QCR9

Summary

Gene Symbol: QCR9
Description: ubiquinol--cytochrome-c reductase subunit 9
Alias: UCR9
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment
    C Hunte
    Max Planck Institut fur Biophysik, Abt Molekulare Membranbiologie, Frankfurt, 60528, Germany
    Structure 8:669-84. 2000
  2. doi The dimerization of the yeast cytochrome bc1 complex is an early event and is independent of Rip1
    Annalea Conte
    Department of Biological and Environmental Sciences and Technologies, University of Salento, via prov le Lecce Monteroni, I 73100 Lecce, Italy
    Biochim Biophys Acta 1853:987-95. 2015
  3. ncbi Deletion of subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex specifically impairs electron transfer at the ubiquinol oxidase site (center P) in the bc1 complex
    L A Graham
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH
    FEBS Lett 313:251-4. 1992
  4. ncbi Subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex is required for insertion of EPR-detectable iron-sulfur cluster into the Rieske iron-sulfur protein
    J D Phillips
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 268:11727-36. 1993
  5. ncbi Mode of action of the qcr9 and cat3 mutations in restoring the ability of Saccharomyces cerevisiae tps1 mutants to grow on glucose
    M A Blazquez
    Unidad de Bioquímica y Genética de Levaduras, Instituto de Investigaciones Biomédicas del C S I C, Madrid, Spain
    Mol Gen Genet 249:655-64. 1995
  6. pmc Role of positively charged transmembrane segments in the insertion and assembly of mitochondrial inner-membrane proteins
    Y Saint-Georges
    Centre de Genetique Moleculaire du Centre National de la Recherche Scientifique, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 98:13814-9. 2001
  7. doi Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain
    Andrew M James
    Wellcome Trust MRC Building, Cambridge, UK
    FEBS J 277:2067-82. 2010
  8. pmc The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria
    Aaron Atkinson
    University of Utah Health Sciences Center, Department of Medicine, Salt Lake City, UT 84132, USA
    Mol Cell Biol 31:3988-96. 2011
  9. pmc Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane
    Vincenzo Zara
    Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Universita del Salento, Lecce, Italy
    FEBS J 276:1900-14. 2009

Patents

  1. RECOMBINANT HUMANIZED ANTI-CYTOMEGALOVIRUS ANTIBODIES

Scientific Experts

  • C Hunte
  • Vincenzo Zara
  • Annalea Conte
  • Aaron Atkinson
  • Andrew M James
  • Alessandra Ferramosca
  • Benedetta Papa
  • Y Saint-Georges
  • Jennifer L Fox
  • Pamela Smith
  • Tie Zhong Cui
  • Dennis R Winge
  • Oleh Khalimonchuk
  • Masatoshi Murai
  • Hideto Miyoshi
  • Helena M Cocheme
  • Michael P Murphy
  • P Hamel
  • C Lemaire
  • G Dujardin
  • M A Blazquez
  • J D Phillips
  • L A Graham
  • B L Trumpower
  • C Gancedo

Detail Information

Publications9

  1. ncbi Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment
    C Hunte
    Max Planck Institut fur Biophysik, Abt Molekulare Membranbiologie, Frankfurt, 60528, Germany
    Structure 8:669-84. 2000
    ..This integral membrane protein complex catalyzes electron transfer from ubiquinol to cytochrome c. It couples the electron transfer to the electrogenic translocation of protons across the membrane via a so-called Q cycle mechanism...
  2. doi The dimerization of the yeast cytochrome bc1 complex is an early event and is independent of Rip1
    Annalea Conte
    Department of Biological and Environmental Sciences and Technologies, University of Salento, via prov le Lecce Monteroni, I 73100 Lecce, Italy
    Biochim Biophys Acta 1853:987-95. 2015
    ..Finally, a new model of cytochrome bc1 complex assembly, in which distinct intermediates sequentially interact during bc1 maturation, has been proposed. ..
  3. ncbi Deletion of subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex specifically impairs electron transfer at the ubiquinol oxidase site (center P) in the bc1 complex
    L A Graham
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH
    FEBS Lett 313:251-4. 1992
    Deletion of QCR9, the nuclear gene encoding subunit 9 of the mitochondrial cytochrome bc1 complex in Saccharomyces cerevisiae, results in inactivation of the bc1 complex and inability of the yeast to grow on non-fermentable carbon sources...
  4. ncbi Subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex is required for insertion of EPR-detectable iron-sulfur cluster into the Rieske iron-sulfur protein
    J D Phillips
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 268:11727-36. 1993
    Deletion of QCR9, the nuclear gene encoding the 7.3-kDa subunit 9 of the cytochrome bc1 complex, impairs respiration of Saccharomyces cerevisiae, coincident with loss of ubiquinol-cytochrome c oxidoreductase activity...
  5. ncbi Mode of action of the qcr9 and cat3 mutations in restoring the ability of Saccharomyces cerevisiae tps1 mutants to grow on glucose
    M A Blazquez
    Unidad de Bioquímica y Genética de Levaduras, Instituto de Investigaciones Biomédicas del C S I C, Madrid, Spain
    Mol Gen Genet 249:655-64. 1995
    ..Antimycin A or disruption of the QCR9 gene, which encodes one subunit of the cytochrome bc1 complex, restore the ability to grow in glucose-containing ..
  6. pmc Role of positively charged transmembrane segments in the insertion and assembly of mitochondrial inner-membrane proteins
    Y Saint-Georges
    Centre de Genetique Moleculaire du Centre National de la Recherche Scientifique, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 98:13814-9. 2001
    ..This model argues in favor of a role of Oxa1p in the insertion and the lateral exit of less hydrophobic TM domains from the translocation site into the lipid bilayer...
  7. doi Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain
    Andrew M James
    Wellcome Trust MRC Building, Cambridge, UK
    FEBS J 277:2067-82. 2010
    ..Using a DeltaCoQ double-knockout library we identified a number of genes that decrease the ability of yeast to grow on exogenous CoQ. Here we suggest that CoQ or its redox state may be a signal for growth during the shift to respiration...
  8. pmc The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria
    Aaron Atkinson
    University of Utah Health Sciences Center, Department of Medicine, Salt Lake City, UT 84132, USA
    Mol Cell Biol 31:3988-96. 2011
    ....
  9. pmc Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane
    Vincenzo Zara
    Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Universita del Salento, Lecce, Italy
    FEBS J 276:1900-14. 2009
    ..The characterization of this novel core structure of the bc(1) complex provides a number of new elements clarifying the molecular events leading to the maturation of the yeast cytochrome bc(1) complex in the inner mitochondrial membrane...

Patents1

  1. RECOMBINANT HUMANIZED ANTI-CYTOMEGALOVIRUS ANTIBODIES
    Patent Number: WO9409136-A1; Date:1994-04-28