ascl1a

Summary

Gene Symbol: ascl1a
Description: achaete-scute family bHLH transcription factor 1a
Alias: Zash-1a, ash, asha, id:ibd5085, im:7138587, si:dkey-264k15.2, zash1a, zasha, achaete-scute homolog 1a, pia, pituitary absent, pituitary-absent protein
Species: zebrafish

Top Publications

  1. ncbi The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis
    Hans Martin Pogoda
    Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Development 133:1079-89. 2006
  2. pmc The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration
    Blake V Fausett
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 28:1109-17. 2008
  3. pmc Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina
    Craig M Nelson
    Department of Biological Sciences and the Center for Zebrafish Research, Galvin Life Science Building, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Comp Neurol 520:4294-311. 2012
  4. ncbi Cohesin-dependent regulation of Runx genes
    Julia A Horsfield
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Development 134:2639-49. 2007
  5. ncbi Time course analysis of gene expression during light-induced photoreceptor cell death and regeneration in albino zebrafish
    Sean C Kassen
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Dev Neurobiol 67:1009-31. 2007
  6. pmc HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration
    Jin Wan
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 22:334-47. 2012
  7. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007
  8. ncbi Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis
    Ji Eun Lee
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84105, USA
    Development 133:4451-61. 2006
  9. ncbi The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons
    Marsha E Lucas
    Center for Molecular Neurobiology, Molecular, Cellular and Developmental Biology Program, Department of Neuroscience, The Ohio State University, 105 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    Development 133:4015-24. 2006
  10. pmc Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
    Zhao Qin
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, 830 North University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 106:9310-5. 2009

Scientific Experts

  • Prisca Chapouton
  • Ting Zhang
  • Marion Coolen
  • BRUCE RILEY
  • Mario F Wullimann
  • Marika Kapsimali
  • Reiko Toyama
  • Steffen Scholpp
  • Xiaomei Wei
  • David M McGaughey
  • Thomas Mueller
  • Travis J Bailey
  • Yi Chuan Cheng
  • Daniel Goldman
  • Lydie C Flasse
  • Rodney A Stewart
  • Kunal Rai
  • Paul D Henion
  • Fu Yu Hsieh
  • Mizuki Azuma
  • David R Hyde
  • Rajesh Ramachandran
  • Elise Cau
  • Zhao Qin
  • Rani E George
  • Nan Yang
  • Julia Mahler
  • Blake V Fausett
  • Sean C Kassen
  • Brigitte L Arduini
  • Victor Muthu
  • Shuqiang Zhang
  • Ruiqin Han
  • Scott M Taylor
  • Vitor Fortuna
  • Ryan R Williams
  • Staci L Solin
  • Clay Conner
  • Michiel van der Vaart
  • Sheng Jia Lin
  • Tsu Lin Ma
  • Ryan Thummel
  • Hung Yu Shih
  • Isabelle Manfroid
  • Myron S Ignatius
  • Gilbert Lauter
  • Gillian Roach
  • Jenny R Lenkowski
  • Bernard Peers
  • Ryan B MacDonald
  • David G Stern
  • Marianne L Voz
  • Desheng Pei
  • Justine L Pirson
  • Kristin M Ackerman
  • Wenchao Wang
  • Birgit Adolf
  • Stefan Hans
  • Curtis Powell
  • Julia Ganz
  • Jin Wan
  • Shizhen Zhu
  • Craig M Nelson
  • Y C Chen
  • Rosa A Uribe
  • Dorian Freudenreich
  • Jan Kaslin
  • Michael Brand
  • Laure Bally-Cuif
  • Akihiko Muto
  • Sebastian S Gerety
  • Judith T M L Paridaen
  • Pei Chen Chung
  • Volker Kroehne
  • Pamela A Raymond
  • Y Guo
  • Su Guo
  • John P Kanki
  • A Thomas Look
  • Wolfgang Driever
  • Stephanie Chidester
  • Adam R Karpf
  • David A Jones
  • Bradley R Cairns
  • Smitha R James
  • David G Wilkinson
  • Philip S Choi
  • Elly Suk Hen Chow
  • Patrick Yurco
  • Soojin Ryu

Detail Information

Publications85

  1. ncbi The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis
    Hans Martin Pogoda
    Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Development 133:1079-89. 2006
    ..the molecular nature of the pia mutation, we investigate the role of the zebrafish achaete-scute homologue ascl1a during development of the adenohypophysis, an endocrine derivative of the placodal ectoderm...
