bbc3

Summary

Gene Symbol: bbc3
Description: BCL2 binding component 3
Alias: BCL2 binding component 3, Puma
Species: zebrafish

Top Publications

  1. ncbi Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis
    Sabine Fischer
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell Cycle 6:2962-9. 2007
  2. pmc Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53
    Shelly Sorrells
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Genet 8:e1002922. 2012
  3. doi Erythropoiesis failure due to RPS19 deficiency is independent of an activated Tp53 response in a zebrafish model of Diamond-Blackfan anaemia
    Hidetsugu Torihara
    Frontier Science Research Centre, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Br J Haematol 152:648-54. 2011
  4. pmc Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    Samuel Sidi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 133:864-77. 2008
  5. ncbi Functional characterization of the Bcl-2 gene family in the zebrafish
    E Kratz
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell Death Differ 13:1631-40. 2006
  6. pmc BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals
    C A Jette
    Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Differ 15:1063-72. 2008
  7. doi Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages
    Xiyan Mu
    College of Sciences, China Agricultural University, Beijing 100913, People s Republic of China Electronic address
    Aquat Toxicol 160:57-68. 2015
  8. doi Toxicity and enantiospecific differences of two β-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio)
    Liwei Sun
    College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032, People s Republic of China
    Environ Toxicol 29:1367-78. 2014
  9. doi A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis
    Paul B Essers
    Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands Electronic address
    Dev Biol 385:304-15. 2014
  10. pmc Analysis of apoptosis in zebrafish embryos by whole-mount immunofluorescence to detect activated Caspase 3
    Shelly Sorrells
    Department of Oncological Sciences, University of Utah
    J Vis Exp . 2013

Scientific Experts

  • Nadia Danilova
  • Tatiana Hochgreb-Hägele
  • Paul B Essers
  • Sergey V Prykhozhij
  • YuanXiang Jin
  • Shelly Sorrells
  • A Thomas Look
  • Lizhen Zhu
  • Xiyan Mu
  • Cristhian Toruno
  • Rodney A Stewart
  • Cicely Jette
  • Zhengwei Fu
  • Seth Carbonneau
  • Xiaofeng Zheng
  • Xinyi Zhao
  • Hidetsugu Torihara
  • Anirban Chakraborty
  • Tom Stiff
  • Andrew Khayrullin
  • Jelena Hrubik
  • Tingting Chai
  • Rong Zhou
  • Chengju Wang
  • Kai Wang
  • Yao Wang
  • J S Chua
  • Liwei Sun
  • Hajime Fukui
  • Wan Yu Pai
  • Dasa Longman
  • Catarina M Henriques
  • Leonard I Zon
  • Alison M Taylor
  • Tamara L Tal
  • Wei Lun Wang
  • Sebastian S Gerety
  • A Michael Forrester
  • Jingyuan Tong
  • E Rodríguez-Aznar
  • Chi Fang Chen
  • Ujwal J Pyati
  • Long Zhao
  • Anming Meng
  • Tian Tian
  • Tamayo Uechi
  • Tracy A Larson
  • Lin Guo
  • Naoya Kenmochi
  • Cicely A Jette
  • Jun Deng
  • C A Jette
  • Samuel Sidi
  • Sabine Fischer
  • E Kratz
  • Dhwani Mistry
  • Kristina Pogrmic-Majkic
  • Penny A Jeggo
  • Dragana Samardzija
  • Lauren Smith
  • Amy Dukes
  • Teresa Casar Tena
  • Svetlana Fa
  • Branka Glisic
  • Mark O'Driscoll
  • Mark W Hamrick
  • Y Albert Pan
  • Melanie Philipp
  • Bojana Stanic
  • Nebojsa Andric
  • D P Lane
  • Jing Si
  • Lu Gan
  • Yang Liu
  • Miaomiao Teng
  • L Guo
  • H P Liew
  • Lihong Qiu
  • Yang Yang
  • Wentao Zhu
  • Hong Zhang
  • Xin Zhou
  • Renke Zhang
  • Zhenguo Wang
  • Jie Zhang
  • Dongzhi Li
  • Zhiqiang Zhou
  • Li Xu
  • Jianzhen Li
  • Xuefeng Li

