EDS16

Summary

Gene Symbol: EDS16
Description: ADC synthase superfamily protein
Alias: ARABIDOPSIS ISOCHORISMATE SYNTHASE 1, ATICS1, ENHANCED DISEASE SUSCEPTIBILITY TO ERYSIPHE ORONTII 16, F25A4.31, ICS1, ISOCHORISMATE SYNTHASE, ISOCHORISMATE SYNTHASE 1, SALICYLIC ACID INDUCTION DEFICIENT 2, SID2
Species: thale cress

Top Publications

  1. ncbi Isochorismate synthase is required to synthesize salicylic acid for plant defence
    M C Wildermuth
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:562-5. 2001
  2. ncbi A plant locus essential for phylloquinone (vitamin K1) biosynthesis originated from a fusion of four eubacterial genes
    Jeferson Gross
    Department Biology I, Botany, Ludwig Maximilians University Munich, Menzinger Strasse 67, D 80638 Munich, Germany
    J Biol Chem 281:17189-96. 2006
  3. ncbi MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis
    Kazuya Ichimura
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    J Biol Chem 281:36969-76. 2006
  4. ncbi Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis
    Tatiana E Mishina
    Julius von Sachs Institute of Biological Sciences, University of Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
    Plant J 50:500-13. 2007
  5. pmc ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis
    Huamin Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China
    Plant Cell 21:2527-40. 2009
  6. pmc Characterization and biological function of the ISOCHORISMATE SYNTHASE2 gene of Arabidopsis
    Christophe Garcion
    UMR 1090, INRA Université Bordeaux 2, 33140 Villenave d Ornon, France
    Plant Physiol 147:1279-87. 2008
  7. pmc Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants
    Ruth K Genger
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Plant Microbe Interact 21:1285-96. 2008
  8. doi TCP transcription factors are critical for the coordinated regulation of isochorismate synthase 1 expression in Arabidopsis thaliana
    Xiaoyan Wang
    State Key Laboratory of Genetic Engineering, Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China
    Plant J 82:151-62. 2015
  9. pmc Isochorismate synthase 1 is required for thylakoid organization, optimal plastoquinone redox status, and state transitions in Arabidopsis thaliana
    Piotr Gawronski
    Department of Plant Genetics, Breeding and Biotechnology, Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw University of Life Sciences SGGW, Nowoursynowska 159, Warsaw, 02 776 Poland
    J Exp Bot 64:3669-79. 2013
  10. doi Roles of CAMTA transcription factors and salicylic acid in configuring the low-temperature transcriptome and freezing tolerance of Arabidopsis
    YongSig Kim
    MSU DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant J 75:364-76. 2013

Scientific Experts

  • Hua Lu
  • Xiaoyan Wang
  • Piotr Gawronski
  • YongSig Kim
  • Marcel C van Verk
  • Sejir Chaouch
  • Huamin Chen
  • Maria Elizabeth Abreu
  • Ruth K Genger
  • Christophe Garcion
  • Bruce A T Adie
  • Tatiana E Mishina
  • Chiara Consonni
  • Kazuo Shinozaki
  • Jeferson Gross
  • Kazuya Ichimura
  • Maeli Melotto
  • Balakrishnan Prithiviraj
  • Benke Kuai
  • Guodong Ren
  • Xiaolei Wang
  • Xin Zhou
  • Zheng Zhu
  • Xianxin Dong
  • Jiong Gao
  • Michael F Thomashow
  • Stanisław Karpiński
  • Sunchung Park
  • Jerzy Kruk
  • Magdalena Bederska
  • Sarah J Gilmour
  • Magdalena Górecka
  • Anna Rusaczonek
  • Ireneusz Slesak
  • M C Wildermuth
  • John F Bol
  • Huub J M Linthorst
  • Amna Mhamdi
  • Sandy Vanderauwera
  • Guillaume Queval
  • Mathilde Langlois-Meurinne
  • Graham Noctor
  • Michaël Vandorpe
  • Patrick Saindrenan
  • Frank Van Breusegem
  • Li Xue
  • Satya Chintamanani
  • Sergi Munne-Bosch
  • Jianru Zuo
  • Xiaoyan Tang
  • Run Cai
  • Jian Min Zhou
  • Xin Li
  • Hugo Germain
  • Hongwei Guo
  • Haitao Cui
  • Huiqiong Lin
  • Jean Pierre Metraux
  • Antony Buchala
  • Jean T Greenberg
  • John M McDowell
  • Antje Lohmann
  • Jérémy Catinot
  • Andrew F Bent
  • Elisabeth Lamodière
  • Peter Doermann
  • Grace I Jurkowski
  • Ho Won Jung
  • Manuel M Perez-Perez
  • Marta Godoy
  • Jose J Sanchez-Serrano
  • Roberto Solano
  • Eric A Schmelz
  • Jürgen Zeier
  • Julián Pérez-Pérez
  • Paul Schulze-Lefert
  • Reinhold G Herrmann
  • Jörg Durner
  • Ralph Panstruga
  • Scott C Peck
  • Birgit Kemmerling
  • Sheng Yang He
  • Karin Krupinska
  • Shauna C Somerville
  • Volker Lipka
  • Lina Lezhneva
  • William Underwood
  • Jessica Koczan
  • Catarina Casais
  • Matthew E Humphry

