NPR1

Summary

Gene Symbol: NPR1
Description: Regulatory protein NPR1
Alias: ARABIDOPSIS NONEXPRESSER OF PR GENES 1, ATNPR1, F15H21.6, F15H21_6, NIM1, NON-INDUCIBLE IMMUNITY 1, NONEXPRESSER OF PR GENES 1, REGULATORY PROTEIN NPR1, SAI1, SALICYLIC ACID INSENSITIVE 1
Species: thale cress

Top Publications

  1. doi Systemic resistance in Arabidopsis conferred by the mycorrhizal fungus Piriformospora indica requires jasmonic acid signaling and the cytoplasmic function of NPR1
    Elke Stein
    Institute of Phytopathology and Applied Zoology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University, Heinrich Buff Ring 26 32, D 35392 Giessen, Germany
    Plant Cell Physiol 49:1747-51. 2008
  2. pmc Benzothiadiazole-induced priming for potentiated responses to pathogen infection, wounding, and infiltration of water into leaves requires the NPR1/NIM1 gene in Arabidopsis
    Annegret Kohler
    Department of Biology, University of Kaiserslautern, D 67653 Kaiserslautern, Germany
    Plant Physiol 128:1046-56. 2002
  3. doi NPR1 preferentially binds to the DNA-inactive form of Arabidopsis TGA2
    Christopher Johnson
    University of Maryland Baltimore County, MD, USA
    Biochim Biophys Acta 1779:583-9. 2008
  4. ncbi NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid
    J M Zhou
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway 08854 8020, USA
    Mol Plant Microbe Interact 13:191-202. 2000
  5. pmc ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis
    Bruce A T Adie
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 19:1665-81. 2007
  6. pmc Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 149:1797-809. 2009
  7. pmc Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity
    Steven H Spoel
    Department of Biology, Duke University, Durham, NC 27708, USA
    Cell 137:860-72. 2009
  8. pmc In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis
    Weihua Fan
    Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, NC 27708 1000, USA
    Plant Cell 14:1377-89. 2002
  9. pmc NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol
    Steven H Spoel
    Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Plant Cell 15:760-70. 2003
  10. pmc OCP3 is an important modulator of NPR1-mediated jasmonic acid-dependent induced defenses in Arabidopsis
    Vicente Ramirez
    Instituto de Biología Molecular y Celular de Plantas IBMCP, Universidad Politécnica de Valencia Consejo Superior de Investigaciones Científicas CSIC, Camino de Vera s n, Valencia, Spain
    BMC Plant Biol 10:199. 2010

Research Grants

Scientific Experts

  • Ralf R Weigel
  • JEAN GREENBERG
  • J Glazebrook
  • Il Pyung Ahn
  • Kohki Yoshimoto
  • Changgen Xie
  • Charles Despres
  • Steven H Spoel
  • Patrick Boyle
  • Yuelin Zhang
  • Pierre R Fobert
  • Juan Vicente Canet
  • Sebastian Pape
  • Smadar Peleg-Grossman
  • Xinnian Dong
  • Yu Ti Cheng
  • Xin Li
  • Mawsheng Chern
  • Amanda Rochon
  • Heather L Shearer
  • Zhonglin Mou
  • Yasuomi Tada
  • Corné M J Pieterse
  • Vinod Kumar
  • Kobi Buxdorf
  • Yue Wu
  • Aizhen Sun
  • Youli Yao
  • Albor Dobon
  • Shi Xiao
  • Pablo Tornero
  • Jee Yan Chu
  • Vicente Ramirez
  • Jaemyung Choi
  • Zi Shi
  • Christian Lindermayr
  • Corinna Thurow
  • Madhumati Mukherjee
  • Christiane Gatz
  • Xudong Zhang
  • Naomi Melamed-Book
  • Alex Levine
  • T Srinivasan
  • Antonio Leon-Reyes
  • Alayne Cuzick
  • Xiaoyun Dong
  • Gargi Meur
  • Ruth K Genger
  • Jörg Durner
  • Christopher Johnson
  • Elke Stein
  • Bruce A T Adie
  • Peng Mao
  • Tatiana E Mishina
  • Patrick E Canlas
  • Pamela C Ronald
  • Chiara Consonni
  • Ragiba Makandar
  • Dong Wang
  • Shelley R Hepworth
  • Jane Larkindale
  • Balakrishnan Prithiviraj
  • Francisca Blanco
  • Inga Mewis
  • Guosheng Liu
  • Annegret Kohler
  • Weihua Fan
  • Han Suk Kim
  • J Shah
  • Sameer G Joshi
  • Alois A Bell
  • Aviva Gafni
  • Ido Rahat
  • Maggie Levy
  • Keerti S Rathore
  • Da Xing
  • Jinman Liu
  • Di Zhang
  • Shengjun Nie
  • Vincenzo De Luca
  • Ian D Brindle
  • Yong Wang
  • Lipu Wang
  • Jana Fajmonová
  • Cristian H Danna
  • Mee Len Chye
  • Ozan Nazim Ciftçi
  • Viktor Titov
