cdh2

Summary

Gene Symbol: cdh2
Description: cadherin 2, type 1, N-cadherin (neuronal)
Alias: glo, lyr, ncad, pac, wu:fb47h04, cadherin-2, cadherin 2, neuronal, glass onion, labyrinth, n-cadherin, neural cadherin, parachute
Species: zebrafish

Top Publications

  1. ncbi Differential expression of cadherins in the developing and adult zebrafish olfactory system
    Qin Liu
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    J Comp Neurol 478:269-81. 2004
  2. pmc Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries
    Xuehui Qiu
    Laboratory of Developmental Signalling and Patterning, Genes and Development Division, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Singapore, Singapore
    Dev Genes Evol 219:339-51. 2009
  3. pmc N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube
    Kavita Chalasani
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Mol Biol Cell 22:1505-15. 2011
  4. ncbi Combined haploid and insertional mutation screen in the zebrafish
    Elizabeth Wiellette
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Genesis 40:231-40. 2004
  5. ncbi Genetic locus half baked is necessary for morphogenesis of the ectoderm
    Karen N McFarland
    University of Virginia Health Systems, Department of Pathology, Charlottesville, Virginia, USA
    Dev Dyn 233:390-406. 2005
  6. ncbi In vivo trafficking and targeting of N-cadherin to nascent presynaptic terminals
    James D Jontes
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Neurosci 24:9027-34. 2004
  7. pmc Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation
    Sayantanee Biswas
    Center for Molecular Neurobiology, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Cell Biol 191:1029-41. 2010
  8. ncbi Cadherin-2 and cadherin-4 in developing, adult and regenerating zebrafish cerebellum
    Q Liu
    Department of Biology, University of Akron, Akron, 185 East Mill Street, Akron, OH 44325 3908, USA
    Brain Res Dev Brain Res 150:63-71. 2004
  9. ncbi Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish
    A E Kerstetter
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    Dev Dyn 230:137-43. 2004
  10. ncbi N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish
    Elim Hong
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Development 133:3895-905. 2006

Research Grants

  1. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
  2. Cell Interactions in Synapes Formation and Function
    Juan Bruses; Fiscal Year: 2005
  3. Role of caderhins in the developing zebrafish CV system
    Brian Bagatto; Fiscal Year: 2005
  4. The Zebrafish Model of Microphthalmia
    Jarema Malicki; Fiscal Year: 2008

Scientific Experts

  • Qin Liu
  • Verena Ruprecht
  • T K Cooper
  • H Baier
  • R R Bernhardt
  • Y J Jiang
  • Mihaela Žigman
  • Allisan Aquilina-Beck
  • Michael J Harrington
  • MICHAEL J BARRESI
  • JUAN L BRUSES
  • Brian Bagatto
  • Holger Knaut
  • Jarema J Malicki
  • Mary C Halloran
  • David A Cameron
  • James D Jontes
  • Rachel M Warga
  • Michelle R Emond
  • Sayantanee Biswas
  • Yu Huan Shih
  • Matthias Hammerschmidt
  • Chris T Dee
  • Masahiro Yamaguchi
  • Jane K Rebman
  • Anoop V Cherian
  • Donald A Kane
  • Cencan Xing
  • Karen N McFarland
  • Laura R Nery
  • Tani Agarwal
  • J Corrales
  • Adam M Tuttle
  • Marco Schiavone
  • Andrew K Lawton
  • B Verstraeten
  • Michael R Dohn
  • Lan Jiang
  • Courtney Easley-Neal
  • Corinne Vannier
  • Ichiro Masai
  • Didier Y R Stainier
  • Sarah J Wanner
  • Jean Léon Maître
  • Lucia Micale
  • Rayk Stengel
  • Thomas F Schilling
  • Yelena Chernyavskaya
  • Grace K W Wong
  • Valentina Lo Sardo
  • Mary Y Wu
  • Mihaela Zigman
  • Kavita Chalasani
  • Yi Yang
  • Katherine E Brown
  • Sarah Piloto
  • Hwee Goon Tay
  • Bruce B Riley
  • James W Smyth
  • Carl Philipp Heisenberg
  • A Lamora
  • Nazlie S Latefi
  • Lisette A Maddison
  • Paul J Scotting
  • Sven Reischauer
  • Caroline S Hirst
  • Sandra Rieger
  • Xuehui Qiu
  • Xiaojun Yang
  • Zsolt Lele
  • Amy L Wilson
  • Chunyue Yin
  • Lilianna Solnica-Krezel
  • Sophia von der Hardt
  • Yu chi Shen
  • James A Marrs
  • Kate F Barald
  • Sherry Babb-Clendenon
  • Elim Hong
  • Jeroen Bakkers
  • Fabian Rentzsch
  • A E Kerstetter
  • Elizabeth Wiellette
  • E Azodi
  • J A Marrs
  • Z M Novince
  • Sruthy Maria Augustine
  • Kathryn E Kirchoff
  • Ryuichi Fukuda
  • Fernando Cortes

