cdc15

Summary

Gene Symbol: cdc15
Description: extended Fer/CIP4 (EFC) domain protein Cdc15
Species: Schizosaccharomyces pombe 972h-

Top Publications

  1. pmc α-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly
    Damien Laporte
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 23:3094-110. 2012
  2. pmc Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis
    Luther W Pollard
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Mol Biol Cell 23:2433-44. 2012
  3. pmc Cytokinesis-based constraints on polarized cell growth in fission yeast
    K Adam Bohnert
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS Genet 8:e1003004. 2012
  4. pmc Characterization of Mid1 domains for targeting and scaffolding in fission yeast cytokinesis
    I Ju Lee
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 125:2973-85. 2012
  5. pmc The SET domain protein, Set3p, promotes the reliable execution of cytokinesis in Schizosaccharomyces pombe
    Stefan Rentas
    Department of Biology, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 7:e31224. 2012
  6. pmc Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast
    Rajesh Arasada
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 21:1450-9. 2011
  7. pmc Assembly and architecture of precursor nodes during fission yeast cytokinesis
    Damien Laporte
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 192:1005-21. 2011
  8. pmc The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring
    Rachel H Roberts-Galbraith
    Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
    J Cell Biol 184:113-27. 2009
  9. pmc The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1
    Dawn M Clifford
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 181:79-88. 2008
  10. pmc Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis
    Mario Pinar
    Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Científicas Departamento de Microbiología y Genética, Universidad de Salamanca, Edificio Departamental, 37007 Salamanca, Spain
    Mol Biol Cell 19:1727-38. 2008

Scientific Experts

  • Jim Karagiannis
  • F Chang
  • Kentaro Nakano
  • Kathleen L Gould
  • Jian Qiu Wu
  • Rajesh Arasada
  • Thomas D Pollard
  • K Adam Bohnert
  • Rebeca Martín-García
  • Nathan A McDonald
  • Alaina H Willet
  • David R Kovar
  • Damien Laporte
  • Rachel H Roberts-Galbraith
  • Pedro M Coll
  • Valerie C Coffman
  • Charnpal Grewal
  • Stefan Rentas
  • I Ju Lee
  • Pilar Perez
  • Dannel McCollum
  • Omaya Dudin
  • Liping Ren
  • Mithilesh Mishra
  • John W Goss
  • Craig W Vander Kooi
  • Yi Hua Zhu
  • Jun Song Chen
  • Luther W Pollard
  • Mohammad Reza Sharifmoghadam
  • Saravana P Selvanathan
  • Samriddha Ray
  • M Henar Valdivieso
  • Aleksandar Vjestica
  • Mario Pinar
  • Dawn M Clifford
  • Sergio A Rincon
  • Volker Wachtler
  • Mohan K Balasubramanian
  • Rafael R Daga
  • Tetsuya Takeda
  • Robert H Carnahan
  • Charles Boone
  • Raphaël Groux
  • Sachdev S Sidhu
  • Michael W Davidson
  • Michelle A Baird
  • Janel R Beckley
  • Anna Feoktistova
  • Felipe O Bendezú
  • Arne Seitz
  • Haiming Huang
  • John R Allen
  • Rodrigo Guillen
  • Melanie D Ohi
  • Thierry Laroche
  • Sophie G Martin
  • Hannah Bledsoe
  • Sunhee Kim
  • Juan Carlos G Cortés
  • Agnieszka P Grzegorzewska
  • V Simanis
  • Jennifer A Sees
  • Zhengrong Wu
  • Yanfang Ye
  • Reza Saberianfar
  • Masayuki Onishi
  • Rachelle Kanippayoor
  • Nikola Ojkic
  • M Ángeles Curto
  • Cristina Doncel
  • Marta Hoya
  • Jack Hickmott
  • Nagore de Leon
  • Dimitrios Vavylonis
  • Matthew Lord
  • John R Pringle
  • M D Jacobson
  • Timothy D Veenstra
  • Ming Zhou
  • Anjan G Thakurta
  • Ravi Dhar
  • Wanzhong Ge
  • Jothy Dhakshnamoorthy
  • Sneha Gupta
  • Dai Hirata
  • Mohan Balasubramanian
  • C F Cullen
  • Kazunori Kume
  • Jianqiu Wang