  • Frederick M Ausubel
  • Roman Przybylski

Detail Information

Publications65

  1. doi Systemic resistance in Arabidopsis conferred by the mycorrhizal fungus Piriformospora indica requires jasmonic acid signaling and the cytoplasmic function of NPR1
    Elke Stein
    Institute of Phytopathology and Applied Zoology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University, Heinrich Buff Ring 26 32, D 35392 Giessen, Germany
    Plant Cell Physiol 49:1747-51. 2008
    ..Piriformospora indica root colonization reduced G. orontii conidia in wild-type (Col-0), npr1-3 (nonexpressor of PR genes 1-3) and NahG plants, but not in the npr1-1 null mutant...
  2. pmc Benzothiadiazole-induced priming for potentiated responses to pathogen infection, wounding, and infiltration of water into leaves requires the NPR1/NIM1 gene in Arabidopsis
    Annegret Kohler
    Department of Biology, University of Kaiserslautern, D 67653 Kaiserslautern, Germany
    Plant Physiol 128:1046-56. 2002
    ..potentiation by BTH pretreatment of PAL gene activation and callose deposition was not seen in the Arabidopsis nonexpresser of PR genes 1/noninducible immunity 1 mutant, which is compromised in SAR...
  3. doi NPR1 preferentially binds to the DNA-inactive form of Arabidopsis TGA2
    Christopher Johnson
    University of Maryland Baltimore County, MD, USA
    Biochim Biophys Acta 1779:583-9. 2008
    ..of transcription factors such as TGA2 through a mechanism that may involve transient physical interaction with the NPR1 protein...
  4. ncbi NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid
    J M Zhou
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway 08854 8020, USA
    Mol Plant Microbe Interact 13:191-202. 2000
    b>NPR1 is a critical component of the salicylic acid (SA)-mediated signal transduction pathway leading to the induction of defense genes, such as the pathogenesis-related (PR)-1 gene, and enhanced disease resistance...
  5. pmc ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis
    Bruce A T Adie
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 19:1665-81. 2007
    ..The results support a model for ABA affecting JA biosynthesis in the activation of defenses against this oomycete...
  6. pmc Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 149:1797-809. 2009
    ..In Arabidopsis (Arabidopsis thaliana), NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1) was demonstrated to be required for SA-mediated suppression of JA-dependent defenses...
  7. pmc Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity
    Steven H Spoel
    Department of Biology, Duke University, Durham, NC 27708, USA
    Cell 137:860-72. 2009
    ..plant immune response involving profound transcriptional changes that are regulated by the coactivator NPR1. Nuclear translocation of NPR1 is a critical regulatory step, but how the protein is regulated in the nucleus is ..
  8. pmc In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis
    Weihua Fan
    Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, NC 27708 1000, USA
    Plant Cell 14:1377-89. 2002
    The Arabidopsis NPR1 protein is a key regulator of salicylic acid (SA)-mediated gene expression in systemic acquired resistance...
  9. pmc NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol
    Steven H Spoel
    Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Plant Cell 15:760-70. 2003
    ..in SA signal transduction, revealed that the antagonistic effect of SA on JA signaling requires the regulatory protein NPR1. Nuclear localization of NPR1, which is essential for SA-mediated defense gene expression, is not ..
  10. pmc OCP3 is an important modulator of NPR1-mediated jasmonic acid-dependent induced defenses in Arabidopsis
    Vicente Ramirez
    Instituto de Biología Molecular y Celular de Plantas IBMCP, Universidad Politécnica de Valencia Consejo Superior de Investigaciones Científicas CSIC, Camino de Vera s n, Valencia, Spain
    BMC Plant Biol 10:199. 2010
    ..In Arabidopsis, different types of induced resistance have been defined based on the signaling pathways involved, particularly those dependent on salicylic acid (SA) and/or jasmonic acid (JA)...
