CLC1

Summary

Gene Symbol: CLC1
Description: Clc1p
Alias: SCD4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast
    W E Gall
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
    Curr Biol 10:1349-58. 2000
  2. ncbi A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo
    B Pishvaee
    Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California 90024, USA
    Nat Cell Biol 2:958-63. 2000
  3. doi Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain
    Douglas R Boettner
    Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, USA
    Traffic 17:754-68. 2016
  4. pmc Clathrin binding by the adaptor Ent5 promotes late stages of clathrin coat maturation
    Chao Wei Hung
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
    Mol Biol Cell 27:1143-53. 2016
  5. pmc The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p
    David Shen
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 202:509-26. 2013
  6. pmc Chs5/6 complex: a multiprotein complex that interacts with and conveys chitin synthase III from the trans-Golgi network to the cell surface
    Siraprapha Sanchatjate
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 17:4157-66. 2006
  7. pmc Adaptor autoregulation promotes coordinated binding within clathrin coats
    Chao Wei Hung
    Department of Biology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 287:17398-407. 2012
  8. ncbi Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif
    Mara C Duncan
    Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Nat Cell Biol 5:77-81. 2003
  9. pmc Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis
    Iwona I Smaczynska-de Rooij
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Traffic 9:559-73. 2008
  10. pmc Ent3p and Ent5p exhibit cargo-specific functions in trafficking proteins between the trans-Golgi network and the endosomes in yeast
    Alenka Copic
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California at Berkeley, CA 94720, USA
    Mol Biol Cell 18:1803-15. 2007

Scientific Experts

  • B Wendland
  • Chao Wei Hung
  • Mara C Duncan
  • Sandra K Lemmon
  • Thomas M Newpher
  • Douglas R Boettner
  • David Shen
  • G S Payne
  • B Pishvaee
  • Iwona I Smaczynska-de Rooij
  • Gregory S Payne
  • Alenka Copic
  • Randy Schekman
  • Siraprapha Sanchatjate
  • G Costaguta
  • Arun Malhotra
  • Nagore de Leon
  • John R Collette
  • John Creagh
  • Balaji T Moorthy
  • VERONICA A SEGARRA
  • Kenneth R Henry
  • Karin Reinisch
  • Alex Hutagalung
  • Xudong Wu
  • Hua Yuan
  • Avani Verma
  • James A McNew
  • Daniel K├╝mmel
  • Peter Novick
  • Ajit P Joglekar
  • O Deloche
  • Quyen L Aoh
  • B G Yeung
  • W E Gall
  • Kathryn R Ayscough
  • Rosaria Costa
  • C J Stefan
  • Trevor L Starr
  • Fatima Zahra Idrissi
  • Maria Isabel Geli
  • K M Huang
  • Giancarlo Costaguta
  • Howard Riezman
  • Kristen Huang
  • JiSuk Chang
  • R Tod Hudson
  • D S Chu
  • Kathleen D'hondt
  • Thomas Newpher
  • E S Bensen
  • R Schekman
  • S D Emr
  • T R Graham
  • T Greener
  • M F Ingram
  • E Eisenberg
  • D M Cyr
  • J M McCaffery
  • S Ryazantsev
  • M A Higginbotham
  • C Chen
  • L E Greene
  • A Munn
  • S K Lemmon
  • L Gullberg
  • K K Nelson
  • K Blumer