  2. pmc The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration
    Blake V Fausett
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 28:1109-17. 2008
    ..of a critical E-box in the alpha1T promoter that mediates transactivation by achaete-scute complex-like 1a (ascl1a) during retina regeneration. More importantly, we show that ascl1a is essential for retina regeneration...
  3. pmc Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina
    Craig M Nelson
    Department of Biological Sciences and the Center for Zebrafish Research, Galvin Life Science Building, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Comp Neurol 520:4294-311. 2012
    We analyzed the role of Stat3, Ascl1a, and Lin28a in Müller glia reentry into the cell cycle following damage to the zebrafish retina...
  4. ncbi Cohesin-dependent regulation of Runx genes
    Julia A Horsfield
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Development 134:2639-49. 2007
    ..monoallelic loss of rad21 caused a reduction in the transcription of runx1 and of the proneural genes ascl1a and ascl1b, indicating that downstream genes are sensitive to Rad21 dose...
  5. ncbi Time course analysis of gene expression during light-induced photoreceptor cell death and regeneration in albino zebrafish
    Sean C Kassen
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Dev Neurobiol 67:1009-31. 2007
    ..Some of the Stat3-positive Müller cells expressed PCNA at 31 h, suggesting that Stat3 may play a role in signaling a subset of Müller cells to proliferate during the regeneration response...
  6. pmc HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration
    Jin Wan
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 22:334-47. 2012
    ..via an EGFR/MAPK signal transduction cascade that regulates the expression of regeneration-associated genes, like ascl1a and pax6(b)...
  7. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007
    ..Furthermore, zebrafish Dnmt2 methylates an RNA species of approximately 80 bases, consistent with tRNA methylation. Thus, Dnmt2 promotes zebrafish development, likely through cytoplasmic RNA methylation...
  8. ncbi Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis
    Ji Eun Lee
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84105, USA
    Development 133:4451-61. 2006
    ..The conserved presence of this pathway in other vertebrates suggests a common mechanism for regulating hypothalamic neurogenesis...
  9. ncbi The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons
    Marsha E Lucas
    Center for Molecular Neurobiology, Molecular, Cellular and Developmental Biology Program, Department of Neuroscience, The Ohio State University, 105 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    Development 133:4015-24. 2006
    ..ganglion primordia characterized by the expression of phox2b, phox2a and the achaete-scute family member zash1a/ascl1...
  10. pmc Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
    Zhao Qin
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, 830 North University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 106:9310-5. 2009
    ..Comparison of gene expression profiles from regenerating zebrafish retina, caudal fin, and heart muscle revealed additional candidate genes potentially implicated in injury-induced epimorphic regeneration in diverse zebrafish tissues...
  11. ncbi Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system
    Mizuki Azuma
    Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:13309-16. 2006
    ..The bap28 mutation provides a genetic approach to study the role of ribosome biogenesis in the development of a vertebrate embryo...
  12. ncbi Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain
    Marc Amoyel
    Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 132:775-85. 2005
    ..The network of genes underlying the regulation of neurogenesis and lateral inhibition of boundary cell formation by Wnt1 has a striking similarity to mechanisms at the dorsoventral boundary in the Drosophila wing imaginal disc...
  13. ncbi Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain
    Bruce B Riley
    Biology Department, Texas A and M University, College Station, Texas 77843 3258, USA
    Dev Dyn 231:278-91. 2004
    ..Similar feedback mechanisms operate in the Drosophila wing disc and vertebrate limb bud, suggesting coaptation of a conserved signaling module that spatially organizes cells in complex organ systems...
  14. pmc Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish
    Y Guo
    W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Neuroscience 172:329-41. 2011
    ..In the injured spinal cord, expression of the neural stem cell associated gene Nestin, and the proneural gene Ascl1a (Mash1a), which are involved in the self-renewal and cell fate specification of endogenous neural stem cells, ..