  11. doi Structure-function analysis of npr1 alleles in Arabidopsis reveals a role for its paralogs in the perception of salicylic acid
    Juan Vicente Canet
    Instituto de Biología Molecular y Celular de Plantas IBMCP, Universidad Politécnica de Valencia UPV Consejo Superior de Investigaciones Científicas CSIC, Ciudad Politécnica de la Innovación CPI, Ed 8E C Ingeniero Fausto Elio s n, 46022 Valencia, Spain
    Plant Cell Environ 33:1911-22. 2010
    Salicylic acid (SA) is necessary for plant defence against some pathogens, whereas NPR1 is necessary for SA perception. Plant defence can be induced to an extreme by several applications of benzothiadiazole (BTH), an analogue of SA...
  12. pmc Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene
    Y Zhang
    Developmental, Cell, and Molecular Biology Group, Department of Botany, Box 91000, Duke University, Durham, NC 27708 1000, USA
    Proc Natl Acad Sci U S A 96:6523-8. 1999
    The Arabidopsis thaliana NPR1 has been shown to be a key regulator of gene expression during the onset of a plant disease-resistance response known as systemic acquired resistance...
  13. doi Nuclear localization of NPR1 is required for regulation of salicylate tolerance, isochorismate synthase 1 expression and salicylate accumulation in Arabidopsis
    Xudong Zhang
    Department of Microbiology and Cell Science, University of Florida, P O Box 110700, Gainesville, FL 32611, USA
    J Plant Physiol 167:144-8. 2010
    ..The Arabidopsis transcription coactivator NPR1 is a key regulator of SAR, which functions at multiple nodes in the SA signaling network...
  14. pmc The BTB/POZ domain of the Arabidopsis disease resistance protein NPR1 interacts with the repression domain of TGA2 to negate its function
    Patrick Boyle
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
    Plant Cell 21:3700-13. 2009
    TGA2 and NONEXPRESSER OF PR GENES1 (NPR1) are activators of systemic acquired resistance (SAR) and of the SAR marker gene pathogenesis-related-1 (PR-1) in Arabidopsis thaliana...
  15. pmc The coactivator function of Arabidopsis NPR1 requires the core of its BTB/POZ domain and the oxidation of C-terminal cysteines
    Amanda Rochon
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada L2S 3A1
    Plant Cell 18:3670-85. 2006
    NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1) regulates systemic acquired resistance (SAR) in Arabidopsis thaliana, and current models propose that after treatment with salicylic acid (SA), Cys-82 and Cys-216 of NPR1 are reduced, ..
  16. ncbi Identification of NPR1-dependent and independent genes early induced by salicylic acid treatment in Arabidopsis
    Francisca Blanco
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Plant Mol Biol 59:927-44. 2005
    ..We also evaluated NPR1 requirement for the induction of the 12 up-regulated genes, and found that only those belonging to Group 2 require ..
  17. ncbi An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance
    Guosheng Liu
    National Research Council, Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, SK S7N 0W9, Canada
    Plant J 41:304-18. 2005
    The Arabidopsis genome contains six NPR1-related genes...
  18. pmc BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis
    Shelley R Hepworth
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Plant Cell 17:1434-48. 2005
    NONEXPRESSOR OF PR GENES1 (NPR1) is a key regulator of the plant defense response known as systemic acquired resistance...
  19. pmc The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1
    Charles Despres
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada L2S 3A1
    Plant Cell 15:2181-91. 2003
    The Arabidopsis NPR1 protein is essential for regulating salicylic acid-dependent gene expression during systemic acquired resistance...
  20. ncbi Genetically engineered resistance to Fusarium head blight in wheat by expression of Arabidopsis NPR1
    Ragiba Makandar
    Division of Biology, Kansas State University, Manhattan 66506, USA
    Mol Plant Microbe Interact 19:123-9. 2006
    ..Sumai 3. Here, we show that the Arabidopsis thaliana NPR1 gene (AtNPR1), which regulates the activation of systemic acquired resistance, when expressed in the FHB-susceptible wheat cv...
  21. pmc The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors
    C Despres
    National Research Council Canada, Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N 0W9
    Plant Cell 12:279-90. 2000
    The Arabidopsis NPR1 gene is essential in activating systemic, inducible plant defense responses...
