badb

Summary

Gene Symbol: badb
Description: BCL2-associated agonist of cell death b
Alias: bad, fa01b12, wu:fa01b12, wu:fa96d04, BCL2-antagonist of cell death b, proapoptotic BH3-only protein
Species: zebrafish

Top Publications

  1. ncbi GLUT1 deficiency links nutrient availability and apoptosis during embryonic development
    Penny J Jensen
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:13382-7. 2006
  2. ncbi Functional characterization of the Bcl-2 gene family in the zebrafish
    E Kratz
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell Death Differ 13:1631-40. 2006
  3. pmc BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals
    C A Jette
    Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Differ 15:1063-72. 2008
  4. doi Aquatic birnavirus capsid protein, VP3, induces apoptosis via the Bad-mediated mitochondria pathway in fish and mouse cells
    Chien Li Chiu
    Institute of Biotechnology, National Cheng Kung University, Tainan, Taiwan, ROC
    Apoptosis 15:653-68. 2010
  5. pmc Akt2 modulates glucose availability and downstream apoptotic pathways during development
    Penny J Jensen
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:17673-80. 2010
  6. pmc Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos
    Jenher Lu
    Department of Pediatrics and Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Biomed Sci 18:73. 2011
  7. pmc Efficient transgenesis mediated by pigmentation rescue in zebrafish
    Itrat Harrold
    Departments of Pharmacology and Medicine, Cancer Research Center, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA
    Biotechniques 60:13-20. 2016
  8. pmc GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish
    Rubén Marín-Juez
    Departament de Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona and Institut de Biomedicina de la Universitat de Barcelona IBUB, Barcelona, Spain
    J Cereb Blood Flow Metab 35:74-85. 2015
  9. pmc Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis
    Cristhian Toruno
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e88151. 2014
  10. doi Development of Cre-loxP technology in zebrafish to study the regulation of fish reproduction
    Heng Ju Lin
    Graduate Institute of Engineering Technology Doctoral, National Taipei University of Technology, 1 Chung Hsiao E Rd, Sec 3, Taipei, 10608, Taiwan
    Fish Physiol Biochem 39:1525-39. 2013

Scientific Experts

  • Jenher Lu
  • Jen Leih Wu
  • Penny J Jensen
  • Wei Lun Wang
  • Hong Yi Gong
  • Itrat Harrold
  • Seth Carbonneau
  • Rubén Marín-Juez
  • Cristhian Toruno
  • Heng Ju Lin
  • Tzu Chun Tsai
  • Galen W Miller
  • Gen Hwa Lin
  • Jiann Ruey Hong
  • Chien Li Chiu
  • Shao Yang Hu
  • Amy T McCurley
  • C A Jette
  • Mary O Carayannopoulos
  • Jing Chen
  • Aseervatham Anusha Amali
  • E Kratz
  • John P Kanki
  • Amandeep S Saini
  • Bethany M Moore
  • Yueh Chun Hsieh
  • Cicely A Jette
  • Gina Nguyen
  • Hui Feng
  • Nicole M Anderson
  • Diego Crespo
  • Mireia Rovira
  • Herman P Spaink
  • Michiel van der Vaart
  • Josep V Planas
  • Cicely Jette
  • Rodney A Stewart
  • Yeh Fang Duann
  • Shu Hua Lee
  • Jyh Yih Chen
  • Shu Yu Yeh
  • Maret G Traber
  • Robert L Tanguay
  • Katie M Lebold
  • Abby Floeter
  • Hsin Yu Lee
  • Ren Bing Tang
  • Sie Lin Choo
  • J Bae
  • Edwin M Labut
  • Wangta Liu
  • Ming Wei Lu
  • Ching Chun Lin
  • Koichi Kawakami
  • Gloria V Callard
  • Guor Mour Her
  • Yi Li Chou
  • Pei Yu Lin
  • Chia Hsuan Liao
  • Laura B Gunter
  • U J Pyati
  • A M Flanagan
  • A T Look
  • Richard E Peterson
  • S Carbonneau
  • A Letai
  • Sara A Carney
  • D M Langenau
  • R A Stewart
  • Warren Heideman
  • J Ryan
  • A Ashkenazi
  • H Stern
  • A Strasser
  • Ravikumar Deepa Rekha
  • J Zha
  • Jonathan D Gitlin
  • K Mukhyala
  • Cliff Ji Fan Lin
  • Gour Mour Her
  • P M Eimon
  • R Hart
  • Jeffrey Jong Young Yen
  • Mau Sun Chang
  • Chih Ming Chou
  • I Ching Lu
  • Chang Jen Huang
  • Jeou Yuan Chen
  • A J Hsueh
  • S Y Hsu