  15. ncbi Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of Notch to inhibit neurogenesis at the midbrain-hindbrain boundary
    Andrea Geling
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675 Munich, Germany
    Development 131:1993-2006. 2004
    ..Together our data demonstrate a role of Her5 as a prepattern factor in the spatial definition of proneural domains in the zebrafish neural plate, in a manner similar to its Drosophila homologue Hairy...
  16. ncbi Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis
    Elise Cau
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:2455-66. 2003
    ..These populations do not simply correspond to the two described epiphysial cell types: photoreceptors and projection neurones. These results suggest that the genetic pathways that involve ash1a and ngn1 are common to both neuronal types...
  17. doi miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors
    Marion Coolen
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR 3294, Institute of Neurobiology Alfred Fessard, 91198 Gif sur Yvette Cedex, France
    Dev Cell 22:1052-64. 2012
    ....
  18. pmc Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus
    Victor Muthu
    The Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 143:2651-63. 2016
    ....
  19. pmc Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration
    Shuqiang Zhang
    Jiangsu Key Lab of Neuroregeneration Co innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China
    Invest Ophthalmol Vis Sci 57:1991-2000. 2016
    ..The purpose of this study was to investigate the effect of the antiviral drug ganciclovir (GCV) on Müller glia dedifferentiation and proliferation and the underlying cellular and molecular mechanisms in adult zebrafish...
  20. pmc Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis
    Rosa A Uribe
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, TX 78712, USA
    Dev Biol 371:280-92. 2012
    ..These data highlight the integral role played by Id2a in the gene regulatory network governing the transition from retinoblast proliferation to terminal differentiation during vertebrate retinogenesis...
  21. pmc Trim69 regulates zebrafish brain development by ap-1 pathway
    Ruiqin Han
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
    Sci Rep 6:24034. 2016
    ..Overall, our results support a role for trim69 in the development of the zebrafish brain through ap-1 pathway. ..
  22. pmc The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling
    Scott M Taylor
    Department of Ophthalmology and Visual Sciences University of Michigan, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
    Invest Ophthalmol Vis Sci 56:7496-515. 2015
    ..The purpose of this study was to identify these pathways, and during photoreceptor genesis, Notch signaling was investigated as the putative mediator of NeuroD function...
  23. pmc Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain
    Nan Yang
    Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    J Neurosci 32:10940-8. 2012
    ..First, our genetic analyses reveal the requirement of the achaete-scute-like genes ascl1a and 1b in serotonergic and GABAergic neuron development, but they are dispensable for the specification of ..
  24. doi Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons
    Vitor Fortuna
    Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510, USA Health Science Institute, Federal University of Bahia, Salvador 40110 902, Brazil
    Cell Rep 11:1786-96. 2015
    ..Thus, PDGFR-mediated mural cell recruitment mediates neurovascular interactions between the aorta and sympathetic precursors and promotes their noradrenergic differentiation. ..
  25. pmc Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b
    Curtis Powell
    The Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor Michigan 48109, USA
    J Neurosci 32:1096-109. 2012
    ..The maximal induction of apobec2b required Ascl1a, but was independent of Lin28, and therefore defines an independent signaling pathway stemming from Ascl1a...
  26. pmc MASH1/Ascl1a leads to GAP43 expression and axon regeneration in the adult CNS
    Ryan R Williams
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States of America
    PLoS ONE 10:e0118918. 2015
    ..The basic helix-loop-helix (bHLH) transcription factor, MASH1/Ascl1a, is transiently expressed during the development of many neuronal subtypes and regulates the expression of genes ..
  27. pmc The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon
    Ryan B MacDonald
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada, K1N 6N5
    Dev Biol 381:276-85. 2013
    ..Here, we have examined the regulatory relationships between the ascl1a, dlx, and gad1b genes in the zebrafish forebrain...
  28. pmc Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis
    Staci L Solin
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 9:e114888. 2014
    ..qRT-PCR confirmed >10-fold overexpression of the Wnt pathway components hbegfa, ascl1a, and insm1a...
  29. doi The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis
    Yi Chuan Cheng
    Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Taoyuan 33383, Taiwan Electronic address
    Dev Biol 397:116-28. 2015
    ..Together, these two mechanisms ensure the proper development of the neural progenitor cell pool. ..
