SIZ1

Summary

Gene Symbol: SIZ1
Description: DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein
Alias: AT5G60420, ATSIZ1, MUF9.5, MUF9_5
Species: thale cress

Top Publications

  1. pmc The Arabidopsis SUMO E3 ligase SIZ1 controls phosphate deficiency responses
    Kenji Miura
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:7760-5. 2005
  2. pmc MMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development
    Takashi Ishida
    RIKEN Plant Science Center, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 7:e46897. 2012
  3. pmc Mutation in SUMO E3 ligase, SIZ1, disrupts the mature female gametophyte in Arabidopsis
    Yu Ling
    Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e29470. 2012
  4. pmc Arabidopsis nitrate reductase activity is stimulated by the E3 SUMO ligase AtSIZ1
    Bong Soo Park
    Department of Plant Science, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Korea
    Nat Commun 2:400. 2011
  5. pmc Arabidopsis SUMO E3 ligase SIZ1 is involved in excess copper tolerance
    Chyi Chuann Chen
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan 11529
    Plant Physiol 156:2225-34. 2011
  6. pmc SIZ1 regulation of phosphate starvation-induced root architecture remodeling involves the control of auxin accumulation
    Kenji Miura
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
    Plant Physiol 155:1000-12. 2011
  7. pmc Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis
    Marcus J Miller
    Department of Genetics, 425 Henry Mall, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 107:16512-7. 2010
  8. doi SIZ1 controls cell growth and plant development in Arabidopsis through salicylic acid
    Kenji Miura
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
    Plant Cell Physiol 51:103-13. 2010
  9. pmc Specific domain structures control abscisic acid-, salicylic acid-, and stress-mediated SIZ1 phenotypes
    Mi Sun Cheong
    Division of Applied Life Science Brain Korea 21 Program, PMBBRC, EB NCRC, Gyeongsang National University, Jinju City 660 701, Korea
    Plant Physiol 151:1930-42. 2009
  10. pmc Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling
    Kenji Miura
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 106:5418-23. 2009

Scientific Experts

  • Kenji Miura
  • Mario Garcia-Dominguez
  • Sung Il Kim
  • Jong Tae Song
  • Hak Soo Seo
  • Jing Bo Jin
  • Bong Soo Park
  • Dae Jin Yun
  • Ray A Bressan
  • Jiyoung Lee
  • Chyi Chuann Chen
  • Mi Sun Cheong
  • Do Youn Kim
  • Paul M Hasegawa
  • Hyeong Cheol Park
  • Chan Yul Yoo
  • Marcus J Miller
  • Hans J Bohnert
  • Xiao Li Lin
  • Pedro Humberto Castro
  • Ga Hyun Son
  • Peng Liu
  • Nabil Elrouby
  • Takashi Ishida
  • Yin Hua Jin
  • Woe Yeon Kim
  • Yuan Zheng
  • Yu Ling
  • Yong Yi Chen
  • Imad Ajjawi
  • Kuo Chen Yeh
  • Richard D Vierstra
  • Sang Yeol Lee
  • Rafael Catala
  • Scott A Saracco
  • David E Salt
  • Bin Cai
  • Jun Soo Kwak
  • Dae Heon Kim
  • De Niu
  • Zi Liang Hu
  • Rongcheng Lin
  • Song Yion Yeu
  • Eduardo Rodríguez Bejarano
  • Herlânder Azevedo
  • Tiago Lourenço
  • Alexandre Papadopoulos Magalhães
  • Rui Manuel Tavares
  • Sang Ik Song
  • Nuno Verde
  • Yun Jung Han
  • Mitzi Villajuana Bonequi
  • George Coupland
  • Aimone Porri
  • Chunyu Zhang
  • Huaiqing Hao
  • Mika Yoshimura
  • Tong Chen
  • Keiko Sugimoto
  • Karen S Schumaker
  • Yan Guo
  • Jinxing Lin
  • Jeng Min Chiou
  • I Chien Tang
  • Robert L Last
  • Ardian Coku
  • Yue Yang
  • Christoph Benning
  • John E Froehlich
  • Katherine W Osteryoung
  • Chong Cheong Lai
  • Hong Ming Liang
  • Zhihua Hua
  • Gregory A Barrett-Wilt
  • Mi Ju Hong
  • Wonkyun Choi
  • Michael Van Oosten
  • Ilha Lee
  • David E Somers
  • Youbong Hyun
  • Gunnam Na
  • Jaesung Nam
  • Qingqiu Gong
  • Jasmina Kurepa
  • Dongwon Baek
  • Xiuren Zhang
  • Tesfaye Mengiste
  • Donggiun Kim
  • Yuxin Hu
  • Shisong Ma