Detail Information

Publications46

  1. pmc α-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly
    Damien Laporte
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 23:3094-110. 2012
    ..Taken together, our work supports a cooperative process of ring self-organization driven by the interaction between actin filaments and myosin II, which is progressively stabilized by the cross-linking proteins...
  2. pmc Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis
    Luther W Pollard
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Mol Biol Cell 23:2433-44. 2012
    ..We suggest that the proposed evolution of animal transglutaminase cross-linking activity from ancestral bacterial thiol proteases was accompanied by the emergence of a subclass whose function does not depend on enzymatic activity...
  3. pmc Cytokinesis-based constraints on polarized cell growth in fission yeast
    K Adam Bohnert
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS Genet 8:e1003004. 2012
    ....
  4. pmc Characterization of Mid1 domains for targeting and scaffolding in fission yeast cytokinesis
    I Ju Lee
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 125:2973-85. 2012
    ..Collectively, our study recognizes domains regulating Mid1 cortical localization and reveals domains sufficient for contractile-ring assembly...
  5. pmc The SET domain protein, Set3p, promotes the reliable execution of cytokinesis in Schizosaccharomyces pombe
    Stefan Rentas
    Department of Biology, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 7:e31224. 2012
    ..Taken together, these findings support the existence of a conserved, multi-protein complex with a role in promoting the successful completion of cytokinesis...
  6. pmc Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast
    Rajesh Arasada
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 21:1450-9. 2011
    ..Many questions remain regarding the interactions of these proteins, particularly the participation of F-BAR proteins in the assembly of actin filaments...
  7. pmc Assembly and architecture of precursor nodes during fission yeast cytokinesis
    Damien Laporte
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 192:1005-21. 2011
    ..Mid1 then independently recruits the F-BAR protein Cdc15 to form module II...
  8. pmc The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring
    Rachel H Roberts-Galbraith
    Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
    J Cell Biol 184:113-27. 2009
    Schizosaccharomyces pombe cdc15 homology (PCH) family members participate in many cellular processes by bridging the plasma membrane and cytoskeleton...
  9. pmc The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1
    Dawn M Clifford
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 181:79-88. 2008
    ..functional consequences of Clp1/Flp1 activity at the CR, including dephosphorylation of the essential CR component Cdc15, reductions in CR protein mobility, and CR resistance to mild perturbation...
  10. pmc Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis
    Mario Pinar
    Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Científicas Departamento de Microbiología y Genética, Universidad de Salamanca, Edificio Departamental, 37007 Salamanca, Spain
    Mol Biol Cell 19:1727-38. 2008
    ..Moreover, Pxl1 colocalizes and interacts with Myo2, and Cdc15, suggesting that it is part of the actomyosin ring...
  11. pmc The actomyosin ring recruits early secretory compartments to the division site in fission yeast
    Aleksandar Vjestica
    Cell Dynamics Group, Temasek Life Sciences Laboratory, 117604 Singapore
    Mol Biol Cell 19:1125-38. 2008
    ..Cdc15p overexpression was sufficient to induce tER polarization in interphase. Thus, fission yeast polarizes its entire secretory machinery to the cell division site by utilizing molecular cues provided by the actomyosin ring...
  12. pmc Contractile ring stability in S. pombe depends on F-BAR protein Cdc15p and Bgs1p transport from the Golgi complex
    Rajesh Arasada
    Department of Molecular Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520 8103 USA
    Cell Rep 8:1533-44. 2014
    ..We estimate that ∼ 2,000 Bgs1p molecules are required to anchor the ring. Without Bgs1p anchors, contractile rings slide along the plasma membrane, a phenomenon that depends on an unconventional type II myosin called Myp2p...
