RPL17A

Summary

Gene Symbol: RPL17A
Description: ribosomal 60S subunit protein L17A
Alias: RPL17
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome
    Markus Pech
    Department of Biochemistry, Ludwig Maximilians Universitat Munchen, Gene Center Munich, Feodor Lynen Strasse 25, 81377 Munich, Germany
    J Biol Chem 285:19679-87. 2010
  2. pmc The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site
    Benjamin Pillet
    Unit of Biochemistry, Department of Biology, University of Fribourg, Fribourg, Switzerland
    PLoS Genet 11:e1005565. 2015
  3. doi Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation
    Basil Johannes Greber
    Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 164:91-102. 2016
  4. pmc Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae
    Ying Zhang
    From the Institute of Biochemistry and Molecular Biology, ZBMZ Centre for Biochemistry and Molecular Cell Research, University of Freiburg, Stefan Meier Strasse 17, D 79104 Freiburg, Germany and
    J Biol Chem 288:33697-707. 2013
  5. pmc Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae
    Kaori Shimoji
    Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Kagamiyama, Higashi Hiroshima 739 8528, Japan
    Nucleic Acids Res 40:4574-88. 2012
  6. pmc Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
    C Saveanu
    Genetique des Interactions Macromoleculaires, Institut Pasteur CNRS URA2171, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 20:6475-84. 2001
  7. pmc The mitotic spindle is required for loading of the DASH complex onto the kinetochore
    Yumei Li
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 16:183-97. 2002
  8. ncbi Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae
    Michael W Van Dyke
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:24323-33. 2004
  9. pmc TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients
    Yoshimi Honma
    Faculty of Science, Shizuoka University, Shizuoka, Japan
    EMBO J 25:3832-42. 2006
  10. pmc Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
    Kristan K Steffen
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 133:292-302. 2008

Scientific Experts

  • Basil Johannes Greber
  • Benjamin Pillet
  • Ying Zhang
  • Kaori Shimoji
  • Marta del Alamo
  • Markus Pech
  • Kristan K Steffen
  • Yoshimi Honma
  • Michael W Van Dyke
  • Stefan Gerhardy
  • Vikram Govind Panse
  • Alexander Leitner
  • Michèle Salem
  • Daniel Boehringer
  • Nenad Ban
  • Ruedi Aebersold
  • Nicolas Leulliot
  • Marc Leibundgut
  • Patrick Pausch
  • Gert Bange
  • Juan J García-Gómez
  • Jesus de la Cruz
  • Dieter Kressler
  • Laurent Falquet
  • Yumei Li
  • Tina Wölfle
  • Sabine Rospert
  • John L Woolford
  • Kanako Tsuchihashi
  • Jason Talkish
  • Jelena Jakovljevic
  • Yuka Umeki
  • Keiko Mizuta
  • Kun Wan
  • C Saveanu
  • Suzuka Kawasaki
  • Judith Frydman
  • Daniel J Hogan
  • Patrick O Brown
  • Sebastian Pechmann
  • Véronique Albanèse
  • Thomas Spreter
  • Roland Beckmann
  • Birgitta Beatrix
  • Elijah D Johnston
  • Emily O Kerr
  • Vivian L MacKay
  • Brian K Kennedy
  • Stanley Fields
  • Di Hu
  • Nick Dang
  • Mitsuhiro Tsuchiya
  • Lindsay A Fox
  • Jonathan A Oakes
  • Bie N Tchao
  • Matt Kaeberlein
  • Diana N Pak
  • Takashi Ushimaru
  • Yasushi Maki
  • Michael N Hall
  • Ed Hurt
  • Kanako Ozaki
  • Kazuyoshi Yonezawa
  • Masaru Ueno
  • Hironori Maruyama
  • Aiko Kitamura
  • Paul Jeno
  • Masahiro Uritani
  • Thierry Mini
  • Ryo Shioda
  • Yoko Oda
  • Dakshesh V Mehta
  • Laura D Nelson
  • Rodney G Weilbaecher
  • Stephen J Elledge
  • Jun Qin
  • Annette A Alcasabas
  • Yanchang Wang
  • Jeff Bachant
  • D Bienvenu
  • N Gas
  • M Fromont-Racine
  • A Namane
  • A Jacquier
  • P E Gleizes
  • E Otaka
  • K Higo
  • T Itoh