Detail Information

Publications41

  1. ncbi Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis
    Sabine Fischer
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell Cycle 6:2962-9. 2007
    ..In addition, we also show that regulation of caf-1b expression in the retina depends on a group of genes that regulate the switch from proliferation to differentiation...
  2. pmc Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53
    Shelly Sorrells
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Genet 8:e1002922. 2012
    ..Future studies in human cancer cells will determine whether pharmacological inactivation of CCDC94 reduces the threshold of the cancer cell apoptotic response...
  3. doi Erythropoiesis failure due to RPS19 deficiency is independent of an activated Tp53 response in a zebrafish model of Diamond-Blackfan anaemia
    Hidetsugu Torihara
    Frontier Science Research Centre, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Br J Haematol 152:648-54. 2011
    ..These results suggest that a Tp53-independent but RPS19-dependent pathway could be responsible for defective erythropoiesis in RPS19-deficient zebrafish...
  4. pmc Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    Samuel Sidi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 133:864-77. 2008
    ..The evolutionarily conserved "Chk1-suppressed" pathway defines a novel apoptotic process, whose responsiveness to Chk1 inhibitors and insensitivity to p53 and BCL2 alterations have important implications for cancer therapy...
  5. ncbi Functional characterization of the Bcl-2 gene family in the zebrafish
    E Kratz
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell Death Differ 13:1631-40. 2006
    ..These data indicate substantial functional similarity between zebrafish and mammalian Bcl-2 family members, and establish the zebrafish as a relevant model for studying the intrinsic apoptosis pathway...
  6. pmc BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals
    C A Jette
    Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Differ 15:1063-72. 2008
    ....
  7. doi Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages
    Xiyan Mu
    College of Sciences, China Agricultural University, Beijing 100913, People s Republic of China Electronic address
    Aquat Toxicol 160:57-68. 2015
    ..At 8 dpe, the modification in the transcription of the tested genes in the embryos and adult fish was similar, except for the genes related to the synthesis of sterols. ..
  8. doi Toxicity and enantiospecific differences of two β-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio)
    Liwei Sun
    College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032, People s Republic of China
    Environ Toxicol 29:1367-78. 2014
    ..These results also demonstrated that the enantiospecific toxicity of chiral β-blockers should be investigated when performing an ecological risk assessment...
  9. doi A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis
    Paul B Essers
    Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands Electronic address
    Dev Biol 385:304-15. 2014
    ....
  10. pmc Analysis of apoptosis in zebrafish embryos by whole-mount immunofluorescence to detect activated Caspase 3
    Shelly Sorrells
    Department of Oncological Sciences, University of Utah
    J Vis Exp . 2013
    ..Overall, the Casp3 assay represents a robust, highly reproducible assay in which to analyze apoptotic cells in early zebrafish embryos. ..
  11. pmc Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis
    Cristhian Toruno
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e88151. 2014
    ..embryonic neurons are highly sensitive to IR-induced apoptosis, and both p53 and its transcriptional target puma are essential mediators of the response...
  12. doi NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis
    A Michael Forrester
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Br J Haematol 155:167-81. 2011
    ..This tool provides a unique opportunity for high-throughput in vivo chemical modifier screens to identify novel therapeutic agents in high risk AML...
  13. pmc The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dis Model Mech 7:895-905. 2014
    ..Furthermore, the rescue of RP-deficient zebrafish with exogenous nucleosides suggests that nucleoside supplements could be beneficial in the treatment of DBA. ..
  14. doi S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish
    Hajime Fukui
    Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Dev Cell 31:128-36. 2014
    ..Consistently, ctgfa morphants showed defects of the endodermal sheet and cardia bifida. Collectively, we show that S1pr2/Yap1-regulated ctgfa expression is essential for the proper endoderm formation required for CPC migration...
  15. doi Znf385C mediates a novel p53-dependent transcriptional switch to control timing of facial bone formation
    Tatiana Hochgreb-Hägele
