REI1

Summary

Gene Symbol: REI1
Description: Rei1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae
    Nai Jung Hung
    Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, 1 University Station, A5000, The University of Texas at Austin, Austin, Texas 78712 0162, USA
    Mol Cell Biol 26:3718-27. 2006
  2. pmc A functional network involved in the recycling of nucleocytoplasmic pre-60S factors
    Alice Lebreton
    Genetique des Interactions Macromoleculaires, Centre National de la Recherche Scientifique URA2171, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 173:349-60. 2006
  3. pmc Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1
    Brigitte Pertschy
    Institut für Molekulare Biowissenschaften Karl Franzens Universität Graz, Universitatsplatz 2, A 8010, Graz, Austria
    Mol Cell Biol 27:6581-92. 2007
  4. pmc The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae
    Emilie Demoinet
    Défenses Antivirales et Antitumorales, CNRS UMR5235, Universite Montpellier II, France
    RNA 13:1570-81. 2007
  5. pmc The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1
    Alison E Meyer
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 285:961-8. 2010
  6. pmc Defining the pathway of cytoplasmic maturation of the 60S ribosomal subunit
    Kai Yin Lo
    Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA
    Mol Cell 39:196-208. 2010
  7. doi Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1
    Chengying Ma
    Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China
    Nat Struct Mol Biol . 2017
  8. doi Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation
    Basil Johannes Greber
    Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 164:91-102. 2016
  9. pmc The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1
    Mathias Loibl
    From the Institut für Molekulare Biowissenschaften, Karl Franzens Universitat Graz, A 8010 Graz, Austria and
    J Biol Chem 289:3913-22. 2014
  10. pmc Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export
    Yoshitaka Matsuo
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 328, Heidelberg D 69120, Germany
    Nature 505:112-6. 2014

Scientific Experts

  • K Mark Parnell
  • Lisa Kappel
  • Brigitte Pertschy
  • Mathias Loibl
  • Helmut Bergler
  • Gertrude Zisser
  • Chengying Ma
  • Basil Johannes Greber
  • Micheline Fromont-Racine
  • Alain Jacquier
  • Alice Lebreton
  • Nenad Ban
  • Daniel Boehringer
  • Yoshitaka Matsuo
  • Amy J Curwin
  • Isabella Klein
  • Basil J Greber
  • Alison E Meyer
  • Juliane Merl
  • Véronique Albanèse
  • Kai Yin Lo
  • Arlen W Johnson
  • Xiaowen Wang
  • Emilie Demoinet
  • Cosmin Saveanu
  • Nai Jung Hung
  • Bin Hu
  • Masayuki Iwase
  • Yan Chen
  • John L Woolford
  • Ning Gao
  • Ningning Li
  • Jianlin Lei
  • Shan Wu
  • Zhifei Li
  • Kaige Yan
  • Lvqin Zheng
  • Marc Leibundgut
  • Alexander Leitner
  • Stefan Gerhardy
  • Ruedi Aebersold
  • Nicolas Leulliot
  • Vikram Govind Panse
  • Michèle Salem
  • Rizos Georgios Manikas
  • Claudia Schmidt
  • David Tollervey
  • Sander Granneman
  • Michael Prattes
  • Elmar Krieger
  • Matthias Thoms
  • Anna Gungl
  • Ed Hurt
  • Marissa A LeBlanc
  • Christopher R McMaster
  • Gregory D Fairn
  • Gernot Fruhmann
  • Christian Montellese
  • Gerald Rechberger
  • Christof Gruber
  • Stefan Unterweger
  • Steffen Jakob
  • Herbert Tschochner
  • Elizabeth A Craig
  • Philipp Milkereit
  • Katrin Ridinger
  • Judith Frydman
  • Rainer Deutzmann
  • Stefan Bresson
  • Thomas Hierlmeier
  • Zhihua Li
  • Edward M Marcotte
  • Cyril Bussiere
  • Stefanie Reissmann
  • Lindsey A Hoover
  • Blanka Kucejova
  • Xin Jie Chen
  • Xiaoming Zuo
  • Ida van der Klei
  • Eva Liebminger
  • Gregor Högenauer
  • Georges Lutfalla
  • Berthold Nobis
  • Martin Tengg
  • Laurence Decourty
  • Jean Christophe Rain
  • Chunyan Liao
  • Barry Panaretou
  • Chrisostomos Prodromou
  • Laurence H Pearl