Detail Information

Publications19

  1. ncbi GLUT1 deficiency links nutrient availability and apoptosis during embryonic development
    Penny J Jensen
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:13382-7. 2006
    ..Strikingly, inhibiting expression of the zebrafish orthologue of the proapoptotic protein Bad resulted in complete rescue of this phenotype, and this occurred even in the absence of restoration of apparent ..
  2. ncbi Functional characterization of the Bcl-2 gene family in the zebrafish
    E Kratz
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell Death Differ 13:1631-40. 2006
    ..These data indicate substantial functional similarity between zebrafish and mammalian Bcl-2 family members, and establish the zebrafish as a relevant model for studying the intrinsic apoptosis pathway...
  3. pmc BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals
    C A Jette
    Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Differ 15:1063-72. 2008
    ..The zebrafish bad gene shows a complete lack of embryonic lethality, but like mammalian BAD, its pro-apoptotic activity is regulated ..
  4. doi Aquatic birnavirus capsid protein, VP3, induces apoptosis via the Bad-mediated mitochondria pathway in fish and mouse cells
    Chien Li Chiu
    Institute of Biotechnology, National Cheng Kung University, Tainan, Taiwan, ROC
    Apoptosis 15:653-68. 2010
    ..the present study, we demonstrated that the submajor capsid protein, VP3, up-regulates the pro-apoptotic protein, Bad, in fish and mouse cells...
  5. pmc Akt2 modulates glucose availability and downstream apoptotic pathways during development
    Penny J Jensen
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:17673-80. 2010
    ..Similar to what was observed in the glut1 morphants, inhibiting the expression of the proapoptotic protein, bad, in the context of impaired akt2 expression results in the inhibition of apoptosis and rescue of the morphant ..
  6. pmc Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos
    Jenher Lu
    Department of Pediatrics and Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Biomed Sci 18:73. 2011
    ..We report aberrant apoptosis and dormant cell growth over head, heart, trunk, fin, and tail of zebrafish embryos with tbx5 deficiency correspond to the dysmorphogenesis of tbx5 morphants...
  7. pmc Efficient transgenesis mediated by pigmentation rescue in zebrafish
    Itrat Harrold
    Departments of Pharmacology and Medicine, Cancer Research Center, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA
    Biotechniques 60:13-20. 2016
    ..Thus, this approach is ideal for generating transgenic fish for large-scale screens. ..
  8. pmc GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish
    Rubén Marín-Juez
    Departament de Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona and Institut de Biomedicina de la Universitat de Barcelona IBUB, Barcelona, Spain
    J Cereb Blood Flow Metab 35:74-85. 2015
    ..These results indicate that glut2 has an essential role during brain development by facilitating the uptake and availability of glucose and support the involvement of glut2 in brain glucose sensing. ..
  9. pmc Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis
    Cristhian Toruno
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e88151. 2014
    ..This distinguishes it from BH3-only proteins like Bad that are thought to indirectly promote apoptosis through binding to anti-apoptotic Bcl-2 family members, thereby ..
  10. doi Development of Cre-loxP technology in zebrafish to study the regulation of fish reproduction
    Heng Ju Lin
    Graduate Institute of Engineering Technology Doctoral, National Taipei University of Technology, 1 Chung Hsiao E Rd, Sec 3, Taipei, 10608, Taiwan
    Fish Physiol Biochem 39:1525-39. 2013
    ..Accordingly, this transgenic zebrafish model system provides a method to produce infertile fish and may be useful for application to genetically modified fish. ..
  11. pmc The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos
    Tzu Chun Tsai
    Department of Medical Research and Education, National Yang Ming University Hospital, Yilan, Taiwan, Republic of China
    J Biomed Sci 19:63. 2012
    ..Dysmorphogenesis and multiple organ defects are well known in zebrafish (Danio rerio) embryos with T-box transcription factor 5 (tbx5) deficiencies, mimicking human Holt-Oram syndrome...
  12. pmc Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality
    Galen W Miller
    The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr Biochem 23:478-86. 2012
    ..05) at 120 h post-fertillization than embryos from parents fed E+ or lab diets. This study documents for the first time that vitamin E is essential for normal zebrafish embryonic development...
  13. pmc Stage-specific expression of TNFα regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells
    Wei Lun Wang
    Institute of Fisheries Science, National Taiwan University, Taipei, Taiwan, Republic of China
    PLoS ONE 6:e16740. 2011
    Infectious pancreatic necrosis virus (IPNV) can induce Bad-mediated apoptosis followed by secondary necrosis in fish cells, but it is not known how these two types of cell death are regulated by IPNV...
  14. pmc Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration
    Amy T McCurley
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215 USA
    J Exp Neurosci 2010:17-33. 2010
    ....
  15. doi Nitroreductase-mediated gonadal dysgenesis for infertility control of genetically modified zebrafish
    Shao Yang Hu
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
    Mar Biotechnol (NY) 12:569-78. 2010
    ..These results show that oocyte-specific nitroreductase-mediated catalysis of metronidazole can cause reliable infertility in zebrafish and could potentially be used as a model for other aquaculture fish species...
  16. doi Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart
    Jing Chen
    Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA
    Physiol Genomics 33:148-58. 2008
    ..Among the genes rapidly induced by RA was Nr2F5, a member of the COUP-TF family of transcriptional repressors. We found that induction of Nr2F5 was both necessary and sufficient for the cardiotoxic response to RA...
  17. ncbi Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis
    Aseervatham Anusha Amali
    Laboratory of Marine Molecular Biology and Biotechnology 301, Institute Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan
    J Biomed Sci 13:225-32. 2006
    ..and the increasing of apoptosis was observed to be associated with the up-regulation of apoptotic genes such as, bad, bax, P-38a, caspase-3 and 8, and JNK-1...
  18. ncbi Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos
    Yueh Chun Hsieh
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Biochem Biophys Res Commun 304:667-75. 2003
    The BH3-only proapoptotic protein, BAD, was cloned from zebrafish embryos and its properties were characterized...
  19. ncbi Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Apoptosis 6:319-30. 2001
    ..activate kinases which, in turn, phosphorylate the proapoptotic Bcl-xl/Bcl-2-associated death promoter homolog (BAD) protein at key serine residues...