Detail Information

Publications81

  1. ncbi Differential expression of cadherins in the developing and adult zebrafish olfactory system
    Qin Liu
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    J Comp Neurol 478:269-81. 2004
    ..We hypothesize that the differential expression of these three cadherins in the developing zebrafish major olfactory structures reflects functionally different roles in the development of the vertebrate olfactory system...
  2. pmc Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries
    Xuehui Qiu
    Laboratory of Developmental Signalling and Patterning, Genes and Development Division, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Singapore, Singapore
    Dev Genes Evol 219:339-51. 2009
    ....
  3. pmc N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube
    Kavita Chalasani
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Mol Biol Cell 22:1505-15. 2011
    ..In addition, these findings are the first to demonstrate a requirement for cadherins in synchronizing cell-cycle exit and differentiation and a reciprocal interaction between AJs and Hh signaling...
  4. ncbi Combined haploid and insertional mutation screen in the zebrafish
    Elizabeth Wiellette
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Genesis 40:231-40. 2004
    ....
  5. ncbi Genetic locus half baked is necessary for morphogenesis of the ectoderm
    Karen N McFarland
    University of Virginia Health Systems, Department of Pathology, Charlottesville, Virginia, USA
    Dev Dyn 233:390-406. 2005
    ....
  6. ncbi In vivo trafficking and targeting of N-cadherin to nascent presynaptic terminals
    James D Jontes
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Neurosci 24:9027-34. 2004
    ..in developing axons, we used in vivo two-photon time-lapse microscopy of N-cadherin--green fluorescent protein (Ncad-GFP), which was expressed in Rohon-Beard neurons of the embryonic zebrafish spinal cord...
  7. pmc Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation
    Sayantanee Biswas
    Center for Molecular Neurobiology, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Cell Biol 191:1029-41. 2010
    ..In this study, we demonstrate that pcdh 19 (protocadherin 19) acts synergistically with n-cadherin (ncad) during anterior neurulation in zebrafish...
  8. ncbi Cadherin-2 and cadherin-4 in developing, adult and regenerating zebrafish cerebellum
    Q Liu
    Department of Biology, University of Akron, Akron, 185 East Mill Street, Akron, OH 44325 3908, USA
    Brain Res Dev Brain Res 150:63-71. 2004
    ..This phenotype was confirmed by examining a cadherin-2 mutant, glass onion. Our results suggest that cadherins are crucial for the normal development of the zebrafish cerebellum, and ..
  9. ncbi Cadherin-2 function in the cranial ganglia and lateral line system of developing zebrafish
    A E Kerstetter
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    Dev Dyn 230:137-43. 2004
    ..These phenotypes were confirmed by analyzing a cadherin-2 mutant, glass onion. Our results suggest that cadherin-2 function is crucial for the normal formation of the zebrafish lateral line ..
  10. ncbi N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish
    Elim Hong
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Development 133:3895-905. 2006
    ....
  11. ncbi Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning
    Jarema Malicki
    Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Dev Biol 259:95-108. 2003
    ..Here, we show that one of them, glass onion, encodes the N-cadherin gene...
  12. ncbi The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion
    Sophia von der Hardt
    Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Curr Biol 17:475-87. 2007
    ....
  13. ncbi Differential expression of cadherin-2 and cadherin-4 in the developing and adult zebrafish visual system
    Q Liu
    Department of Biology, University of Akron, Ohio 44325 3908, USA
    Vis Neurosci 18:923-33. 2001
    ..In this study, we examined distribution of cadherin-2 (Cdh2, N-cadherin) in the visual system of developing and adult zebrafish using both immunocytochemical and in situ ..
  14. ncbi A role for N-cadherin in mesodermal morphogenesis during gastrulation
    Rachel M Warga
    Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008, USA
    Dev Biol 310:211-25. 2007
    ..When knocked down with antisense oligonucleotides, bib mutants phenocopy parachute (pac) null alleles, demonstrating that bib is a gain-of-function mutation...
  15. pmc Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration
    Sarah Piloto
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 137:1981-90. 2010
    ..target gene that controls migration of pigment precursors by regulating the intracellular movements of N-cadherin (Ncad). Ovo1 genetically interacts with Ncad and its depletion causes Ncad to accumulate inside cells...
