aplnra

Summary

Gene Symbol: aplnra
Description: apelin receptor a
Alias: Agtr1, agtrl1, agtrl1a, zgc:152843, apelin receptor A, G-protein coupled receptor APJ A, angiotensin II receptor-like 1a, angiotensin receptor-like 1, angiotensin receptor-like 1a, msr
Species: zebrafish

Top Publications

  1. ncbi The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors
    Ian C Scott
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 12:403-13. 2007
  2. ncbi Zebrafish Angiotensin II Receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia
    B Tucker
    Centre for the Molecular Genetics of Development and Discipline of Genetics, School of Molecular and Biomedical Science, The University of Adelaide, 5005, SA, Australia
    Gene Expr Patterns 7:258-65. 2007
  3. pmc Essential role of Apelin signaling during lymphatic development in zebrafish
    Jun Dae Kim
    From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT J D K, Y K, I P, H K, J W, H P, E N, H J C, S W J Department of Life Systems, Sookmyung Women s University, Seoul, Korea J K and Department of Medicine, Stanford University, School of Medicine, CA S G R
    Arterioscler Thromb Vasc Biol 34:338-45. 2014
  4. doi ELABELA: a hormone essential for heart development signals via the apelin receptor
    Serene C Chng
    Institute of Medical Biology, Human Genetics and Embryology Laboratory, A STAR, Singapore 138648, Singapore
    Dev Cell 27:672-80. 2013
  5. pmc Toddler: an embryonic signal that promotes cell movement via Apelin receptors
    Andrea Pauli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 343:1248636. 2014
  6. pmc The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis
    Christian S M Helker
    University of Muenster, Muenster, Germany
    elife 4:. 2015
  7. pmc The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development
    Ashish R Deshwar
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada
    elife 5:. 2016
  8. pmc Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
    Raphael Wild
    Department of Cell and Developmental Biology, Institute of Zoology ZOO Karlsruhe Institute of Technology KIT, Fritz Haber Weg 4, 76131 Karlsruhe, Germany
    Nat Commun 8:13991. 2017
  9. pmc Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish
    Robert N Wilkinson
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
    Blood 120:477-88. 2012
  10. doi Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis
    Melanie Eyries
    INSERM UMRS 525, Universite Pierre et Marie Curie, Paris, France
    Circ Res 103:432-40. 2008

Scientific Experts

  • Ian C Scott
  • Serene C Chng
  • Bruno Reversade
  • Raphael Wild
  • Ashish R Deshwar
  • Christian S M Helker
  • Stefan Schulte-Merker
  • Lena Ho
  • Andrea Pauli
  • Jun Dae Kim
  • Robert N Wilkinson
  • Kevin Mouillesseaux
  • Jonathan M Rowlinson
  • Trista E North
  • Svanhild Nornes
  • Melanie Eyries
  • B Tucker
  • Yuya Hayashi
  • Ferdinand Le Noble
  • Alina Klems
  • Janna Krueger
  • Koji Ando
  • Uwe Strahle
  • Laetitia Préau
  • Naoki Mochizuki
  • Andreas van Impel
  • Masanari Takamiya
  • Cathrin Pollmann
  • Annika Schuermann
  • Friedemann Kiefer
  • Wiebke Herzog
  • Shengdar Q Tsai
  • Hyeseon Kang
  • Irinna Papangeli
  • Emily Nadelmann
  • Steven Zimmerman
  • Eivind Valen
  • Hyung J Chun
  • James A Gagnon
  • Jingxia Wu
  • Andrew Mitchell
  • Hyekyung Park
  • Guo Liang Chew
  • JongMin Kim
  • Julien Dubrulle
  • Alexander F Schier
  • Stanley G Rockson
  • J Keith Joung
  • Deepak Reyon
  • Alan Saghatelian
  • Jiao Ma
  • Megan L Norris
  • Suk Won Jin
  • Yujung Kang
  • Jing Tian
  • Philip W Ingham
  • Fredericus J M van Eeden
  • Roger K Patient
  • Marco J Koudijs
  • Jau Nian Chen
  • Martin Gering
  • Gerhard J Weber
  • Claire C Cutting
  • Ben Tucker
  • Paul Huang
  • Pulin Li
  • Craig Ceol
  • Michael Lardelli
  • Marian Peeters
  • Leonard I Zon
  • Allegra M Lord
  • James Harris
  • Elaine Dzierzak
  • Wolfram Goessling
  • Geraldine Siegfried
  • Florent Soubrier
  • Monique Agrapart
  • Mariana Ciumas
  • Franck Lebrin
  • Kevin Montagne
  • M Lardelli
  • S Wells
  • B Rainbird
  • A C Oates
  • D Kortschak
  • C Hepperle

