MDM30

Summary

Gene Symbol: MDM30
Description: SCF ubiquitin ligase complex subunit MDM30
Alias: DSG1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro
    Bart M Kus
    Banting and Best Department of Medical Research, University of Toronto, Ontario
    Proteins 54:455-67. 2004
  2. ncbi The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing
    Masafumi Muratani
    Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Cell 120:887-99. 2005
  3. pmc Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae
    Kai Stefan Dimmer
    Institut für Physiologische Chemie der Universität München, D 81377 Munchen, Germany
    Mol Biol Cell 13:847-53. 2002
  4. doi Alterations in the interaction between GAL4 and GAL80 effect regulation of the yeast GAL regulon mediated by the F box protein Dsg1
    Yan Li
    State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan, Shandong, China
    Curr Microbiol 61:210-6. 2010
  5. pmc Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast
    Mark Dürr
    Institut fur Zellbiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    Mol Biol Cell 17:3745-55. 2006
  6. pmc Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion
    Mickael M J Cohen
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD 21702, USA
    Mol Biol Cell 19:2457-64. 2008
  7. pmc Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast
    Stefan Fritz
    Institut fur Physiologische Chemie, Universitat Munchen, Germany
    Mol Biol Cell 14:2303-13. 2003
  8. pmc A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover
    Elizabeth A Amiott
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 20:5026-35. 2009
  9. pmc Mediator acts upstream of the transcriptional activator Gal4
    Keven Ang
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    PLoS Biol 10:e1001290. 2012
  10. pmc Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97
    James L Yen
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697 1700, USA
    Mol Cell 48:288-97. 2012

Scientific Experts

  • Mickael M Cohen
  • Benedikt Westermann
  • Mafalda Escobar-Henriques
  • Thomas Langer
  • James L Yen
  • Keven Ang
  • Ikram Ouni
  • Karin Flick
  • Fabian Anton
  • Lan Huang
  • Peter Kaiser
  • Yan Li
  • Mariam Aghajan
  • Miriam Hammermeister
  • Jin Mi Heo
  • Elizabeth A Amiott
  • Stefan Fritz
  • Abhijit Shukla
  • Kazuhisa Ota
  • Janet M Shaw
  • V Palermo
  • Mark Dürr
  • Noriko Kondo-Okamoto
  • Masafumi Muratani
  • Bart M Kus
  • Nadja Weinbach
  • Kai Stefan Dimmer
  • Edwin Ang
  • Radhika Mathur
  • Elvin Koh
  • Gary Ee
  • An Tyrrell
  • Robyn M Kaake
  • Wee Leng Siew
  • Yee Sun Tan
  • Sabrina Nur
  • Yu Mun Chan
  • Norbert Lehming
  • Christie V Papagiannis
  • Gerrit J K Praefcke
  • Benoit Pinson
  • Astrid Schauss
  • Julia M Fres
  • Xiaolu Cai
  • Raymond J Deshaies
  • Noah Dephoure
  • Steven P Gygi
  • Cheng Li
  • Jeffrey L Brodsky
  • Nurit Livnat-Levanon
  • Guanjun Chen
  • Eric B Taylor
  • Kendall N Houk
  • Kaveh Ashrafi
  • Jared Rutter
  • Weifeng Liu
  • Pierre M Del Moral
  • Nathan Pierce
  • Nao Jonai
  • Jing Huang
  • Manlin Luo
  • Rui Hao
  • Fei Fu
  • Robert Damoiseaux
  • Jianxin Xie
  • Julia Ring
  • Kerstin Schödel
  • Ning Zheng
  • Ying Li
  • Frank Madeo
  • Michael E Jung
  • Xiaobo Tang
  • Rati Verma
  • Michael H Glickman
  • Brett Lomenick
  • Kevin T Jones
  • Jessica Schneider
  • Yann Saint-Georges
  • Thomas Shadle
  • Sukesh R Bhaumik
  • Allan M Weissman
  • Zhen Duan
  • Geetha Durairaj
  • Satoshi Okada
  • Takashi Ito
  • Keiji Kito
  • C Mazzoni
  • C Falcone
  • Koji Okamoto
  • Stefan Geimer

