ada

Summary

Gene Symbol: ada
Description: adenosine deaminase
Alias: zgc:92028, adenosine deaminase, ada1, adenosine aminohydrolase
Species: zebrafish

Top Publications

  1. doi Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
    Blood 112:5228-37. 2008
  2. doi Kinetic characterization of adenosine deaminase activity in zebrafish (Danio rerio) brain
    Denis Broock Rosemberg
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Comp Biochem Physiol B Biochem Mol Biol 151:96-101. 2008
  3. doi Involvement of purinergic system in inflammation and toxicity induced by copper in zebrafish larvae
    Carlos Eduardo Leite
    Instituto de Toxicologia e Farmacologia, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, CEP 90619 900, Brazil Programa de Pós Graduação em Medicina Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, CEP 90035 003, Brazil Electronic address
    Toxicol Appl Pharmacol 272:681-9. 2013
  4. pmc The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dis Model Mech 7:895-905. 2014
  5. doi Benzodiazepines alter nucleotide and nucleoside hydrolysis in zebrafish (Danio rerio) brain
    Stefani Altenhofen
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, Prédio 12D, Sala 301, Porto Alegre, RS, 90619 900, Brazil
    J Neural Transm (Vienna) 122:1077-88. 2015
  6. doi RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate
    Zhouquan Li
    State Key Laboratory of Fresh Water Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Southern East Lake Road, Wuhan, 430072, People s Republic of China
    J Appl Toxicol 36:94-104. 2016
  7. doi Unpredictable Chronic Stress Alters Adenosine Metabolism in Zebrafish Brain
    F F Zimmermann
    Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, Porto Alegre, RS, 90619 900, Brazil
    Mol Neurobiol 53:2518-28. 2016
  8. pmc Hyperglycemia alters E-NTPDases, ecto-5'-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio)
    Katiucia Marques Capiotti
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900, Porto Alegre, RS, Brazil
    Purinergic Signal 12:211-20. 2016
  9. doi PTZ-induced seizures inhibit adenosine deamination in adult zebrafish brain membranes
    Anna Maria Siebel
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Brain Res Bull 86:385-9. 2011
  10. doi Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish
    Anna Maria Siebel
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 104:20-6. 2013

Scientific Experts

  • Nadia Danilova
  • D B Rosemberg
  • Carlos Eduardo Leite
  • Angelo L Piato
  • Carla Denise Bonan
  • Mauricio Reis Bogo
  • Anna Maria Siebel
  • Katiucia Marques Capiotti
  • F F Zimmermann
  • Zhouquan Li
  • Luiza Wilges Kist
  • Stefani Altenhofen
  • Kelly Juliana Seibt
  • Mario Roberto Senger
  • Yong Long
  • Li Yuan
  • Liqiao Zhong
  • Zongbin Cui
  • M R Bogo
  • Xiaohua Zhang
  • G P Cognato
  • S Altenhofen
  • Heping Dai
  • Rosane Souza da Silva
  • C D Bonan
  • L W Kist
  • Guili Song
  • Lauryn Silva Barreto
  • Fernanda Francine Zimmermann
  • Josiane Woutheres Bortolotto
  • Isabel Costa Schaefer
  • Laura Roesler Nery
  • Renato Dutra Dias