Detail Information

Publications20

  1. pmc Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae
    Nai Jung Hung
    Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, 1 University Station, A5000, The University of Texas at Austin, Austin, Texas 78712 0162, USA
    Mol Cell Biol 26:3718-27. 2006
    Arx1 and Rei1 are found on late pre-60S ribosomal particles containing the export adaptor Nmd3...
  2. pmc A functional network involved in the recycling of nucleocytoplasmic pre-60S factors
    Alice Lebreton
    Genetique des Interactions Macromoleculaires, Centre National de la Recherche Scientifique URA2171, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 173:349-60. 2006
    ..In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing...
  3. pmc Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1
    Brigitte Pertschy
    Institut für Molekulare Biowissenschaften Karl Franzens Universität Graz, Universitatsplatz 2, A 8010, Graz, Austria
    Mol Cell Biol 27:6581-92. 2007
    ..under drg1 mutant conditions were blocked on pre-60S particles at a step that precedes the association of Rei1, a later-acting preribosomal factor...
  4. pmc The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae
    Emilie Demoinet
    Défenses Antivirales et Antitumorales, CNRS UMR5235, Universite Montpellier II, France
    RNA 13:1570-81. 2007
    ..are recycled into the nucleus; some of them shuttle between the nucleus and the cytoplasm while a few others, like Rei1, are strictly cytoplasmic and are mostly involved in the dissociation/recycling of the pre-60S shuttling factors...
  5. pmc The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1
    Alison E Meyer
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 285:961-8. 2010
    ..Two cytosolic proteins, Rei1 and Jjj1, are required, but their individual contributions to this step are not understood...
  6. pmc Defining the pathway of cytoplasmic maturation of the 60S ribosomal subunit
    Kai Yin Lo
    Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA
    Mol Cell 39:196-208. 2010
    ..Finally, the release of Tif6 is a prerequisite for the release of the nuclear export adaptor Nmd3. Establishing this pathway provides an important conceptual framework for understanding ribosome maturation...
  7. doi Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1
    Chengying Ma
    Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China
    Nat Struct Mol Biol . 2017
    ..These findings pinpoint a structural checkpoint role for Nmd3 in PTC assembly, and provide information about functional and mechanistic roles of these assembly factors in the maturation of the 60S ribosomal subunit...
  8. doi Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation
    Basil Johannes Greber
    Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 164:91-102. 2016
    ..the cryo-electron microscopy (cryo-EM) structure of the yeast 60S subunit in complex with the biogenesis factors Rei1, Arx1, and Alb1 at 3.4 Å resolution...
  9. pmc The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1
    Mathias Loibl
    From the Institut für Molekulare Biowissenschaften, Karl Franzens Universitat Graz, A 8010 Graz, Austria and
    J Biol Chem 289:3913-22. 2014
    ..Our results identify the first target of an inhibitor of ribosome biogenesis and provide the mechanism of inhibition of a key step in large ribosomal subunit formation. ..
  10. pmc Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export
    Yoshitaka Matsuo
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 328, Heidelberg D 69120, Germany
    Nature 505:112-6. 2014
    ..We conclude that Nug2 is a regulatory GTPase that monitors pre-60S maturation, with release from its placeholder site linked to recruitment of the nuclear export machinery. ..
  11. pmc Localization of lipid raft proteins to the plasma membrane is a major function of the phospholipid transfer protein Sec14
    Amy J Curwin
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 8:e55388. 2013
    ..Localization of both lipid raft proteins was restored upon increased expression of the sec14(ts) allele. We suggest that a major function provided by Sec14 is trafficking and localization of lipid raft proteins...
  12. pmc Rlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturation
    Lisa Kappel
    Institut für Molekulare Biowissenschaften, Karl Franzens Universitat Graz, A 8010 Graz, Austria
    J Cell Biol 199:771-82. 2012
    ..Our results show that release of Rlp24 by Drg1 defines a key event in large subunit formation that is a prerequisite for progression of cytoplasmic pre-60S maturation...
  13. doi Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit
    Basil J Greber
    Institute of Molecular Biology and Biophysics, Eidgenossische Technische Hochschule ETH Zurich, Zurich, Switzerland
    Nat Struct Mol Biol 19:1228-33. 2012
    ..biochemically characterized ribosomal complexes of the yeast 60S-biogenesis factor Arx1 and late-maturation factors Rei1 and Jjj1 and determined their cryo-EM structures...
  14. pmc Analysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes
    Juliane Merl
    Institut fur Biochemie, Genetik und Mikrobiologie, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Nucleic Acids Res 38:3068-80. 2010
    ..The data presented strengthen the idea that assembly of eukaryotic pre-ribosomal particles can result from transient association of distinct building blocks...
  15. pmc A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis
    Véronique Albanèse
    Department of Biology, Stanford University, Palo Alto, CA 94305, USA
    J Cell Biol 189:69-81. 2010
    ..Our results demonstrate that, in addition to their known cytoplasmic roles in de novo protein folding, some ribosome-anchored CLIPS chaperones play a critical role in nuclear steps of ribosome biogenesis...
  16. ncbi Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae
    Masayuki Iwase
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Cell Struct Funct 29:1-15. 2004
    YBR267w designated REI1 (required for isotropic bud growth) was isolated by two-hybrid screening using NIS1 encoding the neck protein as bait. Disruption of REI1 exhibited cold sensitive growth but did not exhibit a morphological defect...
  17. pmc Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation
    K Mark Parnell
    Department of Biochemistry and Howard Hughes Medical Institute, University of Utah School of Medicine, 15 N Medical Drive East, Room 4800, Salt Lake City, UT 84112 5650, USA
    Mol Cell Biol 29:4014-23. 2009
    ..The cytoplasmic protein Rei1, found in all eukaryotes, was previously shown to be necessary for the nuclear reimport of 60S subunit export ..
  18. pmc Reduced cytosolic protein synthesis suppresses mitochondrial degeneration
    Xiaowen Wang
    Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Nat Cell Biol 10:1090-7. 2008
    ..Our finding thus establishes a link between protein homeostasis (proteostasis), cellular bioenergetics and mitochondrial maintenance during ageing...
  19. ncbi Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex
    Bin Hu
    Department of Life Sciences, King s College London, London SE1 9NN, UK
    Mol Microbiol 55:1735-50. 2005
    ..This could imply a role for Nse4 in maintenance of higher order chromosome structure...