GCR1

Summary

Gene Symbol: GCR1
Description: transcription regulator GCR1
Alias: LPF10, SIT3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Rap1p requires Gcr1p and Gcr2p homodimers to activate ribosomal protein and glycolytic genes, respectively
    S J Deminoff
    Department of Biological Sciences and Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS 39406 5018, USA
    Genetics 158:133-43. 2001
  2. ncbi Mutations in GCR1 affect SUC2 gene expression in Saccharomyces cerevisiae
    S Turkel
    Department of Biology, Faculty of Arts and Sciences, Uludag University, 16059 Bursa, Turkey
    Mol Genet Genomics 268:825-31. 2003
  3. ncbi The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level
    Kellie E Barbara
    Mississippi Functional Genomics Network, The University of Southern Mississippi, 118 College Dr, Hattiesburg, MS, USA
    Mol Genet Genomics 277:171-88. 2007
  4. pmc GCR1, a transcriptional activator in Saccharomyces cerevisiae, complexes with RAP1 and can function without its DNA binding domain
    J Tornow
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406 5018
    EMBO J 12:2431-7. 1993
  5. pmc Activation mechanism of the multifunctional transcription factor repressor-activator protein 1 (Rap1p)
    C M Drazinic
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville 32610 0266, USA
    Mol Cell Biol 16:3187-96. 1996
  6. pmc Multiple domains of repressor activator protein 1 contribute to facilitated binding of glycolysis regulatory protein 1
    M C Lopez
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Box 100266, JHMHC, Gainesville, FL 32610 0266, USA
    Proc Natl Acad Sci U S A 95:14112-7. 1998
  7. doi The expression of PHO92 is regulated by Gcr1, and Pho92 is involved in glucose metabolism in Saccharomyces cerevisiae
    Hyun Jun Kang
    School of Life Sciences and Biotechnology, Korea University, Anam Dong, Sungbuk Gu, Seoul, Republic of Korea
    Curr Genet 60:247-53. 2014
  8. pmc Improvement of glucose uptake rate and production of target chemicals by overexpressing hexose transporters and transcriptional activator Gcr1 in Saccharomyces cerevisiae
    Daehee Kim
    School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
    Appl Environ Microbiol 81:8392-401. 2015
  9. pmc Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase
    Jennifer L Stundon
    Department of Molecular Biology, Princeton University, New Jersey 08544
    G3 (Bethesda) 5:2913-8. 2015
  10. ncbi The yeast protein Gcr1p binds to the PGK UAS and contributes to the activation of transcription of the PGK gene
    Y A Henry
    Department of Biochemistry, Oxford University, UK
    Mol Gen Genet 245:506-11. 1994

Scientific Experts

  • S Turkel
  • H Uemura
  • Kristine A Willis
  • George M Santangelo
  • Daehee Kim
  • Jennifer L Stundon
  • Hyun Jun Kang
  • Kellie E Barbara
  • Takayuki Mizuno
  • Zsolt Szijgyarto
  • Nayan J Sarma
  • Hiromi Sasaki
  • Tomoko Kishimoto
  • Tomoko Shinzato
  • S J Deminoff
  • M C Lopez
  • Ji Sook Hahn
  • Ji Yoon Song
  • Virginia A Zakian
  • Tae Hyoung Kim
  • Miwha Chang
  • Yong Sung Park
  • Bong June Yoon
  • Cheol Won Yun
  • Chang Min Kang
  • M E Lenburg
  • H V Baker
  • Assegid Garedew
  • G M Santangelo
  • Terry Haley
  • Adolfo Saiardi
  • Thomas D Buford
  • Kellie Barbara-Haley
  • Cristina Azevedo
  • P Fortes
  • P Herrero
  • Terry M Haley
  • X Zeng
  • C M Drazinic
  • David Sinclair
  • Alistair Chambers
  • Jason Wood
  • J B Smerage
  • Robin Haw
  • Jason Moffat
  • Brenda Andrews
  • Balaraj B Menon
  • E K O'Shea
  • L Flores
  • T de la Cera
  • F Moreno
  • M Fornerod
  • J Kufel
  • I W Mattaj
  • D Lafontaine
  • D Tollervey
  • M Polycarpou-Schwarz
  • Y A Henry
  • J Tornow
  • M A Huie
  • A Chambers
  • C A Stanway
  • S M Kingsman
  • J M Gibbs
  • W Gao
  • I K Hornstra
  • E W Scott
  • M J Holland
  • B Pavlovic
  • T P Yang
  • J P Holland
  • T Yokoi
  • K Myambo
  • M A Innis
  • W Hörz