  16. ncbi Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio
    Y J Jiang
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG
    Development 123:205-16. 1996
    ..The wit phenotype is reminiscent of neurogenic mutants in Drosophila, such as Notch or Delta. In mutant parachute (pac) embryos the general organization of the hindbrain is disturbed and many rounded cells accumulate loosely ..
  17. pmc Cadherin-mediated adhesion regulates posterior body formation
    Michael J Harrington
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    BMC Dev Biol 7:130. 2007
    ..However the lengthening of the axis continues during post-gastrula stages in the tailbud region, and is thought to involve convergent extension movements as well as other cell behaviors specific to posterior regions...
  18. ncbi parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube
    Zsolt Lele
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 129:3281-94. 2002
    ..We report the isolation and characterization of the zebrafish parachute (pac) mutations...
  19. ncbi Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome
    Fernando Cortes
    Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Edinburgh EH4 2XU, Scotland, UK
    Dev Cell 5:865-76. 2003
    ..Removing or altering the expression of either protein within the myotome perturbs migration. These results provide a definitive example of homophilic cell adhesion shaping cellular behavior during vertebrate development...
  20. ncbi Cadherin-1, -2, and -11 expression and cadherin-2 function in the pectoral limb bud and fin of the developing zebrafish
    Q Liu
    Department of Biology, University of Akron, Akron, Ohio 44325, USA
    Dev Dyn 228:734-9. 2003
    ....
  21. ncbi R-cadherin expression in the developing and adult zebrafish visual system
    Q Liu
    Department of Anatomy and Cell Biology, 4610 Medical Science II, University of Michigan, Ann Arbor 48109, USA
    J Comp Neurol 410:303-19. 1999
    ..These results suggest that R-cadherin-mediated adhesion plays a role in development and maintenance of neuronal connections in zebrafish visual system...
  22. pmc Regulated tissue fluidity steers zebrafish body elongation
    Andrew K Lawton
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Development 140:573-82. 2013
    ..Inhibition of Wnt or Fgf signaling or cadherin 2 function reduces the coherence of the flow but has different consequences for trunk and tail extension...
  23. pmc Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain
    Sarah J Wanner
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    Development 140:906-15. 2013
    ..Finally, we have found that the adhesion molecule Cdh2 (N-cadherin) is important for interactions between the MLF and FBMNs, as well as for interactions between the ..
  24. pmc Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons
    Jane K Rebman
    Department of Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 11:e0164433. 2016
    ..We generated stable transgenic zebrafish expressing dominant-negative Cadherin-2 (Cdh2ΔEC) driven by the islet1 promoter...
  25. pmc Late recruitment of synapsin to nascent synapses is regulated by Cdk5
    Courtney Easley-Neal
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Cell Rep 3:1199-212. 2013
    ..Importantly, cyclin-dependent kinase 5 (Cdk5) specifically regulated the late recruitment of synapsin transport packets at synapses. These results point to additional layers of complexity in the established mechanisms of synaptogenesis...
  26. doi Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation
    Michael R Dohn
    Division of Genetic Medicine Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 383:39-51. 2013
    ..Together, our results demonstrate that zebrafish Vangl2/Prickle1a and non-canonical Wnt/Frizzled signaling have opposing effects on ECM organization underlying PCP and gastrulation cell movements. ..
  27. doi Morphological effects of G-quadruplex stabilization using a small molecule in zebrafish
    Tani Agarwal
    CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110 007, India
    Biochemistry 53:1117-24. 2014
    ....
  28. pmc Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[a]pyrene exposure
    J Corrales
    Department of Pharmacology, University of Mississippi, University, MS 38677, USA
    Comp Biochem Physiol C Toxicol Pharmacol 163:37-46. 2014
    ..Further studies are needed to link aberrant CG, CHH, and CHG methylation to heritable epigenetic consequences associated with disease in later life...
  29. pmc Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration
    Adam M Tuttle
    Department of Developmental and Cell Biology, University of California, Irvine, California, United States of America
    PLoS Biol 12:e1001852. 2014
