TAH1

Summary

Gene Symbol: TAH1
Description: Tah1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery
    Séverine Boulon
    Institute of Molecular Genetics of Montpellier, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5535, Montpellier Cedex 5, France
    J Cell Biol 180:579-95. 2008
  2. pmc Chaperone ligand-discrimination by the TPR-domain protein Tah1
    Stefan H Millson
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Biochem J 413:261-8. 2008
  3. pmc The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity
    Kelvin Eckert
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 91198 Gif sur Yvette, France
    J Biol Chem 285:31304-12. 2010
  4. pmc Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90
    Beatriz Jimenez
    Structural Biochemistry Laboratory, Medicinal Chemistry Department, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    J Biol Chem 287:5698-709. 2012
  5. pmc The stability of the small nucleolar ribonucleoprotein (snoRNP) assembly protein Pih1 in Saccharomyces cerevisiae is modulated by its C terminus
    Alexandr Paci
    Department of Biological Sciences, University of Toronto, Toronto, Ontario M1C 1A4, Canada
    J Biol Chem 287:43205-14. 2012
  6. doi High-resolution structural analysis shows how Tah1 tethers Hsp90 to the R2TP complex
    Régis Back
    Ingénierie Moléculaire et Physiopathologie Articulaire IMoPA, UMR 7365 Université de Lorraine CNRS, Biopôle de l Université de Lorraine, Campus Biologie Santé, 9 Avenue de la Forêt de Haye, BP 184, 54505 Vandœuvre Lès Nancy, France
    Structure 21:1834-47. 2013
  7. pmc Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1
    Mohinder Pal
    MRC Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Structure 22:805-18. 2014
  8. doi (1)H, (15)N and (13)C resonance assignments of the yeast Pih1 and Tah1 C-terminal domains complex
    Xavier Manival
    Ingénierie Moléculaire et Physiopathologie Articulaire IMoPA, UMR 7365 CNRS, Université de Lorraine, Biopôle de l Université de Lorraine, Campus Biologie Santé, 9 Avenue de la Forêt de Haye, CS 50184, 54505, Vandœuvre lès Nancy, France
    Biomol NMR Assign 9:71-3. 2015
  9. doi Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones
    Jill L Johnson
    Department of Biological Sciences, University of Idaho, P O Box 443051, Moscow, ID, 83844 3051, USA
    Curr Genet 60:265-76. 2014
  10. pmc Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction
    Benjamin Rothé
    Ingénierie Moléculaire et Physiopathologie Articulaire IMoPA, UMR 7365 CNRS Université de Lorraine, Biopôle, Campus Biologie Santé, 9 Avenue de la Forêt de Haye, CS 50184, 54505 Vandœuvre Lès Nancy, France
    Nucleic Acids Res 42:10731-47. 2014

