chrna1

Summary

Gene Symbol: chrna1
Description: cholinergic receptor, nicotinic, alpha 1 (muscle)
Alias: nic1, zgc:86593, acetylcholine receptor subunit alpha, AChR alpha 1, cholinergic receptor, nicotinic, alpha polypeptide 1, nic, nic-1, nicotinic acetylcholine receptor alpha-1, nicotinic receptor
Species: zebrafish

Top Publications

  1. ncbi Mutation in the delta-subunit of the nAChR suppresses the muscle defects caused by lack of Dystrophin
    Christelle Etard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, CU de Strasbourg, France
    Dev Dyn 234:1016-25. 2005
  2. doi Nicotinic acetylcholine receptors (nAChRs) at zebrafish red and white muscle show different properties during development
    Kazi T Ahmed
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Dev Neurobiol 76:916-36. 2016
  3. doi BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis
    Jichao Sun
    Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore Mechanobiology Institute Singapore, National University of Singapore, Singapore 117411, Singapore
    Dev Cell 34:555-68. 2015
  4. doi Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI
    Eirinn W Mackay
    Hubrecht Institute KNAW and University Medical Center Utrecht, Utrecht 3584 CT, The Netherlands
    Development 142:1095-101. 2015
  5. pmc A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses
    Jee Young Park
    Section on Model Synaptic Systems, Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892
    J Neurosci 34:10211-8. 2014
  6. doi Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity
    Lixing Huang
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, PR China
    Chemosphere 108:55-61. 2014
  7. pmc Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure
    Kandice Fero
    Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Dis Model Mech 7:289-98. 2014
  8. pmc miR-153 regulates SNAP-25, synaptic transmission, and neuronal development
    Chunyao Wei
    Department of Biological Sciences, Vanderbilt University and Medical School, Nashville, Tennessee, United States of America
    PLoS ONE 8:e57080. 2013
  9. ncbi Targeted "knockdown" of channel expression in vivo with an antisense morpholino oligonucleotide
    L J N Brent
    Centre for Research in Neuroscience and Departments of Biology and of Neurology and Neurosurgery, McGill University, 1650 Cedar Street, Montreal, Quebec, Canada H3G 1A4
    Neuroscience 114:275-8. 2002
  10. pmc Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery
    Michael Walogorsky
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 109:17711-6. 2012

Scientific Experts

  • Roger Papke
  • Lisa Maves
  • Tennore Ramesh
  • Fumihito Ono
  • Hua Wen
  • Paul Brehm
  • Michael Walogorsky
  • Rebecca Mongeon
  • Gail Mandel
  • Kazi T Ahmed
  • Jichao Sun
  • Eirinn W Mackay
  • Lixing Huang
  • Jee Young Park
  • Kandice Fero
  • Julie L Lefebvre
  • Chunyao Wei
  • Declan W Ali
  • Yulia Shwartz
  • Vandana Gupta
  • Juliane S Muller
  • Jason M Urban
  • Andrew M Petzold
  • Yuanquan Song
  • Lili Jing
  • Kum Loong Boon
  • KIMBERLY E EPLEY
  • Michael Granato
  • Christelle Etard
  • Caroline Brennan
  • Ines Ibanez-Tallon
  • Fengyi Liang
  • Stefan Schulte-Merker
  • Ti Weng Chew
  • Boon Chuan Low
  • Margit Burmeister
  • Catherine Qiurong Pan
  • Alexander Apschner
  • Hiromi Ikeda
  • Chonggang Wang
  • James J Dowling
  • Meifang Wu
  • L J N Brent
  • Michael Linhoff
  • Harold A Burgess
  • Zhenghong Zuo
  • Youyu Zhang
  • Tory Williams
  • Hiba Codore
  • Grace H Li
  • Meghan Mott
  • Sadie A Bergeron
  • Jackie Jin Lin
  • Eric J Horstick
  • James G Patton
  • Elizabeth J Thatcher
  • Kendal Broadie
  • Bruce D Carter
  • Ana L Perdigoto
  • Andrew F Marshall
  • Abigail F Olena
  • Diana J Cha
  • Zsuzsanna Farkas
  • Elazar Zelzer
  • Attila Aszodi
  • Tomer Stern
  • Nathan R Nelson
  • Genri Kawahara
  • Leonard I Zon
  • Yi Zhou
  • Alan H Beggs
  • Aye T Chen
  • Louis M Kunkel
  • Jason Urban
  • Stacey R Gundry
  • Wayne I Lencer
  • Volker Straub
  • Kate Bushby
  • Michael W Linhoff
  • Steven H Laval
  • Hanns Lochmuller
  • Geng Lin Li
  • Matthew J McGinley
  • Glen M Corson
  • Catherine D Jepson
  • Sridhar Sivasubbu
  • Emma Wolf-Saxon
  • Marion O Scott
  • Jessica A Panzer
  • Paul C Scherer

