melatonin receptor

Summary

Gene Symbol: melatonin receptor
Description: melatonin receptor 1A
Alias: MEL1A, MT1, melatonin receptor type 1A, G-protein coupled receptor, mel-1A-R, mel1a receptor, melatonin receptor 1 A protein, melatonin receptor protein 1A, melatonin receptor subtype A
Species: sheep

Top Publications

  1. doi Polymorphism of the melatonin receptor MT1 gene and its relationship with seasonal reproductive activity in the Sarda sheep breed
    V Carcangiu
    Dipartimento di Biologia Animale, Universita degli Studi di Sassari, Italy
    Anim Reprod Sci 116:65-72. 2009
  2. ncbi Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    Neuron 13:1177-85. 1994
  3. ncbi Cloning and functional analysis of a polymorphic variant of the ovine Mel 1a melatonin receptor
    P Barrett
    Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen, Scotland, UK
    Biochim Biophys Acta 1356:299-307. 1997
  4. ncbi MTNR1A melatonin receptors in the ovine premammillary hypothalamus: day-night variation in the expression of the transcripts
    Martine Migaud
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Universite de Tours Haras Nationaux, 37380 Nouzilly, France
    Biol Reprod 72:393-8. 2005
  5. ncbi Regulation of the ovine MT1 melatonin receptor promoter: interaction between multiple pituitary transcription factors at different phases of development
    Jonathan D Johnston
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Mol Cell Endocrinol 268:59-66. 2007
  6. doi Influence of melatonin receptor 1A gene polymorphisms on seasonal reproduction in Sarda ewes with different body condition scores and ages
    M C Mura
    Dipartimento di Medicina Veterinaria, Universita degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy
    Anim Reprod Sci 149:173-7. 2014
  7. doi Assessment of Genetic Variability in the Coding Sequence of Melatonin Receptor Gene (MTNR1A) in Tropical Arid Sheep Breeds of India
    V K Saxena
    Molecular Physiology Laboratory, Division of Physiology and Biochemistry, Central Sheep and Wool Research Institute, Avikanagar, Rajasthan, India
    Reprod Domest Anim 50:517-21. 2015
  8. ncbi Characterization of MTNR1A gene in terms of genetic variability in a panel of subtemperate and subtropical Indian sheep breeds
    Vijay Kumar Saxena
    Division of Physiology and Biochemistry, Central Sheep and Wool Research Institute, Malpura 304 501, India
    J Genet 94:715-21. 2015
  9. doi Characterisation of the Melatonin Receptor 1A (MTNR1A) gene in the Rasa Aragonesa sheep breed: association with reproductive seasonality
    A Martinez-Royo
    Unidad de Tecnologia en Produccion Animal, CITA, Zaragoza, Spain
    Anim Reprod Sci 133:169-75. 2012
  10. doi Identification and immunolocalisation of melatonin MT(1) and MT(2) receptors in Rasa Aragonesa ram spermatozoa
    Adriana Casao
    Grupo Biología y Fisiología de la Reproducción, Instituto de Investigación de Ciencias Ambientales de Aragón, Universidad de Zaragoza, C Miguel Servet 177, 500013, Zaragoza, Spain
    Reprod Fertil Dev 24:953-61. 2012

Scientific Experts

  • M Migaud
  • Vijay Kumar Saxena
  • Adriana Casao
  • Perry Barrett
  • J D Johnston
  • M C Mura
  • V Carcangiu
  • A Martinez-Royo
  • P P Bini
  • S Luridiana
  • Vincenzo Carcangiu
  • R G Mateescu
  • M L Diaz
  • S Bodano
  • G Cosso
  • C Daga
  • J Folch
  • J H Calvo
  • J L Alabart
  • B Lahoz
  • Maria Consuelo Mura
  • Sebastiano Luridiana
  • Giuseppe Massimo Vacca
  • Cinzia Daga
  • A K Lunsford
  • M L Dettori
  • G M Vacca
  • M L Thonney
  • M Pazzola
  • S M Reppert
  • T Ebisawa
  • D R Weaver