Scientific Experts

  • Jill L Johnson
  • David L Lancaster
  • Xavier Manival
  • Bruno Charpentier
  • Benjamin Rothé
  • Marc Quinternet
  • Régis Back
  • Christiane Branlant
  • Clémence Jacquemin
  • Mohinder Pal
  • Jean Michel Saliou
  • Philippe Meyer
  • Laurence H Pearl
  • Solange Morera
  • Chrisostomos Prodromou
  • Kelvin Eckert
  • Walid A Houry
  • Rhodri M L Morgan
  • S Mark Roe
  • Claude Bobo
  • Alexandr Paci
  • Alain Van Dorsselaer
  • Sarah Sanglier-Cianferani
  • Rongmin Zhao
  • Beatriz Jimenez
  • Kevin L Y Cheung
  • Séverine Boulon
  • Stefan H Millson
  • Muriel Barbier
  • Marie Eve Chagot
  • Sarah Cianférani
  • Sarah E L Phelps
  • Florence Schlotter
  • Jessica A Downs
  • Vlad Pena
  • Séverine Massenet
  • Sigrun Polier
  • Christine Loegler
  • Decebal Tiotiu
  • Sarah Parry-Morris
  • Marc Morgan
  • Cyril Dominguez
  • Chrystel Beaufils
  • Frédéric H T Allain
  • Antonio Pineda-Lucena
  • Leticia Ortí
  • M D Jacobson
  • Taras Makhnevych
  • Francisca Ugwu
  • Xiao Hu Liu
  • Abelyn Lim
  • Hao Huang
  • Armelle Vigouroux
  • Joaquin Ortega
  • Yoshito Kakihara
  • Sylvie Lazereg
  • Christophe Caillat
  • Magali Nicaise
  • Karine Madiona
  • Sophie Quevillon-Cheruel
  • Jennifer Huen
  • Laura Monlezun
  • Noureddine Atmane
  • Christina Pescia
  • Beata E Jady
  • Maruf M U Ali
  • Christine Allmang
  • Bérengère Pradet-Balade
  • Nathalie Marmier-Gourrier
  • Marie Cecile Robert
  • Tamas Kiss
  • Barbara Bardoni
  • Céline Verheggen
  • Chao Zhai
  • Peter W Piper
  • Edouard Bertrand
  • Barry Panaretou
  • Cara K Vaughan
  • Laurence Wurth
  • Alain Krol
  • F R Cross
  • L L Lu
  • E A Vallen
  • K S Knox
  • B E Williams
  • C X Muñoz