    ..Our results suggest that different v-ATPases and associated proteins may play cell-type-specific functions in intracellular trafficking in many contexts. ..
  30. doi Sustained behavioral effects of lithium exposure during early development in zebrafish: involvement of the Wnt-β-catenin signaling pathway
    Laura R Nery
    Laboratório de Biologia e Desenvolvimento do Sistema Nervoso, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande, 90619 900 Porto Alegre, RS, Brazil ZebLab, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande, 90619 900 Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 55:101-8. 2014
    ..These results suggest that zebrafish may be a valuable model for investigation of early effects of lithium that may be mediated by effects on the Wnt signaling pathway. ..
  31. pmc Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer
    Marco Schiavone
    Department of Biology, University of Padua, 35131 Padua, Italy
    Dis Model Mech 7:883-94. 2014
    ....
  32. doi TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway
    Cencan Xing
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Mol Cell Biol 7:48-61. 2015
    ..in embryos depleted of tgfβ1a correlates with the reduced expression of atoh1a, deltaA, and n-cadherin/cdh2, which are known important regulators of the pLLP morphogenesis...
  33. pmc Cortical contractility triggers a stochastic switch to fast amoeboid cell motility
    Verena Ruprecht
    Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria Electronic address
    Cell 160:673-85. 2015
    ..We further show that rearward cortical flows drive stable-bleb cell migration in various adhesive and non-adhesive environments, unraveling a highly versatile amoeboid migration phenotype. ..
  34. pmc N-cadherin relocalization during cardiac trabeculation
    Anoop V Cherian
    Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
    Proc Natl Acad Sci U S A 113:7569-74. 2016
    ..In this study, we examined the distribution of N-cadherin (Cdh2) during cardiac trabeculation in zebrafish...
  35. pmc Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division
    Bruce B Riley
    Department of Biology, Texas A and M University, College Station, Texas, USA
    Dev Dyn 239:828-43. 2010
    ..Despite relatively normal gross patterning, harpy mutants show several defects in morphogenesis, cell migration and differentiation resulting directly or indirectly from the arrest of cell division...
  36. pmc A fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish
    Lucia Micale
    Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    PLoS ONE 7:e46642. 2012
    ..Our data pinpoint a remarkable example of convergent evolution: the exaptation of lineage-specific transposons to shape p53-regulated neuronal morphogenesis-related pathways in both a hominid and a teleost fish...
  37. pmc Kcnh1 voltage-gated potassium channels are essential for early zebrafish development
    Rayk Stengel
    Friedrich Schiller University of Jena and Jena University Hospital, Center for Molecular Biomedicine, Department of Biophysics, Jena, Germany
    J Biol Chem 287:35565-75. 2012
    ..This late phenotype was preceded by transcriptional up-regulation of known cell-cycle inhibitors (p21, p27, cdh2) and down-regulation of pro-proliferative factors, including cyclin D1, at 70% epiboly...
  38. doi Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells
    Jean Léon Maître
    Institute of Science and Technology Austria, Klosterneuburg, Austria
    Science 338:253-6. 2012
    ..Thus, cell adhesion provides the mechanical scaffold for cell cortex tension to drive cell sorting during gastrulation...
  39. pmc A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion
    Michelle R Emond
    Department of Neuroscience, School of Biomedical Science, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 195:1115-21. 2011
    ..we demonstrate a novel mechanism of adhesion, mediated by a complex of Protocadherin-19 (Pcdh19) and N-cadherin (Ncad)...
  40. pmc Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos
    Lan Jiang
    CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
    Cell 153:773-84. 2013
    ..Moreover, inheritance of the sperm methylome facilitates the epigenetic regulation of embryogenesis. Therefore, besides DNA sequences, sperm DNA methylome is also inherited in zebrafish early embryos...
  41. pmc BMP and non-canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish
    Yi Yang
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Development 138:2601-11. 2011
    ..We propose a model in which BMP and the non-canonical Wnt pathway regulate tail morphogenesis by controlling cell migration and cell adhesion within the tailbud...
  42. doi Voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity
    Yelena Chernyavskaya
    Colorado State University, Department of Biology, Fort Collins, Colorado 80523, USA
    Dev Dyn 241:648-62. 2012
