PEX6

Summary

Gene Symbol: PEX6
Description: AAA family ATPase peroxin 6
Alias: PAS8
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Nucleotide-dependent assembly of the peroxisomal receptor export complex
    Immanuel Grimm
    Abteilung für Systembiochemie, Institut für Biochemie und Pathobiochemie, Medizinische Fakultät der Ruhr Universität Bochum, D 44780 Bochum, Germany
    Sci Rep 6:19838. 2016
  2. pmc Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis
    Alison M Motley
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, England, UK
    J Cell Biol 211:1041-56. 2015
  3. pmc Yeast pex1 cells contain peroxisomal ghosts that import matrix proteins upon reintroduction of Pex1
    Kevin Knoops
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, Netherlands
    J Cell Biol 211:955-62. 2015
  4. pmc Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
    Neil B Blok
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115 Department of Cell Biology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:E4017-25. 2015
  5. pmc Molecular snapshots of the Pex1/6 AAA+ complex in action
    Susanne Ciniawsky
    Gene Center Munich, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, Munich 81377, Germany
    Nat Commun 6:7331. 2015
  6. pmc The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits
    Brooke M Gardner
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA Miller Institute for Basic Research in Science, University of California, Berkeley, Berkeley, CA 94720, USA
    J Mol Biol 427:1375-88. 2015
  7. pmc Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae
    James M Nuttall
    Department of Molecular Biology and Biotechnology University of Sheffield, Western Bank Sheffield, UK
    Autophagy 10:835-45. 2014
  8. doi Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes
    Adabella van der Zand
    Cellular Protein Chemistry, Faculty of Science, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Cell 149:397-409. 2012
  9. doi ATP-dependent assembly of the heteromeric Pex1p-Pex6p-complex of the peroxisomal matrix protein import machinery
    Delia Saffian
    Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr Universität Bochum, D 44780 Bochum, Germany
    J Struct Biol 179:126-32. 2012
  10. pmc Ubp15p, a ubiquitin hydrolase associated with the peroxisomal export machinery
    Mykhaylo O Debelyy
    Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr Universität Bochum, Bochum, Germany
    J Biol Chem 286:28223-34. 2011

Scientific Experts

  • Adabella van der Zand
  • Ralf Erdmann
  • Wolfgang Girzalsky
  • Delia Saffian
  • Immanuel Grimm
  • Katja Rosenkranz
  • Alison M Motley
  • James M Nuttall
  • Ingvild Birschmann
  • Harald W Platta
  • Kevin Knoops
  • Brooke M Gardner
  • Neil B Blok
  • Susanne Ciniawsky
  • Ewald H Hettema
  • Wolf H Kunau
  • Adabella van der Zand
  • Mykhaylo O Debelyy
  • Helmut Jungwirth
  • Henk F Tabak
  • Jae Gu Seo
  • Silke Grunau
  • Saikat Chowdhury
  • Andreas Martin
  • Lakhan Ekal
  • Ray Yu Ruei Wang
  • Tom A Rapoport
  • Anita Kram
  • David Baker
  • Frank DiMaio
  • Rinse de Boer
  • Paul C Galvin
  • Pawel A Penczek
  • Thomas Walz
  • Ida J van der Klei
  • Gabriel C Lander
  • Petra Wendler
  • Dongyan Tan
  • Ineke Braakman
  • Jürgen Gent
  • Helmut E Meyer
  • Astrid Hensel
  • Sven Thoms
  • Bettina Warscheid
  • Karl Kuchler
  • Julia Ring
  • Tobias Eisenberg
  • Didac Carmona-Gutierrez
  • Tanja Mayer
  • Sabrina Buttner
  • Alexandra Schauer
  • Frank Madeo
  • Michael V Miceli
  • Chi Yung Lai
  • S Michal Jazwinski
  • Antje Schafer
  • An K Stroobants
  • Marlene van den Berg
  • T Voorn-Brouwer
  • I van der Leij
  • B Distel
  • H F Tabak
  • W Hemrika

