TTG1

Summary

Gene Symbol: TTG1
Description: Transducin/WD40 repeat-like superfamily protein
Alias: ATTTG1, K18P6.4, K18P6_4, TRANSPARENT TESTA GLABRA 1, TTG, UNARMED 23, URM23
Species: thale cress

Top Publications

  1. ncbi The TTG gene is required to specify epidermal cell fate and cell patterning in the Arabidopsis root
    M E Galway
    Department of Biology, University of Michigan, Ann Arbor 48109
    Dev Biol 166:740-54. 1994
  2. doi The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci
    Mingzhe Zhao
    Section of Molecular Cell and Developmental Biology and The Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA
    Development 135:1991-9. 2008
  3. pmc Allele-specific interactions between ttg and gl1 during trichome development in Arabidopsis thaliana
    J C Larkin
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Genetics 151:1591-604. 1999
  4. pmc Functional specialization of the TRANSPARENT TESTA GLABRA1 network allows differential hormonal control of laminal and marginal trichome initiation in Arabidopsis rosette leaves
    Lies Maes
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium
    Plant Physiol 148:1453-64. 2008
  5. ncbi Regulation of the anthocyanin biosynthetic pathway by the TTG1/bHLH/Myb transcriptional complex in Arabidopsis seedlings
    Antonio Gonzalez
    Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78 712, USA
    Plant J 53:814-27. 2008
  6. ncbi TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana
    Antoine Baudry
    Seed Biology Laboratory, UMR 204 INRA INAPG, Jean Pierre Bourgin Institute, Route de Saint Cyr, 78026 Versailles Cedex, France
    Plant J 46:768-79. 2006
  7. ncbi Functional diversification of MYB23 and GL1 genes in trichome morphogenesis and initiation
    Victor Kirik
    Botanical Institute, University of Cologne, Gyrhofstrasse 15, 50931 Cologne, Germany
    Development 132:1477-85. 2005
  8. ncbi TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana
    Antoine Baudry
    Seed Biology Laboratory, UMR 204 INRA INAPG, Jean Pierre Bourgin Institute, Route de Saint Cyr, 78026 Versailles Cedex, France
    Plant J 39:366-80. 2004
  9. ncbi A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis
    Jeffrey J Esch
    Department of Plant Biology, University of Minnesota, St Paul, MN 55108 1095, USA
    Development 130:5885-94. 2003
  10. ncbi A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis
    Fan Zhang
    Molecular Cell and Developmental Biology, and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA
    Development 130:4859-69. 2003

Scientific Experts

  • J C Larkin
  • V Vaughan Symonds
  • A R Walker
  • Martina Pesch
  • Martin Hulskamp
  • Antonio Gonzalez
  • Mingzhe Zhao
  • Antoine Baudry
  • Rachappa Balkunde
  • Daniel Bouyer
  • Mingxun Chen
  • Alan Lloyd
  • Hoai Nguyen Nguyen
  • Janine Höll
  • Hongtao Zhao
  • Daniel R Lewis
  • Xianfeng Morgan Xu
  • Ying Gao
  • Lies Maes
  • Elena Caro
  • Zhi Hui Chen
  • Katja Wester
  • Victor Kirik
  • Loic Lepiniec
  • Michel Caboche
  • Fan Zhang
  • Jeffrey J Esch
  • Christoph S Clemen
  • Fook Tim Chew
  • Harikrishna Kulaveerasingam
  • Hao Yu
  • Chengxiang Li
  • Bin Zhang
  • Joachim F Uhrig
  • Stefanie Weidtkamp-Peters
  • Manfred Koegl
  • Karsten Klopffleisch
  • Rudiger Simon
  • Ilka Schultheiß
  • Burcu Dartan
  • Imre E Somssich
  • Rainer Birkenbihl
  • Jun Hyeok Kim
  • Woo Young Hyun
  • Ian B Dry
  • Thomas Rausch
  • Claudio D'Onofrio
  • Paul K Boss
  • Alessandro Vannozzi
  • Margherita Lucchin
  • Suk Whan Hong
  • Ngoc Trinh Nguyen
  • Hojoung Lee
  • Jochen Bogs
  • Stefan Czemmel
  • Sujuan Cui
  • Ying Cao
  • Dandan Zhu
  • Xia Li
  • Ligeng Ma
  • Xiaoxue Wang
  • Zhenyu Xuan
  • Jing Wang
  • Nisha Hariharan
  • Richard F Helm
  • David Jackson
  • Brenda S J Winkel
  • Alexander Goldshmidt
  • Philippa G M Borrill
  • Nathan D Miller
  • Prashanthi Vallabhaneni
  • Jae Yean Kim
  • Gloria K Muday
  • W Keith Ray
  • Melissa V Ramirez
  • C T Payne
  • John Mendenhall
  • Yujia Huo
  • Yan Guo
  • Ximing Gong
  • Erich Grotewold
  • Xuechen Wang
  • Jens Timmer
  • Alain Goossens
  • Kengo Morohashi
  • Greg Hatlestad
  • Arp Schnittger
  • Wanhong Cao
  • Christian Fleck
  • Friedrich Kragler