Detail Information

Publications18

  1. ncbi Isochorismate synthase is required to synthesize salicylic acid for plant defence
    M C Wildermuth
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:562-5. 2001
    ..Some bacteria such as Pseudomonas aeruginosa synthesize SA using isochorismate synthase (ICS) and pyruvate lyase...
  2. ncbi A plant locus essential for phylloquinone (vitamin K1) biosynthesis originated from a fusion of four eubacterial genes
    Jeferson Gross
    Department Biology I, Botany, Ludwig Maximilians University Munich, Menzinger Strasse 67, D 80638 Munich, Germany
    J Biol Chem 281:17189-96. 2006
    ..Therefore, gene fusion, duplication, and fission events adapted a eubacterial multienzymatic system to the metabolic requirements of plants...
  3. ncbi MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis
    Kazuya Ichimura
    Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    J Biol Chem 281:36969-76. 2006
    ..cell death and H(2)O(2) accumulation that are partly dependent on both RAR1, a key component in resistance protein function, and SID2, an isochorismate synthase required for salicylic acid production upon pathogen infection.
  4. ncbi Pathogen-associated molecular pattern recognition rather than development of tissue necrosis contributes to bacterial induction of systemic acquired resistance in Arabidopsis
    Tatiana E Mishina
    Julius von Sachs Institute of Biological Sciences, University of Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
    Plant J 50:500-13. 2007
    ..Our data indicate that PAMPs significantly contribute to SAR initiation in Arabidopsis and that tissue necroses at inoculation sites are dispensable for SAR activation...
  5. pmc ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis
    Huamin Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China
    Plant Cell 21:2527-40. 2009
    ..Further analyses indicated that SALICYLIC ACID INDUCTION DEFICIENT2 (SID2), which encodes isochorismate synthase required for pathogen-induced biosynthesis of salicylic acid (SA), is a key target of EIN3 and EIL1...
  6. pmc Characterization and biological function of the ISOCHORISMATE SYNTHASE2 gene of Arabidopsis
    Christophe Garcion
    UMR 1090, INRA Université Bordeaux 2, 33140 Villenave d Ornon, France
    Plant Physiol 147:1279-87. 2008
    ..derive mainly from isochorismate, itself produced from chorismate through the activity of ISOCHORISMATE SYNTHASE1 (ICS1)...
  7. pmc Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants
    Ruth K Genger
    Department of Plant Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Plant Microbe Interact 21:1285-96. 2008
    ..We examined the contributions of NPR1, SID2 (EDS16), NDR1, and EIN2 to dnd phenotypes...
  8. doi TCP transcription factors are critical for the coordinated regulation of isochorismate synthase 1 expression in Arabidopsis thaliana
    Xiaoyan Wang
    State Key Laboratory of Genetic Engineering, Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China
    Plant J 82:151-62. 2015
    ..mechanism of SA synthesis and signaling, we used a yeast one-hybrid system to screen for regulators of isochorismate synthase 1 (ICS1), a gene encoding the key enzyme in SA biosynthesis in Arabidopsis thaliana...
  9. pmc Isochorismate synthase 1 is required for thylakoid organization, optimal plastoquinone redox status, and state transitions in Arabidopsis thaliana
    Piotr Gawronski
    Department of Plant Genetics, Breeding and Biotechnology, Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw University of Life Sciences SGGW, Nowoursynowska 159, Warsaw, 02 776 Poland
    J Exp Bot 64:3669-79. 2013