Detail Information

Publications28

  1. pmc Rap1p requires Gcr1p and Gcr2p homodimers to activate ribosomal protein and glycolytic genes, respectively
    S J Deminoff
    Department of Biological Sciences and Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS 39406 5018, USA
    Genetics 158:133-43. 2001
    ..Dichotomous Rap1p activation and its striking requirement for distinct homodimeric subunits give cells the capacity to switch between coordinated and uncoupled RP and glycolytic gene regulation...
  2. ncbi Mutations in GCR1 affect SUC2 gene expression in Saccharomyces cerevisiae
    S Turkel
    Department of Biology, Faculty of Arts and Sciences, Uludag University, 16059 Bursa, Turkey
    Mol Genet Genomics 268:825-31. 2003
    ..We show that, in addition to these factors, expression of SUC2 is affected by mutations in the gene GCR1 that encodes the glycolysis regulatory protein Gcr1p...
  3. ncbi The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level
    Kellie E Barbara
    Mississippi Functional Genomics Network, The University of Southern Mississippi, 118 College Dr, Hattiesburg, MS, USA
    Mol Genet Genomics 277:171-88. 2007
    ..In Saccharomyces cerevisiae, the transcription factor Gcr1 contributes to this coordination by supporting maximum expression of G1 cyclins in addition to regulating both ..
  4. pmc GCR1, a transcriptional activator in Saccharomyces cerevisiae, complexes with RAP1 and can function without its DNA binding domain
    J Tornow
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406 5018
    EMBO J 12:2431-7. 1993
    ..of glycolytic and translational component genes requires two DNA binding proteins, RAP1 (which binds to UASRPG) and GCR1 (which binds to the CT box)...
  5. pmc Activation mechanism of the multifunctional transcription factor repressor-activator protein 1 (Rap1p)
    C M Drazinic
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville 32610 0266, USA
    Mol Cell Biol 16:3187-96. 1996
    ..This work demonstrates that the role of the Rap1p in the activation of glycolytic enzyme genes is to bind in their UAS elements and to facilitate the binding of Gcr1p at adjacent binding sites...
  6. pmc Multiple domains of repressor activator protein 1 contribute to facilitated binding of glycolysis regulatory protein 1
    M C Lopez
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Box 100266, JHMHC, Gainesville, FL 32610 0266, USA
    Proc Natl Acad Sci U S A 95:14112-7. 1998
    ..DNA.Gcr1p complexes was inhibited by all but the DNA-binding domain of Rap1p itself; however, the ability of each individual protein to bind the DNA probe was unaffected...
  7. doi The expression of PHO92 is regulated by Gcr1, and Pho92 is involved in glucose metabolism in Saccharomyces cerevisiae
    Hyun Jun Kang
    School of Life Sciences and Biotechnology, Korea University, Anam Dong, Sungbuk Gu, Seoul, Republic of Korea
    Curr Genet 60:247-53. 2014
    ..Furthermore, two conserved Gcr1-binding regions were identified in the upstream, untranslated region of PHO92...
  8. pmc Improvement of glucose uptake rate and production of target chemicals by overexpressing hexose transporters and transcriptional activator Gcr1 in Saccharomyces cerevisiae
    Daehee Kim
    School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
    Appl Environ Microbiol 81:8392-401. 2015
    ..In addition, improved cell growth and glucose uptake rates could be achieved by overexpression of GCR1, which led to increased transcription levels of HXT1 and ribosomal protein genes...
  9. pmc Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase
    Jennifer L Stundon
    Department of Molecular Biology, Princeton University, New Jersey 08544
    G3 (Bethesda) 5:2913-8. 2015
    ..This study identified eleven genes that were synthetic lethal (APM1, ARG80, CDH1, GCR1, GTO3, PRK1, RAD10, SKT5, SOP4, UMP1, and YCK1) and three genes that were synthetic sick (DEF1, YIP4, and HOM3) ..