Detail Information

Publications21

  1. ncbi Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro
    Bart M Kus
    Banting and Best Department of Medical Research, University of Toronto, Ontario
    Proteins 54:455-67. 2004
    ..Ubc4 thus interacts with multiple SCFs in vitro, and the interactions among SCF and E2 components of the ubiquitination machinery may allow further diversification of the roles of SCFs in vivo...
  2. ncbi The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing
    Masafumi Muratani
    Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Cell 120:887-99. 2005
    ..Destruction of transcriptionally active Gal4 depends on an F box protein called Dsg1/Mdm30. In the absence of Dsg1, Gal4 is stable, nonubiquitylated, and unable to productively stimulate transcription...
  3. pmc Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae
    Kai Stefan Dimmer
    Institut für Physiologische Chemie der Universität München, D 81377 Munchen, Germany
    Mol Biol Cell 13:847-53. 2002
    ..These data provide a comprehensive picture of the cellular processes and molecular components required for mitochondrial function and structure in a simple eukaryotic cell...
  4. doi Alterations in the interaction between GAL4 and GAL80 effect regulation of the yeast GAL regulon mediated by the F box protein Dsg1
    Yan Li
    State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan, Shandong, China
    Curr Microbiol 61:210-6. 2010
    ..In this study, we showed that deletion of dsg1 coding for the F box protein Dsg1/Mdm30 delayed but did not eliminate growth of yeast on galactose...
  5. pmc Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast
    Mark Dürr
    Institut fur Zellbiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    Mol Biol Cell 17:3745-55. 2006
    ..Here, we analyzed the roles of two yeast F-box proteins, Mfb1 and Mdm30, in mitochondrial dynamics. Mfb1 is a novel mitochondria-associated F-box protein...
  6. pmc Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion
    Mickael M J Cohen
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, Frederick, MD 21702, USA
    Mol Biol Cell 19:2457-64. 2008
    ..This study provides a framework for developing an understanding of the function of Mdm30p-mediated Fzo1p degradation in the multistep process of mitochondrial fusion...
  7. pmc Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast
    Stefan Fritz
    Institut fur Physiologische Chemie, Universitat Munchen, Germany
    Mol Biol Cell 14:2303-13. 2003
    Mitochondrial fusion and fission play important roles for mitochondrial morphology and function. We identified Mdm30 as a novel component required for maintenance of fusion-competent mitochondria in yeast...
  8. pmc A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover
    Elizabeth A Amiott
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 20:5026-35. 2009
    ..in the GTPase domain of Mfn2) not only abolishes GTP hydrolysis and mitochondrial membrane fusion but also reduces Mdm30-mediated ubiquitylation and degradation of the mutant protein...
  9. pmc Mediator acts upstream of the transcriptional activator Gal4
    Keven Ang
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    PLoS Biol 10:e1001290. 2012
    ..The deletion of the gene encoding the F-box protein Mdm30 had been reported to stabilize the transcriptional activator Gal4 under inducing conditions and to lead to defects ..
  10. pmc Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97
    James L Yen
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697 1700, USA
    Mol Cell 48:288-97. 2012
    ..Our results not only provide an additional layer of ubiquitin ligase regulation but also suggest that targeted, signal-dependent dissociation of multisubunit enzyme complexes is an important mechanism in control of enzyme function...
  11. ncbi Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae
    V Palermo
    Department of Cell and Developmental Biology, Pasteur Institute Cenci Bolognetti Foundation, University of Rome La Sapienza, 5 00185 Rome, Italy
    Folia Microbiol (Praha) 52:479-83. 2007
    ..b>MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in ..
  12. doi A proteomic screen reveals the mitochondrial outer membrane protein Mdm34p as an essential target of the F-box protein Mdm30p
    Kazuhisa Ota
    Department of Computational Biology and Center for Omics and Bioinformatics, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa 277 8561, Japan
    Genes Cells 13:1075-85. 2008
    ..Furthermore, we found that mitochondrial defects induced by deletion of MDM30 are not only recapitulated by a mutant Mdm34p defective in interaction with Mdm30p but alleviated by ..
  13. doi Stimulation of mRNA export by an F-box protein, Mdm30p, in vivo
    Abhijit Shukla
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, 1245 Lincoln Drive, Carbondale, IL 62901, USA
    J Mol Biol 389:238-47. 2009
    ..Together, our data demonstrate that Mdm30p selectively controls mRNA export independently of mitochondrial fusion, revealing a novel function of an F-box protein in mRNA export...
  14. pmc The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 17:3756-67. 2006
    ..We propose that Mfb1p operates in a novel pathway regulating mitochondrial tubular connectivity...
  15. pmc Mdm36 is a mitochondrial fission-promoting protein in Saccharomyces cerevisiae
    Miriam Hammermeister
    Institut fur Zellbiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    Mol Biol Cell 21:2443-52. 2010
    ..Double mutant analyses indicate that Mdm36 acts antagonistically to fusion-promoting components, such as Fzo1 and Mdm30. The cell cortex-associated protein Num1 was shown previously to interact with Dnm1 and promote mitochondrial ..
  16. pmc Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
    Mariam Aghajan
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, and the Molecular Biology Institute, University of California, Los Angeles, California, USA
    Nat Biotechnol 28:738-42. 2010
    ..Our results show that there is no fundamental barrier to obtaining specific inhibitors to modulate function of individual SCF complexes...
  17. pmc A stress-responsive system for mitochondrial protein degradation
    Jin Mi Heo
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Cell 40:465-80. 2010
    ..We demonstrate that Vms1 is a required component of an evolutionarily conserved system for mitochondrial protein degradation, which is necessary to maintain mitochondrial, cellular, and organismal viability...
  18. doi Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion
    Fabian Anton
    Institute for Genetics, University of Cologne, 50674 Cologne, Germany
    J Cell Sci 124:1126-35. 2011
    ..OM fusion depends on self-assembly and GTPase activity of mitofusins as well as on two other proteins, Ugo1 and Mdm30. Here, we define distinct steps of the OM fusion cycle using in vitro and in vivo approaches...
  19. pmc Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion
    Mickael M Cohen
    Center for Cancer Research, NCI Frederick, MD 21702, USA
    J Cell Sci 124:1403-10. 2011
    ..Furthermore, the ubiquitin ligase SCF(Mdm30) (a SKP1-cullin-1-F-box complex that contains Mdm30 as the F-box protein), which targets Fzo1 for ubiquitylation ..
  20. pmc Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1
    Mafalda Escobar-Henriques
    Institute of Genetics and Center for Molecular Medicine, University of Cologne, D 50923 Cologne, Germany
    J Cell Biol 173:645-50. 2006
    ..b>Mdm30, an F-box protein required for mitochondrial fusion in vegetatively growing cells, affects the cellular Fzo1 ..