SET1

Summary

Gene Symbol: SET1
Description: histone methyltransferase SET1
Alias: KMT2, YTX1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression
    Douglas P Mersman
    Department of Biochemistry and Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 287:2652-65. 2012
  2. pmc Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae
    Ian M Fingerman
    Department of Biochemistry and the Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:28761-5. 2005
  3. pmc Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9
    Robert Wysocki
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 25:8430-43. 2005
  4. ncbi Set1- and Clb5-deficiencies disclose the differential regulation of centromere and telomere dynamics in Saccharomyces cerevisiae meiosis
    Edgar Trelles-Sticken
    MPI for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    J Cell Sci 118:4985-94. 2005
  5. pmc The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae
    John E Mueller
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    Genetics 173:557-67. 2006
  6. ncbi Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation
    Pierre Marie Dehé
    Laboratoire d InstabilitéduGénome et Cancérogénèse, Institut de Biologie Structurale et Microbiologie, CNRS, Marseille 13402, France
    J Biol Chem 281:35404-12. 2006
  7. ncbi The multiple faces of Set1
    Pierre Marie Dehé
    Instabilité du Génome et Cancerogénèse IGC, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille, Cedex 20, France
    Biochem Cell Biol 84:536-48. 2006
  8. doi Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes
    Vérane Sommermeyer
    Institut Curie, Centre de Recherche, 75248 Paris, France
    Mol Cell 49:43-54. 2013
  9. doi The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination
    Laurent Acquaviva
    Marseille Cancer Research Center, U1068 Inserm, UMR7258 CNRS, Aix Marseille University, Institut Paoli Calmettes, Marseille 13009, France
    Science 339:215-8. 2013
  10. pmc Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human
    Yoh hei Takahashi
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 108:20526-31. 2011

Scientific Experts

  • Michael J Law
  • Yakun Wan
  • Helena Santos-Rosa
  • Kitty F Verzijlbergen
  • Vincent Geli
  • Ali Shilatifard
  • Yoh hei Takahashi
  • Jung Shin Lee
  • Pierre Marie Dehé
  • Luis M Soares
  • Stephen Buratowski
  • Nevan J Krogan
  • Erin M Green
  • Jung Ae Kim
  • Mary Bryk
  • Sharon Y R Dent
  • Selene K Swanson
  • Laurence Florens
  • Michael P Washburn
  • Julie Sollier
  • Adeline Vitaliano-Prunier
  • Bernhard Dichtl
  • C David Allis
  • John A Latham
  • Marina Pinskaya
  • John E Mueller
  • Saravanan Ramakrishnan
  • Andria Schibler
  • Wen Pin Su
  • Ian M Fingerman
  • Huck Hui Ng
  • Delphine Albrecht
  • Shanshan Li
  • Scott D Briggs
  • Elena Ezhkova
  • Janet L Thornton
  • Gloria Mas Martin
  • Brian D Strahl
  • Renée J Chosed
  • Jaehoon Kim
  • Kelly Williamson
  • Oliver J Rando
  • Laurent Acquaviva
  • Vérane Sommermeyer
  • Mahesh B Chandrasekharan
  • Gerwin H Westfield
  • Georgios Skiniotis
  • Douglas P Mersman
  • Zhuo Ma
  • Assaf Weiner
  • Thanasis Margaritis
  • Xiaobing Shi
  • Jessica Schneider
  • Amy Leung
  • Nihal Terzi
  • Shan Shan Wang
  • Bradley R Cairns
  • Suting Zheng
  • Raymond C Trievel
  • David Faucher
  • Catherine Dargemont
  • Anna Shevchenko
  • Elinor R Foster
  • Andre Halbach
  • Shima Nakanishi
  • William W Hwang
  • Or Gozani
  • Daniel S Ginsburg
  • Antonin Morillon
  • Alain Nicolas
  • Julia Berretta
  • William P Tansey
  • Kristin Ingvarsdottir
  • Klaas W Mulder
  • Mary A Braun
  • Lionel Trésaugues
  • Mercè Pamblanco
  • Ja Hwan Seol
  • David G E Martin
  • Sebastián Chávez
  • Myriam Ruault
  • Vicente Tordera
  • Debabrata Biswas
  • Alfonso Rodriguez-Gil
  • V Schramke
  • Edgar Trelles-Sticken
  • Lian Zhang
  • Ke Zhang
  • Alisha Schlichter
  • Nobuyuki Morohashi

Detail Information

Publications75

  1. pmc Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression
    Douglas P Mersman
    Department of Biochemistry and Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 287:2652-65. 2012
    ..The yeast H3K4 methyltransferase complex, Set1 complex or complex of proteins associated with Set1 (COMPASS), consists of Set1 and conserved Set1-associated ..