  10. ncbi The yeast protein Gcr1p binds to the PGK UAS and contributes to the activation of transcription of the PGK gene
    Y A Henry
    Department of Biochemistry, Oxford University, UK
    Mol Gen Genet 245:506-11. 1994
    ..In this report we show by in vivo footprinting that the regulatory factor encoded by GCR1 binds to two elements in the 3' half of the PGK UAS...
  11. pmc The nuclear pore complex mediates binding of the Mig1 repressor to target promoters
    Nayan J Sarma
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi, United States of America
    PLoS ONE 6:e27117. 2011
    ..We propose that the NPC contributes to both repression and activation at the level of transcription...
  12. pmc Functional characterization of transcriptional regulatory elements in the upstream region of the yeast GLK1 gene
    P Herrero
    Departamento de Bioqu approximately ímica y Biolog approximately ía Molecular, Instituto Universitario de Biotecnolog approximately ía de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain
    Biochem J 343:319-25. 1999
    ..First, the expression seemed to be mediated mainly by one GCR1 and three stress-responsive element (STRE) activating elements...
  13. doi Influence of inositol pyrophosphates on cellular energy dynamics
    Zsolt Szijgyarto
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 334:802-5. 2011
    ..We demonstrate that inositol pyrophosphates control the activity of the major glycolytic transcription factor GCR1. Thus, inositol pyrophosphates regulate ATP concentration by altering the glycolytic/mitochondrial metabolic ratio...
  14. pmc Genetic and physical interactions involving the yeast nuclear cap-binding complex
    P Fortes
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Mol Cell Biol 19:6543-53. 1999
    ..Mutants lacking yCBC were found to be defective in rRNA processing. Analysis of the yCBC deletion phenotype suggests that this is likely to be due to a defect in the splicing of a subset of ribosomal protein mRNA precursors...
  15. ncbi Expression of GCR1, the transcriptional activator of glycolytic enzyme genes in the yeast Saccharomyces cerevisiae, is positively autoregulated by Gcr1p
    Hiromi Sasaki
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, 305 8566, Japan
    Yeast 22:305-19. 2005
    When regulation of GCR1 expression was analysed using a GCR1-lacZ fusion, lacZ expression levels were decreased in the Deltagcr1 or Deltagcr2 mutant...
  16. ncbi Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae
    Takayuki Mizuno
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan
    Yeast 21:851-66. 2004
    ..Disruption of gcr1 and/or gcr2 in the two-hybrid reporter strain demonstrated that the interaction with Gcr1p does not require Gcr2p, ..
  17. pmc The global transcriptional activator of Saccharomyces cerevisiae, Gcr1p, mediates the response to glucose by stimulating protein synthesis and CLN-dependent cell cycle progression
    Kristine A Willis
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, USA
    Genetics 165:1017-29. 2003
    ..known to mediate passage through Start and determine cell size by modulating levels of Cln3p, we hypothesized that GCR1 regulates cell cycle progression by coordinating it with growth...
  18. pmc Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase
    M E Lenburg
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 0448, USA
    Genetics 157:39-51. 2001
    ..Pho Eighty-Five Requiring or Efr loci, six of which are previously identified genes-BEM2 (YER155C), SPT7 (YBR081C), GCR1 (YPL075W), SRB5 (YGR104C), HFI1 (YPL254W), and BCK1 (YJL095W)-with one novel gene (YMR212C)...
  19. pmc Role of GCR2 in transcriptional activation of yeast glycolytic genes
    H Uemura