Detail Information

Publications29

  1. ncbi The TTG gene is required to specify epidermal cell fate and cell patterning in the Arabidopsis root
    M E Galway
    Department of Biology, University of Michigan, Ann Arbor 48109
    Dev Biol 166:740-54. 1994
    ..This normal positional relationship was absent in ttg (transparent testa glabrous) mutants (lacking trichomes, anthocyanins, and seed coat mucilage); epidermal cells in ..
  2. doi The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci
    Mingzhe Zhao
    Section of Molecular Cell and Developmental Biology and The Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA
    Development 135:1991-9. 2008
    ..of proteins consisting of bHLH and MYB transcription factors, and a WD40 repeat protein, TRANSPARENT TESTA GLABRA1 (TTG1), act in concert to activate trichome initiation and patterning...
  3. pmc Allele-specific interactions between ttg and gl1 during trichome development in Arabidopsis thaliana
    J C Larkin
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Genetics 151:1591-604. 1999
    ..Two genes that play an essential role in the initiation of trichome development are GL1 and TTG. Mutations in either gene prevent the initiation of most trichomes...
  4. pmc Functional specialization of the TRANSPARENT TESTA GLABRA1 network allows differential hormonal control of laminal and marginal trichome initiation in Arabidopsis rosette leaves
    Lies Maes
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium
    Plant Physiol 148:1453-64. 2008
    Trichome initiation in Arabidopsis (Arabidopsis thaliana) is controlled by the TRANSPARENT TESTA GLABRA1 (TTG1) network that consists of R2R3- and R1-type MYB-related transcription factors, basic helix-loop-helix (bHLH) proteins, and the ..
  5. ncbi Regulation of the anthocyanin biosynthetic pathway by the TTG1/bHLH/Myb transcriptional complex in Arabidopsis seedlings
    Antonio Gonzalez
    Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78 712, USA
    Plant J 53:814-27. 2008
    ..Myb regulators remain to be conclusively identified, and little is known about anthocyanin pathway regulation by TTG1-dependent transcriptional complexes...
  6. ncbi TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana
    Antoine Baudry
    Seed Biology Laboratory, UMR 204 INRA INAPG, Jean Pierre Bourgin Institute, Route de Saint Cyr, 78026 Versailles Cedex, France
    Plant J 46:768-79. 2006
    ..Moreover, the activity of this reporter construct was strongly affected in ttg1, TT2 overexpressers (OE), and PAP1-OE, suggesting interplay between TT2, PAP1, TTG1 and the activation of the TT8 ..
  7. ncbi Functional diversification of MYB23 and GL1 genes in trichome morphogenesis and initiation
    Victor Kirik
    Botanical Institute, University of Cologne, Gyrhofstrasse 15, 50931 Cologne, Germany
    Development 132:1477-85. 2005
    ....
  8. ncbi TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana
    Antoine Baudry
    Seed Biology Laboratory, UMR 204 INRA INAPG, Jean Pierre Bourgin Institute, Route de Saint Cyr, 78026 Versailles Cedex, France
    Plant J 39:366-80. 2004
    Genetic analyses have demonstrated that together with TTG1, a WD-repeat (WDR) protein, TT2 (MYB), and TT8 (bHLH) are necessary for the correct expression of BANYULS (BAN)...
  9. ncbi A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis
    Jeffrey J Esch
    Department of Plant Biology, University of Minnesota, St Paul, MN 55108 1095, USA
    Development 130:5885-94. 2003
    ..Yeast interaction assays comparing GL3 with gl3-sst proteins show that the mutant protein interaction with GL1 and TTG1 is decreased by 75% and 50%, respectively, but there is no difference in its interaction with TRY...
  10. ncbi A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis
    Fan Zhang
    Molecular Cell and Developmental Biology, and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA
    Development 130:4859-69. 2003
    GLABRA3 (GL3) encodes a bHLH protein that interacts with the WD repeat protein, TTG1. GL3 overexpression suppresses the trichome defect of the pleiotropic ttg1 mutations...
  11. pmc GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1
    C T Payne
    Molecular Cell and Developmental Biology and the Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712 1095, USA
    Genetics 156:1349-62. 2000
    ..Mutations in TRANSPARENT TESTA GLABRA1 (TTG1) result in several pleiotropic defects including an almost complete lack of trichomes...
  12. pmc The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein
    A R Walker
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    Plant Cell 11:1337-50. 1999
    The TRANSPARENT TESTA GLABRA1 (TTG1) locus regulates several developmental and biochemical pathways in Arabidopsis, including the formation of hairs on leaves, stems, and roots, and the production of seed mucilage and anthocyanin pigments...
  13. pmc TRANSPARENT TESTA GLABRA1 and GLABRA1 Compete for Binding to GLABRA3 in Arabidopsis
    Martina Pesch
    Biocenter, Cologne University, Botanical Institute, 50674 Cologne, Germany M P, I S, K K, J F U, M H Preclinical Target Development and Genomics and Proteomics Core Facilities, German Cancer Research Center, 69120 Heidelberg, Germany M K Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, Cologne University, 50931 Cologne, Germany C S C andHeinrich Heine Universität Düsseldorf, 40225 Dusseldorf, Germany R S, S W P
    Plant Physiol 168:584-97. 2015
    ..Arabidopsis thaliana) is governed by GLABRA1 (GL1; R2R3MYB), GL3 (bHLH), and transparent TESTA GLABRA1 (TTG1; WD40). They are thought to form a trimeric complex that acts as a transcriptional activation complex...
  14. pmc Arabidopsis TTG2 regulates TRY expression through enhancement of activator complex-triggered activation
    Martina Pesch
    Biocenter, Cologne University, Botanical Institute, 50674 Cologne, Germany
    Plant Cell 26:4067-83. 2014
    ..thaliana is regulated by a regulatory feedback loop of the trichome promoting factors TRANSPARENT TESTA GLABRA1 (TTG1), GLABRA3 (GL3)/ENHANCER OF GL3 (EGL3), and GL1 and a group of homologous R3MYB proteins that act as their ..
  15. pmc The R2R3-MYB transcription factors MYB14 and MYB15 regulate stilbene biosynthesis in Vitis vinifera
    Janine Höll
    Centre for Organismal Studies Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany
    Plant Cell 25:4135-49. 2013
    ..These results demonstrate the involvement of MYB14 and MYB15 in the transcriptional regulation of stilbene biosynthesis in grapevine. ..
  16. pmc TRANSPARENT TESTA GLABRA1 Regulates the Accumulation of Seed Storage Reserves in Arabidopsis
    Mingxun Chen
    College of Agronomy, Northwest A and F University, Yangling, Shaanxi 712100, China M C Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543 M C, B Z, C L, F T C, H Y Sime Darby Technology Centre, Lebuh Silikon, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia H K andTemasek Life Sciences Laboratory, National University of Singapore, Singapore 117604 H Y
    Plant Physiol 169:391-402. 2015
    ..Here, we show that TRANSPARENT TESTA GLABRA1 (TTG1), which encodes a WD40 repeat transcription factor involved in many aspects of plant development, plays an ..
  17. doi Chaperonins facilitate KNOTTED1 cell-to-cell trafficking and stem cell function
    Xianfeng Morgan Xu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 333:1141-4. 2011
    ..Our study shows that chaperonins are essential for the cell-to-cell trafficking of a subset of mobile transcription factors and demonstrates the importance of chaperonin-dependent protein trafficking for plant stem cell function...
  18. pmc Auxin and ethylene induce flavonol accumulation through distinct transcriptional networks
    Daniel R Lewis