    ..2 is a membrane associated guanylate kinase (MAGUK) protein. A major role of MAGUK proteins is to scaffold cellular junctions and multiprotein complexes...
  43. pmc A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration
    Lisette A Maddison
    Vollum Institute, Oregon Health and Science University, Portland, OR, USA
    Mol Genet Genomics 281:551-63. 2009
    ..From this study, we propose that this gain-of-function approach can be applied to large-scale genetic screens in a vertebrate model organism and may reveal previously unknown gene function...
  44. pmc Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development
    Corinne Vannier
    Developmental Biology, Institute Biology I, Faculty of Biology, Albert Ludwigs University Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    J Biol Chem 288:18643-59. 2013
    ..Thus, Zeb1 proteins employ several evolutionary conserved mechanisms to regulate cell-cell adhesion during development and cancer. ..
  45. ncbi Cellular and molecular bases of axonal pathfinding during embryogenesis of the fish central nervous system
    R R Bernhardt
    Department of Neurobiology Swiss Federal Institute of Technology, Zurich, Switzerland
    J Neurobiol 38:137-60. 1999
    ..Experimental evidence for the functions of these molecules in the zebrafish nervous system is accumulating. In the future, this analysis is expected to profit greatly from genetic screens that have recently been initiated...
  46. pmc Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells
    Grace K W Wong
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 32:223-8. 2012
    ..These results suggest that Slit-Robo signaling downregulates N-cadherin activity to allow apical retraction in newly generated RGCs...
  47. doi An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin
    Valentina Lo Sardo
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    Nat Neurosci 15:713-21. 2012
    ....
  48. doi N-cadherin is required for cytodifferentiation during zebrafish odontogenesis
    B Verstraeten
    Evolutionary Developmental Biology, Ghent University, Belgium
    J Dent Res 92:365-70. 2013
    ..of N-cadherin knockout mice prevents any functional study of N-cadherin in mouse odontogenesis, zebrafish parachute (pac) mutants, deficient for N-cadherin, survive beyond the age when primary teeth normally start to form...
  49. pmc N-cadherin regulates primary motor axon growth and branching during zebrafish embryonic development
    JUAN L BRUSES
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 661610, USA
    J Comp Neurol 519:1797-815. 2011
    ..Analysis of N-cadherin mutants (cdh2(hi3644Tg) ) and embryos injected with N-cadherin antisense morpholinos showed primary motor axons extending ..
  50. pmc SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos
    Mary Y Wu
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, London, United Kingdom
    PLoS Biol 9:e1000593. 2011
    ..We conclude that through its ability to regulate a specific domain of BMP activity in the vertebrate embryo, SNW1 is a critical regulator of neural plate border formation and thus neural crest specification...
  51. pmc Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions
    Mihaela Zigman
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 21:79-86. 2011
    ....
  52. pmc Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis
    Michael J F Barresi
    Biological Sciences, Smith College, Northampton, Massachusetts 01063, USA
    Dev Dyn 239:2603-18. 2010
    ..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS...
  53. ncbi Cadherin-2 participates in the morphogenesis of the zebrafish inner ear
    Sherry Babb-Clendenon
    Department of Medicine, Indiana University Medical Center, 950 West Walnut Street, Indianapolis, IN 46202, USA
    J Cell Sci 119:5169-77. 2006
    ..otic vesicle morphogenesis was investigated by examining morpholino antisense oligonucleotide knockdown and glass onion (glo) (Cdh2 mutant) zebrafish embryos...
  54. ncbi The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
    P Haffter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:1-36. 1996
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish...
  55. ncbi Cadherin-catenin complexes during zebrafish oogenesis: heterotypic junctions between oocytes and follicle cells
    J Cerda
    Division of Cell Biology, German Cancer Research Center, D 69120 Heidelberg, Germany
    Biol Reprod 61:692-704. 1999
    ..These findings suggest possible roles of these junctional proteins during early embryogenesis...
  56. ncbi Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish
    Q Liu
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    Exp Neurol 177:396-406. 2002
    ..In this study, we examined expression of zebrafish cadherin-2 (Cdh2, N-cadherin) and cadherin-4 (Cdh4, R-cadherin) in the visual system of adult zebrafish after eye or optic nerve ..