Detail Information

Publications13

  1. doi Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
    Blood 112:5228-37. 2008
    ..Ribosomal stress syndromes represent a broader spectrum of human congenital diseases caused by genotoxic stress; therefore, imbalance of p53 family members may become a new target for therapeutics...
  2. doi Kinetic characterization of adenosine deaminase activity in zebrafish (Danio rerio) brain
    Denis Broock Rosemberg
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Comp Biochem Physiol B Biochem Mol Biol 151:96-101. 2008
    b>Adenosine deaminase (ADA; EC 3.5.4.4) activity is responsible for cleaving adenosine to inosine...
  3. doi Involvement of purinergic system in inflammation and toxicity induced by copper in zebrafish larvae
    Carlos Eduardo Leite
    Instituto de Toxicologia e Farmacologia, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, CEP 90619 900, Brazil Programa de Pós Graduação em Medicina Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, CEP 90035 003, Brazil Electronic address
    Toxicol Appl Pharmacol 272:681-9. 2013
    ..the mechanisms that control the ADO levels were the most involved, mainly the reactions performed by the isoenzyme ADA 2...
  4. pmc The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dis Model Mech 7:895-905. 2014
    ..Another hallmark of DBA is the upregulation of adenosine deaminase (ADA), indicating changes in nucleotide metabolism...
  5. doi Benzodiazepines alter nucleotide and nucleoside hydrolysis in zebrafish (Danio rerio) brain
    Stefani Altenhofen
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, Prédio 12D, Sala 301, Porto Alegre, RS, 90619 900, Brazil
    J Neural Transm (Vienna) 122:1077-88. 2015
    ..in the induction of several behavioral patterns and their actions are inactivated by ectonucleotidases and adenosine deaminase (ADA)...
  6. doi RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate
    Zhouquan Li
    State Key Laboratory of Fresh Water Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Southern East Lake Road, Wuhan, 430072, People s Republic of China
    J Appl Toxicol 36:94-104. 2016
    ..These results provide insight into the genome-wide response of ZF4 cells following exposure to MMS, and this knowledge will inform future toxicogenomic data analysis and environmental health risk assessment...
  7. doi Unpredictable Chronic Stress Alters Adenosine Metabolism in Zebrafish Brain
    F F Zimmermann
    Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, Porto Alegre, RS, 90619 900, Brazil
    Mol Neurobiol 53:2518-28. 2016
    ..ATP hydrolysis by ectonucleotidases is an important source of adenosine, and adenosine deaminase (ADA) contributes to the control of the nucleoside concentrations...
  8. pmc Hyperglycemia alters E-NTPDases, ecto-5'-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio)
    Katiucia Marques Capiotti
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900, Porto Alegre, RS, Brazil
    Purinergic Signal 12:211-20. 2016
    ..A significant increase in ecto-adenosine deaminase activity was observed in 111-mM glucose group, which remain elevated after 7 days of glucose withdrawal...
  9. doi PTZ-induced seizures inhibit adenosine deamination in adult zebrafish brain membranes
    Anna Maria Siebel
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Brain Res Bull 86:385-9. 2011
    ..The hydrolysis of ATP by ectonucleotidases is an important source of adenosine, and adenosine deaminase (ADA) contributes to the regulation of this nucleoside concentration through its deamination...
  10. doi Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish
    Anna Maria Siebel
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 104:20-6. 2013
    ..The modulation of extracellular adenosine levels by ectonucleotidase and adenosine deaminase (ADA) activities may represent a key mechanism in the control of epileptogenesis...
  11. ncbi Adenosine deaminase-related genes: molecular identification, tissue expression pattern and truncated alternative splice isoform in adult zebrafish (Danio rerio)
    Denis Broock Rosemberg
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Life Sci 81:1526-34. 2007
    b>Adenosine deaminase (ADA) is responsible for cleaving the neuromodulator adenosine to inosine...
  12. doi Influence of mercury chloride on adenosine deaminase activity and gene expression in zebrafish (Danio rerio) brain
    Mario Roberto Senger
    Programa de Pós Graduação em Ciências Biológicas Bioquímica, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Neurotoxicology 31:291-6. 2010
    ..In this study we investigated the effects of mercury chloride on soluble and membrane adenosine deaminase (ADA) activity and gene expression in zebrafish brain...
  13. doi Acute restraint stress in zebrafish: behavioral parameters and purinergic signaling
    Angelo L Piato
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681 Predio 12D, Sala 340, Porto Alegre, RS 90619 900, Brazil
    Neurochem Res 36:1876-86. 2011
    ..Furthermore, we analyzed ectonucleotidase and adenosine deaminase activities and their gene expression profile, as well as transcription of adenosine receptors...