  13. ncbi The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring
    Rebeca Martín-García
    Departamento de Microbiología y Genética Instituto de Microbiología Bioquímica, Universidad de Salamanca CSIC, Edificio Departamental, Laboratorio 231, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    J Cell Sci 119:2768-79. 2006
    ..In synchronous cultures, chs2Delta cells exhibit a delay in septation with respect to the control strain. All these results show that Chs2p participates in the correct functioning of the medial ring...
  14. pmc Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe
    Volker Wachtler
    Cell Division Laboratory, Temasek Life Sciences Laboratory, Singapore 117604, Singapore
    Mol Biol Cell 17:3254-66. 2006
    ..The FER/CIP4-homology (FCH) domain protein Cdc15p is a component of the actomyosin ring. Mutations in cdc15 lead to failure in cytokinesis and result in the formation of elongated, multinucleate cells without a division ..
  15. ncbi Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast
    Tetsuya Takeda
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th St, New York, NY 10032, USA
    Nat Cell Biol 6:1142-4. 2004
    ..b>cdc15 mutants have membrane domains in the shape of spirals...
  16. ncbi The Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe
    Mithilesh Mishra
    Cell Division Laboratory, Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, NUS, Singapore 117604, Rep of Singapore
    J Cell Sci 117:3897-910. 2004
    ..We conclude that the Clp1p/Flp1p-dependent cytokinesis checkpoint provides a previously unrecognized cell survival advantage when the cell division apparatus is mildly perturbed...
  17. ncbi Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis
    Jian Qiu Wu
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Dev Cell 5:723-34. 2003
    ..Ring contraction and disassembly begin 37 min after SPB separation. This spatial and temporal hierarchy provides the framework for analysis of molecular mechanisms...
  18. pmc The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe
    Robert H Carnahan
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 162:851-62. 2003
    ..Here we investigate the role of the S. pombe Cdc15 homology family protein, Cdc15p, in CAR assembly and find that it interacts with proteins from both of these ..
  19. ncbi Localization of the (1,3)beta-D-glucan synthase catalytic subunit homologue Bgs1p/Cps1p from fission yeast suggests that it is involved in septation, polarized growth, mating, spore wall formation and spore germination
    Juan Carlos G Cortés
    Departamento de Microbiologia y Genetica, Consejo Superior de Investigaciones Científicas CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    J Cell Sci 115:4081-96. 2002
    ....
  20. pmc Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton
    K Nakano
    Division of Biology, Department of Life Sciences, Graduate Program in Interdisciplinary Sciences, School of Arts and Sciences, University of Tokyo, Komaba, Meguro ku, Tokyo 153 8902, Japan
    Mol Biol Cell 12:3515-26. 2001
    ..Finally, genetic studies suggested that Fim1 may function in cytokinesis in cooperation with Cdc15 (PSTPIP) and Rng2 (IQGAP), respectively.
  21. ncbi The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis
    C Fankhauser
    Swiss Institute for Experimental Cancer Research
    Cell 82:435-44. 1995
    The S. pombe cdc15 gene is essential for cell division. cdc15ts mutants do not form a septum, but growth and nuclear division continue, leading to formation of multinucleate cells...
  22. pmc cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin
    F Chang
    Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 137:169-82. 1997
    ..cdc8 (tropomyosin homologue), cdc3 (profilin homologue), and cdc15 mutants exhibit no specific cdc12p staining during mitosis...
  23. ncbi The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe
    S Schmidt
    Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research ISREC, Epalinges
    Genes Dev 11:1519-34. 1997
    ..These data indicate that Spg1p is a key element in controlling the onset of septum formation in Schizosaccharomyces pombe, and that it acts through the Cdc7p kinase...
  24. pmc imp2, a new component of the actin ring in the fission yeast Schizosaccharomyces pombe
    J Demeter
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biol 143:415-27. 1998