Detail Information

Publications32

  1. pmc The Arabidopsis SUMO E3 ligase SIZ1 controls phosphate deficiency responses
    Kenji Miura
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:7760-5. 2005
    ..Herein, evidence establishes that AtSIZ1 is a plant small ubiquitin-like modifier (SUMO) E3 ligase and is a focal controller of Pi starvation-dependent ..
  2. pmc MMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development
    Takashi Ishida
    RIKEN Plant Science Center, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 7:e46897. 2012
    ..reported in yeast and animals, but only two types of E3 ligases have been identified in Arabidopsis: SAP and Miz 1 (SIZ1) and Methyl Methanesulfonate-Sensitivity protein 21 (MMS21)/HIGH PLOIDY 2 (HPY2), hereafter referred to as HPY2...
  3. pmc Mutation in SUMO E3 ligase, SIZ1, disrupts the mature female gametophyte in Arabidopsis
    Yu Ling
    Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e29470. 2012
    ..Previous reports found that the small ubiquitin-like modifier (SUMO) E3 ligase, SIZ1, participated in many processes depending on particular target substrates and suppression of salicylic acid (SA) ..
  4. pmc Arabidopsis nitrate reductase activity is stimulated by the E3 SUMO ligase AtSIZ1
    Bong Soo Park
    Department of Plant Science, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Korea
    Nat Commun 2:400. 2011
    ..The nitrate reductases, NIA1 and NIA2, are sumoylated by AtSIZ1, which dramatically increases their activity. Both sumoylated and non-sumoylated NIA1 and NIA2 can form dimers...
  5. pmc Arabidopsis SUMO E3 ligase SIZ1 is involved in excess copper tolerance
    Chyi Chuann Chen
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan 11529
    Plant Physiol 156:2225-34. 2011
    ..Arabidopsis thaliana), several stress-responsive SUMO conjugations are mediated mainly by the SUMO E3 ligase SIZ1. In this study, we observed a phenotype of hypersensitivity to excess copper in the siz1-2 and siz1-3 mutants...
  6. pmc SIZ1 regulation of phosphate starvation-induced root architecture remodeling involves the control of auxin accumulation
    Kenji Miura
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
    Plant Physiol 155:1000-12. 2011
    ..Previously, we reported that the Arabidopsis (Arabidopsis thaliana) SUMO E3 ligase SIZ1 regulates root architecture remodeling in response to Pi limitation; namely, the siz1 mutations cause the ..
  7. pmc Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis
    Marcus J Miller
    Department of Genetics, 425 Henry Mall, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 107:16512-7. 2010
    ..Taken together, we propose that SUMOylation represents a rapid and global mechanism for reversibly manipulating plant chromosomal functions, especially during environmental stress...
  8. doi SIZ1 controls cell growth and plant development in Arabidopsis through salicylic acid
    Kenji Miura
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
    Plant Cell Physiol 51:103-13. 2010
    ..Previously, we demonstrated that the siz1 mutant, which is impaired in SUMO E3 ligase, showed a dwarf-like shoot phenotype with accumulation of salicylic ..
  9. pmc Specific domain structures control abscisic acid-, salicylic acid-, and stress-mediated SIZ1 phenotypes
    Mi Sun Cheong
    Division of Applied Life Science Brain Korea 21 Program, PMBBRC, EB NCRC, Gyeongsang National University, Jinju City 660 701, Korea
    Plant Physiol 151:1930-42. 2009
    b>SIZ1 (for yeast SAP and MIZ1) encodes the sole ortholog of mammalian PIAS (for protein inhibitor of activated STAT) and yeast SIZ SUMO (for small ubiquitin-related modifier) E3 ligases in Arabidopsis (Arabidopsis thaliana)...
  10. pmc Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling
    Kenji Miura
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 106:5418-23. 2009
    ..This paper presents evidence that the SUMO E3 ligase SIZ1 negatively regulates abscisic acid (ABA) signaling, which is dependent on the bZIP transcripton factor ABI5...
  11. doi The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins
    Mario Garcia-Dominguez
    Centro Andaluz de Biología Molecular y Medicina Regenerativa Consejo Superior de Investigaciones Científicas Universidad de Sevilla, Seville, Spain
    J Biol Chem 283:21469-77. 2008
