BMPR1B

Summary

Gene Symbol: BMPR1B
Description: bone morphogenetic protein receptor type 1B
Alias: ALK6, BMPR-IB, FecB, bone morphogenetic protein receptor type-1B, BMP receptor IB, activin receptor-like kinase 6, bone morphogenetic protein receptor, type IB, bone morphogenetic protein type recepter 1B
Species: sheep

Top Publications

  1. ncbi Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development
    Feng Guan
    College of Life Sciences, China Jiliang University, Hangzhou 310018, Zhejiang Province, China
    Anim Reprod Sci 99:44-52. 2007
  2. ncbi Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells
    T Wilson
    AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biol Reprod 64:1225-35. 2001
  3. ncbi The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene
    C J Souza
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers St, Edinburgh, EH3 9ET, UK
    J Endocrinol 169:R1-6. 2001
  4. pmc Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes
    P Mulsant
    Institut National de la Recherche Agronomique, Laboratoire de Genetique Cellulaire, BP, 27, 31326 Castanet Tolosan, France
    Proc Natl Acad Sci U S A 98:5104-9. 2001
  5. doi Flow cytometric analysis of FSHR, BMRR1B, LHR and apoptosis in granulosa cells and ovulation rate in merino sheep
    Sheena L P Regan
    School of Biomedical SciencesCurtin Health Innovation Research Institute, Curtin University, GPO Box U1987, Perth, Western Australia 6845, AustraliaCentre of Bioactive Discovery in Health and AgeingUniversity of New England, Armidale, New South Wales, Australia
    Reproduction 150:151-63. 2015
  6. doi Mutation in BMPR-IB gene is associated with litter size in Iranian Kalehkoohi sheep
    Morteza Mahdavi
    Department of Animal Science, Faculty of Agriculture, Broujerd Branch, Islamic Azad University, Broujerd, Iran Electronic address
    Anim Reprod Sci 147:93-8. 2014
  7. pmc Polymorphisms of the Ovine BMPR-IB, BMP-15 and FSHR and Their Associations with Litter Size in Two Chinese Indigenous Sheep Breeds
    Weimin Wang
    College of Animal Science and Technology, Gansu Agriculture University, Lanzhou 730000, China
    Int J Mol Sci 16:11385-97. 2015
  8. doi Association of BMPR-1B and GDF9 genes polymorphisms and secondary protein structure changes with reproduction traits in Mehraban ewes
    R Abdoli
    Department of Animal Science, Faculty of Agriculture, Bu Ali Sina University, Hamedan, Iran
    Gene 524:296-303. 2013
  9. doi Booroola BMPR1B mutation alters early follicular development and oocyte ultrastructure in sheep
    Karen L Reader
    AgResearch, Animal Production, Invermay Agricultural Centre, Private Bag 50034, Mosgiel 9053, New Zealand
    Reprod Fertil Dev 24:353-61. 2012
  10. doi Differential expression of mRNAs encoding BMP/Smad pathway molecules in antral follicles of high- and low-fecundity Hu sheep
    Yefen Xu
    Laboratory of Animal Reproductive Genetics and Breeding, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China
    Anim Reprod Sci 120:47-55. 2010

Scientific Experts

  • MingXing Chu
  • Morteza Mahdavi
  • Karen L Reader
  • T Wilson
  • Julia M Young
  • J L Crawford
  • F Lecerf
  • P Mulsant
  • Feng Guan
  • Shamik Polley
  • Li Guo Yang
  • Weimin Wang
  • Sheena L P Regan
  • R Abdoli
  • Joyabrata Roy
  • Biswajit Brahma
  • Tirtha Kumar Datta
  • Surender Lal Goswami
  • Subhransu Pan
  • Subhasis Batabyal
  • Ayan Mukherjee
  • Sachinandan De
  • Yefen Xu
  • Guo Hua Hua
  • Guo qing Shi
  • Shou ren Liu
  • Xiaoxue Zhang
  • Frank Arfuso
  • Ghanim Almahbobi
  • Youji Ma
  • James R McFarlane
  • Shijia Liu
  • Arun Dharmarajan
  • Nicholas Andronicos
  • Tim O'Shea
  • Fadi Li
  • Chong Li
  • Yongfu La
  • Rui Xi
  • Tingfu Li
  • Xiangyu Pan
  • A Deljou
  • H Rezvan
  • P Zamani
  • C J Souza
  • Ling Chen
  • Erlin Li
  • Yedong Han
  • P V Vinesh
  • Ashis Kumar Samanta
  • Zhuang Xie
  • Jaspreet Singh Arora
  • Da Gan Mao
  • Jun Tao Ai
  • B K Campbell
  • C MacDougall
  • D T Baird
  • A S McNeilly

