TOK1

Summary

Gene Symbol: TOK1
Description: Tok1p
Alias: DUK1, YKC1, YPK1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. doi Plasma-membrane hyperpolarization diminishes the cation efflux via Nha1 antiporter and Ena ATPase under potassium-limiting conditions
    Jaromir Zahradka
    Department of Membrane Transport, Institute of Physiology Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    FEMS Yeast Res 12:439-46. 2012
  2. doi Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter
    Jaromir Zahradka
    Department of Membrane Transport, Institute of Physiology Academy of Sciences of the Czech Republic, v v i, 142 20 Prague 4, Czech Republic
    Biochim Biophys Acta 1820:849-58. 2012
  3. ncbi A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem
    K A Ketchum
    Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    Nature 376:690-5. 1995
  4. ncbi Mechanisms of salt tolerance conferred by overexpression of the HAL1 gene in Saccharomyces cerevisiae
    G Rios
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia CSIC, Spain
    Yeast 13:515-28. 1997
  5. ncbi Potassium uptake through the TOK1 K+ channel in the budding yeast
    C Fairman
    Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Dr, Madison, WI 53706, USA
    J Membr Biol 168:149-57. 1999
  6. ncbi Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis
    Omri Erez
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Biochem Biophys Res Commun 295:1142-9. 2002
  7. ncbi MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction
    Markus Proft
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 118:351-61. 2004
  8. ncbi In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance
    A Roller
    Botanisches Institut I, Universitat Karlsruhe, Kaiserstrasse 12, 76128 Karlsruhe, Germany
    Pflugers Arch 451:362-70. 2005
  9. pmc Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity
    Ingela Johansson
    Laboratory of Plant Physiology and Biophysics, IBLS Plant Sciences, Bower Building, University of Glasgow, Glasgow G12 8QQ, UK
    Biochem J 393:645-55. 2006
  10. doi Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p
    Anja Roller
    Botanisches Institut I, Universitat Karlsruhe TH, Kaiserstrasse 12, 76128, Karlsruhe, Germany
    Pflugers Arch 456:883-96. 2008

Patents

  1. Saccharomyces cerevisiae yeast strain with stable integration and expression of the nucleic acid sequence for a heterologous potassium ion channel

Detail Information

Publications11

  1. doi Plasma-membrane hyperpolarization diminishes the cation efflux via Nha1 antiporter and Ena ATPase under potassium-limiting conditions
    Jaromir Zahradka
    Department of Membrane Transport, Institute of Physiology Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    FEMS Yeast Res 12:439-46. 2012
    ..efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells...
  2. doi Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter
    Jaromir Zahradka
    Department of Membrane Transport, Institute of Physiology Academy of Sciences of the Czech Republic, v v i, 142 20 Prague 4, Czech Republic
    Biochim Biophys Acta 1820:849-58. 2012
    ..However, the mechanism of 14-3-3 involvement in the cell answer to salt or osmotic stresses is weakly understood...
  3. ncbi A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem
    K A Ketchum
    Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    Nature 376:690-5. 1995
    ..Here we describe a novel K+ channel (TOK1) from Saccharomyces cerevisiae that contains two P domains within one continuous polypeptide...
  4. ncbi Mechanisms of salt tolerance conferred by overexpression of the HAL1 gene in Saccharomyces cerevisiae
    G Rios
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia CSIC, Spain
    Yeast 13:515-28. 1997
    ..The effect of HAL1 on intracellular K+ was independent of the TRK1 and TOK1 genes, corresponding to a major K+ uptake system and to a K+ efflux system activated by depolarization, ..
  5. ncbi Potassium uptake through the TOK1 K+ channel in the budding yeast
    C Fairman
    Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Dr, Madison, WI 53706, USA
    J Membr Biol 168:149-57. 1999
    The current through TOK1 (YKC1), the outward-rectifying K+ channel in Saccharomyces cerevisiae, was amplified by expressing TOK1 from a plasmid driven by a strong constitutive promoter...
  6. ncbi Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis
    Omri Erez
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Biochem Biophys Res Commun 295:1142-9. 2002
    ..A model that integrates these results to explain the mechanism of ion transport across the plasma membrane is proposed...
  7. ncbi MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction
    Markus Proft
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 118:351-61. 2004
    ..which phosphorylates at least two proteins located at the plasma membrane, the Nha1 Na+/H+ antiporter and the Tok1 potassium channel...
  8. ncbi In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance
    A Roller
    Botanisches Institut I, Universitat Karlsruhe, Kaiserstrasse 12, 76128 Karlsruhe, Germany
    Pflugers Arch 451:362-70. 2005
    ..Similar but smaller changes are seen in the Asp426Asn mutant, implying that pore geometry in the functional channel has twofold, not fourfold, symmetry...
  9. pmc Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity
    Ingela Johansson
    Laboratory of Plant Physiology and Biophysics, IBLS Plant Sciences, Bower Building, University of Glasgow, Glasgow G12 8QQ, UK
    Biochem J 393:645-55. 2006
    Gating of the outward-rectifying K+ channel TOK1 of Saccharomyces cerevisiae is controlled by membrane voltage and extracellular K+ concentration...
  10. doi Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p
    Anja Roller
    Botanisches Institut I, Universitat Karlsruhe TH, Kaiserstrasse 12, 76128, Karlsruhe, Germany
    Pflugers Arch 456:883-96. 2008
    ..lt;twofold for the single mutants)...
  11. doi The role of K(+) and H(+) transport systems during glucose- and H(2)O(2)-induced cell death in Saccharomyces cerevisiae
    Frank A Hoeberichts
    Instituto de BiologĂ­a Molecular y Celular de Plantas IBMCP, Universidad Politecnica de Valencia CSIC, Spain
    Yeast 27:713-25. 2010
    ..A triple mutant ena1-4 tok1 nha1, devoid of K(+) efflux systems, is more tolerant to both glucose- and H(2)O(2)-induced cell death...

Patents1

  1. Saccharomyces cerevisiae yeast strain with stable integration and expression of the nucleic acid sequence for a heterologous potassium ion channel
    Patent Number: WO03031600-A1; Date:2003-04-17