Detail Information

Publications15

  1. pmc The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery
    Séverine Boulon
    Institute of Molecular Genetics of Montpellier, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5535, Montpellier Cedex 5, France
    J Cell Biol 180:579-95. 2008
    ..the AAA + adenosine triphosphatases hRvb1 and hRvb2 and with the Hsp90 chaperone through two conserved adaptors, Tah1/hSpagh and Pih1...
  2. pmc Chaperone ligand-discrimination by the TPR-domain protein Tah1
    Stefan H Millson
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Biochem J 413:261-8. 2008
    b>Tah1 [TPR (tetratricopeptide repeat)-containing protein associated with Hsp (heat-shock protein) 90] has been identified as a TPR-domain protein...
  3. pmc The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity
    Kelvin Eckert
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 91198 Gif sur Yvette, France
    J Biol Chem 285:31304-12. 2010
    ..TPR (TetratricoPeptide Repeat)-containing protein associated with Hsp90 (Tah1) and protein interacting with Hsp90 (Pih1) have been identified in Saccharomyces cerevisiae as two Hsp90 ..
  4. pmc Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90
    Beatriz Jimenez
    Structural Biochemistry Laboratory, Medicinal Chemistry Department, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    J Biol Chem 287:5698-709. 2012
    b>Tah1 and Pih1 are novel Hsp90 interactors. Tah1 acts as a cofactor of Hsp90 to stabilize Pih1...
  5. pmc The stability of the small nucleolar ribonucleoprotein (snoRNP) assembly protein Pih1 in Saccharomyces cerevisiae is modulated by its C terminus
    Alexandr Paci
    Department of Biological Sciences, University of Toronto, Toronto, Ontario M1C 1A4, Canada
    J Biol Chem 287:43205-14. 2012
    ..complex that, in yeast Saccharomyces cerevisiae, also contains the helicases Rvb1, Rvb2, and the Hsp90 cofactor Tah1. Pih1 and the R2TP complex are required for the box C/D small nucleolar ribonucleoprotein (snoRNP) assembly and ..
  6. doi High-resolution structural analysis shows how Tah1 tethers Hsp90 to the R2TP complex
    Régis Back
    Ingénierie Moléculaire et Physiopathologie Articulaire IMoPA, UMR 7365 Université de Lorraine CNRS, Biopôle de l Université de Lorraine, Campus Biologie Santé, 9 Avenue de la Forêt de Haye, BP 184, 54505 Vandœuvre Lès Nancy, France
    Structure 21:1834-47. 2013
    ..This complex includes the proteins Tah1, Pih1, Rvb1, and Rvb2. Tah1 bridges Hsp90 to R2TP...
  7. pmc Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1
    Mohinder Pal
    MRC Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    Structure 22:805-18. 2014
    ..complexes depends on the TTT (Tel2-Tti1-Tti2), and R2TP complexes-consisting of the AAA-ATPases Rvb1 and Rvb2, Tah1 (Spagh/RPAP3 in metazoa), and Pih1 (Pih1D1 in humans)-that together provide the connection to Hsp90...
  8. doi (1)H, (15)N and (13)C resonance assignments of the yeast Pih1 and Tah1 C-terminal domains complex
    Xavier Manival
    Ingénierie Moléculaire et Physiopathologie Articulaire IMoPA, UMR 7365 CNRS, Université de Lorraine, Biopôle de l Université de Lorraine, Campus Biologie Santé, 9 Avenue de la Forêt de Haye, CS 50184, 54505, Vandœuvre lès Nancy, France
    Biomol NMR Assign 9:71-3. 2015
    We report the nearly complete (1)H, (15)N and (13)C resonance assignment of the complex formed by the C-terminal domains of Pih1 and Tah1 from S. cerevisiae and evidence the folding ability of Tah1 under complex formation.
  9. doi Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones
    Jill L Johnson
    Department of Biological Sciences, University of Idaho, P O Box 443051, Moscow, ID, 83844 3051, USA
    Curr Genet 60:265-76. 2014
    ..This provides new evidence that co-chaperones selectively compete for binding to subpopulations of cellular Hsp90 and suggest that changes in the relative levels of co-chaperones may have dramatic effects on Hsp90 function...
  10. pmc Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction
    Benjamin Rothé
    Ingénierie Moléculaire et Physiopathologie Articulaire IMoPA, UMR 7365 CNRS Université de Lorraine, Biopôle, Campus Biologie Santé, 9 Avenue de la Forêt de Haye, CS 50184, 54505 Vandœuvre Lès Nancy, France
    Nucleic Acids Res 42:10731-47. 2014
    ..Our biochemical data show that C/D snoRNAs and the core protein Nop58 can interact with the purified Snu13p-Rsa1p-Hit1p heterotrimer. ..
  11. pmc Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes
    Rhodri M L Morgan
    Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, England
    Acta Crystallogr D Biol Crystallogr 71:1197-206. 2015
    Specific co-chaperone adaptors facilitate the recruitment of client proteins to the Hsp90 system. Tah1 binds the C-terminal conserved MEEVD motif of Hsp90, thus linking an eclectic set of client proteins to the R2TP complex for their ..
  12. doi Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly
    Marc Quinternet
    FR 3209 CNRS Université de Lorraine, Bioingénierie Moléculaire, Cellulaire et Thérapeutique, Biopôle, Campus Biologie Santé, CS 50184, 54505 Vandœuvre lès Nancy Cedex, France
    J Mol Biol 427:2816-39. 2015
    ..Our data suggest that these two interactions are mutually exclusive. The implication of this finding for box C/D small nucleolar ribonucleoparticle assembly is discussed. ..
  13. pmc Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae
    David L Lancaster
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 288:1266-76. 2013
    ..Together, our results demonstrate a role for chaperones in regulating the prion variant complement of a cell...
  14. pmc Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase
    M D Jacobson
    The Rockefeller University, New York, New York 10021, USA
    Genetics 159:17-33. 2001
    ..Consistent with this hypothesis, sid2-1 rad9 cells are dead or very slow growing even when SIC1 is expressed...
  15. pmc Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags
    Kevin L Y Cheung
    Department of Biochemistry and Biomedical Sciences and M G DeGroote Institute for Infectious Diseases Research, Health Sciences Center, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Mol Biol 404:478-92. 2010
    ..These results demonstrate that some of the differences between the reported structures are caused by histidine tags and imply that further studies on the purified proteins should be carried out using untagged constructs...