GH

Summary

Gene Symbol: GH
Description: growth hormone
Alias: GH1, somatotropin, growth hormone 12
Species: sheep

Top Publications

  1. ncbi Cloning and nucleotide sequencing of sheep growth hormone cDNA
    C Guron
    Embryo Biotechnology Laboratory, National Institute of Immunology, New Delhi, India
    Indian J Exp Biol 30:659-63. 1992
  2. doi Influence of season and nutritional status on the direct effects of leptin, orexin-A and ghrelin on luteinizing hormone and growth hormone secretion in the ovine pituitary explant model
    K Kirsz
    Laboratory of Biotechnology and Genomics, Department of Swine and Small Ruminant Breeding, Agricultural University in Krakow, Krakow, Poland
    Domest Anim Endocrinol 48:69-76. 2014
  3. doi Growth hormone polymorphisms and growth traits in Chinese Tibetan sheep Ovis aries
    Y C Han
    The Animal Genetics and Breeding Laboratory, Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, China
    Genet Mol Res 15:. 2016
  4. ncbi Cloning, sequence and expression in Escherichia coli of cDNA for ovine pregrowth hormone
    J M Warwick
    Biochemistry Laboratory, School of Biological Sciences, University of Sussex, Brighton U K
    Biochim Biophys Acta 1008:247-50. 1989
  5. pmc Cloning and sequencing of the ovine growth hormone gene
    J M Orian
    Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia
    Nucleic Acids Res 16:9046. 1988
  6. ncbi The isolation and characterisation of the ovine growth hormone gene
    C R Byrne
    Division of Animal Production, CSIRO, Blacktown, N S W, Australia
    Aust J Biol Sci 40:459-68. 1987
  7. ncbi The primary structure of sheep pituitary growth hormone
    C H Li
    Arch Biochem Biophys 156:493-508. 1973
  8. ncbi Ovine growth hormone. Sequence of the C-terminal 68 amino acids
    J T Bellair
    Biochem Biophys Res Commun 46:1128-34. 1972
  9. ncbi Expression of the growth hormone gene in ovine placenta: detection and cellular localization of the protein
    M C Lacroix
    Unité de Recherche sur l Endocrinologie du Placenta et de la Périnatalité, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Endocrinology 137:4886-92. 1996
  10. ncbi Ovine growth hormone gene duplication--structural and evolutionary implications
    R Ofir
    Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
    Mamm Genome 8:770-2. 1997

Patents

  1. Sheep growth hormone

Scientific Experts

  • Y C Han
  • K Kirsz
  • Mojtaba Tahmoorespur
  • Jolanta Polkowska
  • H Takahashi
  • D Grouselle
  • S Reicher
  • J A Daniel
  • E Gootwine
  • K Dudek
  • M Szczesna
  • P M Bartlewski
  • D A Zieba
  • Hamid Gholami
  • Maziar Ansary
  • Amir Taheri
  • Marta Wańkowska
  • Y Yoshida
  • Y Suzuki
  • K Kangawa
  • Y Azuma
  • T Sugino
  • T Yamaguchi
  • Y Kurose
  • K Hodate
  • M Kojima
  • S Kobayashi
  • M Ogino
  • Y Hasegawa
  • P Zizzari
  • Y Tillet
  • J Epelbaum
  • L Niv-Spector
  • A Caraty
  • M T Bluet-Pajot
  • A Gertler
  • E Chaillou
  • J L Sartin
  • T H Elsasser
  • A Martinez
  • B K Whitlock
  • B Steele
  • R Ofir
  • M C Lacroix
  • E Devinoy
  • C Puissant
  • G Kann
  • J L Servely
  • C Guron
  • S M Totey
  • J M Orian
  • K B Rao
  • G P Talwar
  • S K Jain
  • C H Li
  • J T Bellair
  • C R Byrne
  • J M Warwick
  • J V O'Mahoney
  • M R Brandon
  • K A Ward
  • B W Wilson
  • O C Wallis
  • D Gordon
  • J Knorr
  • M Wallis