    Division of Biological Chemistry, Tsukuba Research Center MITI, Ibaraki, Japan
    Mol Cell Biol 12:3834-42. 1992
    ..Fairly homologous regions were found between Gcr2 and Gcr1 proteins. To test potential interactions, the genetic method of S. Fields and O...
  20. ncbi Transcription of the HXT4 gene is regulated by Gcr1p and Gcr2p in the yeast S. cerevisiae
    S Turkel
    Abant Izzet Baysal University, Faculty of Arts and Sciences, Department of Biology, 14280 Bolu, Turkey
    Yeast 15:1045-57. 1999
    ..Transcription of HXT4 decreased about 35-fold in gcr1 mutant and two-fold in gcr2 mutant yeast cells...
  21. pmc The role of Gcr1p in the transcriptional activation of glycolytic genes in yeast Saccharomyces cerevisiae
    H Uemura
    Department of Molecular Biology, National Institute of Bioscience and Human Technology, Tsukuba Research Center, Ibaraki, Japan
    Genetics 147:521-32. 1997
    ..However, it was dependent on both GCR1 and GCR2...
  22. pmc Specialized Rap1p/Gcr1p transcriptional activation through Gcr1p DNA contacts requires Gcr2p, as does hyperphosphorylation of Gcr1p
    X Zeng
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406 5018, USA
    Genetics 147:493-505. 1997
    ..form of Gcr1p disappears in delta gcr2 cells but reappears if they harbor a doubly point-mutated GCR1 allele that bypasses the Gcr2- growth defect...
  23. ncbi GCR1-dependent transcriptional activation of yeast retrotransposon Ty2-917
    S Turkel
    Department of Biology, Faculty of Arts and Sciences, Abant Izzet Baysal University, Bolu, Turkey
    Yeast 13:917-30. 1997
    ..Here we show that activation by both of these sites depends on the GCR1 product, a transcription factor which also regulates the genes encoding yeast glycolytic enzymes...
  24. pmc Mutations in GCR1, a transcriptional activator of Saccharomyces cerevisiae glycolytic genes, function as suppressors of gcr2 mutations
    H Uemura
    Department of Molecular Biology, Tsukuba Research Center MITI, Ibaraki, Japan
    Genetics 139:511-21. 1995
    The Saccharomyces cerevisiae GCR1 and GCR2 genes affect expression of most of the glycolytic genes...
  25. pmc The GCR1 gene encodes a positive transcriptional regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families in Saccharomyces cerevisiae
    M J Holland
    Mol Cell Biol 7:813-20. 1987
    ..TDH2, and TDH3) genes were coordinately reduced more than 20-fold in a Saccharomyces cerevisiae strain carrying the gcr1-1 mutation...
  26. pmc The chromatin structure at the promoter of a glyceraldehyde phosphate dehydrogenase gene from Saccharomyces cerevisiae reflects its functional state
    B Pavlovic
    Institut fur Physiologische Chemie, Universitat Munchen, Federal Republic of Germany
    Mol Cell Biol 8:5513-20. 1988
    ..In a mutant which lacks the trans-activating protein GCR1 and which as a consequence expresses TDH3 at less than 5% of the wild-type level, the chromatin structure is ..
  27. pmc GCR1 of Saccharomyces cerevisiae encodes a DNA binding protein whose binding is abolished by mutations in the CTTCC sequence motif
    H V Baker
    Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville 32610
    Proc Natl Acad Sci U S A 88:9443-7. 1991
    In Saccharomyces cerevisiae, glycolysis enzymes constitute 30-60% of the soluble protein. GCR1 gene function is required for high-level glycolytic gene expression...
  28. pmc Characterization of the DNA-binding activity of GCR1: in vivo evidence for two GCR1-binding sites in the upstream activating sequence of TPI of Saccharomyces cerevisiae
    M A Huie
    Department of Immunology and Medical Microbiology, University of Florida College of Medicine, Gainesville 32610 0266
    Mol Cell Biol 12:2690-700. 1992
    b>GCR1 gene function is required for high-level glycolytic gene expression in Saccharomyces cerevisiae...