Muralidharan
    Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 49:149-63. 2015
    ..Our results indicate that various ethanol-sensitive events underlie FASD-associated retinal defects. Nutrient supplements like retinoids and folate were effective in alleviating ethanol-induced retinal defects. ..
  30. pmc Spectrum of Fates: a new approach to the study of the developing zebrafish retina
    Alexandra D Almeida
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Development 141:1971-80. 2014
    ....
  31. pmc Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F
    Imelda T Sandoval
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Chem Biol 20:753-63. 2013
    ..Our data support this mechanism of action for kalihinol F and the utility of zebrafish as an effective system for identifying therapeutic and target pathways. ..
  32. pmc Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina
    Marie A Forbes-Osborne
    Department of Biology, University of Kentucky, Lexington, KY 40506 0225, USA
    Dev Biol 380:157-71. 2013
    ..upstream of the bHLH transcription factors ath5/atoh7 and neurod, and the photoreceptor specification genes crx and nr2e3. Finally, we show that insm1a is negatively regulated by Notch-Delta signaling...
  33. doi Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway
    Hsin Yu Chung
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
    Neurotoxicol Teratol 38:92-103. 2013
    ..ethanol treatment of embryos reduced expression of the mature neural and photoreceptor markers elavl3/huC, rho, and crx; in addition, expression of the neural and retinal progenitor markers ascl1b and pax6b was maintained at the ..
  34. pmc Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae
    Hongxing Yang
    State Key Laboratory of Genetic Engineering, Institute of Plant Biology, Center of Evolutionary Biology, School of Life Science, Fudan University, Shanghai, China
    PLoS ONE 8:e64058. 2013
    ..Our study provides ample information for further study about the molecular and cellular mechanisms underlying vertebrate development...
  35. pmc CERKL knockdown causes retinal degeneration in zebrafish
    Marina Riera
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e64048. 2013
    ..Overall, we propose that this zebrafish model is a powerful tool to unveil CERKL contribution to human retinal degeneration...
  36. pmc Trimethyltin chloride (TMT) neurobehavioral toxicity in embryonic zebrafish
    Jiangfei Chen
    Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, Institute of Watershed Science and Environmental Ecology, Wenzhou Medical College, Wenzhou, China
    Neurotoxicol Teratol 33:721-6. 2011
    ..Our study demonstrates the morphological and behavioral sensitivity of the developing zebrafish to TMT and establishes a platform for future identification of the affected pathways and chemical modulators of TMT toxicity...
  37. pmc Quantitative genetic analysis of retinal degeneration in the blind cavefish Astyanax mexicanus
    Kelly E O'Quin
    Department of Biology, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e57281. 2013
    ..The regions we identify serve as a starting point for future studies on the genetics of retinal degeneration and eye disease using the evolutionary mutant model Astyanax...
  38. pmc The role of egr1 in early zebrafish retinogenesis
    Liyun Zhang
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 8:e56108. 2013
    ..This abnormal and prolonged expression of ptf1a during retinogenesis might affect the differentiation of ACs and HCs in the Egr1-knockdown retinas...
  39. pmc Protocadherin-17 function in Zebrafish retinal development
    Yun Chen
    Department of Biology and Integrated Bioscience Program, University of Akron, Akron, Ohio 44325, USA
    Dev Neurobiol 73:259-73. 2013
    ..Injection of a vivo-protocadherin-17 MO into one eye of embryonic zebrafish resulted in similar eye defects. Our results suggest that protocadherin-17 plays an important role in the normal formation of the zebrafish retina...
  40. ncbi Embryonic retinal gene expression in sonic-you mutant zebrafish
    Deborah L Stenkamp
    Department of Biological Sciences, University of Idaho, Moscow, Idaho 83844 3051, USA
    Dev Dyn 225:344-50. 2002
    ..We also find that Hh signaling is important for retinal cell proliferation and retinal cell survival; together, these functions provide an explanation for progressive microphthalmia in the syu-/- mutant...
  41. pmc Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish
    Ying Li
    CAS MPG Partner Institute for Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Comput Biol 9:e1002940. 2013
    ..Our study describes a systematic method to discover previously unidentified TFs involved in circadian physiology in complex organisms...
  42. ncbi Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish
    Deborah L Stenkamp
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844 3051, USA
    Dev Biol 258:349-63. 2003
    ....
  43. ncbi dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina
    Brian D Perkins
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Dev Dyn 233:680-94. 2005
    ..Taken together, our studies suggest a role for the dazed gene in rod and Muller cell development and overall retinal cell survival and maintenance...