    Division of Biology, California Institute of Technology, 1200 E California Blvd, MC139 74, Pasadena, CA 91125, USA Electronic address
    Dev Biol 400:23-32. 2015
    ..Taken together, the results suggest that Znf385C acts as a developmental switch for p53 function that modulates cell cycle arrest of chondrocytes and regulates timing of jaw cartilage maturation and ossification. ..
  16. pmc Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish
    J S Chua
    p53 Laboratory, Biomedical Sciences Institutes, Agency for Science, Technology and Research A STAR, Singapore, Singapore
    Oncogene 34:5933-41. 2015
    ..Our results are suggestive of the hypothesis that p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 pathway. ..
  17. doi Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio)
    Lizhen Zhu
    College of Sciences, China Agricultural University, Beijing, People s Republic of China
    Environ Pollut 203:40-9. 2015
    ..Therefore, we speculated that oxidative stress-induced apoptosis should be responsible for abnormal development during embryogenesis after cyhalofop-butyl exposure. ..
  18. doi Enantioselective bioaccumulation of hexaconazole and its toxic effects in adult zebrafish (Danio rerio)
    Yao Wang
    Department of Applied Chemistry, China Agricultural University, Beijing, China
    Chemosphere 138:798-805. 2015
    ..Significant up-regulation of p53, Puma, Apaf-1, caspase-3 and caspase-9 expression and down-regulation of Bcl-2/Bax expression ratio were proved...
  19. doi The developmental toxicity and apoptosis in zebrafish eyes induced by carbon-ion irradiation
    Rong Zhou
    Department of Heavy Ion Irradiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, China Key Laboratory of Heavy Ion Irradiation Biology and Medicine of Chinese Academy of Sciences, China Key Laboratory of Heavy Ion Irradiation Medicine of Gansu Province, China
    Life Sci 139:114-22. 2015
    ..However, studies of the effects on development of normal organs were limited. Using a zebrafish model, this study investigated the potential developmental toxicity and cell apoptosis rates in eyes exposed to carbon-ion irradiation...
  20. pmc ATR promotes cilia signalling: links to developmental impacts
    Tom Stiff
    Double Strand Break Repair Laboratory and
    Hum Mol Genet 25:1574-87. 2016
    ..Our findings reveal a novel role for ATR in cilia signalling distinct from its canonical function during replication and strengthen emerging links between cilia function and development...
  21. doi Effect of PMA-induced protein kinase C activation on development and apoptosis in early zebrafish embryos
    Jelena Hrubik
    University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Laboratory for Ecotoxicology, Novi Sad, Serbia
    Comp Biochem Physiol C Toxicol Pharmacol 190:24-31. 2016
    ..acridine orange staining and caused up-regulation of caspase 9 (casp9) and p53 up-regulated modulator of apoptosis (puma) mRNA in whole embryos...
  22. doi Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle
    Andrew Khayrullin
    Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 479:590-595. 2016
    ..Furthermore, zebrafish may serve as a useful model for better understanding the role of microRNAs in alcohol-related tissue damage...
  23. pmc DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans
    Dasa Longman
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 41:8319-31. 2013
    ..Furthermore, the conservation of a mechanism to tightly control NMD homeostasis across different species highlights the importance of the NMD response in the control of gene expression. ..
  24. doi Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio)
    YuanXiang Jin
    College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China
    Fish Shellfish Immunol 34:717-23. 2013
    ..The information presented in this study will help with elucidating the differences and environmental risk of the two enantiomers of cis-BF-induced toxicity in aquatic organisms...
  25. doi Cannabinoid receptor 1 promotes hepatic lipid accumulation and lipotoxicity through the induction of SREBP-1c expression in zebrafish
    Wan Yu Pai
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, 2 Pei Ning Road, Keelung 20224, Taiwan
    Transgenic Res 22:823-38. 2013
    ..This study is the first to report CB1R as a potential hepatic stimulator for zebrafish liver steatosis. ..
  26. pmc Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos
    Xiaofeng Zheng
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Biol Chem 287:38254-64. 2012
    ..Our findings shed new light on developmental function of Nup107 in vertebrates...
  27. pmc MicroRNAs control neurobehavioral development and function in zebrafish
    Tamara L Tal
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, 28645 East HWY 34, Corvallis, OR 97333, USA
    FASEB J 26:1452-61. 2012
    ..Together, these data support an integral role for miRNAs in the establishment of vertebrate neurobehavioral and skeletal systems...