  2. pmc Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae
    Ian M Fingerman
    Department of Biochemistry and the Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:28761-5. 2005
    ..In Saccharomyces cerevisiae, Set1 has been identified as the sole histone methyltransferase required for histone H3 lysine 4 (Lys(4)) methylation...
  3. pmc Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9
    Robert Wysocki
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 25:8430-43. 2005
    ..These results indicate a key role for chromatin and methylation of histone H3 Lys 79 in yeast DNA damage signaling...
  4. ncbi Set1- and Clb5-deficiencies disclose the differential regulation of centromere and telomere dynamics in Saccharomyces cerevisiae meiosis
    Edgar Trelles-Sticken
    MPI for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    J Cell Sci 118:4985-94. 2005
    ..Absence of the B-type cyclin Clb5 or the Set1 histone methyltransferase leads to a delay of premeiotic S phase by separate mechanisms...
  5. pmc The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae
    John E Mueller
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    Genetics 173:557-67. 2006
    The Set1-containing complex, COMPASS, methylates histone H3 on lysine 4 (K4) in Saccharomyces cerevisiae...
  6. ncbi Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation
    Pierre Marie Dehé
    Laboratoire d InstabilitéduGénome et Cancérogénèse, Institut de Biologie Structurale et Microbiologie, CNRS, Marseille 13402, France
    J Biol Chem 281:35404-12. 2006
    b>Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates histone 3 lysine 4 (H3K4)...
  7. ncbi The multiple faces of Set1
    Pierre Marie Dehé
    Instabilité du Génome et Cancerogénèse IGC, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille, Cedex 20, France
    Biochem Cell Biol 84:536-48. 2006
    In Saccharomyces cerevisiae, H3 methylation at lysine 4 (H3K4) is mediated by Set1. Set1 is a large protein bearing a conserved RNA recognition motif in addition to its catalytic C-terminal SET domain...
  8. doi Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes
    Vérane Sommermeyer
    Institut Curie, Centre de Recherche, 75248 Paris, France
    Mol Cell 49:43-54. 2013
    ..Here we show that Spp1, a conserved member of the histone H3K4 methyltransferase Set1 complex, is required for normal levels of DSB formation and is associated with chromosome axes during meiosis, ..
  9. doi The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination
    Laurent Acquaviva
    Marseille Cancer Research Center, U1068 Inserm, UMR7258 CNRS, Aix Marseille University, Institut Paoli Calmettes, Marseille 13009, France
    Science 339:215-8. 2013
    ..Thus, by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis, allowing Spo11 cleavage at nearby nucleosome-depleted regions...
  10. pmc Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human
    Yoh hei Takahashi
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 108:20526-31. 2011
    ..H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively...
  11. pmc SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes
    C Nislow
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
    Mol Biol Cell 8:2421-36. 1997
    ..Here we present analysis of SET1, a yeast member of the trithorax gene family that was identified by sequence inspection to encode a 1080-amino acid ..
  12. pmc H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway
    Nihal Terzi
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 31:3569-83. 2011
    ..Both Nrd1 and the Set1 histone H3K4 methyltransferase complex interact with RNA polymerase II (Pol II) during early elongation, leading us ..