Detail Information

Publications14

  1. ncbi The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors
    Ian C Scott
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Dev Cell 12:403-13. 2007
    ..Data from transplantation and transgenic approaches indicate that Agtrl1 signaling plays a cell-autonomous role in myocardial specification, with activity being required coincident with ..
  2. ncbi Zebrafish Angiotensin II Receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia
    B Tucker
    Centre for the Molecular Genetics of Development and Discipline of Genetics, School of Molecular and Biomedical Science, The University of Adelaide, 5005, SA, Australia
    Gene Expr Patterns 7:258-65. 2007
    ..We report the identification and expression of the zebrafish ortholog of the human gene AGTRL1. Zebrafish agtrl1a is first expressed before epiboly in dorsal precursors...
  3. pmc Essential role of Apelin signaling during lymphatic development in zebrafish
    Jun Dae Kim
    From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT J D K, Y K, I P, H K, J W, H P, E N, H J C, S W J Department of Life Systems, Sookmyung Women s University, Seoul, Korea J K and Department of Medicine, Stanford University, School of Medicine, CA S G R
    Arterioscler Thromb Vasc Biol 34:338-45. 2014
    ..In this report, we aim to delineate the functions of Apelin signaling during lymphatic development...
  4. doi ELABELA: a hormone essential for heart development signals via the apelin receptor
    Serene C Chng
    Institute of Medical Biology, Human Genetics and Embryology Laboratory, A STAR, Singapore 138648, Singapore
    Dev Cell 27:672-80. 2013
    ..Our results reveal the existence of a peptide hormone, ELA, which, together with APLNR, forms an essential signaling axis for early cardiovascular development. ..
  5. pmc Toddler: an embryonic signal that promotes cell movement via Apelin receptors
    Andrea Pauli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 343:1248636. 2014
    ..These results indicate that Toddler is an activator of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a series of uncharacterized developmental signals. ..
  6. pmc The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis
    Christian S M Helker
    University of Muenster, Muenster, Germany
    elife 4:. 2015
    ....
  7. pmc The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development
    Ashish R Deshwar
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Canada
    elife 5:. 2016
    ..Elevating Nodal levels in aplnra/b morphant and double mutant embryos is sufficient to rescue cardiac differentiation defects...
  8. pmc Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
    Raphael Wild
    Department of Cell and Developmental Biology, Institute of Zoology ZOO Karlsruhe Institute of Technology KIT, Fritz Haber Weg 4, 76131 Karlsruhe, Germany
    Nat Commun 8:13991. 2017
    ..Conceptually, our data suggest that spinal cord vascularization proceeds from veins involving two-tiered regulation of neuronal sFlt1 and Vegfaa via a novel sprouting mode...
  9. pmc Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish
    Robert N Wilkinson
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
    Blood 120:477-88. 2012
    ..Finally, our experiments establish a dual function of Hh during induction of runx1(+) HSCs...
  10. doi Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis
    Melanie Eyries
    INSERM UMRS 525, Universite Pierre et Marie Curie, Paris, France
    Circ Res 103:432-40. 2008
    ..The hypoxia-induced apelin expression may, thus, provide a new mechanism involved in adaptive physiological and pathophysiological response of vascular cells to low oxygen level...
  11. pmc Hematopoietic stem cell development is dependent on blood flow
    Trista E North
    Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:736-48. 2009
    ..This work links blood flow to AGM hematopoiesis and identifies NO as a conserved downstream regulator of HSC development...
  12. pmc Zebrafish aplnra functions in epiboly
    Svanhild Nornes
    Centre for the Molecular Genetics of Development and Discipline of Genetics, School of Molecular and Biomedical Science, The University of Adelaide, Australia
    BMC Res Notes 2:231. 2009
    The zebrafish, Danio rerio, possesses the paralogous genes aplnra and aplnrb that are duplicates of an ancestral orthologue of the human APLNR gene encoding a G-protein coupled receptor that binds the peptide ligand APELIN and is required ..
  13. doi Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos
    Jonathan M Rowlinson
    Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Blood 116:2046-56. 2010
    ..These results establish an essential role for Hey2 upstream of Notch in HSC formation...
  14. pmc Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryos
    Kevin Mouillesseaux
    Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e25013. 2011
    ..Using the zebrafish as a model organism, we sought to identify genes that influence normal vascular patterning...