  22. ncbi Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs
    Yuelin Zhang
    National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, People s Republic of China 102206
    Plant J 48:647-56. 2006
    b>NPR1 is required for systemic acquired resistance, and there are five NPR1 paralogs in Arabidopsis. Here we report knockout analysis of two of these, NPR3 and NPR4...
  23. pmc The epiphytic fungus Pseudozyma aphidis induces jasmonic acid- and salicylic acid/nonexpressor of PR1-independent local and systemic resistance
    Kobi Buxdorf
    Department of Plant Pathology and Microbiology, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Plant Physiol 161:2014-22. 2013
    ..cinerea infection via induced resistance in a manner independent of SA, JA, and Nonexpressor of PR1 (NPR1). P. aphidis primed the plant defense machinery and induced stronger activation of PDF1.2 after B...
  24. pmc UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants
    Youli Yao
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Plant Cell 23:3842-52. 2011
    ..The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 (npr1) mutant, defective in SA signaling, is impaired in both the production and the perception of the volatile signals, ..
  25. ncbi Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene
    J Shah
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855, USA
    Mol Plant Microbe Interact 10:69-78. 1997
    ..These genes also were not induced in sai1 by 2,6-dichloroisonicotinic acid (INA) or benzothiadiazole (BTH), two chemical inducers of SAR...
  26. pmc The BLADE-ON-PETIOLE genes of Arabidopsis are essential for resistance induced by methyl jasmonate
    Juan Vicente Canet
    Instituto de Biología Molecular y Celular de Plantas IBMCP, Universidad Politécnica de Valencia UPV Consejo Superior de Investigaciones Científicas CSIC, Ciudad Politécnica de la Innovación CPI, Valencia, Spain
    BMC Plant Biol 12:199. 2012
    b>NPR1 is a gene of Arabidopsis thaliana required for the perception of salicylic acid. This perception triggers a defense response and negatively regulates the perception of jasmonates...
  27. pmc Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins
    Yasuomi Tada
    Department of Biology, Post Office Box 90338, Duke University, Durham, NC 27708, USA
    Science 321:952-6. 2008
    ..In plants, these redox changes regulate the conformation of NPR1, a master regulator of salicylic acid (SA)-mediated defense genes...
  28. doi Enhanced resistance against Thielaviopsis basicola in transgenic cotton plants expressing Arabidopsis NPR1 gene
    Vinod Kumar
    Institute for Plant Genomics and Biotechnology, Texas A and M University, College Station, TX 77843 2123, USA
    Transgenic Res 22:359-68. 2013
    ..We studied the response of Arabidopsis NPR1 (AtNPR1)-expressing cotton lines, previously shown to be highly resistant to a diverse set of pathogens, to a challenge ..
  29. doi The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid
    Yue Wu
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada L2S 3A1
    Cell Rep 1:639-47. 2012
    ..The transcriptional coregulator NPR1 is central to the activation of SA-dependent defense genes, and we previously found that Cys(521) and Cys(529) of ..
  30. pmc Nitric oxide-mediated maintenance of redox homeostasis contributes to NPR1-dependent plant innate immunity triggered by lipopolysaccharides
    Aizhen Sun
    Ministry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
    Plant Physiol 160:1081-96. 2012
    ..This work investigated the biosynthetic origin of NO and the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1) to gain insight into the mechanism involved in LPS-induced resistance of Arabidopsis (Arabidopsis thaliana)...
  31. doi Arabidopsis clade I TGA transcription factors regulate plant defenses in an NPR1-independent fashion
    Heather L Shearer
    National Research Council Canada, Saskatoon, Canada
    Mol Plant Microbe Interact 25:1459-68. 2012
    Transcriptional reprogramming during induction of salicylic acid (SA)-mediated defenses is regulated primarily by NPR1 (NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1), likely through interactions with TGA bZIP transcription factors...
  32. doi PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62
    Changgen Xie
    College of Life Sciences, Peking University, Beijing, China
    J Genet Genomics 37:359-69. 2010
    b>NPR1 (Nonexpressor of Pathogenesis-Related gene 1) is a major co-activator of plant defense...