  13. pmc Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter
    Shan Shan Wang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cell Biol 31:3171-81. 2011
    ..We found that derepression of the PHO5 promoter by SET1 deletion resulted in a labile chromatin structure, allowing more binding of RNA polymerase II (Pol II) but not the ..
  14. ncbi Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS
    Jung Shin Lee
    Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, MO 64110, USA
    Cell 131:1084-96. 2007
    ..the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4 (H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including Cps35, the only essential subunit...
  15. pmc A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae
    Julia Berretta
    Centre de Genetique Moleculaire Centre National de la Recherche Scientifique CGM CNRS, 91198 Gif Yvette, France
    Genes Dev 22:615-26. 2008
    ..Furthermore, the Ty1 silencing is partially mediated by histone deacetylation and requires Set1-dependent histone methylation, pointing out an analogy with heterochromatin gene silencing...
  16. doi Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation
    Adeline Vitaliano-Prunier
    Institut Jacques Monod, Universite Paris VII, Universite Paris VI, CNRS, 2 place Jussieu, Tour 43, 75251 Paris Cedex 05, France
    Nat Cell Biol 10:1365-71. 2008
    ..transcriptional activation and is required for di- and trimethylation at Lys 4 on the histone H3 tail (H3K4) by the SET1/COMPASS methyltransferase complex through a poorly characterized trans-tail pathway...
  17. pmc Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation
    Elinor R Foster
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, England, UK
    J Cell Biol 184:631-8. 2009
    ..Finally, we show that strains lacking the ubiquitin ligase Bre1 are defective for H3 methylation, suggesting that there is an additional Bre1 substrate that in combination with H2B K123 facilitates H3 methylation...
  18. pmc Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1
    Yoh hei Takahashi
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Mol Cell Biol 29:3478-86. 2009
    The multiprotein complex Set1/COMPASS is the founding member of the histone H3 lysine 4 (H3K4) methyltransferases, whose human homologs include the MLL and hSet1 complexes...
  19. pmc H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activation
    Marina Pinskaya
    Centre de Genetique Moleculaire CNRS, Universite Pierre et Marie Curie, Gif sur Yvette, France
    EMBO J 28:1697-707. 2009
    b>Set1-dependent H3K4 di- and tri-methylation (H3K4me2/3) have been associated with active transcription. Recent data indicate that the H3K4me2/3 also plays a poorly characterized RNA-dependent repressive role...
  20. pmc Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains
    Alisha Schlichter
    Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112 0555, USA
    EMBO J 24:1222-31. 2005
    Trimethylation of lysine 4 of histone H3 occurs at the 5' end of active genes and is catalyzed by Set1 in Saccharomyces cerevisiae...
  21. pmc The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes
    V Schramke
    Laboratoire d Ingenierie des Systemes Macromoleculaires, Institut de Biologie Structurale et Microbiologie IBSM, Centre National de la Recherche Scientifique CNRS, 13402, Marseille, Cedex 20, France
    Genes Dev 15:1845-58. 2001
    ..We show that deletion of SET1 induces a response relayed by the signaling kinase Rad53p that leads to the MEC1/TEL1-independent ..
  22. pmc COMPASS: a complex of proteins associated with a trithorax-related SET domain protein
    T Miller
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 98:12902-7. 2001
    ..the subunits of a protein complex in the yeast Saccharomyces cerevisiae that includes the trithorax-related protein Set1. This protein complex, which we have named COMPASS (Complex Proteins Associated with Set1), consists of seven ..
  23. pmc The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4
    A Roguev
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 20:7137-48. 2001
    ..The SET domains of the Saccharomyces cerevisiae Set1 and Drosophila trithorax proteins are closely related to each other but distinct from SUV39 and G9a...
  24. pmc A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
    Peter L Nagy
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:90-4. 2002
    ..We report here the purification, molecular identification, and genetic and biochemical characterization of the Set1 protein complex that is necessary for methylation of histone H3 at lysine residue 4 in Saccharomyces cerevisiae...