Detail Information

Publications28

  1. ncbi Mutation in the delta-subunit of the nAChR suppresses the muscle defects caused by lack of Dystrophin
    Christelle Etard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, CU de Strasbourg, France
    Dev Dyn 234:1016-25. 2005
    ..The myofiber detachment phenotype of Dystroglycan-deficient embryos was not suppressed, suggesting that Dystrophin and Dystroglycan play distinct roles in muscle formation and maintenance of muscle integrity...
  2. doi Nicotinic acetylcholine receptors (nAChRs) at zebrafish red and white muscle show different properties during development
    Kazi T Ahmed
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Dev Neurobiol 76:916-36. 2016
    ..RT-qPCR of mRNA for nicotinic receptor subunits supports a switch from γ to ε subunits in white fibers but not in red...
  3. doi BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis
    Jichao Sun
    Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore Mechanobiology Institute Singapore, National University of Singapore, Singapore 117411, Singapore
    Dev Cell 34:555-68. 2015
    ..Therefore, precise targeting of the cholinergic machinery through BNIP-H is essential for the local production of ACh for morphogenesis and neurotransmission...
  4. doi Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI
    Eirinn W Mackay
    Hubrecht Institute KNAW and University Medical Center Utrecht, Utrecht 3584 CT, The Netherlands
    Development 142:1095-101. 2015
    ..Additionally, we found that abcc6a is strongly expressed at the site of mineralisation rather than the liver, as it is in mammals, which has significant implications for our understanding of the function of ABCC6. ..
  5. pmc A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses
    Jee Young Park
    Section on Model Synaptic Systems, Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892
    J Neurosci 34:10211-8. 2014
    ..Both wild-type and mutant larvae lacked ε/γ subunits in slow muscle synapses. These findings in zebrafish suggest that some mutations in human congenital myasthenic syndromes may affect slow and fast muscle fibers differently. ..
  6. doi Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity
    Lixing Huang
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, PR China
    Chemosphere 108:55-61. 2014
    ..Our results were helpful for an understanding of the toxicity of BaP. This study also indicated that microarray analysis was effective for predicting the potential toxicity of chemicals with high sensitivity and accuracy. ..
  7. pmc Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure
    Kandice Fero
    Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Dis Model Mech 7:289-98. 2014
    ..These findings are the first to implicate a functional role of dusp27 as a gene required for myofiber maturation and provide an animal model for analyzing the mechanisms governing myofibril assembly. ..
  8. pmc miR-153 regulates SNAP-25, synaptic transmission, and neuronal development
    Chunyao Wei
    Department of Biological Sciences, Vanderbilt University and Medical School, Nashville, Tennessee, United States of America
    PLoS ONE 8:e57080. 2013
    ..Together, our results indicate that precise control of SNAP-25 expression by miR-153 is critically important for proper neuronal patterning as well as neurotransmission...
  9. ncbi Targeted "knockdown" of channel expression in vivo with an antisense morpholino oligonucleotide
    L J N Brent
    Centre for Research in Neuroscience and Departments of Biology and of Neurology and Neurosurgery, McGill University, 1650 Cedar Street, Montreal, Quebec, Canada H3G 1A4
    Neuroscience 114:275-8. 2002
    ..Because of their stability and specificity, morpholinos should prove useful for targeted deletion of transmitter receptors and channels in developing zebrafish and possibly in other preparations...
  10. pmc Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery
    Michael Walogorsky
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 109:17711-6. 2012
    ..Thus, the continued expression of α(twi) into adulthood is tolerated because of the ε expression and associated recovery, raising the likelihood of unappreciated myasthenic cases that benefit from the γ-ε switch...
  11. doi Muscle contraction controls skeletal morphogenesis through regulation of chondrocyte convergent extension
    Yulia Shwartz
    Department of Molecular Genetics, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
    Dev Biol 370:154-63. 2012
    ....
  12. pmc Acetylcholine receptor gating in a zebrafish model for slow-channel syndrome
    Michael Walogorsky
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 32:7941-8. 2012
    ..The effective block by quinidine on synaptic currents as well as nonliganded openings points to dual sources for the calcium-dependent myopathy in certain forms of SCS...
  13. pmc The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study
    Roger L Papke
    Department of Pharmacology, University of Florida College of Medicine, Gainesville, FL, USA
    Biochem Pharmacol 84:352-65. 2012
    ..Our data therefore indicate that while some pharmacological tools used in zebrafish may function as expected, others will not...
  14. pmc A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease
    Tennore Ramesh