    ..pombe cdc15 and the mouse PSTPIP that are localized to, and thought to be involved in actin ring organization...
  25. ncbi Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe
    X Le Goff
    Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research ISREC, Epalinges
    Mol Gen Genet 262:163-72. 1999
    ..Analysis of the interaction of cps1 with other mutations suggests the existence of a septation checkpoint, which requires the activity of the protein kinase weel for function...
  26. doi F-BAR domain protein Rga7 collaborates with Cdc15 and Imp2 to ensure proper cytokinesis in fission yeast
    Rebeca Martín-García
    Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, 37007 Salamanca, Spain
    J Cell Sci 127:4146-58. 2014
    ..Moreover, we demonstrate that Rga7 cooperates with the two F-BAR proteins Cdc15 and Imp2 to ensure proper cytokinesis...
  27. pmc Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis
    Nathan A McDonald
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dev Cell 35:725-36. 2015
    ..Here, we investigate the F-BAR domain of the essential cytokinetic scaffold, Schizosaccharomyces pombe Cdc15, during cytokinesis...
  28. pmc A role for F-BAR protein Rga7p during cytokinesis in S. pombe
    Rajesh Arasada
    Department of Molecular Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520 8103, USA
    J Cell Sci 128:2259-68. 2015
    ..The late arrival and lower than normal numbers of Bgs4p result in septal defects late in cytokinesis, and in the lysis of separating cells, similar to that in cells with mutations in the cwg1(+) gene (which encodes Bgs4p). ..
  29. pmc Characterization of the roles of Blt1p in fission yeast cytokinesis
    John W Goss
    Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103Department of Biological Sciences, Wellesley College, Wellesley, MA 02481 8203
    Mol Biol Cell 25:1946-57. 2014
    ..We find three defects that likely contribute to this delay. Without Blt1p, contractile rings recruited and retained less Sid2p/Mob1p and Clp1p phosphatase, and β-glucan synthase Bgs1p accumulated slowly at the cleavage site. ..
  30. pmc The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12
    Alaina H Willet
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232
    J Cell Biol 208:391-9. 2015
    ..a short motif within the N terminus of Cdc12 that binds directly to the F-BAR domain of the scaffolding protein Cdc15. Mutations preventing the Cdc12-Cdc15 interaction resulted in reduced Cdc12, F-actin, and actin-binding proteins ..
  31. pmc A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast
    Omaya Dudin
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland
    J Cell Biol 208:897-911. 2015
    ..Thus, the fusion focus focalizes cell wall dissolution within a broader cell wall synthesis zone to shift from cell growth to cell fusion. ..
  32. pmc The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast
    Liping Ren
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232
    Mol Biol Cell 26:256-69. 2015
    Schizosaccharomyces pombe cdc15 homology (PCH) family members participate in numerous biological processes, including cytokinesis, typically by bridging the plasma membrane via their F-BAR domains to the actin cytoskeleton...
  33. pmc Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis
    Yi Hua Zhu
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210 Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210 Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210
    Mol Biol Cell 24:3187-204. 2013
    ..contractile-ring localization of Nod1 and Gef2 also depends on the interaction between Nod1 and the F-BAR protein Cdc15, where the Nod1/Gef2 complex plays a role in contractile-ring maintenance and affects the septation initiation ..
  34. pmc SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis
    K Adam Bohnert
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Genes Dev 27:2164-77. 2013
    ..Taken together, our findings identify a SIN-triggered oligomeric switch that modulates cytokinetic formin function, revealing a novel mechanism of actin cytoskeleton regulation during cell division. ..
  35. pmc The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis
    Valerie C Coffman
    Department of Molecular Genetics and 2 Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210
    J Cell Biol 203:101-14. 2013