  25. ncbi COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression
    Nevan J Krogan
    Department of Biochemistry, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 277:10753-5. 2002
    ..the isolation and characterization of COMPASS, a multiprotein complex that includes the Trx-related protein Set1 of the yeast Saccharomyces cerevisiae...
  26. ncbi Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism
    Mary Bryk
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 12:165-70. 2002
    ..In a screen for rDNA silencing mutants, we identified a mutation in SET1, previously shown to regulate silencing at telomeres and HML...
  27. ncbi Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity
    Huck Hui Ng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 11:709-19. 2003
    b>Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation machinery to a highly localized domain at the 5' portion of active mRNA coding regions...
  28. ncbi The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation
    Nevan J Krogan
    Banting and Best Department of Medical Research, Department of Molecular and Medical Genetics, University of Toronto, Toronto, M5G 1L6, Ontario, Canada
    Mol Cell 11:721-9. 2003
    ..Methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively, is required for silencing of expression of genes located near ..
  29. ncbi Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression
    Simon Boa
    Room 427A, Molecular Biology Building, Department of Molecular and Cellular Biology, University of Cape Town, University Private Bag, Rondebosch 7700, South Africa
    Yeast 20:827-35. 2003
    ..cerevisiae. Hierarchical clustering analysis of the set1(-) expression profile revealed a correspondence to that of a mad2(-) strain, suggesting that the transcriptional ..
  30. pmc Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression
    Julie Sollier
    LISM, CNRS, Marseille Cedex, France
    EMBO J 23:1957-67. 2004
    The Set1 protein of Saccharomyces cerevisiae is a histone methyltransferase (HMTase) acting on lysine 4 of histone H3. Inactivation of the SET1 gene in a diploid leads to a sporulation defect...
  31. ncbi Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin
    Helena Santos-Rosa
    Wellcome Trust Cancer Research United Kingdom Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
    J Biol Chem 279:47506-12. 2004
    ..The inability of Sir3p to bind methylated H3 Lys-4 tails suggests a model whereby H3 Lys-4 methylation prevents Sir3p association at euchromatic sites and therefore concentrates Sir3p at unmodified, heterochromatic regions of the genome...
  32. pmc The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation
    Ke Zhang
    Program in Genes and Development, Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Cell 122:723-34. 2005
    ..We report here that this balance is modulated by the Set1 methyltransferase. Deletion of SET1 suppresses chromosome loss in ipl1-2 cells...
  33. ncbi Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions
    Y Corda
    Laboratoire d Ingénierie et de Dynamique des Systèmes Macromoléculaires, CNRS, Marseille, France
    Nat Genet 21:204-8. 1999
    ..We show here that the SET domain of Set1p interacts with Mec3p. Deletion of SET1 increases the viability of mec3delta mutants after DNA damage (in a process that is mostly independent of Rad53p ..
  34. pmc Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation
    Janet L Thornton
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genes Dev 28:115-20. 2014
    ..Cps35/Swd2 within COMPASS (complex of proteins associated with Set1) is considered to bridge these different processes...
  35. pmc Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2
    Andria Schibler
    Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA The Graduate School of Biomedical Sciences GSBS at Houston, Houston, Texas 77030, USA Center for Cancer Epigenetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 30:1187-97. 2016
    ..In Saccharomyces cerevisiae, Set1 is the sole lysine methyltransferase required for mono-, di-, and trimethylation of this site...
  36. pmc Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons
    Gloria Mas Martin
    Department of Biology Stanford University Stanford, CA USA
    Epigenetics 9:513-22. 2014
    ..We previously determined that the budding yeast histone H4 methyltransferase Set5 functions together with Set1, the H3K4 methyltransferase, in specific cellular contexts...
  37. pmc Combined Interactions of Plant Homeodomain and Chromodomain Regulate NuA4 Activity at DNA Double-Strand Breaks
    Wen Pin Su
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Genetics 202:77-92. 2016
    ..Cells harboring the H3K4R, H3K4R, K36R, or set1Δ set2Δ mutant that disrupts H3K4 and H3K36 methylation also show very similar phenotypes to the PHD and ..