  33. doi Ascorbic acid deficiency in arabidopsis induces constitutive priming that is dependent on hydrogen peroxide, salicylic acid, and the NPR1 gene
    Madhumati Mukherjee
    Department of Biology, West Virginia University, 53 Campus Drive, Morgantown, USA
    Mol Plant Microbe Interact 23:340-51. 2010
    ..double mutants defective in the AA-biosynthetic gene VTC1 and the SA signaling pathway genes PAD4, EDS5, and NPR1, respectively. All vtc mutants were more resistant to P. syringae than the wild type...
  34. pmc NPR1 protein regulates pathogenic and symbiotic interactions between Rhizobium and legumes and non-legumes
    Smadar Peleg-Grossman
    Department of Plant and Environmental Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 4:e8399. 2009
    ..One major defense pathway is mediated by salicylic acid (SA). SA is sensed and transduced to downstream defense components by a redox-regulated protein called NPR1.
  35. doi Strong suppression of systemic acquired resistance in Arabidopsis by NRR is dependent on its ability to interact with NPR1 and its putative repression domain
    Mawsheng Chern
    Department of Plant Pathology, University of California, Davis, CA 95616, USA
    Mol Plant 1:552-9. 2008
    ..Arabidopsis NPR1/NIM1 is a key regulator of the SAR response...
  36. pmc Exchanging the as-1-like element of the PR-1 promoter by the as-1 element of the CaMV 35S promoter abolishes salicylic acid responsiveness and regulation by NPR1 and SNI1
    Sebastian Pape
    Albrecht von Haller Institut fur Pflanzenwissenschaften, Georg August Universitat Gottingen, Gottingen, Germany
    Plant Signal Behav 5:1669-71. 2010
    ..Activation is mediated by the transcriptional co-activator NPR1 (NON EXPRESSOR OF PR GENES1), which physically interacts with TGA factors...
  37. doi The cytokinin-activated transcription factor ARR2 promotes plant immunity via TGA3/NPR1-dependent salicylic acid signaling in Arabidopsis
    Jaemyung Choi
    Department of Life Sciences, Pohang University of Science and Technology, Korea
    Dev Cell 19:284-95. 2010
    ..Taken together, these results show that cytokinins modulate the SA signaling to augment resistance against Pst, a process in which the interaction between TGA3 and ARR2 is important...
  38. pmc Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxide
    Christian Lindermayr
    Institute of Biochemical Plant Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    Plant Cell 22:2894-907. 2010
    The role of reactive oxygen and nitrogen species in local and systemic defense reactions is well documented. NPR1 and TGA1 are key redox-controlled regulators of systemic acquired resistance in plants...
  39. pmc The Arabidopsis PR-1 promoter contains multiple integration sites for the coactivator NPR1 and the repressor SNI1
    Sebastian Pape
    Albrecht von Haller Institut fur Pflanzenwissenschaften, Georg August Universitat Gottingen, D 37073 Goettingen, Germany
    Plant Physiol 154:1805-18. 2010
    ..the control of two proteins that do not directly contact the DNA: the positive regulator NONEXPRESSOR OF PR GENES1 (NPR1), which physically interacts with TGA factors, and the repressor SUPPRESSOR OF NPR1, INDUCIBLE1 (SNI1)...
  40. pmc Cytoplasmic H2O2 prevents translocation of NPR1 to the nucleus and inhibits the induction of PR genes in Arabidopsis
    Smadar Peleg-Grossman
    Department of Plant and Environmental Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Plant Signal Behav 5:1401-6. 2010
    ..SA is sensed and transduced by NPR1 protein, which is a redox sensitive protein that acts as a central transcription activator of many pathogenesis ..
  41. pmc Functional analysis of the Theobroma cacao NPR1 gene in Arabidopsis
    Zi Shi
    Huck Institute of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Plant Biol 10:248. 2010
    The Arabidopsis thaliana NPR1 gene encodes a transcription coactivator (NPR1) that plays a major role in the mechanisms regulating plant defense response...
  42. pmc Overexpression of Arabidopsis ACBP3 enhances NPR1-dependent plant resistance to Pseudomonas syringe pv tomato DC3000
    Shi Xiao
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China
    Plant Physiol 156:2069-81. 2011
    ..Using the ACBP3 OE-1 line in combination with nonexpressor of PR genes1 (npr1-5) or coronatine-insensitive1 (coi1-2), we concluded that the enhanced PR gene expression and P...
