VC1457

Summary

Gene Symbol: VC1457
Description: cholera enterotoxin subunit A
Species: Vibrio cholerae O1 biovar El Tor str. N16961

Top Publications

  1. ncbi The arrangement of subunits in cholera toxin
    D M Gill
    Biochemistry 15:1242-8. 1976
  2. ncbi Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
    Claire J O'Neal
    Department of Chemistry and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 43:3772-82. 2004
  3. pmc Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm
    Yukako Fujinaga
    GI Cell Biology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 14:4783-93. 2003
  4. ncbi The three-dimensional crystal structure of cholera toxin
    R G Zhang
    Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, IL 60439, USA
    J Mol Biol 251:563-73. 1995
  5. ncbi Isolation and characterization of a precursor form of the 'A' subunit of cholera toxin
    L K Duffy
    FEBS Lett 126:187-90. 1981
  6. ncbi Covalent structure of the gamma chain of the A subunit of cholera toxin
    L K Duffy
    J Biol Chem 256:12252-6. 1981
  7. ncbi Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development
    J J Mekalanos
    Nature 306:551-7. 1983
  8. ncbi Nucleotide sequence analysis of the A2 and B subunits of Vibrio cholerae enterotoxin
    H Lockman
    J Biol Chem 258:13722-6. 1983
  9. pmc Vibrio cholerae enterotoxin genes: nucleotide sequence analysis of DNA encoding ADP-ribosyltransferase
    H A Lockman
    J Bacteriol 159:1086-9. 1984
  10. ncbi Stimulation of intestinal adenyl cyclase by cholera toxin
    G W Sharp
    Nature 229:266-9. 1971

Detail Information

Publications14

  1. ncbi The arrangement of subunits in cholera toxin
    D M Gill
    Biochemistry 15:1242-8. 1976
    ..This binding increases the effective concentration of the toxin in the vicinity of the plasma membrane. Possible ways in which A1 then crosses the membrane are considered in the Discussion...
  2. ncbi Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
    Claire J O'Neal
    Department of Chemistry and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 43:3772-82. 2004
    ..On the basis of these six new views of the CT holotoxin, we propose a model for how the activational modifications experienced by wild-type CT are communicated to the active site...
  3. pmc Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm
    Yukako Fujinaga
    GI Cell Biology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Biol Cell 14:4783-93. 2003
    ..Our results explain why LTIIb does not cause disease in humans and suggest that gangliosides with high affinity for lipid rafts may provide a general vehicle for the transport of toxins to the ER...
  4. ncbi The three-dimensional crystal structure of cholera toxin
    R G Zhang
    Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, IL 60439, USA
    J Mol Biol 251:563-73. 1995
    ..These structures, along with those of related toxins from Shigella dysenteria and Bordetella pertussis, offer a first step towards the rational design of new vaccines and anti-microbial agents...
  5. ncbi Isolation and characterization of a precursor form of the 'A' subunit of cholera toxin
    L K Duffy
    FEBS Lett 126:187-90. 1981
  6. ncbi Covalent structure of the gamma chain of the A subunit of cholera toxin
    L K Duffy
    J Biol Chem 256:12252-6. 1981
    ..The chemical similarity between the gamma chain regions of these two enterotoxins was thus considerably less than that of their beta chains which were shown to be 79% identical...
  7. ncbi Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development
    J J Mekalanos
    Nature 306:551-7. 1983
    ..Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development...
  8. ncbi Nucleotide sequence analysis of the A2 and B subunits of Vibrio cholerae enterotoxin
    H Lockman
    J Biol Chem 258:13722-6. 1983
    ..cholerae and E. coli LT demonstrates two regions of highly conserved sequences: 12 and 22 uninterrupted amino acids are the same among the A2 and B subunits, respectively, from the three strains...
  9. pmc Vibrio cholerae enterotoxin genes: nucleotide sequence analysis of DNA encoding ADP-ribosyltransferase
    H A Lockman
    J Bacteriol 159:1086-9. 1984
    ..The primary structure of the A1 fragment from cholera enterotoxin is more related to that from a human enterotoxigenic Escherichia coli than to that from a porcine enterotoxigenic E. coli...
  10. ncbi Stimulation of intestinal adenyl cyclase by cholera toxin
    G W Sharp
    Nature 229:266-9. 1971
  11. ncbi Nucleotide sequence analysis of the CT operon of the Vibrio cholerae classical strain 569B
    E Dams
    RUCA Laboratory for Human Biochemistry, University of Antwerp, Belgium
    Biochim Biophys Acta 1090:139-41. 1991
    ..The results prove the exactness of the amino acid CT B sequence published by Takao et al. (1985, Eur. J. Biochem. 146, 503-508). A comparison is made with already reported CT genes...
  12. ncbi Subunit structure and N-terminal amino acid sequence of the three chains of cholera enterotoxin
    D G Klapper
    Immunochemistry 13:605-11. 1976
  13. ncbi Primary structure of cholera toxin subunit A1: isolation, partial sequences and alignment of the BrCN fragments
    C Y Lai
    FEBS Lett 100:85-9. 1979
  14. ncbi Structural basis for the activation of cholera toxin by human ARF6-GTP
    Claire J O'Neal
    Department of Chemistry, University of Washington, Seattle, WA 98195, USA
    Science 309:1093-6. 2005
    ..The extensive toxin:ARF-GTP interface surface mimics ARF-GTP recognition of normal cellular protein partners, which suggests that the toxin has evolved to exploit promiscuous binding properties of ARFs...