  57. ncbi N-cadherin is essential for retinal lamination in the zebrafish
    Bettina Erdmann
    Max Delbruck Center for Molecular Medicine, Department of Developmental Neurobiology, Berlin, Germany
    Dev Dyn 226:570-7. 2003
    ..Here, we analyze eye development in the zebrafish N-cadherin loss-of-function mutant parachute(paR2.10) (pac(paR2.10)). The zebrafish visual system is fully developed by the time pac(paR2...
  58. ncbi N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites
    Ichiro Masai
    Masai Initiative Research Unit, The Institute of Physical and Chemical Research RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Development 130:2479-94. 2003
    ..Using genetic analyses in zebrafish, we demonstrate that N-cadherin (Ncad) has several distinct and crucial functions during the establishment of retinal organization...
  59. ncbi Cadherin expression in the inner ear of developing zebrafish
    Z M Novince
    Department of Biology, University of Akron, Akron, OH 44325 3908, USA
    Gene Expr Patterns 3:337-9. 2003
    ..In contrast, cadherin-11mRNA was widely expressed earlier in the otic placode, and later became restricted to a subset of cells in the inner ear, including hair cells...
  60. ncbi Cadherin-1, -2 and -4 expression in the cranial ganglia and lateral line system of developing zebrafish
    Q Liu
    Department of Biology, University of Akron, Akron, OH 44325 3908, USA
    Gene Expr Patterns 3:653-8. 2003
    ....
  61. ncbi Current progress in neural crest cell motility and migration and future prospects for the zebrafish model system
    Mary C Halloran
    Departments of Zoology and Anatomy and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, USA
    Dev Dyn 228:497-513. 2003
    ..The zebrafish is particularly well suited for the study of neural crest motility because of the ability to combine genetic manipulation with live imaging of migrating NCCs...
  62. ncbi Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition
    Fabian Rentzsch
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Dev Dyn 231:750-7. 2004
    ....
  63. ncbi Assembly of trigeminal sensory ganglia by chemokine signaling
    Holger Knaut
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:653-66. 2005
    ..These results indicate that ganglion formation depends on the interplay of birthplace, chemokine attraction, cell-cell interaction, and cadherin-mediated adhesion...
  64. ncbi Gene expression profiles of intact and regenerating zebrafish retina
    David A Cameron
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Mol Vis 11:775-91. 2005
    ..Investigate the molecular determinants of retinal regeneration in adult vertebrates by analyzing the gene expression of control and post-lesion retina of adult zebrafish, a system that regenerates following injury...
  65. pmc Cadherin2 (N-cadherin) plays an essential role in zebrafish cardiovascular development
    Brian Bagatto
    Department of Biology, University of Akron, Akron, Ohio, USA
    BMC Dev Biol 6:23. 2006
    ..To gain insight into cadherin2 role in the formation and function of the heart, we analyzed cardiac differentiation and performance in a cadherin2 mutant, glass onion (glo).
  66. pmc Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin2 mutant glass onion and zebrafish cadherin4 morphants
    Q Liu
    Department of Biology, University of Akron, 302 Buchtel Common, Akron, OH 44325, USA
    Exp Eye Res 84:163-75. 2007
    ..rx1, and uv opsin) and/or a cone photoreceptor marker (zpr-1) in the retina of a zebrafish cadherin2 mutant, glass onion (glo) and in zebrafish embryos injected with a cadherin4 specific antisense morpholino oligonucleotide (cdh4MO)...
  67. doi SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling
    Yu Huan Shih
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Development 137:2671-81. 2010
    ..It therefore seems that the broad expression of these SoxB1 genes throughout the early epiblast and their subsequent restriction to the ectoderm is a primary regulator of when and where the organizer forms...
  68. pmc Cadherin-4 plays a role in the development of zebrafish cranial ganglia and lateral line system
    Amy L Wilson
    Department of Biology, University of Akron, Akron, OH 44325 3908, USA
    Dev Dyn 236:893-902. 2007
    ..These results indicate that Cdh4 plays a role in the normal formation of the zebrafish lateral line system and a subset of the cranial ganglia...
  69. ncbi Convergence and extension movements affect dynamic notochord-somite interactions essential for zebrafish slow muscle morphogenesis
    Chunyue Yin
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Dev Dyn 236:2742-56. 2007
    ..We propose that in the double mutants, impaired C&E movements disrupt notochord development, which impedes the adaxial cell shape changes...