  43. pmc Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis
    Kohki Yoshimoto
    RIKEN, Plant Science Center, Tsurumi ku, Yokohama, Japan
    Plant Cell 21:2914-27. 2009
    ..Application of an SA agonist induces the senescence/cell death phenotype in SA-deficient atg mutants but not in atg npr1 plants, suggesting that the cell death phenotypes in the atg mutants are dependent on the SA signal transducer ..
  44. pmc Uncoupling salicylic acid-dependent cell death and defense-related responses from disease resistance in the Arabidopsis mutant acd5
    J T Greenberg
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Genetics 156:341-50. 2000
    ..of PR1, in which SA signaling is partially blocked, show greatly attenuated cell death, indicating a role for NPR1 in controlling cell death...
  45. ncbi WRKY62 transcription factor acts downstream of cytosolic NPR1 and negatively regulates jasmonate-responsive gene expression
    Peng Mao
    Peking Yale Joint Center for Plant Molecular Genetics and Agrobiotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, PR China
    Plant Cell Physiol 48:833-42. 2007
    Cytosolic NPR1 has been shown to be essential for the salicylic acid (SA)-mediated suppression of jasmonic acid (JA)-responsive gene expression. However, factors downstream of NPR1 in the cross-talk between SA and JA signaling are unclear...
  46. ncbi Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis
    Tatiana E Mishina
    Julius von Sachs Institute of Biological Sciences, University of Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
    Plant J 50:500-13. 2007
    ..Our data indicate that PAMPs significantly contribute to SAR initiation in Arabidopsis and that tissue necroses at inoculation sites are dispensable for SAR activation...
  47. pmc Vitamin B1-induced priming is dependent on hydrogen peroxide and the NPR1 gene in Arabidopsis
    Il Pyung Ahn
    National Institute of Agricultural Biotechnology, Suwon 441 100, Korea
    Plant Physiol 143:838-48. 2007
    ..etr1), or abscisic acid (abi3-3), but not in plants expressing bacterial NahG and lacking regulation of SAR (npr1 [nonexpressor of PR genes 1])...
  48. ncbi Over-expression of TGA5, which encodes a bZIP transcription factor that interacts with NIM1/NPR1, confers SAR-independent resistance in Arabidopsis thaliana to Peronospora parasitica
    Han Suk Kim
    Cornell University, Department of Plant Pathology, 360 Plant Science Bldg, Ithaca, NY 14853, USA
    Plant J 32:151-63. 2002
    The Arabidopsis thaliana NIM1/NPR1 gene product is required for induction of systemic acquired resistance (SAR) by pathogens, salicylic acid (SA) or synthetic SA analogs...
  49. pmc Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects
    Inga Mewis
    Department of Entomology, Chemical Ecology Laboratory, Pennsylvania State University, State College, Pennsylvania 16802, USA
    Plant Physiol 138:1149-62. 2005
    ..hrl1) mutants reduced constitutive GS concentrations, while blocking SA signaling at the mediator protein npr1 mutant (NPR) increased them...
  50. pmc Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance
    Jane Larkindale
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    Plant Physiol 138:882-97. 2005
    ....
  51. ncbi Induction of protein secretory pathway is required for systemic acquired resistance
    Dong Wang
    Developmental, Cell and Molecular Biology Group, Department of Biology, Post Office Box 91000, Duke University, Durham, NC 27708, USA
    Science 308:1036-40. 2005
    In plants, systemic acquired resistance (SAR) is established as a result of NPR1-regulated expression of pathogenesis-related (PR) genes...
  52. ncbi Staphylococcus aureus pathogenicity on Arabidopsis thaliana is mediated either by a direct effect of salicylic acid on the pathogen or by SA-dependent, NPR1-independent host responses
    Balakrishnan Prithiviraj
    Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO 80523 1173, USA
    Plant J 42:417-32. 2005
    ..in jasmonic acid production and hyper-accumulator of SA), and mutants ics1 (depleted in SA accumulation), and npr1-1 (non-expressor of pathogenesis-related protein) we show that resistance of Arabidopsis to typical plant pathogens ..
  53. doi Constitutive expression of Arabidopsis NPR1 confers enhanced resistance to the early instars of Spodoptera litura in transgenic tobacco
    Gargi Meur
    School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
    Physiol Plant 133:765-75. 2008
    In Arabidopsis, NPR1 (AtNPR1) regulates salicylic acid (SA)-mediated activation of PR genes at the onset of systemic acquired resistance...
  54. pmc Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants
    Ruth K Genger
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Plant Microbe Interact 21:1285-96. 2008
    ..We examined the contributions of NPR1, SID2 (EDS16), NDR1, and EIN2 to dnd phenotypes...