  28. pmc Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation
    Alison M Taylor
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Mass, USA
    Exp Hematol 40:228-237.e5. 2012
    ..Together, our studies demonstrate a role of p53 in mediating the cellular defects associated with rps29 and establish a role for rps29 and p53 in hematopoietic stem cells and red blood cell development...
  29. pmc Telomerase is required for zebrafish lifespan
    Catarina M Henriques
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    PLoS Genet 9:e1003214. 2013
    ..Thus, telomerase is limiting for zebrafish lifespan, enabling the study of telomere shortening in naturally ageing individuals...
  30. pmc Establishment of a transgenic zebrafish line for superficial skin ablation and functional validation of apoptosis modulators in vivo
    Chi Fang Chen
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
    PLoS ONE 6:e20654. 2011
    ..Previous studies demonstrated that fish skin is extremely sensitive to external stimuli. However, little is known about the molecular mechanisms that modulate skin cell apoptosis in zebrafish...
  31. pmc Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response
    Anirban Chakraborty
    Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan
    PLoS ONE 4:e4152. 2009
    ..These results suggest that ribosomal dysfunction due to the loss of L11 activates a p53-dependent checkpoint response to prevent improper embryonic development...
  32. doi Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos
    Jun Deng
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, China
    Aquat Toxicol 93:29-36. 2009
    ..1, 0.5, and 1.0 mg L(-1) HBCD. To test the apoptotic pathway, several genes related to cell apoptosis, such as p53, Puma, Apaf-1, caspase-9, and caspase-3, were examined using real-time PCR...
  33. ncbi Detection of the 113p53 protein isoform: a p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish
    Lin Guo
    p53 Laboratory, Immunos, Singapore
    Cell Cycle 9:1998-2007. 2010
    ....
  34. pmc Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish
    Xinyi Zhao
    Protein Science Laboratory of the Ministry of the Education, College of Life Sciences, Tsinghua University, Beijing 100084, China
    J Biol Chem 285:27924-34. 2010
    ..Taken together, our findings uncover an essential role of cenph in mitosis and embryonic development and its association with tumor development...
  35. pmc Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation
    Tracy A Larson
    Department of Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Dev Biol 346:296-309. 2010
    ..Here, we analyze the zebrafish puma mutant, isolated originally for pigment pattern defects limited to the adult stage...
  36. pmc In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish
    Sergey V Prykhozhij
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS ONE 5:e13549. 2010
    ..Thus, an unsolved question is how the same signalling molecule can regulate such distinct cell processes as proliferation, cell survival and differentiation...
  37. pmc Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development
    Sebastian S Gerety
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, UK
    Dev Biol 350:279-89. 2011
    ..We find that the pro-apoptotic Bcl genes puma and bax-a are required for hindbrain boundary marker expression, and that gain of function of the Bcl-caspase ..
  38. pmc Repression of Puma by scratch2 is required for neuronal survival during embryonic development
    E Rodríguez-Aznar
    Instituto de Neurociencias CSIC UMH, Avenida Ramon y Cajal s n, San Juan de Alicante 03550, Spain
    Cell Death Differ 18:1196-207. 2011
    ..p53 and Snail2 act antagonistically to regulate p53 upregulated modulator of apoptosis (Puma) and cell death in hematopoietic progenitors following DNA damage...
  39. pmc Stage-specific expression of TNFα regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells
    Wei Lun Wang
    Institute of Fisheries Science, National Taiwan University, Taipei, Taiwan, Republic of China
    PLoS ONE 6:e16740. 2011
    ..i.). Taken together, our results indicate that IPNV triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNFα, and these results may provide new insights into the pathogenesis of RNA viruses...
  40. doi Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio)
    YuanXiang Jin
    College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China
    Fish Shellfish Immunol 30:1049-54. 2011
    ..The mRNA levels of some key genes including P53, Puma, Bax, Apaf1, Cas9 and Cas3 on the mitochondrial pathway of cell apoptosis were significantly up-regulated at the ..
  41. pmc p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis
    Ujwal J Pyati
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 21:492-505. 2011
    ..Focusing on the tail epidermis, we uncover an apoptotic response that depends on Puma, but not on p53 or Chop...