BTT1

Summary

Gene Symbol: BTT1
Description: CCR4-NOT core subunit BTT1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane
    B Wiedmann
    Department of Biochemistry, Humboldt University, Berlin, Germany
    FEBS Lett 458:51-4. 1999
  2. pmc A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes
    Ansgar Koplin
    Laboratory of Molecular Microbiology, Department of Biology, and 2 Konstanz Research School of Chemical Biology, University of Konstanz, 78457 Konstanz, Germany
    J Cell Biol 189:57-68. 2010
  3. ncbi Initial characterization of the nascent polypeptide-associated complex in yeast
    B Reimann
    Humboldt University, Charite, Department of Biochem, Berlin, Germany
    Yeast 15:397-407. 1999
  4. pmc Prion-Associated Toxicity is Rescued by Elimination of Cotranslational Chaperones
    Kathryn M Keefer
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 12:e1006431. 2016
  5. pmc Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo
    G Z Hu
    Ludwig Institute for Cancer Research, Uppsala Biomedical Center, Sweden
    Nucleic Acids Res 22:2740-3. 1994
  6. doi Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes
    Yajun Cui
    Department of Biochemistry and Molecular Biology, Rudman Hall, University of New Hampshire, Durham, New Hampshire, 03824, USA
    Mol Genet Genomics 279:323-37. 2008
  7. pmc Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes
    Marta del Alamo
    Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America
    PLoS Biol 9:e1001100. 2011
  8. pmc The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo
    R George
    School of Biochemistry, La Trobe University, Bundoora 3083, Australia
    Proc Natl Acad Sci U S A 95:2296-301. 1998

Scientific Experts

  • B Wiedmann
  • Kathryn M Keefer
  • Marta del Alamo
  • Ansgar Koplin
  • Yajun Cui
  • Heather L True
  • Daniel J Hogan
  • Patrick O Brown
  • Véronique Albanèse
  • Sebastian Pechmann
  • Judith Frydman
  • Annika Scior
  • Marc Erhardt
  • Miriam Koch
  • Elke Deuerling
  • Yulia Ilina
  • Steffen Preissler
  • Liang Hao Ding
  • Deepti B Ramnarain
  • Clyde L Denis
  • Jeffrey S McMahon
  • B Reimann
  • Yueh Chin Chiang
  • R George
  • E Hartmann
  • J Bradsher
  • J Franke
  • M Wiedmann
  • S Prehn
  • T Lithgow
  • G Z Hu
  • K Landl
  • T Beddoe
  • H Ronne

Detail Information

Publications9

  1. ncbi The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane
    B Wiedmann
    Department of Biochemistry, Humboldt University, Berlin, Germany
    FEBS Lett 458:51-4. 1999
    ..In the absence of NAC, signal-less RNCs are able to bind to ER membranes. However, following puromycin treatment, only very few nascent chains translocate into the lumen, as detected by glycosylation...
  2. pmc A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes
    Ansgar Koplin
    Laboratory of Molecular Microbiology, Department of Biology, and 2 Konstanz Research School of Chemical Biology, University of Konstanz, 78457 Konstanz, Germany
    J Cell Biol 189:57-68. 2010
    ..These findings emphasize the concept that ribosome production is coordinated with the protein-folding capacity of ribosome-associated chaperones...
  3. ncbi Initial characterization of the nascent polypeptide-associated complex in yeast
    B Reimann
    Humboldt University, Charite, Department of Biochem, Berlin, Germany
    Yeast 15:397-407. 1999
    ..complex (alpha, beta1, beta3) in Saccharomyces cerevisiae are encoded by three genes (EGD2, EGD1, BTT1)...
  4. pmc Prion-Associated Toxicity is Rescued by Elimination of Cotranslational Chaperones
    Kathryn M Keefer
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 12:e1006431. 2016
    ..This toxicity rescue demonstrates that chaperone modification can block key steps of the prion life cycle and has exciting implications for potential treatment of many human protein conformational disorders...
  5. pmc Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo
    G Z Hu
    Ludwig Institute for Cancer Research, Uppsala Biomedical Center, Sweden
    Nucleic Acids Res 22:2740-3. 1994
    ..Mol. Cell. Biol. 12, 5683-5689, 1992]. We have cloned a second yeast gene, BTT1, which also encodes a BTF3 homologue...
  6. doi Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes
    Yajun Cui
    Department of Biochemistry and Molecular Biology, Rudman Hall, University of New Hampshire, Durham, New Hampshire, 03824, USA
    Mol Genet Genomics 279:323-37. 2008
    ..b>BTT1, a member of the nascent polypeptide association complex that binds the ribosome, was shown to be a tenth member of ..
  7. pmc Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes
    Marta del Alamo
    Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America
    PLoS Biol 9:e1001100. 2011
    ..The strategy we used should be generally applicable to mapping the specificity, interplay, and dynamics of the cotranslational protein homeostasis network...
  8. pmc The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo
    R George
    School of Biochemistry, La Trobe University, Bundoora 3083, Australia
    Proc Natl Acad Sci U S A 95:2296-301. 1998
    ..We suggest that NAC provides a ribosomal environment for nascent mitochondrial targeting sequences to achieve secondary structure, thereby enhancing the efficiency of protein targeting...