    ..We have studied the Arabidopsis SUMO ligase AtSIZ1, belonging to the PIAS family, and describe self-sumoylation and AtSIZ1-mediated sumoylation of the E2 enzyme ..
  12. pmc The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure
    Jing Bo Jin
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 2010, USA
    Plant J 53:530-40. 2008
    Loss-of-function siz1 mutations caused early flowering under short days. siz1 plants have elevated salicylic acid (SA) levels, which are restored to wild-type levels by expressing nahG, bacterial salicylate hydroxylase...
  13. pmc Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential
    Scott A Saracco
    Department of Genetics, University of Wisconsin, Madison, WI 53706 1574, USA
    Plant Physiol 145:119-34. 2007
    ..This increase involves SUMO1 and SUMO2 and is mainly driven by the SUMO protein ligase SIZ1, with most of the conjugates accumulating in the nucleus...
  14. pmc SIZ1-mediated sumoylation of ICE1 controls CBF3/DREB1A expression and freezing tolerance in Arabidopsis
    Kenji Miura
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, Indiana 47907 2010, USA
    Plant Cell 19:1403-14. 2007
    b>SIZ1 is a SUMO E3 ligase that facilitates conjugation of SUMO to protein substrates...
  15. ncbi Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase
    Jiyoung Lee
    Division of Applied Life Science BK21 program, Plant Molecular Biology and Biotechnolgy Research Center and Environmental Biotechnology National Core Research Center, Graduate School of Gyeongsang National University, Jinju, Korea
    Plant J 49:79-90. 2007
    ..Yet little is known about the function of sumoylation in plants. Here, we show that the SIZ1 gene, which encodes an Arabidopsis SUMO E3 ligase, regulates innate immunity...
  16. pmc SIZ1 small ubiquitin-like modifier E3 ligase facilitates basal thermotolerance in Arabidopsis independent of salicylic acid
    Chan Yul Yoo
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, Indiana 47907, USA
    Plant Physiol 142:1548-58. 2006
    ..b>SIZ1 is a SUMO E3 ligase that facilitates SUMO conjugation to substrate target proteins (sumoylation) in Arabidopsis (..
  17. doi SIZ1, a small ubiquitin-related modifier ligase, controls cold signaling through regulation of salicylic acid accumulation
    Kenji Miura
    Graduate School of Life and Environmental Sciences, Initiative for the Promotion of Young Scientists Independent Research, University of Tsukuba, Gene Research Center 220, 1 1 1 Ten nou dai, Tsukuba 305 8572, Japan
    J Plant Physiol 167:555-60. 2010
    ..The SA-accumulating mutant siz1 exhibits sensitivity to chilling and freezing conditions and decreased expression of DREB1A/CBF3 and its regulon ..
  18. pmc The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses
    Rafael Catala
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Plant Cell 19:2952-66. 2007
    ..SUMO E3 ligase functions are executed by SIZ1/SIZ2 and Mms21 in yeast, the PIAS family members RanBP2, and Pc2 in human...
  19. doi The E3 SUMO ligase AtSIZ1 functions in seed germination in Arabidopsis
    Sung Il Kim
    Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul, 151 921, Korea
    Physiol Plant 158:256-271. 2016
    ..Here, we show that the E3 SUMO ligase AtSIZ1 regulates seed dormancy and germination...
  20. pmc An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity
    Xiao Li Lin
    Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 12:e1006016. 2016
    ..Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function siz1 mutant seedlings exhibit a weak constitutive photomorphogenic phenotype...
  21. doi SIZ1-Dependent Post-Translational Modification by SUMO Modulates Sugar Signaling and Metabolism in Arabidopsis thaliana
    Pedro Humberto Castro
    BioSystems and Integrative Sciences Institute BioISI, Plant Functional Biology Center, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal These authors contributed equally to this work
    Plant Cell Physiol 56:2297-311. 2015
    ..The Arabidopsis SUMO E3 ligase SAP and Miz 1 (SIZ1) is the major SUMO conjugation enhancer in response to stress, and is implicated in several aspects of plant ..
  22. doi Arabidopsis CMT3 activity is positively regulated by AtSIZ1-mediated sumoylation
    Do Youn Kim
    Department of Plant Science and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Republic of Korea