    ..For3 localization at the division site depended on the F-BAR protein Cdc15, and for3 deletion was synthetic lethal with mutations that cause defects in contractile ring formation...
  36. pmc The integrity of the cytokinesis machinery under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p
    Mohammad Reza Sharifmoghadam
    Departamento de Microbiología y Genética Instituto de Biología Funcional y Genómica, Universidad de Salamanca Consejo Superior de Investigaciones Cientificas, Salamanca, Spain
    PLoS ONE 7:e42726. 2012
    ..The results show that the contractile actomyosin ring is very sensitive to stress, and that cells have efficient mechanisms to remedy the damage produced in this structure...
  37. pmc A conserved histone deacetylase with a role in the regulation of cytokinesis in Schizosaccharomyces pombe
    Charnpal Grewal
    Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada
    Cell Div 7:13. 2012
    ..Since MLL5, NCOR2, and TBL1X form a complex with the histone deacetylase, HDAC3, we sought to determine if an orthologous counterpart played a regulatory role in fission yeast cytokinesis...
  38. pmc Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast
    David R Kovar
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mol Biol Cell 16:2313-24. 2005
    ..Given that capping protein arrives at the division site 20 min later than Cdc12p, capping protein may slowly replace Cdc12p on filament barbed ends in preparation for filament disassembly during ring constriction...
  39. pmc The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe
    Samriddha Ray
    Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 190:793-805. 2010
    ..Together, our results reveal a mutually antagonistic relationship between the SIN and MOR pathways, which is important for completion of cytokinesis and coordination of cytoskeletal remodeling at the mitosis-to-interphase transition...
  40. pmc Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks
    Saravana P Selvanathan
    Basic Research Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 285:14122-33. 2010
    ..We suggest that the sequestration of Cdc25p to DNA damage sites could provide a mechanism for S. pombe cells to arrest at G(2)/M boundary in response to DNA damage...
  41. pmc Hob3p, the fission yeast ortholog of human BIN3, localizes Cdc42p to the division site and regulates cytokinesis
    Pedro M Coll
    Consejo Superior de Investigaciones Científicas CSIC Departamento de Microbiología y Genética, Instituto de Microbiologia Bioquimica, Universidad de Salamanca, Edificio Departamental, Salamanca 37007, Spain
    EMBO J 26:1865-77. 2007
    ..These results suggest that Hob3p is required to recruit and activate Cdc42p at the cell division site and that this function might be conserved in other eukaryotes...
  42. pmc Etd1p is a novel protein that links the SIN cascade with cytokinesis
    Rafael R Daga
    Centro Andaluz de Biologia del Desarrollo, CSIC Universidad Pablo de Olavide, Carretera de Utrera Km1, Sevilla, Spain
    EMBO J 24:2436-46. 2005
    ..Etd1p peaks during cytokinesis and is degraded by the ubiquitin-dependent 26S-proteasome pathway at the end of septation, providing a mechanism to couple inactivation of SIN to completion of cytokinesis...
  43. pmc Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase
    M D Jacobson
    The Rockefeller University, New York, New York 10021, USA
    Genetics 159:17-33. 2001
    ..Consistent with this hypothesis, sid2-1 rad9 cells are dead or very slow growing even when SIC1 is expressed...
  44. pmc A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast
    C F Cullen
    Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Genetics 155:1521-34. 2000
    ..Among the 14 pld mutants with septation defects, 12 mapped to known loci: cdc7, cdc15, cdc11 spg1, and sid2. One of the pld mutants, cdc7-PD1, was selected for suppressor analysis...
  45. ncbi Genetic interactions in the control of septation in Schizosaccharomyces pombe
    J Marks
    Unité de Recherches sur le Cycle Cellulaire, Institut Suisse de Recherches Experimentales sur le Cancer
    J Cell Sci 101:801-8. 1992
    ..Our data suggest that the products of the cdc7, cdc11, cdc14 and cdc16 genes interact. These activities may regulate the function of the cdc15 gene product. A model for the control of septation in fission yeast is presented.