    Department of Biology, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Plant Physiol 156:144-64. 2011
    ..This study also provides new evidence that quercetin is the flavonol that modulates basipetal auxin transport...
  19. ncbi A chromatin link that couples cell division to root epidermis patterning in Arabidopsis
    Elena Caro
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Nature 447:213-7. 2007
    ..GEM also interacts with TTG1 (TRANSPARENT TESTA GLABRA1), a WD40-repeat protein involved in GL2-dependent cell fate decision, and modulates both ..
  20. pmc BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis
    Zhi Hui Chen
    Plant Science Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Biochem J 405:191-8. 2007
    ..Furthermore, several Arabidopsis proteins that regulate epidermal cell differentiation [TTG1 (TRANSPARENT TESTA GLABRA1), GL3 (GLABRA3) and EGL3 (ENHANCER OF GL3)] positively regulate PPCK gene expression in ..
  21. pmc A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis
    Hongtao Zhao
    Hebei Key Laboratory of Molecular Cell Biology, College of Biological Sciences, Hebei Normal University, Shijiazhuang 050016 Hebei, China
    J Biol Chem 287:14109-21. 2012
    ..requires a combination of three groups of proteins, including the WD40 repeat protein transparent TESTA GLABRA1 (TTG1), R2R3 repeat MYB protein GLABRA1 (GL1), or werewolf (WER) and the IIIf subfamily of basic helix-loop-helix (bHLH) ..
  22. doi TTG1-mediated flavonols biosynthesis alleviates root growth inhibition in response to ABA
    Hoai Nguyen Nguyen
    College of Life Sciences and Biotechnology, Korea University, 1, 5 ka Anam dong, Seongbuk gu, Seoul, 136 713, Republic of Korea
    Plant Cell Rep 32:503-14. 2013
    ..The recessive TRANSPARENT TESTA GLABRA 1 (ttg1) mutant was characterized on ABA and sucrose treatments...
  23. pmc Natural allelic variation defines a role for ATMYC1: trichome cell fate determination
    V Vaughan Symonds
    Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, United States of America
    PLoS Genet 7:e1002069. 2011
    ..thaliana and indicate that the transcription factors that make up the TTG1 genetic pathway generally may be important sources of epidermal variation in plants.
  24. doi Nuclear trapping by GL3 controls intercellular transport and redistribution of TTG1 protein in Arabidopsis
    Rachappa Balkunde
    University of Cologne, Botanical Institute III, Zülpicher Strasse 47b, 50674 Koln, Germany
    Development 138:5039-48. 2011
    ..operate during this process such that GLABRA3 (GL3) traps the trichome-promoting factor TRANSPARENT TESTA GLABRA1 (TTG1) in trichomes that, in turn, results in a depletion of TTG1 in trichome neighbouring cells...
  25. doi TTG1 complex MYBs, MYB5 and TT2, control outer seed coat differentiation
    Antonio Gonzalez
    Section of Molecular Cell and Developmental Biology and The Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA
    Dev Biol 325:412-21. 2009
    ..Although the TTG1-dependent R2R3 MYBs are considered to be highly pathway specific, identification of MYBs responsible for outer seed ..
  26. doi SAD2 in Arabidopsis functions in trichome initiation through mediating GL3 function and regulating GL1, TTG1 and GL2 expression
    Ying Gao
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    J Integr Plant Biol 50:906-17. 2008
    ..transcriptional networks and include GLABROUS1 (GL1), GLABRA2 (GL2), GLABRA3 (GL3) and TRANSPARENT TESTA GLABRA1 (TTG1)...
  27. pmc Two-dimensional patterning by a trapping/depletion mechanism: the role of TTG1 and GL3 in Arabidopsis trichome formation
    Daniel Bouyer
    Botanical Institute III, University of Cologne, Koln, Germany, 2 Department of Biology, University of Freiburg, Freiburg, Germany
    PLoS Biol 6:e141. 2008
    ..involved by which patterning is governed by the removal of the trichome-promoting factor TRANSPARENT TESTA GLABRA1 (TTG1) from non-trichome cells...