Gene Symbol: L
Description: RNA-dependent RNA polymerase
Species: Zaire Ebola virus
- RNA polymerase I-driven minigenome system for Ebola virusesAllison Groseth
National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
J Virol 79:4425-33. 2005..roles for transcription and replication in the reduced pathogenicity of Reston ebolavirus, we developed an RNA polymerase I (Pol I)-driven minigenome system...
- DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genomeKei Takahashi
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
J Virol 87:8862-9. 2013Ebola virus (EBOV) protein L (EBOL) acts as a viral RNA-dependent RNA polymerase. To better understand the mechanisms underlying the transcription and replication of the EBOV genome, we sought to identify cellular factors involved in ..
- The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antiviralsMartina Trunschke
Department of Virology, Philipps University of Marburg, Hans Meerwein Strβe 2, 35043 Marburg, Germany
Virology 441:135-45. 2013The Ebola virus (EBOV) RNA-dependent RNA polymerase (RdRp) complex consists of the catalytic subunit of the polymerase, L, and its cofactor VP35...
- Molecular detection of a novel paramyxovirus in fruit bats from IndonesiaMichihito Sasaki
Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
Virol J 9:240. 2012..Fruit bats are known to harbor zoonotic paramyxoviruses including Nipah, Hendra, and Menangle viruses. The aim of this study was to detect the presence of paramyxovirus RNA in fruit bats from Indonesia...
- Ebola virus transcription activator VP30 is a zinc-binding proteinJens Modrof
Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
J Virol 77:3334-8. 2003....
- Rescue of Ebola virus from cDNA using heterologous support proteinsSteven Theriault
Special Pathogens Program, National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Health Canada, Canada
Virus Res 106:43-50. 2004..Protein interactions between the nucleoprotein NP and the virion protein VP35 and the polymerase L and VP35 seemed to be the most critical steps...
- Filovirus buddingLuke D Jasenosky
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive West, Madison, WI 53706, USA
Virus Res 106:181-8. 2004..Possible budding functions of the viral glycoprotein (GP), as well as the membrane-associated viral protein 24 (VP24), will also be described, and a model for filovirus budding will be proposed...
- A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus ZaireYannik Boehmann
Department of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
Virology 332:406-17. 2005..Although these two proteins did not constitute an active polymerase complex, it was shown by immunofluorescence analysis that they were still able to interact.
- [The properties of Ebola virus proteins]E L Subbotina
Vopr Virusol 51:4-10. 2006..It also presents information on the role of structural (NP, VP40, VP35, GP, VP30, VP24, and L) and secreted (sGP, delta-peptide, GP1, GP(1,2delta), ssGP) proteins in the viral replication cycle and in the ..
- Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United StatesAllison Groseth
Special Pathogens Program, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
Virus Res 87:155-63. 2002..The sequence determination provides the basis for the development of a reverse genetics system for Ebola virus Reston, which is needed to study differences in pathogenicity among filoviruses...
- Biosynthesis and role of filoviral glycoproteinsH Feldmann
Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
J Gen Virol 82:2839-48. 2001
- Characterization of the L gene and 5' trailer region of Ebola virusV E Volchkov
Institut fur Virologie, Philipps Universitat, Marburg, Germany
J Gen Virol 80:355-62. 1999..The presence of several conserved linear domains commonly found within L proteins of other members of the order Mononegavirales identified this protein as the RNA-dependent RNA polymerase of Ebola virus.
- Descriptive analysis of Ebola virus proteinsL H Elliott
Virology 147:169-76. 1985..Seven virion proteins were described; an L (180K), GP (125K), NP (104K), VP40 (40K), VP35 (35K), VP30 (30K), and VP24 (24K)...
- The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strainA A Bukreyev
State Research Center of Virology and Biotechnology Vector Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russia
Arch Virol 140:1589-600. 1995..Amino acid substitutions in the L protein, the main component of viral RNA-dependent RNA polymerase, were also distributed extremely non-randomly...
- The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola virusesA A Bukreyev
Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russian Federation
FEBS Lett 322:41-6. 1993..It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA transcription. Homology between the MBG and EBO proteins was discovered...
- GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerasesV E Volchkov
State Research Centre of Virology and Biotechnology Vector, Institute of Molecular Biology, Koltsovo, Novosibirsk Region, Russia
Virology 214:421-30. 1995..Expression of the glycoprotein by an in vitro transcription/translation system, by the vaccinia virus/T7 polymerase system, and by recombinant vaccinia virus revealed that full-length glycoprotein was synthesized not only when ..
- Processing of the Ebola virus glycoprotein by the proprotein convertase furinV E Volchkov
Institut fur Virologie, Philipps Universitat Marburg, 35011 Marburg, Germany
Proc Natl Acad Sci U S A 95:5762-7. 1998..As a result of these observations, it should now be considered that proteolytic processing of GP may be an important determinant for the pathogenicity of Ebola virus...
- Release of viral glycoproteins during Ebola virus infectionV E Volchkov
Institut fur Virologie, Philipps Universitat Marburg, Germany
Virology 245:110-9. 1998..The abundant shedding of soluble GP1 may play an important role in the immunopathology of Ebola hemorrhagic fever in experimentally and naturally infected hosts...
- Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cellsB H Harcourt
Winship Cancer Center, Emory University, Atlanta, Georgia 30322, USA
Virology 252:179-88. 1998..Inhibition of IFN and dsRNA responsiveness could play a role in the immunosuppression seen in EZ infections and would play a role in the pathogenesis of disease caused by EZ...
- Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systemsE Muhlberger
Institut für Virologie der Philipps Universität Marburg, 35037 Marburg, Germany
J Virol 73:2333-42. 1999..As it was shown previously for MBGV, three of the four EBOV nucleocapsid proteins, NP, VP35, and L, were essential and sufficient for replication...
- Physicochemical properties of Marburg virus: evidence for three distinct virus strains and their relationship to Ebola virusM P Kiley
Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333
J Gen Virol 69:1957-67. 1988..In addition, these studies confirm the belief that MBG and EBO viruses are members of the new virus family, the Filoviridae...