LGE1

Summary

Gene Symbol: LGE1
Description: Lge1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi A conserved RING finger protein required for histone H2B monoubiquitination and cell size control
    William W Hwang
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 11:261-6. 2003
  2. ncbi Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination
    Xiaoting Zhang
    Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:2759-70. 2005
  3. pmc Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast
    Denise Hanway
    Department of Chemistry and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:10605-10. 2002
  4. pmc Genetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape
    M Mattiazzi
    Department of Molecular and Biomedical Sciences, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
    Mol Genet Genomics 283:519-30. 2010
  5. pmc A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation
    Young Ha Song
    Division of Molecular and Life Science, College of Science and Technology, Hanyang University, 1271 Sa 3 dong, Sangnok gu, Ansan, Gyeonggi do 426 791, Republic of Korea
    J Biol Chem 285:2361-7. 2010
  6. pmc Novel roles for selected genes in meiotic DNA processing
    Philip W Jordan
    Institute of Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 3:e222. 2007
  7. pmc Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae
    Mary A Braun
    Department of Biological Sciences, University of Pittsburgh, 269 Crawford Hall, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA
    Mol Cell Biol 27:2800-11. 2007
  8. pmc The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes
    Tiaojiang Xiao
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, 405 Mary Ellen Jones, Chapel Hill, NC 27599 7260, USA
    Mol Cell Biol 27:721-31. 2007
  9. pmc The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3
    David G E Martin
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Mol Cell Biol 26:7871-9. 2006
  10. pmc The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720, USA
    Genetics 173:1951-68. 2006

Research Grants

Scientific Experts

  • John Game
  • Young Ha Song
  • M Mattiazzi
  • Philip W Jordan
  • Tiaojiang Xiao
  • Mary A Braun
  • David G E Martin
  • Xiaoting Zhang
  • William W Hwang
  • Denise Hanway
  • J L DeRisi
  • I Krizaj
  • U Petrovic
  • Seong Hoon Ahn
  • P Kaferle
  • A Jambhekar
  • Karen M Arndt
  • Michael J Buck
  • Elia M Crisucci
  • Patrick J Costa
  • R Nicholas Laribee
  • David R F Leach
  • Franz Klein
  • Jack F Greenblatt
  • Yoichiro Shibata
  • Bhargavi Rao
  • Jason D Lieb
  • Rose O'Rourke
  • Brian D Strahl
  • Nevan J Krogan
  • LeAnn Howe
  • Martin J Wlodarski
  • Vicki E MacDonald
  • Kay L Walter
  • Or Gozani
  • Xiaobing Shi
  • Kristin Baetz
  • Philip Hieter
  • Sneh Lata Panwar
  • Frederic Devaux
  • Ania Kolaczkowska
  • Timothy C Hallstrom
  • Claude Jacq
  • W Scott Moye-Rowley
  • Shivkumar Venkatasubrahmanyam
  • Charles Boone
  • Hiten D Madhani
  • Amy Tong
  • Alexandra G Ianculescu
  • Floyd E Romesberg
  • Jodie K Chin
  • Guy Oshiro
  • Elizabeth A Winzeler
  • Gang Xia

Detail Information

Publications11

  1. ncbi A conserved RING finger protein required for histone H2B monoubiquitination and cell size control
    William W Hwang
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 11:261-6. 2003
    ..The RING domain of Bre1 is essential for both of these modifications as is Lge1 (Large 1), a protein required for cell size control that copurifies with Bre1...
  2. ncbi Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination
    Xiaoting Zhang
    Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:2759-70. 2005
    ..These findings provide a strong argument that Lge1p has roles in gene regulation independent of its participation in the Rad6p-dependent ubiquitination of H2B...
  3. pmc Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast
    Denise Hanway
    Department of Chemistry and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:10605-10. 2002
    ..Epistatsis analysis of four of the genes was performed to determine the DNA damage repair pathways in which the protein products function...
  4. pmc Genetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape
    M Mattiazzi
    Department of Molecular and Biomedical Sciences, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
    Mol Genet Genomics 283:519-30. 2010
    ....
  5. pmc A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation
    Young Ha Song
    Division of Molecular and Life Science, College of Science and Technology, Hanyang University, 1271 Sa 3 dong, Sangnok gu, Ansan, Gyeonggi do 426 791, Republic of Korea
    J Biol Chem 285:2361-7. 2010
    ..Here, we show that Lge1 (Large 1) is found in a complex containing Rad6...
  6. pmc Novel roles for selected genes in meiotic DNA processing
    Philip W Jordan
    Institute of Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 3:e222. 2007
    ..We show how existing datasets may be used to define gene sets enriched for specific roles and how these can be evaluated by experimental analysis...
  7. pmc Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae
    Mary A Braun
    Department of Biological Sciences, University of Pittsburgh, 269 Crawford Hall, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA
    Mol Cell Biol 27:2800-11. 2007
    ..Taken together, our results identify a new participant in a protein ubiquitylation pathway within the nucleus that acts to modulate chromatin function and transcription...
  8. pmc The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes
    Tiaojiang Xiao
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, 405 Mary Ellen Jones, Chapel Hill, NC 27599 7260, USA
    Mol Cell Biol 27:721-31. 2007
    ....
  9. pmc The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3
    David G E Martin
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Mol Cell Biol 26:7871-9. 2006
    ..These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation...
  10. pmc The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18
    John C Game
    Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720, USA
    Genetics 173:1951-68. 2006
    ..We conclude that IR resistance conferred by BRE1 and DOT1 is mediated through homologous recombinational repair, not postreplication repair, and confirm findings of a G1 checkpoint role for the RAD6/BRE1/DOT1 pathway...

Research Grants1

  1. Repair Pathways for Ionizing Radiation Damage Yeast
    John Game; Fiscal Year: 2006
    ..Recent and existing mutants will be studied in detail with this system to determine the molecular involvement of each gene in DSB repair, sister chromatid exchange and recombination between chromosomes. ..