CYP19

Summary

Gene Symbol: CYP19
Description: cytochrome P450, family 19
Alias: CYP19A1, aromatase, CYPXIX, cytochrome P-450AROM, cytochrome P450 19A1, estrogen synthase
Species: sheep

Top Publications

  1. ncbi Distribution of aromatase mRNA in the ram hypothalamus: an in situ hybridization study
    C E Roselli
    Department of Physiology and Pharmacology, School of Medicine, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Neuroendocrinol 12:656-64. 2000
  2. ncbi DNA methylation and chromatin accessibility of the proximal Cyp 19 promoter region 1.5/2 correlate with expression levels in sheep placentomes
    Rainer Fürbass
    Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Mol Reprod Dev 75:1-7. 2008
  3. pmc Aromatase immunoreactivity in fetal ovine neuronal cell cultures exposed to oxidative injury
    G Lepore
    Department of Animal Biology, University of Sassari, Italy
    Eur J Histochem 53:e28. 2009
  4. ncbi Placenta-specific transcripts of the aromatase encoding gene include different untranslated first exons in sheep and cattle
    J Vanselow
    Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Eur J Biochem 265:318-24. 1999
  5. ncbi Expression of the aromatase cytochrome P450 encoding gene in cattle and sheep
    J Vanselow
    Research Institute for the Biology of Farm Animals, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    J Steroid Biochem Mol Biol 79:279-88. 2001
  6. doi DNA methylation of placenta-specific Cyp19 promoters of cattle and sheep
    J Vanselow
    Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Exp Clin Endocrinol Diabetes 116:437-42. 2008
  7. pmc The ovine sexually dimorphic nucleus, aromatase, and sexual partner preferences in sheep
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    J Steroid Biochem Mol Biol 118:252-6. 2010
  8. ncbi Expression and distribution of P450-aromatase in the ovine hypothalamus at different stages of fetal development
    Arcadia Mura
    Department of Animal Biology, University of Sassari, Italy
    Neuro Endocrinol Lett 31:690-9. 2010

Research Grants

Scientific Experts

Detail Information

Publications8

  1. ncbi Distribution of aromatase mRNA in the ram hypothalamus: an in situ hybridization study
    C E Roselli
    Department of Physiology and Pharmacology, School of Medicine, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Neuroendocrinol 12:656-64. 2000
    The regional distribution of neurones expressing aromatase mRNA in the ram hypothalamus was examined by in situ hybridization using 33P-labelled cRNA probes...
  2. ncbi DNA methylation and chromatin accessibility of the proximal Cyp 19 promoter region 1.5/2 correlate with expression levels in sheep placentomes
    Rainer Fürbass
    Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Mol Reprod Dev 75:1-7. 2008
    ..They are synthesized within the fetal cotyledons of placentomes by aromatase cytochrome P450 (P450arom; EC 1.14.14.1), the product of the Cyp 19 gene...
  3. pmc Aromatase immunoreactivity in fetal ovine neuronal cell cultures exposed to oxidative injury
    G Lepore
    Department of Animal Biology, University of Sassari, Italy
    Eur J Histochem 53:e28. 2009
    A lot of evidence testifies that aromatase is expressed in the central nervous system where it has been detected not only in hypothalamic and limbic regions but also in the cerebral cortex and spinal cord...
  4. ncbi Placenta-specific transcripts of the aromatase encoding gene include different untranslated first exons in sheep and cattle
    J Vanselow
    Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Eur J Biochem 265:318-24. 1999
    The aim of the present study was the characterization of the ovine aromatase cytochrome P450 encoding gene (Cyp19) and the analysis of its tissue-specific expression...
  5. ncbi Expression of the aromatase cytochrome P450 encoding gene in cattle and sheep
    J Vanselow
    Research Institute for the Biology of Farm Animals, Wilhelm Stahl Allee 2, 18196, Dummerstorf, Germany
    J Steroid Biochem Mol Biol 79:279-88. 2001
    During this report the tissue-specific expression and promoter usage of the aromatase cytochrome P450 encoding gene, Cyp19, are compared between cattle and sheep...
  6. doi DNA methylation of placenta-specific Cyp19 promoters of cattle and sheep
    J Vanselow
    Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Exp Clin Endocrinol Diabetes 116:437-42. 2008
    ..The key enzyme of estrogen biosynthesis, aromatase cytochrome P450, is encoded by CYP19...
  7. pmc The ovine sexually dimorphic nucleus, aromatase, and sexual partner preferences in sheep
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    J Steroid Biochem Mol Biol 118:252-6. 2010
    We are using the domestic ram as an experimental model to examine the role of aromatase in the development of sexual partner preferences...
  8. ncbi Expression and distribution of P450-aromatase in the ovine hypothalamus at different stages of fetal development
    Arcadia Mura
    Department of Animal Biology, University of Sassari, Italy
    Neuro Endocrinol Lett 31:690-9. 2010
    An important step of sexual differentiation is the conversion of testosterone to estrogen by aromatase leading to masculinization and defeminization of the fetal brain areas crucial for normal sexual behavior and reproduction...

Research Grants1

  1. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..Specific Aim 2: To correlate the effects of PC-SPES on prostate growth with 5a-reductase, aromatase, and androgen receptor concentrations, in order to determine the level(s) at which PC-SPES interacts with the ..