Detail Information

Publications12

  1. doi Polymorphism of the melatonin receptor MT1 gene and its relationship with seasonal reproductive activity in the Sarda sheep breed
    V Carcangiu
    Dipartimento di Biologia Animale, Universita degli Studi di Sassari, Italy
    Anim Reprod Sci 116:65-72. 2009
    The aim was to study the polymorphisms of the melatonin receptor 1A gene (MTNR1A) and its relationship with seasonal reproduction in the Sarda sheep breed...
  2. ncbi Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    Neuron 13:1177-85. 1994
    ..Functional studies of NIH 3T3 cells stably expressing the sheep receptor show that the mammalian melatonin receptor is coupled to inhibition of adenylyl cyclase through a pertussis toxin-sensitive mechanism...
  3. ncbi Cloning and functional analysis of a polymorphic variant of the ovine Mel 1a melatonin receptor
    P Barrett
    Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen, Scotland, UK
    Biochim Biophys Acta 1356:299-307. 1997
    We have isolated a novel variant of the Mel 1a melatonin receptor from an ovine PT cDNA library. Relative to the reported sequence for the Mel 1a melatonin receptor there are 8 changes in the DNA sequence...
  4. ncbi MTNR1A melatonin receptors in the ovine premammillary hypothalamus: day-night variation in the expression of the transcripts
    Martine Migaud
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Universite de Tours Haras Nationaux, 37380 Nouzilly, France
    Biol Reprod 72:393-8. 2005
    ..Overall, these results show that MTNR1A transcripts are expressed in the ovine PMH and that their expression follows a diurnal rhythm, which is different from the pattern of expression observed in the PT...
  5. ncbi Regulation of the ovine MT1 melatonin receptor promoter: interaction between multiple pituitary transcription factors at different phases of development
    Jonathan D Johnston
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Mol Cell Endocrinol 268:59-66. 2007
    ..data, in conjunction with our previous study of the rat MT(1) promoter, suggests a general model in which melatonin receptor expression in the mammalian pituitary is determined by the developmentally changing balance between ..
  6. doi Influence of melatonin receptor 1A gene polymorphisms on seasonal reproduction in Sarda ewes with different body condition scores and ages
    M C Mura
    Dipartimento di Medicina Veterinaria, Universita degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy
    Anim Reprod Sci 149:173-7. 2014
    ..In sheep, two silent mutations in the melatonin receptor 1A gene (MTNR1A) at positions 606 and 612 of the exon II are associated with seasonal reproduction...
  7. doi Assessment of Genetic Variability in the Coding Sequence of Melatonin Receptor Gene (MTNR1A) in Tropical Arid Sheep Breeds of India
    V K Saxena
    Molecular Physiology Laboratory, Division of Physiology and Biochemistry, Central Sheep and Wool Research Institute, Avikanagar, Rajasthan, India
    Reprod Domest Anim 50:517-21. 2015
    ..b>Melatonin receptor is the membrane-bound G-coupled receptor, sensing the message of photoperiodic cues thorough melatonin...
  8. ncbi Characterization of MTNR1A gene in terms of genetic variability in a panel of subtemperate and subtropical Indian sheep breeds
    Vijay Kumar Saxena
    Division of Physiology and Biochemistry, Central Sheep and Wool Research Institute, Malpura 304 501, India
    J Genet 94:715-21. 2015
    ..hormone which is secreted by the pineal gland in proportion to darkness and its effect is mediated by melatonin receptor subtypes, principally MTNR1A...
  9. doi Characterisation of the Melatonin Receptor 1A (MTNR1A) gene in the Rasa Aragonesa sheep breed: association with reproductive seasonality
    A Martinez-Royo
    Unidad de Tecnologia en Produccion Animal, CITA, Zaragoza, Spain
    Anim Reprod Sci 133:169-75. 2012
    The ovine Melatonin Receptor 1A (MTNR1A) gene was structurally characterised and association between its variants and the reproductive seasonality was examined in a daughter design comprising three families of Rasa Aragonesa sheep breed...
  10. doi Identification and immunolocalisation of melatonin MT(1) and MT(2) receptors in Rasa Aragonesa ram spermatozoa
    Adriana Casao
    Grupo Biología y Fisiología de la Reproducción, Instituto de Investigación de Ciencias Ambientales de Aragón, Universidad de Zaragoza, C Miguel Servet 177, 500013, Zaragoza, Spain
    Reprod Fertil Dev 24:953-61. 2012
    ..In conclusion, we provide evidence of the presence of MT(1) and MT(2) receptors in ram spermatozoa, although the biochemical pathway triggered by these receptors and their function in terms of fertility remains to be elucidated...
  11. doi Association between melatonin receptor 1A gene polymorphism and reproductive performance in Dorset ewes
    R G Mateescu
    Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA
    J Anim Sci 87:2485-8. 2009
    ..To evaluate the relationship between the melatonin receptor 1A (MTNR1A) gene and reproductive performance, records were compared in Dorset and 3/4-Dorset x 1/4-East ..
  12. doi A polymorphism at the melatonin receptor 1A (MTNR1A) gene in Sarda ewes affects fertility after AI in the spring
    Vincenzo Carcangiu
    Dipartimento di Biologia Animale, Universita degli Studi di Sassari, Via Vienna 2, 07100, Sassari, Italy
    Reprod Fertil Dev 23:376-80. 2011
    ..01). In conclusion, there was a positive correlation between MTNR1A allele polymorphisms the reproductive response following synchronisation and AI in the spring...