Detail Information

Publications20

  1. ncbi Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development
    Feng Guan
    College of Life Sciences, China Jiliang University, Hangzhou 310018, Zhejiang Province, China
    Anim Reprod Sci 99:44-52. 2007
    Nine sheep breeds or strains, including 615 individuals were screened with forced PCR RFLP method for the FecB gene to study the polymorphism and its effects on litter sizes, body weights and body sizes...
  2. ncbi Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells
    T Wilson
    AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biol Reprod 64:1225-35. 2001
    The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is additive for ovulation rate (increasing by about 1...
  3. ncbi The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene
    C J Souza
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers St, Edinburgh, EH3 9ET, UK
    J Endocrinol 169:R1-6. 2001
    ..The BMPR1B gene in the human is located at the region linked with the Booroola mutation, syntenic to chromosome 6 in the ..
  4. pmc Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes
    P Mulsant
    Institut National de la Recherche Agronomique, Laboratoire de Genetique Cellulaire, BP, 27, 31326 Castanet Tolosan, France
    Proc Natl Acad Sci U S A 98:5104-9. 2001
    ..This phenotype is due to the action of the FecB(B) allele of a major gene named FecB, as determined by statistical analysis of phenotypic data...
  5. doi Flow cytometric analysis of FSHR, BMRR1B, LHR and apoptosis in granulosa cells and ovulation rate in merino sheep
    Sheena L P Regan
    School of Biomedical SciencesCurtin Health Innovation Research Institute, Curtin University, GPO Box U1987, Perth, Western Australia 6845, AustraliaCentre of Bioactive Discovery in Health and AgeingUniversity of New England, Armidale, New South Wales, Australia
    Reproduction 150:151-63. 2015
    ..up-regulation of FSH receptor (FSHR), transforming growth factor beta type 1, bone morphogenetic protein receptor (BMPR1B), and LH receptor (LHR) in BB sheep...
  6. doi Mutation in BMPR-IB gene is associated with litter size in Iranian Kalehkoohi sheep
    Morteza Mahdavi
    Department of Animal Science, Faculty of Agriculture, Broujerd Branch, Islamic Azad University, Broujerd, Iran Electronic address
    Anim Reprod Sci 147:93-8. 2014
    ..The same FecB (Booroola) mutation occurred in the BMPR-IB gene in Kalehkoohi sheep as found in Booroola Merino...
  7. pmc Polymorphisms of the Ovine BMPR-IB, BMP-15 and FSHR and Their Associations with Litter Size in Two Chinese Indigenous Sheep Breeds
    Weimin Wang
    College of Animal Science and Technology, Gansu Agriculture University, Lanzhou 730000, China
    Int J Mol Sci 16:11385-97. 2015
    ..Consequently, three polymorphisms, FecB mutation in BMPR-IB (c.746A>G), FecG mutation in BMP-15 (c.718C>T) and the mutation (g...
  8. doi Association of BMPR-1B and GDF9 genes polymorphisms and secondary protein structure changes with reproduction traits in Mehraban ewes
    R Abdoli
    Department of Animal Science, Faculty of Agriculture, Bu Ali Sina University, Hamedan, Iran
    Gene 524:296-303. 2013
    ..Marker assisted selection using BMPR-IB gene could be noticed to improve the reproduction traits in Mehraban sheep...
  9. doi Booroola BMPR1B mutation alters early follicular development and oocyte ultrastructure in sheep
    Karen L Reader
    AgResearch, Animal Production, Invermay Agricultural Centre, Private Bag 50034, Mosgiel 9053, New Zealand
    Reprod Fertil Dev 24:353-61. 2012
    Booroola ewes homozygous (BB) for a mutation in the bone morphogenetic protein receptor-1b (BMPR1B) gene exhibit higher ovulation rates, have larger diameter oocytes at earlier stages of follicular development (i.e...
  10. doi Differential expression of mRNAs encoding BMP/Smad pathway molecules in antral follicles of high- and low-fecundity Hu sheep
