penicillin binding protein 2

Summary

Gene Symbol: penicillin binding protein 2
Description: penicillin-binding protein 2
Species: Staphylococcus aureus subsp. aureus MRSA252

Top Publications

  1. pmc Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance
    C J Hackbarth
    Division of Infectious Diseases, San Francisco General Hospital, California 94110
    Antimicrob Agents Chemother 39:103-6. 1995
  2. ncbi Nucleotide sequence of the structural gene for the penicillin-binding protein 2 of Staphylococcus aureus and the presence of a homologous gene in other staphylococci
    K Murakami
    Kanzakigawa Laboratory, Shionogi and Co, Ltd, Osaka, Japan
    FEMS Microbiol Lett 117:131-6. 1994
  3. pmc Transcriptional induction of the penicillin-binding protein 2 gene in Staphylococcus aureus by cell wall-active antibiotics oxacillin and vancomycin
    Susan Boyle-Vavra
    Department of Pediatrics, The University of Chicago, Illinois 60637, USA
    Antimicrob Agents Chemother 47:1028-36. 2003
  4. pmc Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex
    Anatoly Severin
    The Rockefeller University, New York, New York 10021, USA
    Antimicrob Agents Chemother 48:4566-73. 2004
  5. pmc Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A
    Tomasz A Łeski
    The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Bacteriol 187:1815-24. 2005
  6. pmc Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2
    Patricia Bernal
    School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Biol Chem 285:24055-65. 2010

Scientific Experts

  • Susan Boyle-Vavra
  • Patricia Bernal
  • Tomasz A Łeski
  • Alexander Tomasz
  • Anatoly Severin
  • Mariana G Pinho
  • Jason Hinds
  • Peter W Taylor
  • Shahriar Mobashery
  • Sandrine Lemaire
  • Keiko Tabei
  • Shang Wei Wu
  • C J Hackbarth
  • K Murakami
  • H F Chambers
  • T Kocagoz
  • S Kocagoz
  • T Fujimura
  • M Doi

Detail Information

Publications6

  1. pmc Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance
    C J Hackbarth
    Division of Infectious Diseases, San Francisco General Hospital, California 94110
    Antimicrob Agents Chemother 39:103-6. 1995
    ..These structural and biochemical changes may contribute to the strains' resistance to beta-lactam antibiotics...
  2. ncbi Nucleotide sequence of the structural gene for the penicillin-binding protein 2 of Staphylococcus aureus and the presence of a homologous gene in other staphylococci
    K Murakami
    Kanzakigawa Laboratory, Shionogi and Co, Ltd, Osaka, Japan
    FEMS Microbiol Lett 117:131-6. 1994
    ..Nucleotide sequences having some homology with the PBP2 gene and proteins cross-reactive with anti-PBP2 antibody were detected in some other species of staphylococci by polymerase chain reaction and Western blot analysis, respectively...
  3. pmc Transcriptional induction of the penicillin-binding protein 2 gene in Staphylococcus aureus by cell wall-active antibiotics oxacillin and vancomycin
    Susan Boyle-Vavra
    Department of Pediatrics, The University of Chicago, Illinois 60637, USA
    Antimicrob Agents Chemother 47:1028-36. 2003
    ..These data support the idea that pbpB expression is modulated by a trans-acting factor in response to the presence of the cell wall-active antibiotics vancomycin and oxacillin...
  4. pmc Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex
    Anatoly Severin
    The Rockefeller University, New York, New York 10021, USA
    Antimicrob Agents Chemother 48:4566-73. 2004
    ..aureus (A. Severin, K. Tabei, F. Tenover, M. Chung, N. Clarke, and A. Tomasz, J. Biol. Chem. 279:3398-3407, 2004) is penicillin binding protein 2.
  5. pmc Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A
    Tomasz A Łeski
    The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Bacteriol 187:1815-24. 2005
    ..aureus transpeptidases (PBP2 and PBP4) and an acquired transpeptidase (PBP2A) in staphylococcal cell wall biosynthesis and susceptibility to antimicrobial agents...
  6. pmc Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2
    Patricia Bernal
    School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Biol Chem 285:24055-65. 2010
    ..We argue that many features of the ECg-induced phenotype can be explained by changes in the fluid dynamics of the CM...