  38. pmc Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription
    Saravanan Ramakrishnan
    Department of Radiation Oncology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Nat Commun 7:11949. 2016
    ..We investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in S. cerevisiae...
  39. pmc Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns
    Luis M Soares
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell Rep 6:961-72. 2014
    Methylation of histone H3 lysine 4 by the Set1 subunit of COMPASS correlates with active transcription. Here, we show that Set1 levels are regulated by protein degradation in response to multiple signals...
  40. doi Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism
    Shanshan Li
    Stowers Institute for Medical Research, 1000 E 50 th Street, Kansas City, MO 64110, USA
    Mol Cell 60:408-21. 2015
    ..SESAME interacts with the Set1 H3K4 methyltransferase complex, which requires SAM synthesized from SESAME, and recruits SESAME to target genes, ..
  41. pmc Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II
    Michael J Law
    Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Stratford, New Jersey 08084
    Genetics 199:435-53. 2015
    ..These studies implicate the CDK8 subcomplex in fine-tuning H3 Lys4 methylation levels during pseudohyphal differentiation. ..
  42. pmc Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans
    Delphine Albrecht
    Universite de Bordeaux, IBGC UMR 5095, F 33077 Bordeaux, France
    Genetics 204:1447-1460. 2016
    ..Here, we found that loss of several histone-modifying enzymes, including Bre1 (histone H2B ubiquitination) and Set1 (histone H3 lysine 4 methylation), greatly enhanced AICAR inhibition on growth via the combined effects of both the ..
  43. pmc Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex
    Klaas W Mulder
    Department of Physiological Chemistry, University Medical Centre Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
    Nucleic Acids Res 35:2428-39. 2007
    ..These results suggest a mechanism in which the Ccr4-Not complex functions parallel to or downstream of the Bur1/2 kinase to facilitate H3K4me3 via PAF complex recruitment...
  44. pmc The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation
    Jaehoon Kim
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 49:1121-33. 2013
    ..Here, we took advantage of an in vitro histone methyltransferase assay employing a reconstituted yeast Set1 complex (ySet1C) and a recombinant chromatin template containing fully ubiquitylated H2B to gain valuable insights...
  45. pmc Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription
    Thanasis Margaritis
    Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS Genet 8:e1002952. 2012
    ..of H3K4 methylation in Saccharomyces cerevisiae by determining genome-wide expression-profiles of mutants in the Set1 complex, COMPASS, that lays down these marks...
  46. pmc Systematic dissection of roles for chromatin regulators in a yeast stress response
    Assaf Weiner
    School of Computer Science and Engineering, The Hebrew University, Jerusalem, Israel
    PLoS Biol 10:e1001369. 2012
    ..We followed up on one pathway, finding that Set1-dependent H3K4 methylation primarily acts as a gene repressor during multiple stresses, specifically at genes ..
  47. pmc Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle
    Zhuo Ma
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Mol Cell Biol 32:3594-607. 2012
    ..Thus, Ess1 has direct effects on RNA polymerase transcription by controlling cofactor binding via conformationally induced changes in the CTD and indirect effects by influencing chromatin modification...
  48. pmc Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast
    Jung Ae Kim
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:5779-84. 2012
    ..Altogether, these data suggest that the N-tails of core histones share previously unrecognized, potentially redundant functions that, in some cases are different from those of the widely accepted H2A/H2B and H3/H4 dimer pairs...
  49. pmc Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor
    Luis M Soares
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 287:15219-31. 2012
    The Set1 complex (also known as complex associated with Set1 or COMPASS) methylates histone H3 on lysine 4, with different levels of methylation affecting transcription by recruiting various factors to distinct regions of active genes...
  50. pmc Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
    Erin M Green
    Department of Biology, Stanford University, Stanford, California, USA
    Nat Struct Mol Biol 19:361-3. 2012
    ..Set5's enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses...
  51. pmc Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1
    Kelly Williamson
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 8:e57974. 2013
    In S. cerevisiae, the lysine methyltransferase Set1 is a member of the multiprotein complex COMPASS...