    b>Isochorismate synthase 1 (ICS1) is a crucial enzyme in the salicylic acid (SA) synthesis pathway, and thus it is important for immune defences...
  10. doi Roles of CAMTA transcription factors and salicylic acid in configuring the low-temperature transcriptome and freezing tolerance of Arabidopsis
    YongSig Kim
    MSU DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant J 75:364-76. 2013
    ..We show that this chilling-induced SA biosynthesis proceeds through the isochorismate synthase (ICS) pathway, with cold induction of ICS1 (which encodes ICS), and two genes encoding transcription ..
  11. pmc Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis
    Hua Lu
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Plant J 58:401-12. 2009
    ..to identify two genes disrupted in acd6-1 suppressor (sup) mutants: one encodes a known SA biosynthetic component (SID2) and the other encodes an uncharacterized putative metalloprotease (At5g20660)...
  12. pmc Salicylic acid deficiency in NahG transgenic lines and sid2 mutants increases seed yield in the annual plant Arabidopsis thaliana
    Maria Elizabeth Abreu
    Departament de Biologia Vegetal, Universitat de Barcelona, Facultat de Biologia, Avinguda Diagonal 645, E 08028 Barcelona, Spain
    J Exp Bot 60:1261-71. 2009
    ..It is concluded that (i) the sid2 gene, which encodes for isochorismate synthase, plays a central role in salicylic acid biosynthesis during plant development in A...
  13. pmc ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis
    Bruce A T Adie
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 19:1665-81. 2007
    ..The results support a model for ABA affecting JA biosynthesis in the activation of defenses against this oomycete...
  14. pmc Peroxisomal hydrogen peroxide is coupled to biotic defense responses by ISOCHORISMATE SYNTHASE1 in a daylength-related manner
    Sejir Chaouch
    Institut de Biologie des Plantes, UMR8618 CNRS, Universite de Paris Sud, 91405 Orsay Cedex, France
    Plant Physiol 153:1692-705. 2010
    ..H(2)O(2) was modified by introducing secondary mutations into the cat2 background and was completely absent in cat2 sid2 double mutants, in which ISOCHORISMATE SYNTHASE1 (ICS1) activity is defective...
  15. pmc WRKY transcription factors involved in activation of SA biosynthesis genes
    Marcel C van Verk
    Institute of Biology, Leiden University, Leiden, The Netherlands
    BMC Plant Biol 11:89. 2011
    ..in SA biosynthesis in Arabidopsis is the conversion of chorismate to isochorismate through the action of isochorismate synthase, encoded by the ICS1 gene...
  16. ncbi Plant stomata function in innate immunity against bacterial invasion
    Maeli Melotto
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Cell 126:969-80. 2006
    ..We provide evidence that supports a model in which stomata, as part of an integral innate immune system, act as a barrier against bacterial infection...
  17. ncbi Conserved requirement for a plant host cell protein in powdery mildew pathogenesis
    Chiara Consonni
    Max Planck Institute for Plant Breeding Research, Department of Plant Microbe Interactions, Carl von Linne Weg 10, D 50829 Köln, Germany
    Nat Genet 38:716-20. 2006
    ....
  18. ncbi Staphylococcus aureus pathogenicity on Arabidopsis thaliana is mediated either by a direct effect of salicylic acid on the pathogen or by SA-dependent, NPR1-independent host responses
    Balakrishnan Prithiviraj
    Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO 80523 1173, USA
    Plant J 42:417-32. 2005
    ..SA) accumulation], and 35S-LOX2- (defective in jasmonic acid production and hyper-accumulator of SA), and mutants ics1 (depleted in SA accumulation), and npr1-1 (non-expressor of pathogenesis-related protein) we show that resistance ..