  30. pmc Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish
    Lydie C Flasse
    Laboratory of zebrafish development and disease models, University of Liege ULg, Liege 4000, Belgium
    BMC Biol 11:78. 2013
    ..It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state...
  31. pmc Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling
    Jenny R Lenkowski
    Molecular, Cellular, and Developmental Biology, University of Michigan, 830 N University, Ann Arbor, Michigan, USA
    Glia 61:1687-97. 2013
    ..Tgif1 expression and regulation of TGFβ signaling are implicated in the function of several types of stem cells, but this is the first demonstration that this regulatory network is necessary for regeneration of neurons...
  32. doi The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]
    Michiel van der Vaart
    Institute of Biology, Leiden University, 2333 CC Leiden, The Netherlands
    Cell Host Microbe 15:753-67. 2014
    ..We propose that DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide...
  33. pmc Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells
    Clay Conner
    Department of Biological Sciences and the Center for Zebrafish Research, Galvin Life Sciences Building, University of Notre Dame, Notre Dame, Indiana 46556
    J Neurosci 34:14403-19. 2014
    ..This RO4929097-induced proliferation requires Ascl1a expression and Jak1-mediated Stat3 phosphorylation/activation, analogous to the light-damaged retina...
  34. pmc Activated ALK collaborates with MYCN in neuroblastoma pathogenesis
    Shizhen Zhu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 21:362-73. 2012
    ..Coexpression of activated ALK with MYCN provides prosurvival signals that block this apoptotic response and allow continued expansion and oncogenic transformation of hyperplastic neuroblasts, thus promoting progression to neuroblastoma...
  35. doi MANF regulates dopaminergic neuron development in larval zebrafish
    Y C Chen
    Neuroscience Center and Institute of Biomedicine AnatomyUniversity of Helsinki, Finland
    Dev Biol 370:237-49. 2012
    ..Strikingly, manf mRNA could partly restore the decrease of th1 positive cells in Nr4a2-deficient larvae. These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish...
  36. doi Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon
    Gilbert Lauter
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    J Comp Neurol 521:1093-118. 2013
    ..Our comparative gene expression analysis conformed with the idea of a common bauplan for the diencephalon of anamniote and amniote vertebrates from fish to mammals...
  37. doi The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine
    Lydie C Flasse
    Unit of Molecular Biology and Genetic Engineering, GIGA Research, University of Liege, 1 Avenue de l Hôpital B34, B 4000 Sart Tilman Liège, Belgium
    Dev Biol 376:187-97. 2013
    ..b>ascl1a was found to be the earliest factor detected in the intestine...
  38. pmc Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome
    Akihiko Muto
    Department of Developmental and Cell Biology, University of California, Irvine, California, United States of America
    PLoS Biol 9:e1001181. 2011
    ....
  39. doi Subdivisions of the adult zebrafish subpallium by molecular marker analysis
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany
    J Comp Neurol 520:633-55. 2012
    ..Further, the septal nuclei derive from both the pallium and subpallium. On this basis, we present a new model for the subdivisions of the subpallium in teleost fish...
  40. pmc Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility
    Gillian Roach
    Department of Biology, Clarkson University, 8 Clarkson Ave, Potsdam, NY 13699, USA
    Dev Biol 376:171-86. 2013
    ..Here, we demonstrate that in contrast to the atoh1 in mammals, ascl1a is responsible for formation of secretory cells in zebrafish...
  41. doi Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish
    Fu Yu Hsieh
    Graduate Institute of Biomedical Sciences, School of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Dev Biol 375:1-12. 2013
    ..This is the first study to demonstrate a role for Dner in neural progenitors and neuronal differentiation and provides new insights into mediation of neuronal development and differentiation by the Notch signaling pathway...
  42. pmc Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development
    Myron S Ignatius
    Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e63218. 2013
    ..Our study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development...
  43. pmc Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models
    Desheng Pei
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 9:e1003533. 2013
    ....