  52. doi The functional role of SUMO E3 ligase Mms21p in the maintenance of subtelomeric silencing in budding yeast
    Yakun Wan
    The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, China
    Biochem Biophys Res Commun 438:746-52. 2013
    ..Taken together, our findings suggest an important role of Mms21p; it contributes to subtelomeric silencing during the formation of a heterochromatin boundary. ..
  53. pmc Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated
    Myriam Ruault
    Division of Biological Sciences, UCSD Moores Cancer Center, University of California, San Diego, California 92093 0347, USA
    Genetics 174:1135-49. 2006
    ..A catalytically dead Hsl7p retained wild-type interactions, implying that modification of histone H3 or H4 N termini by Gcn5p, Esa1p, Rpd3p, and Set1p, but not by Hsl7p, was needed to bypass the morphogenesis checkpoint...
  54. ncbi Association of SET domain and myotubularin-related proteins modulates growth control
    X Cui
    Department of Pathology, Stanford University Medical Center, California 94305, USA
    Nat Genet 18:331-7. 1998
    ..We conclude that myotubularin-type phosphatases link SET-domain containing components of the epigenetic regulatory machinery with signalling pathways involved in growth and differentiation...
  55. pmc The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3
    David G E Martin
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Mol Cell Biol 26:7871-9. 2006
    ..These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation...
  56. ncbi Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation
    Lionel Trésaugues
    Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, UMR8619 CNRS, Universite de Paris Sud, Orsay, France
    J Mol Biol 359:1170-81. 2006
    The yeast Set1 histone H3 lysine 4 (H3K4) methyltransferase contains, in addition to its catalytic SET domain, a conserved RNA recognition motif (RRM1)...
  57. pmc Altered nucleosome occupancy and histone H3K4 methylation in response to 'transcriptional stress'
    Lian Zhang
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, UCHSC at Fitzsimons, Aurora, CO 80045, USA
    EMBO J 24:2379-90. 2005
    ..H3K4Me3 at 3' positions was dynamic and could be rapidly removed when transcription recovered. Set1 and Chd1 are required for H3K4 trimethylation at 3' positions when transcription is inhibited by 6-AU...
  58. pmc The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiae
    Vardit Dror
    Department of Genetics, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 24:8227-35. 2004
    ..This repression appears to be independent of both Sir2 and Set1, two factors known to be required for rDNA silencing...
  59. ncbi Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3
    Elena Ezhkova
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724 USA
    Mol Cell 13:435-42. 2004
    ..These data reveal that proteasome subunits function in epigenetic gene regulation by linking chromatin modifications that establish the histone code...
  60. ncbi The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B
    Huck Hui Ng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:33625-8. 2003
    ..cells, the Rtf1 and Paf1 components of the Paf1 transcriptional elongation complex are important for recruitment of Set1, the histone H3-lysine 4 (H3-Lys4) methylase, to a highly localized domain at the 5' portion of active mRNA coding ..
  61. ncbi Deciphering protein complexes and protein interaction networks by tandem affinity purification and mass spectrometry: analytical perspective
    Anna Shevchenko
    Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Mol Cell Proteomics 1:204-12. 2002
    ..Concordance with the results of genome-wide two-hybrid screening was poor (14% of identified interactors overlapped) suggesting that the two approaches may provide complementary views on physical interactions within the proteome...
  62. pmc Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae
    Kitty F Verzijlbergen
    Fred van Leeuwen, Division of Gene Regulation B4, Netherlands Cancer Institute, The Netherlands
    BMC Mol Biol 10:76. 2009
    ....
  63. ncbi Different roles of histone H3 lysine 4 methylation in chromatin maintenance
    Ja Hwan Seol
    College of Pharmacy Sungkyunkwan University, 300 Cheoncheon dong, Jangan gu, Suwon, Gyeonggi do 440 746, South Korea
    Biochem Biophys Res Commun 349:463-70. 2006
    ..In Saccharomyces cerevisiae, deletion of a histone H3 methyltransferase SET1 leads to the induction of a subset of stress responsive genes in a Rad53 dependent manner...