Detail Information

Publications12

  1. pmc Dual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome
    Markus Pech
    Department of Biochemistry, Ludwig Maximilians Universitat Munchen, Gene Center Munich, Feodor Lynen Strasse 25, 81377 Munich, Germany
    J Biol Chem 285:19679-87. 2010
    ..In contrast, alphaNAC (Egd2p) contacts Rpl17, the direct neighbor of Rpl31 at the ribosomal tunnel exit site...
  2. pmc The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site
    Benjamin Pillet
    Unit of Biochemistry, Department of Biology, University of Fribourg, Fribourg, Switzerland
    PLoS Genet 11:e1005565. 2015
    ..Taken together, our findings indicate that the dedicated chaperone Acl4 accompanies Rpl4 from the cytoplasm to its pre-60S assembly site in the nucleus. ..
  3. doi Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation
    Basil Johannes Greber
    Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 164:91-102. 2016
    ..We provide genetic and biochemical evidence that failure to insert the C terminus of Rei1 precludes subsequent steps of 60S maturation. ..
  4. pmc Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae
    Ying Zhang
    From the Institute of Biochemistry and Molecular Biology, ZBMZ Centre for Biochemistry and Molecular Cell Research, University of Freiburg, Stefan Meier Strasse 17, D 79104 Freiburg, Germany and
    J Biol Chem 288:33697-707. 2013
    ..Three ribosomal proteins, termed Rpl4, Rpl17, and Rpl39 expose domains to the interior of the exit tunnel of eukaryotic ribosomes...
  5. pmc Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae
    Kaori Shimoji
    Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Kagamiyama, Higashi Hiroshima 739 8528, Japan
    Nucleic Acids Res 40:4574-88. 2012
    ....
  6. pmc Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
    C Saveanu
    Genetique des Interactions Macromoleculaires, Institut Pasteur CNRS URA2171, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 20:6475-84. 2001
    ..These results suggest that transient, possibly GTP-dependent association of Nog2p with the pre-ribosomes might trigger late rRNA maturation steps in ribosomal large subunit biogenesis...
  7. pmc The mitotic spindle is required for loading of the DASH complex onto the kinetochore
    Yumei Li
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 16:183-97. 2002
    ..We propose that DASH is a microtubule-binding complex that is transferred to the kinetochore prior to mitosis, thereby defining a new step in kinetochore maturation...
  8. ncbi Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae
    Michael W Van Dyke
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:24323-33. 2004
    ..We discuss the implications of our findings in relation to prior genetic, genomic, and proteomic studies that have identified STM1 and/or Stm1p as well as the possible biological role of Stm1p...
  9. pmc TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients
    Yoshimi Honma
    Faculty of Science, Shizuoka University, Shizuoka, Japan
    EMBO J 25:3832-42. 2006
    ..Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes...
  10. pmc Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
    Kristan K Steffen
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 133:292-302. 2008
    ..Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and Gcn4 activation extend yeast life span by similar mechanisms...
  11. ncbi Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes
    E Otaka
    Department of Biochemistry and Biophysics, Research Institute for Nuclear Medicine and Biology, Hiroshima University, 2 3, Kasumi 1 Chome, Minamiku, Hiroshima, 734 Japan
    Mol Gen Genet 195:544-6. 1984
    ..Comparison of the amino-terminal sequences with all other ribosomal protein sequences so far available indicates that YS9 shows sequence homology to rat liver ribosomal protein S8 (Wittmann-Liebold et al. 1979)...
  12. pmc Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes
    Marta del Alamo
    Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America
    PLoS Biol 9:e1001100. 2011
    ..The strategy we used should be generally applicable to mapping the specificity, interplay, and dynamics of the cotranslational protein homeostasis network...