  44. ncbi On the organisation of the regulatory region of the zebrafish deltaD gene
    Stefan Hans
    Institut fur Entwicklungsbiologie, Universitat zu Koln, 50923 Koln, Germany
    Development 129:4773-84. 2002
    ..controlled by two relatively small genomic regions, which are regulated by the proneural proteins neurogenin 1 and zash1a/b acting as transcriptional activators that bind to so-called E-boxes...
  45. pmc Dnmt3 and G9a cooperate for tissue-specific development in zebrafish
    Kunal Rai
    Department of Oncological Sciences, oward Hughes Medical Institute, and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 285:4110-21. 2010
    ..We propose a model wherein specific DNMT-histone methyltransferase networks are utilized to silence critical regulators of cell fate in a tissue-specific manner...
  46. doi Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors
    Volker Kroehne
    Biotechnology Center and DFG Research Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Tatzberg 47 49, 01307 Dresden, Germany
    Development 138:4831-41. 2011
    ..Thus, regeneration after traumatic lesion of the adult zebrafish brain occurs efficiently from radial glia-type stem/progenitor cells...
  47. doi Fgf signaling controls pharyngeal taste bud formation through miR-200 and Delta-Notch activity
    Marika Kapsimali
    Ecole Normale Superieure, Institut de Biologie, 75005 Paris, France
    Development 138:3473-84. 2011
    ..Conversely, larvae with increased Notch activity and ascl1a(-/-) mutants are devoid of 5HT(+) cells, but have maintained and increased Calb2b(+) cells, respectively...
  48. doi The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish
    Judith T M L Paridaen
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Dev Biol 355:286-301. 2011
    ..Finally, the data suggest that Gnl2 and NS affect cell cycle exit of neural progenitors by regulating the expression of cell cycle regulators independently of p53...
  49. pmc Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis
    Pei Chen Chung
    School of Medicine, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan
    PLoS ONE 6:e19394. 2011
    ....
  50. doi Expression of hairy/enhancer of split genes in neural progenitors and neurogenesis domains of the adult zebrafish brain
    Prisca Chapouton
    Zebrafish Neurogenetics Department, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    J Comp Neurol 519:1748-69. 2011
    ....
  51. ncbi Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant
    Naoto Matsuda
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and SORST, Japan Science and Technology Agency, Tokyo 113 0033, Japan
    Development 131:1913-25. 2004
    ..Similarly, the expression of brn3b was normal in the tectum of ntn mutants, but tectal neuropil formation was abolished. These results suggest that the gamma subunit of chaperonin CCT plays an essential role in retinotectal development...
  52. pmc Glucocorticoids play a key role in circadian cell cycle rhythms
    Thomas Dickmeis
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    PLoS Biol 5:e78. 2007
    ..Instead, they act in concert with a systemic signaling environment of which glucocorticoids are an essential part...
  53. pmc A subunit of the mediator complex regulates vertebrate neuronal development
    Xiaoqun Wang
    Program in Genetics, Neuroscience, and Developmental Biology, Department of Biopharmaceutical Sciences, and Center for Human Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:17284-9. 2006
    ..when overexpressed is capable of increasing, the expression of distinct neuronal determination genes, including zash1a and lim1, and serves as an in vivo cofactor for Sox9 in this process...
  54. ncbi her5 expression reveals a pool of neural stem cells in the adult zebrafish midbrain
    Prisca Chapouton
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
    Development 133:4293-303. 2006
    ..In addition, the first transcription factor characteristic of this cell population, Her5, points to the E(Spl) as a promising family of candidate adult neural stem cell regulators...
  55. ncbi Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon
    Birgit Adolf
    Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
    Dev Biol 295:278-93. 2006
    ....
  56. ncbi Proneural gene requirement for hair cell differentiation in the zebrafish lateral line
    Andres F Sarrazin
    Millennium Nucleus in Developmental Biology, Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Dev Biol 295:534-45. 2006
    ..We propose that the emergence of two atonal homologs, ath1 and ngn1, allowed the cellular segregation of mechanoreception and signal transmission that were originally performed by a single cell type as found in insects...
  57. ncbi Zebrafish foxd3 is selectively required for neural crest specification, migration and survival
    Rodney A Stewart
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:174-88. 2006
    ....