  64. pmc Opposing roles for Set2 and yFACT in regulating TBP binding at promoters
    Debabrata Biswas
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, 84112, USA
    EMBO J 25:4479-89. 2006
    ..Set2 methylates K36 of histone H3, and K36 substitutions also suppress yFACT mutations. In contrast, set1 enhances yFACT mutations. Methylation at H3 K4 by Set1 is required for set2 to suppress yFACT defects...
  65. ncbi Effect of histone methyltransferase gene mutations on sporulation in S. cerevisiae
    Nobuyuki Morohashi
    Department of Chemistry, Meisei University, 2 1 1 Hodokubo, Hino, 191 8506, Japan
    Nucleic Acids Symp Ser (Oxf) . 2005
    ..Because set1delta and set2delta affect this process additively, we suggest that Set1p and Set2p have overlapping functions in this developmental process...
  66. pmc Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae
    Mary A Braun
    Department of Biological Sciences, University of Pittsburgh, 269 Crawford Hall, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA
    Mol Cell Biol 27:2800-11. 2007
    ..Taken together, our results identify a new participant in a protein ubiquitylation pathway within the nucleus that acts to modulate chromatin function and transcription...
  67. pmc Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination
    John A Latham
    Program in Genes and Development, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    Cell 146:709-19. 2011
    Histone H3K4 trimethylation by the Set1/MLL family of proteins provides a hallmark for transcriptional activity from yeast to humans. In S...
  68. pmc Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
    Amy Leung
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Biol Cell 22:2741-53. 2011
    ..Our data reveal that H2B ubiquitylation/H3K4 methylation play an important role in limiting ectopic association of silencing proteins with euchromatic genes important for cell wall integrity and the response to heat...
  69. pmc Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae
    Kristin Ingvarsdottir
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:7856-64. 2007
    ..Thus, analysis of lysine demethylation in yeast provides new insight into the physiological roles of jumonji demethylase enzymes...
  70. pmc Methylated H3K4, a transcription-associated histone modification, is involved in the DNA damage response pathway
    David Faucher
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS Genet 6:. 2010
    ..Given the high degree of conservation for the methyltransferase and the histone mark in a broad variety of organisms, these results could have similar implications for genome stability mechanisms in vertebrate and mammalian cells...
  71. pmc Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A
    Suting Zheng
    Department of Biochemistry and Molecular Biology, Center for Eukaryotic Gene Regulation, Penn State University, University Park, Pennsylvania 16802, USA
    Mol Cell Biol 30:3635-45. 2010
    ..Interestingly, the HAR is partially occluded by nucleosomal DNA, suggesting that the function of the H2A cross talk pathway is to restrict histone modifications to nucleosomes altered by transcription...
  72. pmc NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5
    Daniel S Ginsburg
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Mol Cell Biol 29:6473-87. 2009
    ..Whereas histone methylation by Set1 and Set2 is dispensable for NuA4's interaction with Pol II and targeting to some coding regions, it stimulates NuA4-..
  73. pmc Cotranslational assembly of the yeast SET1C histone methyltransferase complex
    Andre Halbach
    Institute of Molecular Biology, University of Zurich, Zurich, Switzerland
    EMBO J 28:2959-70. 2009
    While probing the role of RNA for the function of SET1C/COMPASS histone methyltransferase, we identified SET1RC (SET1 mRNA-associated complex), a complex that contains SET1 mRNA and Set1, Swd1, Spp1 and Shg1, four of the eight ..
  74. pmc Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1
    Shima Nakanishi
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    J Cell Biol 186:371-7. 2009
    ..Therefore, we generated the entire histone H2A and H2B alanine-scanning mutant strains in another background, which does not express wild-type histones...
  75. pmc Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin
    William W Hwang
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000588. 2009
    ..The nonredundant role for these modifications in this context contrasts with the notion of a highly combinatorial code by which histone marks act to control biological processes...