Detail Information

Publications19

  1. ncbi The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast
    W E Gall
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
    Curr Biol 10:1349-58. 2000
    ..Removal of the clathrin coat in vitro requires the uncoating ATPase Hsc70 and its DnaJ cofactor auxilin. To date, a requirement for auxilin and Hsc70 in clathrin function in vivo has not been demonstrated...
  2. ncbi A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo
    B Pishvaee
    Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California 90024, USA
    Nat Cell Biol 2:958-63. 2000
    ..Our results demonstrate an in vivo uncoating function of a J domain co-chaperone and establish the physiological significance of uncoating in transport mediated by clathrin-coated vesicles...
  3. doi Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain
    Douglas R Boettner
    Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, USA
    Traffic 17:754-68. 2016
    ..both the clathrin heavy (CHC) and clathrin light (CLC) chain, since Chc1 does not form stable trimers without Clc1. To further delineate clathrin subunit functions, we constructed a chimeric CHC protein (Chc-YR) , which fused the ..
  4. pmc Clathrin binding by the adaptor Ent5 promotes late stages of clathrin coat maturation
    Chao Wei Hung
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
    Mol Biol Cell 27:1143-53. 2016
    ..These findings support a model in which Ent5 clathrin binding performs a mechanistic role in coat maturation, whereas Ent5 adaptor binding promotes cargo incorporation...
  5. pmc The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p
    David Shen
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 202:509-26. 2013
    ..We propose that the exocyst is recruited to secretory vesicles by the combinatorial signals of Sec4-GTP and the Snc proteins. This could help to confer both specificity and directionality to vesicular traffic. ..
  6. pmc Chs5/6 complex: a multiprotein complex that interacts with and conveys chitin synthase III from the trans-Golgi network to the cell surface
    Siraprapha Sanchatjate
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 17:4157-66. 2006
    ..Our results suggest a model of protein sorting at the TGN that involves a peripheral, possibly coat, complex that includes multiple related copies of a specificity determining subunit...
  7. pmc Adaptor autoregulation promotes coordinated binding within clathrin coats
    Chao Wei Hung
    Department of Biology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 287:17398-407. 2012
    ..This autoregulation influences the temporal and/or spatial location of the Gga2-Ent5 interaction. We propose that this synergistic binding provides built-in regulation to ensure the correct assembly of clathrin coats...
  8. ncbi Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif
    Mara C Duncan
    Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Nat Cell Biol 5:77-81. 2003
    ..On the basis of our results and the established roles of epsin and epsin-related proteins in endocytosis, we propose that ENTH-domain-containing proteins are a universal component of CCV formation...
  9. pmc Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis
    Iwona I Smaczynska-de Rooij
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Traffic 9:559-73. 2008
    ..Our data provide evidence for a mechanism in yeast to positively regulate plasma membrane production of PtdIns(4,5)P2 levels and that these changes impact on endocytosis...
  10. pmc Ent3p and Ent5p exhibit cargo-specific functions in trafficking proteins between the trans-Golgi network and the endosomes in yeast
    Alenka Copic
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California at Berkeley, CA 94720, USA
    Mol Biol Cell 18:1803-15. 2007
    ..We conclude that the clathrin adaptors AP-1, Ent3p, Ent5p, and the Ggas cooperate in different ways to sort proteins between the TGN and the endosomes...
  11. pmc Novel function of clathrin light chain in promoting endocytic vesicle formation
    Thomas M Newpher
    Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL 33101, USA
    Mol Biol Cell 17:4343-52. 2006
    ..We propose that LC binding to Sla2p positively regulates Sla2p for efficient endocytic vesicle formation...
  12. pmc Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast
    Thomas M Newpher
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Traffic 7:574-88. 2006
    ..These data demonstrate an important role for clathrin in organization and progression of early endocytic patches to the late stages of endocytosis...
  13. ncbi The light chain subunit is required for clathrin function in Saccharomyces cerevisiae
    D S Chu
    Molecular Biology Institute and the Department of Biological Chemistry, University of California, Los Angeles, California 90095 1737, USA
    J Biol Chem 271:33123-30. 1996
    ..Upon disruption (clc1Delta) of the single Clc-encoding gene (CLC1) in yeast, the steady state protein levels of Chc decreased 5-10-fold compared with wild type cells; consequently, ..
  14. pmc Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast
    Kenneth R Henry
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland Ohio 44106, USA
    Mol Biol Cell 13:2607-25. 2002
    ..Therefore, Scd5p and clathrin are important for actin organization and endocytosis, and Sla2p may provide a critical link between clathrin and the actin cytoskeleton in yeast, similar to HIP1(R) in animal cells...
  15. pmc Yeast Gga coat proteins function with clathrin in Golgi to endosome transport
    G Costaguta
    Department of Biological Chemistry, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    Mol Biol Cell 12:1885-96. 2001
    ..Our results indicate that yeast Gga proteins play an important role in cargo-selective clathrin-mediated protein traffic from the trans-Golgi network to endosomes...
  16. pmc Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles
    O Deloche
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, 229 Stanley Hall, Berkeley, California 94720 3206, USA
    Mol Biol Cell 12:475-85. 2001
    ..The Vps10p C-terminal domain appears to play a principal role in retrieval of Vps10p from the prevacuolar compartment rather than in sorting from the TGN...
  17. pmc Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis
    B Wendland
    Howard Hughes Medical Institute, Division of Cellular and Molecular Medicine, University of California at San Diego, School of Medicine, La Jolla, California 92093 0668, USA
    J Cell Biol 141:71-84. 1998
    ..We suggest that Pan1p (and by extension eps15) serves as a multivalent adaptor around which dynamic interactions between structural and regulatory components of the endocytic pathway converge...
  18. pmc A novel structural model for regulation of clathrin function
    B Pishvaee
    Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90095, USA
    EMBO J 16:2227-39. 1997
    ..On the basis of this conclusion, we propose a new model for the organization of the triskelion vertex which provides a structural basis for regulatory effects of Clc on clathrin function...
  19. ncbi Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast
    K M Huang
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4960, USA
    J Cell Sci 110:899-910. 1997
    ..of the clathrin light chain, we characterized yeast strains carrying a disruption of the clathrin light chain gene (CLC1)...