Detail Information

Publications16

  1. ncbi Cloning and nucleotide sequencing of sheep growth hormone cDNA
    C Guron
    Embryo Biotechnology Laboratory, National Institute of Immunology, New Delhi, India
    Indian J Exp Biol 30:659-63. 1992
    ..The sequence for the sheep growth hormone (GH) is in agreement with the amino acid sequence of the protein determined previously except for the asparagine residue ..
  2. doi Influence of season and nutritional status on the direct effects of leptin, orexin-A and ghrelin on luteinizing hormone and growth hormone secretion in the ovine pituitary explant model
    K Kirsz
    Laboratory of Biotechnology and Genomics, Department of Swine and Small Ruminant Breeding, Agricultural University in Krakow, Krakow, Poland
    Domest Anim Endocrinol 48:69-76. 2014
    ..ie, independently of hypothalamic influences) affect the secretion of luteinizing hormone (LH) and growth hormone (GH) by adenohypophyseal (AP) explants obtained from normally fed or fasted (48 h) ewes during the breeding and ..
  3. doi Growth hormone polymorphisms and growth traits in Chinese Tibetan sheep Ovis aries
    Y C Han
    The Animal Genetics and Breeding Laboratory, Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, China
    Genet Mol Res 15:. 2016
    Growth hormone (GH) plays an important role in promoting growth, protein and muscle accretion, and fat catabolism, suggesting that GH is a potential candidate gene affecting growth traits in vertebrates...
  4. ncbi Cloning, sequence and expression in Escherichia coli of cDNA for ovine pregrowth hormone
    J M Warwick
    Biochemistry Laboratory, School of Biological Sciences, University of Sussex, Brighton U K
    Biochim Biophys Acta 1008:247-50. 1989
    ..The predicted sequence for ovine GH agrees with that determined previously on the protein, except that residue 99 is asparagine rather than aspartic ..
  5. pmc Cloning and sequencing of the ovine growth hormone gene
    J M Orian
    Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia
    Nucleic Acids Res 16:9046. 1988
  6. ncbi The isolation and characterisation of the ovine growth hormone gene
    C R Byrne
    Division of Animal Production, CSIRO, Blacktown, N S W, Australia
    Aust J Biol Sci 40:459-68. 1987
    ..The gene is flanked by artiodactyl-specific middle-repetitive DNA, consisting mainly of elements belonging to the 'C-A3' family of repeated DNA. A previously unreported sequence has been found, which we have named an 'E' element...
  7. ncbi The primary structure of sheep pituitary growth hormone
    C H Li
    Arch Biochem Biophys 156:493-508. 1973
  8. ncbi Ovine growth hormone. Sequence of the C-terminal 68 amino acids
    J T Bellair
    Biochem Biophys Res Commun 46:1128-34. 1972
  9. ncbi Expression of the growth hormone gene in ovine placenta: detection and cellular localization of the protein
    M C Lacroix
    Unité de Recherche sur l Endocrinologie du Placenta et de la Périnatalité, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Endocrinology 137:4886-92. 1996
    In several species, placenta has been found to express GH-related proteins...
  10. ncbi Ovine growth hormone gene duplication--structural and evolutionary implications
    R Ofir
    Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
    Mamm Genome 8:770-2. 1997
  11. ncbi Interleukin-1beta and tumor necrosis factor-alpha mediation of endotoxin action on growth hormone
    J A Daniel
    Animal and Range Sciences, South Dakota State University, Brookings, South Dakota, USA
    Am J Physiol Endocrinol Metab 289:E650-7. 2005
    In humans and sheep, endotoxin (LPS) administration results in increased growth hormone (GH) concentrations. To determine the role of cytokines in the effect of LPS on GH, sheep were challenged with IL-1beta or TNF-alpha...
  12. ncbi Pituitary and placental ovine growth hormone variants differ in their receptor-binding ability and in their biological properties
    S Reicher
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Gen Comp Endocrinol 155:368-77. 2008
    ..Thus the product of the oGH duplicated copy has higher affinity for GHR and higher somatogenic activity. As the GH2-Z gene copy is expressed in the placenta, allelic differences at the oGH locus may influence feto-placental development...
  13. doi Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep
    D Grouselle
    UMR 894 INSERM, Centre de Psychiatrie and Neuroscience, Faculte de Medecine, Universite Paris Descartes, Paris, France
    J Neuroendocrinol 20:1138-46. 2008
    As in other species, exogenous administration of ghrelin, an endogenous ligand for the growth hormone (GH) secretagogue receptors can stimulates feeding behaviour and GH secretion in the sheep...
  14. doi Ghrelin differentially modulates the GH secretory response to GHRH between the fed and fasted states in sheep
    H Takahashi
    School of Veterinary Medicine and Animal Science, Kitasato University, Towada shi, Aomori, Japan
    Domest Anim Endocrinol 37:55-60. 2009
    The effect of energy balance on the growth hormone (GH) secretory responsiveness to growth hormone-releasing hormone (GHRH) has not been determined in ruminant animals. Therefore, we examined the effects of intravenous injections of 0, 3...
  15. doi Effects of maternal deprivation on the somatotrophic axis and neuropeptide Y in the hypothalamus and pituitary in female lambs. The histomorphometric study
    Jolanta Polkowska
    Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences
    Folia Histochem Cytobiol 48:299-305. 2010
    ..the neurons of the periventricular nucleus (PEV) and in nerve terminals of the median eminence (ME), growth hormone (GH) in the adenohypophyseal cells and NPY in the neurons of the PEV and arcuate (ARC) nuclei of the hypothalamus using ..
  16. doi PCR-SSCP variation of GH and STAT5A genes and their association with estimated breeding values of growth traits in Baluchi sheep
    Mojtaba Tahmoorespur
    Department of Animal Science, Ferdowsi University of Mashhad, Iran
    Anim Biotechnol 22:37-43. 2011
    Growth hormone (GH) selected for its important role in economically relevant traits and signal transducers and activators of transcription 5A (STAT5A) is also known as a main mediator of growth hormone action on target genes...

Patents1

  1. Sheep growth hormone
    Patent Number: EP0363063-A2; Date:1990-04-11