    Plant Sci 239:209-15. 2015
    ..the DNA methylation activity of Arabidopsis CHROMOMETHYLASE 3 (CMT3) is positively regulated by the E3 SUMO ligase AtSIZ1. The methylation level of the Arabidopsis genome, including transposons, was significantly lower in the siz1-2 ..
  23. doi E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signalling and plant development
    Sung Il Kim
    Department of Plant Science and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea
    Biochem J 469:299-314. 2015
    ..In the present study, we show that the E3 SUMO (small ubiquitin-related modifier) ligase AtSIZ1 regulates gibberellic acid signalling in Arabidopsis species by sumoylating SLY1...
  24. pmc Identification of Arabidopsis SUMO-interacting proteins that regulate chromatin activity and developmental transitions
    Nabil Elrouby
    Department of Plant Developmental Biology, Max Planck Institute for Plant Breeding Research, Cologne 50829, Germany
    Proc Natl Acad Sci U S A 110:19956-61. 2013
    ..It reduces protein levels of CYCLING DOF FACTOR 2, hence increasing transcript levels of CONSTANS and promoting flowering through the photoperiodic pathway. ..
  25. pmc FLC-mediated flowering repression is positively regulated by sumoylation
    Ga Hyun Son
    Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 151 921, Korea
    J Exp Bot 65:339-51. 2014
    ..and in vitro pull-down analyses showed that FLC interacts with the E3 small ubiquitin-like modifier (SUMO) ligase AtSIZ1, suggesting that AtSIZ1 is an E3 SUMO ligase for FLC...
  26. doi SIZ1 deficiency causes reduced stomatal aperture and enhanced drought tolerance via controlling salicylic acid-induced accumulation of reactive oxygen species in Arabidopsis
    Kenji Miura
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tukuba, 305 8572, Japan
    Plant J 73:91-104. 2013
    ..Here, we demonstrate that SIZ1-mediated endogenous salicylic acid (SA) accumulation plays an important role in stomatal closure and drought ..
  27. doi Structural and functional studies of SIZ1, a PIAS-type SUMO E3 ligase from Arabidopsis
    Mi Sun Cheong
    Division of Applied Life Science BK21 program, PMBBRC, EB NCRC, Gyeongsang National University, Jinju, Korea
    Plant Signal Behav 5:567-9. 2010
    ..Arabidopsis SIZ1, a SUMO E3 ligase, is an ortholog of the mammalian PIAS (Protein Inhibitor of Activated STAT) and yeast SIZ (SAP/..
  28. pmc Sumoylation of transcription factor MYB30 by the small ubiquitin-like modifier E3 ligase SIZ1 mediates abscisic acid response in Arabidopsis thaliana
    Yuan Zheng
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Proc Natl Acad Sci U S A 109:12822-7. 2012
    ..A K283R substitution in MYB30 blocks its SUMO E3 ligase SIZ1-mediated sumoylation in Arabidopsis protoplasts, indicating that MYB30 is sumoylated by SIZ1 and that K283 is the ..
  29. ncbi Arabidopsis SIZ1 positively regulates alternative respiratory bypass pathways
    Bong Soo Park
    Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 151 921, Korea
    BMB Rep 45:342-7. 2012
    ..These results indicate that low nitrate reductase activity due to the AtSIZ1 mutation is correlated with an overall decrease in alternative respiration and with a low carbohydrate content to ..
  30. pmc Effect of Cu content on the activity of Cu/ZnSOD1 in the Arabidopsis SUMO E3 ligase siz1 mutant
    Chyi Chuann Chen
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
    Plant Signal Behav 6:1428-30. 2011
    ..we found copper (Cu) accumulated to a higher level in the aerial parts of soil-grown plants of the SUMO E3 ligase siz1 mutant than in those of the wild type...
  31. doi Increased tolerance to salt stress in the phosphate-accumulating Arabidopsis mutants siz1 and pho2
    Kenji Miura
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, 305 8572, Japan
    Planta 234:1191-9. 2011
    ..We report here that mutations in SIZ1 or PHO2, which cause more accumulation of phosphate compared with the wild type, enhance tolerance to salt stress...
  32. pmc A J-like protein influences fatty acid composition of chloroplast lipids in Arabidopsis
    Imad Ajjawi
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 6:e25368. 2011
    ..These results provide a starting point for future investigations of how mutations in CJD1 affect lipid composition...