NOG2

Summary

Gene Symbol: NOG2
Description: putative GTPase NOG2
Alias: NUG2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi Identification of a 60S preribosomal particle that is closely linked to nuclear export
    J Bassler
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Mol Cell 8:517-29. 2001
  2. pmc Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
    C Saveanu
    Genetique des Interactions Macromoleculaires, Institut Pasteur CNRS URA2171, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 20:6475-84. 2001
  3. ncbi Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs
    Alice Lebreton
    Unité de Génétique des Interactions Macromoléculaires, CNRS URA2171, Institut Pasteur, 75724 Paris Cedex 15, France
    J Biol Chem 281:27099-108. 2006
  4. ncbi In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1
    Jennifer L Fuentes
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109, USA
    Mol Genet Genomics 278:105-23. 2007
  5. pmc 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes
    Alice Lebreton
    Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS URA2171, Paris, France
    Nucleic Acids Res 36:4988-99. 2008
  6. pmc Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export
    Yoshitaka Matsuo
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 328, Heidelberg D 69120, Germany
    Nature 505:112-6. 2014
  7. doi Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit
    Anshuk Sarkar
    Biochemistry Centre, University of Heidelberg, Heidelberg, Germany
    Nat Struct Mol Biol 23:1074-1082. 2016
  8. pmc Hierarchical recruitment into nascent ribosomes of assembly factors required for 27SB pre-rRNA processing in Saccharomyces cerevisiae
    Jason Talkish
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Nucleic Acids Res 40:8646-61. 2012
  9. ncbi Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae
    Agnieszka Białkowska
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa
    Acta Biochim Pol 49:421-5. 2002
  10. pmc Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export
    Yanhua Yao
    Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS URA2171, F 75724 Paris Cedex 15, France
    RNA 16:1007-17. 2010

Detail Information

Publications12

  1. ncbi Identification of a 60S preribosomal particle that is closely linked to nuclear export
    J Bassler
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Mol Cell 8:517-29. 2001
    ..Eight of these proteins were copurified with nuclear pore complexes, suggesting that this complex represents the transport intermediate for 60S subunit export...
  2. pmc Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
    C Saveanu
    Genetique des Interactions Macromoleculaires, Institut Pasteur CNRS URA2171, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 20:6475-84. 2001
    ..These results suggest that transient, possibly GTP-dependent association of Nog2p with the pre-ribosomes might trigger late rRNA maturation steps in ribosomal large subunit biogenesis...
  3. ncbi Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs
    Alice Lebreton
    Unité de Génétique des Interactions Macromoléculaires, CNRS URA2171, Institut Pasteur, 75724 Paris Cedex 15, France
    J Biol Chem 281:27099-108. 2006
    ..Indeed, when ribosome biogenesis was blocked upstream of Nsa2, this short half-lived protein was largely depleted, suggesting that its cellular levels are tightly regulated...
  4. ncbi In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1
    Jennifer L Fuentes
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109, USA
    Mol Genet Genomics 278:105-23. 2007
    ..Several conserved charge-to-alanine substitutions outside the GTPase domain display modest growth phenotypes indicating that these residues are not critical for function...
  5. pmc 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes
    Alice Lebreton
    Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS URA2171, Paris, France
    Nucleic Acids Res 36:4988-99. 2008
    ..from strains in which rRNA processing was affected by individual depletion of five factors: Ebp2, Nog1, Nsa2, Nog2 or Pop3...
  6. pmc Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export
    Yoshitaka Matsuo
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 328, Heidelberg D 69120, Germany
    Nature 505:112-6. 2014
    ..Here we show that a conserved Saccharomyces cerevisiae GTPase Nug2 (also known as Nog2, and as NGP-1, GNL2 or nucleostemin 2 in human) has a key role in the timing of export ..
  7. doi Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit
    Anshuk Sarkar
    Biochemistry Centre, University of Heidelberg, Heidelberg, Germany
    Nat Struct Mol Biol 23:1074-1082. 2016
    ..Thus, a spatiotemporal mark on the ribosomal stalk controls the recruitment of an RNA-export receptor to the nascent 60S subunit...
  8. pmc Hierarchical recruitment into nascent ribosomes of assembly factors required for 27SB pre-rRNA processing in Saccharomyces cerevisiae
    Jason Talkish
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Nucleic Acids Res 40:8646-61. 2012
    ..model in which assembly of the B-factors into nascent ribosomes ultimately leads to the recruitment of the GTPase Nog2. A more detailed analysis suggests that this occurs in a hierarchical manner via two largely independent recruiting ..
  9. ncbi Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae
    Agnieszka Białkowska
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa
    Acta Biochim Pol 49:421-5. 2002
    ..Here we describe two dosage suppressors (IST2, NOG2) overcoming the inability to form colonies of an Irr1p-deficient strain...
  10. pmc Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export
    Yanhua Yao
    Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS URA2171, F 75724 Paris Cedex 15, France
    RNA 16:1007-17. 2010
    ..These data highlight the involvement of many factors acting together to export pre-60S particles...
  11. pmc A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis
    Véronique Albanèse
    Department of Biology, Stanford University, Palo Alto, CA 94305, USA
    J Cell Biol 189:69-81. 2010
    ..Our results demonstrate that, in addition to their known cytoplasmic roles in de novo protein folding, some ribosome-anchored CLIPS chaperones play a critical role in nuclear steps of ribosome biogenesis...
  12. ncbi Screening for novel essential genes of Saccharomyces cerevisiae involved in protein secretion
    Svetlana G Davydenko
    VTT Biotechnology, PO Box 1500, FIN 02044 VTT, Finland
    Yeast 21:463-71. 2004
    ..Four of the genes detected, NOG2, NOP15, RRP40 and SDA1, encode proteins involved in ribosome assembly, suggesting a possible new signalling pathway ..