  44. ncbi Zebrafish R-cadherin (Cdh4) controls visual system development and differentiation
    Sherry G Babb
    Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 56202 5130, USA
    Dev Dyn 233:930-45. 2005
    ..Cdh4 is necessary for neural retina survival and differentiation, and required for normal retinotectal projection formation and tectal arborization...
  45. pmc Genomic organization of zebrafish cone-rod homeobox gene and exclusion as a candidate gene for retinal degeneration in niezerka and mikre oko
    Deborah C Otteson
    Guerrieri Center for Genetic Engineering and Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Vis 11:986-95. 2005
    To determine the genomic organization of the zebrafish crx gene and to evaluate if mutations in crx are responsible for the retinal degeneration phenotype in the zebrafish (Danio rerio) mutants niezerka (nie(m743)) and mikre oko (mok(..
  46. pmc Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development
    Lincoln D Nadauld
    Department of Oncological Sciences and Medicinal Chemistry and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 103:13409-14. 2006
    ....
  47. pmc Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin2 mutant glass onion and zebrafish cadherin4 morphants
    Q Liu
    Department of Biology, University of Akron, 302 Buchtel Common, Akron, OH 44325, USA
    Exp Eye Res 84:163-75. 2007
    ..of zebrafish photoreceptors, we have analyzed expression patterns of several photoreceptor-specific genes (crx, gnat1, gnat2, irbp, otx5, rod opsin, rx1, and uv opsin) and/or a cone photoreceptor marker (zpr-1) in the retina ..
  48. pmc Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos
    Bhavani Kashyap
    Department of Biological Sciences, and Neuroscience Graduate Program, University of Idaho, Moscow, Idaho 83844 3051, USA
    Vis Neurosci 24:409-21. 2007
    ..We conclude that ethanol exposure over the time of retinal neurogenesis resulted in persistent microphthalmia due to a combination of an overall developmental delay, lens abnormalities, and reduced retinal cell differentiation...
  49. pmc Cadherin-6 function in zebrafish retinal development
    Qin Liu
    Department of Biology, University of Akron, Akron, OH 44325, USA
    Dev Neurobiol 68:1107-22. 2008
    ..Our results suggest that cadherin-6 plays an important role in the normal formation of the zebrafish retina. (c) 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008...
  50. ncbi [Influence of CRX gene on development of photoreceptors in zebrafish]
    Yan Qiong Zhang
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China
    Zhonghua Yan Ke Za Zhi 44:448-54. 2008
    To study the development and opsin expression of zebrafish photoreceptors after CRX gene knock-down.
  51. pmc Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation
    Hayato Yokoi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 329:1-15. 2009
    ..Results identified genes expressed in cartilage (col2a1a and col11a2), retina (calb2a, calb2b, crx, neurod, rs1, sox4a and vsx1) and pectoral fin bud (klf2b and EST AI722369) as candidate targets for Sox9...
  52. pmc A zebrafish retinal graded photochemical stress model
    Joseph W Eichenbaum
    Department of Ophthalmology, Mount Sinai School of Medicine, USA
    J Pharmacol Toxicol Methods 59:121-7. 2009
    ....
  53. pmc Transcriptome analysis of the zebrafish pineal gland
    Reiko Toyama
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
    Dev Dyn 238:1813-26. 2009
    ..Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development...
  54. pmc Dnmt3 and G9a cooperate for tissue-specific development in zebrafish
    Kunal Rai
    Department of Oncological Sciences, oward Hughes Medical Institute, and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 285:4110-21. 2010
    ..We propose a model wherein specific DNMT-histone methyltransferase networks are utilized to silence critical regulators of cell fate in a tissue-specific manner...
  55. pmc Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay
    Xiaomei Wei
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Mar Drugs 8:1769-78. 2010
    ..Compounds 1-6 were evaluated in a zebrafish phenotype-based assay. Amphimedine (4) was the only compound that caused a phenotype in zebrafish embryos at 30 muM. No phenotype other than death was observed for compounds 1-3, 5, 6...
  56. pmc Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics
    Rosa A Uribe
    Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, TX 78722, USA
    Development 137:3763-74. 2010
    ....
  57. pmc Functional analysis of BBS3 A89V that results in non-syndromic retinal degeneration
    Pamela R Pretorius
    Department of Biology, Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Mol Genet 20:1625-32. 2011
    ..These data aid in our understanding of why patients with the BBS3 A89V missense mutation only present with isolated retinitis pigmentosa...
  58. pmc Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa
    Jun Yin
    Department of Biological Sciences National University of Singapore 117543, Singapore
    Mol Neurodegener 6:56. 2011
    ..Mutations in pre-mRNA splicing factors including PRPF31 have been identified as cause for RP, raising the question how mutations in general factors lead to tissue specific defects...