ail

Summary

Gene Symbol: ail
Description: attachment invasion locus protein
Species: Yersinia pestis CO92

Top Publications

  1. pmc Expression, refolding, and initial structural characterization of the Y. pestis Ail outer membrane protein in lipids
    Leigh A Plesniak
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1808:482-9. 2011
  2. pmc Structural insights into Ail-mediated adhesion in Yersinia pestis
    Satoshi Yamashita
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
    Structure 19:1672-82. 2011
  3. pmc Differential contribution of tryptophans to the folding and stability of the attachment invasion locus transmembrane β-barrel from Yersinia pestis
    Ankit Gupta
    1 Molecular Biophysics Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal India 2
    Sci Rep 4:6508. 2014
  4. pmc Influence of the lipid membrane environment on structure and activity of the outer membrane protein Ail from Yersinia pestis
    Yi Ding
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1848:712-20. 2015
  5. pmc Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague
    Bethany L Tiner
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
    Infect Immun 83:1318-38. 2015
  6. pmc Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plague
    B Joseph Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 79:4984-9. 2011

Scientific Experts

  • B J Hinnebusch
  • Bethany L Tiner
  • Yi Ding
  • Ankit Gupta
  • Francesca M Marassi
  • Radhakrishnan Mahalakshmi
  • Satoshi Yamashita
  • Leigh A Plesniak
  • Vladimir L Motin
  • Jourdan A Andersson
  • Jian Sha
  • Christina J van Lier
  • Ashok K Chopra
  • Gregory V Plano
  • Duraisamy Ponnusamy
  • Wallace B Baze
  • Sadhana Chauhan
  • L Miya Fujimoto
  • Tatiana E Erova
  • Michelle L Kirtley
  • Yong Yao
  • Vsevolod L Popov
  • Punit Zadafiya
  • Eric S Krukonis
  • Candace Rypien
  • Travis J Barnard
  • Nicholas Noinaj
  • Petra Lukacik
  • Susan K Buchanan
  • Tiffany M Tsang
  • Yuan Yang
  • Jasmina Racic
  • Suleyman Felek

Detail Information

Publications6

  1. pmc Expression, refolding, and initial structural characterization of the Y. pestis Ail outer membrane protein in lipids
    Leigh A Plesniak
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1808:482-9. 2011
    b>Ail is an outer membrane protein and virulence factor of Yersinia pestis, an extremely pathogenic, category A biothreat agent, responsible for precipitating massive human plague pandemics throughout history...
  2. pmc Structural insights into Ail-mediated adhesion in Yersinia pestis
    Satoshi Yamashita
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
    Structure 19:1672-82. 2011
    b>Ail is an outer membrane protein from Yersinia pestis that is highly expressed in a rodent model of bubonic plague, making it a good candidate for vaccine development...
  3. pmc Differential contribution of tryptophans to the folding and stability of the attachment invasion locus transmembrane β-barrel from Yersinia pestis
    Ankit Gupta
    1 Molecular Biophysics Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal India 2
    Sci Rep 4:6508. 2014
    Attachment invasion locus (Ail) protein of Yersinia pestis is a crucial outer membrane protein for host invasion and determines bacterial survival within the host...
  4. pmc Influence of the lipid membrane environment on structure and activity of the outer membrane protein Ail from Yersinia pestis
    Yi Ding
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1848:712-20. 2015
    ..Here we describe how the sample environment affects the activity of the outer membrane protein Ail (attachment invasion locus) from Yersinia pestis...
  5. pmc Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague
    Bethany L Tiner
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
    Infect Immun 83:1318-38. 2015
    ..Here, we deleted the ail gene (encoding the attachment-invasion locus) from wild-type (WT) strain CO92 or its lpp single and Δlpp ΔmsbB ..
  6. pmc Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plague
    B Joseph Hinnebusch
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 79:4984-9. 2011
    ..In this study, we examined the effect of Ail, a 17-kDa outer membrane protein that protects Y...