BUL2

Summary

Gene Symbol: BUL2
Description: ubiquitin-ubiquitin ligase BUL2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions
    H Yashiroda
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Gene 225:39-46. 1998
  2. pmc Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease
    S B Helliwell
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 153:649-62. 2001
  3. pmc Quality control of plasma membrane proteins by Saccharomyces cerevisiae Nedd4-like ubiquitin ligase Rsp5p under environmental stress conditions
    Takeki Shiga
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Eukaryot Cell 13:1191-9. 2014
  4. doi An impaired ubiquitin ligase complex favors initial growth of auxotrophic yeast strains in synthetic grape must
    Ana Mangado
    Instituto de Ciencias de la Vid y del Vino, ICVV, CSIC Universidad de La Rioja Gobierno de La Rioja, Madre de Dios 51, 26006, Logrono, La Rioja, Spain
    Appl Microbiol Biotechnol 99:1273-86. 2015
  5. doi Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2
    Daisuke Watanabe
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Biochem Biophys Res Commun 463:76-81. 2015
  6. pmc Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast
    Elizabeth X Kwan
    Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 7:e1002250. 2011
  7. pmc Bul proteins, a nonredundant, antagonistic family of ubiquitin ligase regulatory proteins
    Tatiana V Novoselova
    School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom
    Eukaryot Cell 11:463-70. 2012
  8. pmc Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors
    Ahmad Merhi
    Molecular Physiology of the Cell, Universite Libre de Bruxelles, IBMM, Gosselies, Belgium
    Mol Cell Biol 32:4510-22. 2012
  9. doi Phosphorylation of a conserved Thr357 in yeast Nedd4-like ubiquitin ligase Rsp5 is involved in down-regulation of the general amino acid permease Gap1
    Toshiya Sasaki
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Genes Cells 18:459-75. 2013
  10. pmc Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
    T Andoh
    Department of Biochemistry, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
    Mol Cell Biol 20:6712-20. 2000

Detail Information

Publications13

  1. ncbi The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions
    H Yashiroda
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Gene 225:39-46. 1998
    ..We have identified the BUL2 gene as a functional homologue of BUL1...
  2. pmc Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease
    S B Helliwell
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 153:649-62. 2001
    ..These results indicate that Bul1p and Bul2p, together with Rsp5p, generate a polyubiquitin signal on Gap1p that specifies its intracellular targeting to the vacuole...
  3. pmc Quality control of plasma membrane proteins by Saccharomyces cerevisiae Nedd4-like ubiquitin ligase Rsp5p under environmental stress conditions
    Takeki Shiga
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Eukaryot Cell 13:1191-9. 2014
    ..Our findings suggest that stress-induced quality control is a common process requiring Rsp5p for plasma membrane proteins in yeast...
  4. doi An impaired ubiquitin ligase complex favors initial growth of auxotrophic yeast strains in synthetic grape must
    Ana Mangado
    Instituto de Ciencias de la Vid y del Vino, ICVV, CSIC Universidad de La Rioja Gobierno de La Rioja, Madre de Dios 51, 26006, Logrono, La Rioja, Spain
    Appl Microbiol Biotechnol 99:1273-86. 2015
    ..In addition, the use of very stable continuous fermentation conditions might lead to the selection of a rather limited number of adaptive responses that would mask other possible targets for genetic improvement. ..
  5. doi Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2
    Daisuke Watanabe
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Biochem Biophys Res Commun 463:76-81. 2015
    ..of the general amino acid permease Gap1 via interaction with the arrestin-like adaptor proteins Bul1 and Bul2 (Bul1/2), we investigated the effects of the double mutations that abrogate the recognition of PY motifs on target ..
  6. pmc Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast
    Elizabeth X Kwan
    Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 7:e1002250. 2011
    ..We found that a single nucleotide polymorphism in BUL2, encoding a component of an ubiquitin ligase complex involved in trafficking of amino acid permeases, controls ..
  7. pmc Bul proteins, a nonredundant, antagonistic family of ubiquitin ligase regulatory proteins
    Tatiana V Novoselova
    School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom
    Eukaryot Cell 11:463-70. 2012
    ....
  8. pmc Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors
    Ahmad Merhi
    Molecular Physiology of the Cell, Universite Libre de Bruxelles, IBMM, Gosselies, Belgium
    Mol Cell Biol 32:4510-22. 2012
    ..This ubiquitylation requires the Rsp5 ubiquitin ligase and the redundant arrestin-like Bul1 and Bul2 adaptors...
  9. doi Phosphorylation of a conserved Thr357 in yeast Nedd4-like ubiquitin ligase Rsp5 is involved in down-regulation of the general amino acid permease Gap1
    Toshiya Sasaki
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Genes Cells 18:459-75. 2013
    ..From these results, we propose a possible mechanism involved in the regulation of Rsp5 activity for Gap1 down-regulation via the phosphorylation of a conserved Thr357 in the Nedd4 family...
  10. pmc Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
    T Andoh
    Department of Biochemistry, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
    Mol Cell Biol 20:6712-20. 2000
    ..Suppression of temperature sensitivity by an osmotic stabilizer is also observed in the bul1 bul2 double null mutant, and the temperature sensitivity of the bul1 bul2 double null mutant is suppressed by multiple ..
  11. ncbi Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae
    André Feller
    Institut de Recherches Microbiologiques J M Wiame, Laboratoire de Microbiologie, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Biol Chem 281:28546-54. 2006
    ..The apparent Rsp5-, Bul1/2-dependent Gln3 activation keeps to the cellular status, as it is only observed in cells having left the balanced phase of exponential growth...
  12. pmc Different ubiquitin signals act at the Golgi and plasma membrane to direct GAP1 trafficking
    April L Risinger
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 19:2962-72. 2008
    ....
  13. ncbi Rsp5-Bul1/2 complex is necessary for the HSE-mediated gene expression in budding yeast
    Daisuke Kaida
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 306:1037-41. 2003
    ..Bul1 or its homologue Bul2 binds to Rsp5 through the PY-motif and the bul1 bul2 double mutant is sensitive to various stresses...