Detail Information

Publications17

  1. pmc Nucleotide-dependent assembly of the peroxisomal receptor export complex
    Immanuel Grimm
    Abteilung für Systembiochemie, Institut für Biochemie und Pathobiochemie, Medizinische Fakultät der Ruhr Universität Bochum, D 44780 Bochum, Germany
    Sci Rep 6:19838. 2016
    ..The data indicate that receptor release in peroxisomal protein import is associated with a nucleotide-depending Pex1/6p-cycle of Pex15p-binding and release. ..
  2. pmc Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis
    Alison M Motley
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, England, UK
    J Cell Biol 211:1041-56. 2015
    ..This model proposes a role in vesicle fusion for the Pex1/Pex6 complex, which has an established role in matrix protein import...
  3. pmc Yeast pex1 cells contain peroxisomal ghosts that import matrix proteins upon reintroduction of Pex1
    Kevin Knoops
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, Netherlands
    J Cell Biol 211:955-62. 2015
    Pex1 and Pex6 are two AAA-ATPases that play a crucial role in peroxisome biogenesis...
  4. pmc Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
    Neil B Blok
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115 Department of Cell Biology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:E4017-25. 2015
    ..Here, we report structures of the Pex1/Pex6 complex; mutations in these proteins frequently cause peroxisomal diseases...
  5. pmc Molecular snapshots of the Pex1/6 AAA+ complex in action
    Susanne Ciniawsky
    Gene Center Munich, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, Munich 81377, Germany
    Nat Commun 6:7331. 2015
    The peroxisomal proteins Pex1 and Pex6 form a heterohexameric type II AAA+ ATPase complex, which fuels essential protein transport across peroxisomal membranes...
  6. pmc The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits
    Brooke M Gardner
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA Miller Institute for Basic Research in Science, University of California, Berkeley, Berkeley, CA 94720, USA
    J Mol Biol 427:1375-88. 2015
    Pex1 and Pex6 are Type-2 AAA+ ATPases required for the de novo biogenesis of peroxisomes. Mutations in Pex1 and Pex6 account for the majority of the most severe forms of peroxisome biogenesis disorders in humans...
  7. pmc Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae
    James M Nuttall
    Department of Molecular Biology and Biotechnology University of Sheffield, Western Bank Sheffield, UK
    Autophagy 10:835-45. 2014
    ..mutants disturbed in peroxisomal protein import, and found that a deficiency in the exportomer subunits Pex1, Pex6, and Pex15 results in enhanced turnover of peroxisomal membrane structures compared with other mutants...
  8. doi Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes
    Adabella van der Zand
    Cellular Protein Chemistry, Faculty of Science, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Cell 149:397-409. 2012
    ..Our findings demonstrate a remarkable mechanism to maintain biochemical identity of organelles by transporting crucial components via different routes to their final destination...
  9. doi ATP-dependent assembly of the heteromeric Pex1p-Pex6p-complex of the peroxisomal matrix protein import machinery
    Delia Saffian
    Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr Universität Bochum, D 44780 Bochum, Germany
    J Struct Biol 179:126-32. 2012
    ..Disassembly of the complex into its Pex1p and Pex6p subunits is also observed upon ATP-depletion, indicating that formation of the Pex1p/Pex6p-complex requires the presence of ATP...
  10. pmc Ubp15p, a ubiquitin hydrolase associated with the peroxisomal export machinery
    Mykhaylo O Debelyy
    Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr Universität Bochum, Bochum, Germany
    J Biol Chem 286:28223-34. 2011
    ..The results merge into a picture in which removal of ubiquitin from the PTS1 receptor Pex5p is a specific event and might represent a vital step in receptor recycling...
  11. ncbi Sequence of the PAS8 gene, the product of which is essential for biogenesis of peroxisomes in Saccharomyces cerevisiae
    T Voorn-Brouwer
    Department of Biochemistry, E C Slater Institute, University of Amsterdam, The Netherlands
    Biochim Biophys Acta 1216:325-8. 1993
    ..Here, we report the sequence of the complementing gene (PAS8), coding for a protein of 1030 amino acids that appears to be a novel member of the AAA-protein family which also ..
  12. doi Loss of peroxisome function triggers necrosis
    Helmut Jungwirth
    Institute of Molecular Biosciences IMB, University of Graz, Austria
    FEBS Lett 582:2882-6. 2008
    ..Here, we show that in yeast deletion of PEX6, encoding a protein involved in a key step of peroxisomal protein import, results in an increased accumulation of ..
  13. ncbi A novel role of peroxin PEX6: suppression of aging defects in mitochondria
    Jae Gu Seo
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Aging Cell 6:405-13. 2007
    ..This decline has implications for stem cell aging in higher organisms. PEX6, a peroxisome biogenesis gene, has been isolated as a multicopy suppressor of an atp2 age asymmetry mutant...
  14. ncbi Functional association of the AAA complex and the peroxisomal importomer
    Katja Rosenkranz
    Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr Universität Bochum, Germany
    FEBS J 273:3804-15. 2006
    ....
  15. ncbi Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol
    Harald W Platta
    Institut fur Physiologische Chemie, Abt Systembiochemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Nat Cell Biol 7:817-22. 2005
    ..Here we demonstrate that the AAA peroxins mediate the ATP-dependent dislocation of the peroxisomal targeting signal-1 (PTS1) receptor from the peroxisomal membrane to the cytosol...
  16. ncbi Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p
    Ingvild Birschmann
    Abteilung für Zellbiochemie, Medizinische Fakultät der Ruhr Universität Bochum, Germany
    FEBS J 272:47-58. 2005
    ..Furthermore, we could prove that the second AAA-cassettes (D2) of both Pex1p and Pex6p were essential for peroxisomal biogenesis and thus probably comprise the overall activity of the proteins...
  17. pmc Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes
    Ingvild Birschmann
    Abteilung für Zellbiochemie, Medizinische Fakultät der Ruhr Universität Bochum, Germany
    Mol Biol Cell 14:2226-36. 2003
    ..On the basis of these results, we propose that Pex6p exerts at least part of its function by an ATP-dependent cycle of recruitment and release to and from Pex15p...