    Yefen Xu
    Laboratory of Animal Reproductive Genetics and Breeding, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China
    Anim Reprod Sci 120:47-55. 2010
    ..in Hu sheep and its relationship with the BMP/Smad pathway, 147 Hu sheep were blood sampled for detection of the FecB mutation (A746G) in the BMPRIB gene by PCR-SSCP, and sixteen adult Hu ewes classified as either high-fecundity (HF) ..
  11. doi Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep
    Joyabrata Roy
    Animal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana, India
    Anim Biotechnol 22:151-62. 2011
    ..The FecB locus of the BMPR1B gene and two loci (G1 and G4) of GDF9 gene were found to be polymorphic...
  12. doi Oocytes in sheep homozygous for a mutation in bone morphogenetic protein receptor 1B express lower mRNA levels of bone morphogenetic protein 15 but not growth differentiation factor 9
    Janet L Crawford
    School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
    Reproduction 142:53-61. 2011
    ..test the hypothesis that the high ovulation rate in ewes (BB) homozygous for a mutation in the bone morphogenetic protein receptor type 1B (BMPR1B) gene is linked to lower BMP15 and/or GDF9 mRNA in oocytes compared with those in wild-..
  13. doi Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep
    MingXing Chu
    Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
    Mol Biol Rep 38:4071-6. 2011
    ....
  14. doi Polymorphism of BMPR1B, BMP15 and GDF9 fecundity genes in prolific Garole sheep
    Shamik Polley
    Animal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana, 132001, India
    Trop Anim Health Prod 42:985-93. 2010
    ..bone morphogenetic protein 15 (BMP15/FecX) and associated type I receptors, bone morphogenetic protein receptor (BMPR1B/FecB), are major determinant of ovulation rate and consequent increase in litter size...
  15. doi A review of research progress of FecB gene in Chinese breeds of sheep
    Guo Hua Hua
    Huazhong Agricultural University, Wuhan, China
    Anim Reprod Sci 116:1-9. 2009
    b>FecB gene is a major gene responsible for high prolificacy firstly identified in Booroola Merino sheep. Subsequently, many other aspects of the FecB including endocrinology, fetal and postnatal growth were studied...
  16. doi The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures
    Julia M Young
    AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    J Endocrinol 196:251-61. 2008
    ..cultured from Booroola ewes homozygous for a mutation in activin receptor-like kinase 6 (ALK6) also known as BMP receptor IB (BMPRIB), and from wild-type (WT) ewes to determine if the mutation caused alterations in FSH secretion in ..
  17. ncbi Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries)
    M X Chu
    Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China
    J Anim Sci 85:598-603. 2007
    ..The results indicated that the same FecB mutation (Q249R) occurred in the BMPR-IB gene in Small Tailed Han ewes as found in Booroola Merino ewes...
  18. ncbi Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development
    Feng Guan
    Research Institute of Animal Breeding and Reproduction, Nanjing Agricultural University, Nanjing 210095, China
    Yi Chuan Xue Bao 33:117-24. 2006
    Nine sheep breeds or strains, including 615 individuals were screened with forced PCR RFLP method for the FecB gene to study the polymorphism and its effects on litter size, body weight and body size...
  19. pmc A novel method to isolate the common fraction of two DNA samples: hybrid specific amplification (HSA)
    F Lecerf
    Laboratoire de Genetique Cellulaire, INRA Toulouse, Chemin de Borde Rouge, BP 27, F 31326 Castanet Tolosan, France
    Nucleic Acids Res 29:E87-7. 2001
    ..Here we have successfully applied HSA to a particular tissue, but it should be possible to trap the common fraction of two DNA samples, whatever their nature...