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Dis Model Mech 3:652-62. 2010
    ..These phenotypes were more severe in lines expressing higher levels of mutant Sod1 and were absent in lines overexpressing wild-type Sod1. Thus, we have generated a vertebrate model of ALS to complement existing mammal models...
  15. pmc Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction
    Hua Wen
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 107:13906-11. 2010
    ..Through these features, we further determined that during the height of shared synchronous and asynchronous transmission these two modes compete for the same release sites...
  16. pmc The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies
    Vandana Gupta
    Genomics Program and Division of Genetics, The Manton Center for Orphan Disease Research, Children s Hospital Boston, Boston, MA 02115, USA
    Hum Mol Genet 20:1712-25. 2011
    ....
  17. pmc An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses
    Rebecca Mongeon
    Vollum Institute, Oregon Health and Science University, Portland, USA
    J Gen Physiol 138:353-66. 2011
    ..The unique functional features offered by the α(2)βδ(2) receptor likely play a central role in mediating the persistent contractions characteristic to this muscle type...
  18. doi Dok-7 promotes slow muscle integrity as well as neuromuscular junction formation in a zebrafish model of congenital myasthenic syndromes
    Juliane S Muller
    Institute of Human Genetics, International Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Hum Mol Genet 19:1726-40. 2010
    ..Our findings in the zebrafish model contribute to a better understanding of the signalling pathways at the NMJ and the pathomechanisms of DOK7 CMSs...
  19. pmc Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)
    Yuanquan Song
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e8329. 2009
    ..These results show that mitochondrial dysfunction, leading to an increase in aerobic glycolysis, affects neurogenesis through the PPARG-ERK pathway, a potential target for therapeutic intervention...
  20. pmc Nicotine response genetics in the zebrafish
    Andrew M Petzold
    University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:18662-7. 2009
    ....
  21. pmc Zebrafish survival motor neuron mutants exhibit presynaptic neuromuscular junction defects
    Kum Loong Boon
    Center for Molecular Neurobiology, Department of Neuroscience, Ohio State University, Columbus, OH, USA
    Hum Mol Genet 18:3615-25. 2009
    ..Our analysis indicates the requirement for Smn in motoneurons to maintain SV2 in presynaptic terminals indicating that Smn, either directly or indirectly, plays a role in presynaptic integrity...
  22. pmc Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor
    Lili Jing
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Neuron 61:721-33. 2009
    ..We propose that Wnt ligands activate unplugged/MuSK signaling in muscle fibers to restrict growth cone guidance and AChR prepatterns to the muscle center through a mechanism reminiscent of the planar cell polarity pathway...
  23. pmc A modified acetylcholine receptor delta-subunit enables a null mutant to survive beyond sexual maturation
    KIMBERLY E EPLEY
    The Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, Florida 32080, USA
    J Neurosci 28:13223-31. 2008
    ..In the rescued fish, a foreign promoter drove the transgene expression and the NMJ had altered synaptic strength. The survival of the transgenic animal delineates requirements for gene therapies of NMJ...
  24. ncbi Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Development 134:3371-82. 2007
    ..Our results reveal that Pbx proteins modulate Myod activity to drive fast-muscle gene expression, thus showing that homeodomain proteins can direct bHLH proteins to establish a specific cell-type identity...
  25. ncbi Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo
    Caroline Brennan
    School of Biological Sciences, Queen Mary, University of London, London, E1 4NS, UK
    J Cell Sci 118:5181-90. 2005
    ....
  26. ncbi Tethering naturally occurring peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo
    Ines Ibanez-Tallon
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Neuron 43:305-11. 2004
    ..When combined with specific methods of cell and temporal expression, the extension of this approach to hundreds of naturally occurring peptide toxins opens a new landscape for cell-autonomous regulation of cellular physiology in vivo...
  27. ncbi Increased neuromuscular activity causes axonal defects and muscular degeneration
    Julie L Lefebvre
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 131:2605-18. 2004
    ..a novel, dominant gain-of-function mutation in the muscle-specific nicotinic acetylcholine receptor alpha-subunit, CHRNA1. Moreover, electrophysiological analysis demonstrates that the mutant subunit increases synaptic decay times, ..
  28. ncbi Autonomous expression of the nic1 acetylcholine receptor mutation in zebrafish muscle cells
    D S Sepich
    Institute of Neuroscience, University of Oregon, Eugene 97403
    Dev Biol 161:84-90. 1994
    The nic1b107 (nic1) mutation blocks expression of both functional and clustered acetylcholine receptors (AChRs) in zebrafish muscle. Normally, signaling between motoneurons and muscles regulates AChR clustering...