  58. ncbi A phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse
    Thomas Mueller
    Centre National de la Recherche Scientifique, Institute of Neurobiology A Fessard, Development, Evolution, and Plasticity of the Nervous System, Research Unit 2197, 91198 Gif sur Yvette, France
    J Comp Neurol 494:620-34. 2006
    ..expression patterns of developmentally relevant genes, for example, of proneural (Neurogenin1, NeuroD, Mash1/Zash1a) genes involved in neurogenesis at a particular time window (mouse: embryonic day 12.5/13.5; zebrafish: 3 days)...
  59. ncbi Lhx2 mediates the activity of Six3 in zebrafish forebrain growth
    Hideki Ando
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Dev Biol 287:456-68. 2005
    ..Our results suggest that Lhx2 may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3...
  60. ncbi Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development
    Soojin Ryu
    Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    Curr Biol 17:873-80. 2007
    ..Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system...
  61. ncbi Identification and morphogenesis of the eminentia thalami in the zebrafish
    Mario F Wullimann
    Centre National de la Recherche Scientifique Institute of Neurobiology A Fessard, Development, Evolution, Plasticity of the Nervous System Research Unit 2197, F 91198 Gif sur Yvette Cedex, France
    J Comp Neurol 471:37-48. 2004
    ..In contrast, the migrated teleostean entopeduncular complex does not correspond to a pallidal division but is indeed the adult derivative of the early-recognized eminentia thalami as shown in this study...
  62. ncbi Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development
    Jennifer Walshe
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Development 130:4337-49. 2003
    ..Analysis of embryos treated with an FGFR inhibitor suggests that continuous FGF signalling is required from gastrulation stages for normal forebrain patterning, and identifies additional requirements for FGFR activity...
  63. ncbi Selective control of neuronal cluster size at the forebrain/midbrain boundary by signaling from the prechordal plate
    Alexandra Tallafuss
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Munich, Germany
    Dev Dyn 227:524-35. 2003
    ..Together, our results suggest that a combination of patterning-related and -unrelated mechanisms specifically controls the size of individual early neuronal clusters within the anterior neural plate...
  64. ncbi Expression of Zash-1a in the postembryonic zebrafish brain allows comparison to mouse Mash1 domains
    Mario F Wullimann
    Brain Research Institute, FB 2, University of Bremen, P O Box 330440, 2834 Bremen, Germany
    Brain Res Gene Expr Patterns 1:187-92. 2002
    ..Furthermore, previous initial identification of early postembryonic brain subdivisions in the zebrafish is strongly corroborated by these expression patterns...
  65. ncbi Role of hlx1 in zebrafish brain morphogenesis
    Jensen T Hjorth
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
    Int J Dev Biol 46:583-96. 2002
    ..Our results indicate multiple roles for hlx1 during zebrafish brain morphogenesis...
  66. ncbi alyron, an insertional mutation affecting early neural crest development in zebrafish
    C J Cretekos
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, 84112, USA
    Dev Biol 210:322-38. 1999
    ....
  67. ncbi floating head and masterblind regulate neuronal patterning in the roof of the forebrain
    I Masai
    Developmental Biology Research Centre, Randall Institute, King s College, London, United Kingdom
    Neuron 18:43-57. 1997
    ..We propose a role for Flh in linking the signaling pathways that regulate regional patterning to the signaling pathways that regulate neurogenesis...
  68. ncbi Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain
    Q Xu
    DBRC, The Randall Institute, King s College, London, UK
    Nature 381:319-22. 1996
    ..We find that expression of a truncated receptor leads to expansion of the eye field into diencephalic territory and loss of diencephalic structures, indicating a role for Rtk1 in patterning the developing forebrain...
  69. pmc The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods
    Thomas Mueller
    Department of Biopharmaceutical Sciences, Programs in Human Genetics and Biological Sciences, School of Pharmacy, University of California, San Francisco, California 94143 2811, USA
    J Comp Neurol 516:553-68. 2009
    ....
  70. pmc Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development
    Sebastian S Gerety
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, UK
    Dev Biol 350:279-89. 2011
    ..In light of these findings, we discuss the precautions needed in performing morpholino knockdowns and in interpreting the data derived from their use...
  71. pmc Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway
    Rajesh Ramachandran
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Cell Biol 12:1101-7. 2010
    ..Interestingly, the proneural transcription factor, Ascl1a, and the pluripotency factor, Lin-28, are induced in Müller glia within 6 h following retinal injury and are ..