  55. pmc Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis
    Yu Ti Cheng
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Plant Cell 21:2503-16. 2009
    ..nuclear accumulation of snc1 and the defense signaling components Enhanced Disease Susceptibility 1 and Nonexpresser of PR genes 1 is significantly reduced in mos7-1 plants, while nuclear retention of other tested proteins is ..
  56. ncbi Conserved requirement for a plant host cell protein in powdery mildew pathogenesis
    Chiara Consonni
    Max Planck Institute for Plant Breeding Research, Department of Plant Microbe Interactions, Carl von Linne Weg 10, D 50829 Köln, Germany
    Nat Genet 38:716-20. 2006
    ....
  57. doi Heterologous expression of Arabidopsis NPR1 (AtNPR1) enhances oxidative stress tolerance in transgenic tobacco plants
    T Srinivasan
    Department of Plant Sciences, University of Hyderabad, Hyderabad 500046, India
    Biotechnol Lett 31:1343-51. 2009
    In Arabidopsis, NPR1 (non-expressor of pathogenesis related genes 1, AtNPR1) functions downstream of salicylic acid (SA) and modulates the SA mediated systemic acquired resistance...
  58. ncbi Genes controlling expression of defense responses in Arabidopsis--2001 status
    J Glazebrook
    Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA
    Curr Opin Plant Biol 4:301-8. 2001
    ..Genes required for jasmonic-acid-dependent signaling and for induced systemic resistance have also been identified...
  59. pmc Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis
    Ralf R Weigel
    Albrecht von Haller Institut fuer Pflanzenwissenschaften, Allgemeine und Entwicklungsphysiologie, Georg August Universitaet Goettingen, 37073 Goettingen, Germany
    Plant Cell 17:1279-91. 2005
    The Arabidopsis thaliana NONEXPRESSER OF PR GENES1 (NPR1, also known as NIM1) protein is an essential positive regulator of salicylic acid (SA)-induced PATHOGENESIS-RELATED (PR) gene expression and systemic acquired resistance (SAR)...
  60. doi NPR1 and EDS11 contribute to host resistance against Fusarium culmorum in Arabidopsis buds and flowers
    Alayne Cuzick
    Centre for Sustainable Pest and Disease Management, Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, Hertfordshire AL52JQ, UK
    Mol Plant Pathol 9:697-704. 2008
    ..susceptibility and higher concentrations of deoxynivalenol mycotoxin were observed in buds and flowers of the npr1 and eds11 mutants than in the wild-type Col-0 plants...
  61. ncbi NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants
    R R Weigel
    Universitat Hohenheim, Institut fur Genetik, FG Allgemeine Virologie, Stuttgart, Germany
    Plant Mol Biol 46:143-60. 2001
    b>NPR1/NIM1 is a key regulator of systemic acquired resistance (SAR) in Arabidopsis...
  62. doi Expression of callose synthase genes and its connection with Npr1 signaling pathway during pathogen infection
    Xiaoyun Dong
    Plant Biotechnology Center, Department of Plant Pathology and Department of Molecular Genetics, The Ohio State University, 240 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210 1002, USA
    Planta 229:87-98. 2008
    ..Among the genes that are induced, CalS1 and CalS12 showed the highest responses. In Arabidopsis npr1 mutant, impaired in response of pathogenesis related (PR) genes to SA, the induction of CalS1 and CalS12 genes by ..
  63. ncbi Rice NRR, a negative regulator of disease resistance, interacts with Arabidopsis NPR1 and rice NH1
    Mawsheng Chern
    Department of Plant Pathology, University of California, Davis, CA 95616, USA
    Plant J 43:623-35. 2005
    Arabidopsis NPR1/NIM1 is a key regulator of systemic acquired resistance (SAR), which confers lasting broad-spectrum resistance...
  64. ncbi The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats
    H Cao
    Department of Botany, Duke University, Durham, North Carolina 27708 1000, USA
    Cell 88:57-63. 1997
    The Arabidopsis NPR1 gene controls the onset of systemic acquired resistance (SAR), a plant immunity, to a broad spectrum of pathogens that is normally established after a primary exposure to avirulent pathogens...

Research Grants1

  1. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2009
    ..Because experimental progress using a plant model is rapid, the results obtained and quickly be related to human biology and disease. ..