  70. pmc Nodal signaling is required for closure of the anterior neural tube in zebrafish
    Allisan Aquilina-Beck
    Department of Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, USA
    BMC Dev Biol 7:126. 2007
    ..Nodals are secreted signaling proteins with many roles in vertebrate development. Here, we identify a new role for Nodal signaling in regulating closure of the rostral neural tube of zebrafish...
  71. doi Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm
    Chris T Dee
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Dev Biol 320:289-301. 2008
    ....
  72. pmc Cranial sensory ganglia neurons require intrinsic N-cadherin function for guidance of afferent fibers to their final targets
    A Lamora
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Neuroscience 159:1175-84. 2009
    ..Reduction of cdh2 in this line was achieved by either crosses to the cdh2-mutant strain, glass onion (glo) or injection of a cdh2 morpholino (MO) into single-cell embryos...
  73. pmc N-cadherin prodomain cleavage regulates synapse formation in vivo
    Nazlie S Latefi
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Dev Neurobiol 69:518-29. 2009
    ..synapse formation, we imaged Rohon-Beard cells in zebrafish embryos expressing GFP-tagged wild-type N-cadherin (NCAD-GFP) or a GFP-tagged N-cadherin mutant expressing an uncleavable prodomain (PRON-GFP) rendering it nonadhesive...
  74. ncbi Broad spectrum pan-cadherin antibodies, reactive with the C-terminal 24 amino acid residues of N-cadherin
    B Geiger
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 97:607-14. 1990
    ..We thus propose that the pan-cadherin antibodies may be used as ubiquitous cadherin probes and serve as markers for adherens junctions...
  75. pmc Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation
    Xiaojun Yang
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 29:11426-40. 2009
    ..Furthermore, precocious overexpression of Lin7c induces multiaxial mirror symmetry in zebrafish neurulation. Our data suggest that stepwise maturation of apicobasal polarity plays an essential role in vertebrate neurulation...
  76. pmc Cadherin-2 controls directional chain migration of cerebellar granule neurons
    Sandra Rieger
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich Neuherberg, Germany
    PLoS Biol 7:e1000240. 2009
    ....
  77. pmc Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis
    Sven Reischauer
    Department of Genetics, Max Planck Institut fur Entwicklungsbiologie, Tuebingen, Germany
    PLoS Genet 5:e1000720. 2009
    ..Our data reveal that pen/lgl2 functions as a tumor suppressor gene in vertebrates, establishing zebrafish pen/lgl2 mutants as a valuable cancer model...
  78. doi Nlcam modulates midline convergence during anterior neural plate morphogenesis
    Katherine E Brown
    Developmental Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 339:14-25. 2010
    ....
  79. pmc Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
    James W Smyth
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 120:266-79. 2010
    ..We anticipate that protecting the microtubule-based forward delivery apparatus of connexons could improve cell-cell coupling and reduce ischemia-related cardiac arrhythmias...
  80. doi Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina
    Masahiro Yamaguchi
    Developmental Neurobiology Unit, Okinawa Institute of Science and Technology OIST, Azatancha 1919 1, Onna, Okinawa 904 0412, Japan
    Mech Dev 127:247-64. 2010
    ..progenitor cells to the total number of retinal cells increases in the neurogenic stages in zebrafish n-cadherin (ncad) and nagie oko (nok) mutants, in which the apicobasal cell polarity and adherens junctions in the retinal ..
  81. pmc A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly
    Hwee Goon Tay
    Rho GTPases in Stem Cells Group, Institute of Medical Biology, Singapore, Singapore
    PLoS ONE 5:e10125. 2010
    ..However, in this context nothing is known of the intracellular signals that participate in the correct localization of E-cadh, other than a need for Rab5c signaling...

Research Grants4

  1. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
    ..This research will lead to a better understanding of events critical to establishing neural connections across the midline in the vertebrate brain. ..
  2. Cell Interactions in Synapes Formation and Function
    Juan Bruses; Fiscal Year: 2005
    ....
  3. Role of caderhins in the developing zebrafish CV system
    Brian Bagatto; Fiscal Year: 2005
    ..The use of glass onion (cadherin-2) mutant zebrafish will also be a major aspect of this study...
  4. The Zebrafish Model of Microphthalmia
    Jarema Malicki; Fiscal Year: 2008
    ..These studies will provide insight into the genetic basis of this debilitating disorder that affects 1 in 5,000 children. [unreadable] [unreadable] [unreadable]..