  72. pmc The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina
    Travis J Bailey
    Department of Biological Sciences and the Center for Zebrafish Research, University of Notre Dame, Galvin Life Science Building, Notre Dame, IN 46556, USA
    Exp Eye Res 91:601-12. 2010
    ..Furthermore, ascl1a and stat3 expression were unaffected in either the L-SOP or MSOP-injected retinas relative to controls, suggesting ..
  73. pmc Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay
    Xiaomei Wei
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Mar Drugs 8:1769-78. 2010
    ..Compounds 1-6 were evaluated in a zebrafish phenotype-based assay. Amphimedine (4) was the only compound that caused a phenotype in zebrafish embryos at 30 muM. No phenotype other than death was observed for compounds 1-3, 5, 6...
  74. doi Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells
    Prisca Chapouton
    Zebrafish Neurogenetics Department, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    J Neurosci 30:7961-74. 2010
    ....
  75. pmc Efficient discovery of ASCL1 regulatory sequences through transgene pooling
    David M McGaughey
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Genomics 95:363-9. 2010
    ..These data demonstrate the utility of this approach and its potential for further adaptation and higher throughput application...
  76. ncbi Expression of two zebrafish orthodenticle-related genes in the embryonic brain
    Y Li
    Department of Neuroscience, University of Pennsylvania, Philadelphia 19104
    Mech Dev 48:229-44. 1994
    ..However, there are a number of interesting differences between the forebrain and midbrain regions which express the genes in the two species...
  77. pmc Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, United Kingdom
    Proc Natl Acad Sci U S A 106:19895-900. 2009
    ..Thus, the presence or absence of a single upstream regulator of proneural gene expression, Her6, leads to the establishment of discrete neuronal domains in the thalamus...
  78. doi DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish
    Julia Mahler
    Developmental Biology, Institute Biology I, Faculty of Biology, University of Freiburg, and Freiburg Institute for Advanced Studies, University of Freiburg, D 79104 Freiburg, Germany
    J Neurosci 30:16621-35. 2010
    ..Rather, DeltaA/D limits the size of the sim1a- and otpa-expressing precursor pool from which dopaminergic neurons differentiate...
  79. pmc Transcriptome analysis of the zebrafish pineal gland
    Reiko Toyama
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
    Dev Dyn 238:1813-26. 2009
    ..Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development...
  80. pmc Genetic ablation of neural crest cell diversification
    Brigitte L Arduini
    Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, USA
    Development 136:1987-94. 2009
    ..Our results identify a genetic regulatory pathway functionally discrete from the process of neural crest induction that is required for the initiation of neural crest cell diversification during embryonic development...
  81. doi Notch resolves mixed neural identities in the zebrafish epiphysis
    Elise Cau
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, Université Paul Sabatier Bât 4R3, Toulouse Cedex 9, France
    Development 135:2391-401. 2008
    ..We propose a novel model in which Notch resolves mixed neural identities by repressing an undesired genetic program...
  82. doi Cadmium inhibits neurogenesis in zebrafish embryonic brain development
    Elly Suk Hen Chow
    Division of Biology, California Institute of Technology, 1200 California Boulevard, Pasadena, CA 91125, USA
    Aquat Toxicol 87:157-69. 2008
    ..We observe prominent reductions in the expression of several proneuronal genes including ngn1 in cell clusters, zash1a in the developing optic tectum, and zash1b in the telencephalon and tectum...
  83. pmc Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo
    Mizuki Azuma
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e979. 2007
    ..Despite the involvement of EWSR1 in these diverse sarcomas, the in vivo function of wild type EWSR1 remains unclear...
  84. ncbi Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina
    Patrick Yurco
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Vis Neurosci 24:437-43. 2007
    ..A model of vertebrate retinal repair is suggested in which damage-induced expression of proneural genes, plus canonical Notch-Delta signaling, could contribute to retinal stem cell promotion and subsequent regenerative neurogenesis...
  85. pmc Members of the miRNA-200 family regulate olfactory neurogenesis
    Philip S Choi
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 57:41-55. 2008
    ....