Genomes and Genes
Gene Symbol: BCK2
Species: Saccharomyces cerevisiae S288c
- A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathwayK S Lee
Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
Mol Cell Biol 13:5843-53. 1993..The other suppressor gene, designated BCK2 (for bypass of C kinase), is predicted to encode a 92-kDa protein that is rich in serine and threonine residues...
- Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle STARTC B Epstein
Rockefeller University, New York, New York 10021
Mol Cell Biol 14:2041-7. 1994..at a low copy number; the gene responsible was distinct from BYC1 and was identical to the recently described BCK2 gene...
- Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shockVenkata K Kuravi
Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Biol Cell 22:4892-907. 2011..Here we establish that Cbk1 is critical for heat shock and cell wall stress signaling via Bck2, a protein associated with the Pkc1-Mpk1 cell integrity pathway...
- Bck2 is a phase-independent activator of cell cycle-regulated genes in yeastFrancisco Ferrezuelo
Departament de Ciencies Mediques Basiques, Institut the Recerca Biomèdica de Lleida, Universitat de Lleida, Lleida, Spain
Cell Cycle 8:239-52. 2009..b>Bck2 becomes essential in the absence of Cln3, the most upstream activator of this transcriptional program...
- CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeastMichael Costanzo
Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, M5S 1A8, Canada
Cell 117:899-913. 2004..Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes...
- Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5Robertus A M de Bruin
Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Cell 117:887-98. 2004..Like mammalian Rb, Whi5 is a G1-specific transcriptional repressor antagonized by CDK...
- G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1Michael Costanzo
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Mol Cell Biol 23:5064-77. 2003..Chromatin immunoprecipitation experiments confirm that Stb1 localizes to promoters of MBF-regulated genes. Our data indicate that, contrary to previous models, MBF and SBF have unique components and might be distinctly regulated...
- Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiaeIvan Munoz
Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona
Yeast 20:157-69. 2003..The screening yielded several genes known to perform key roles in cell cycle events, such as CLN3, BCK2 or SWI4, thus proving its usefulness as a tool for this type of studies...
- KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2, a gene involved in cell cycle progression in Saccharomyces cerevisiaeHelene Martin-Yken
Centre de Bioingenierie Gilbert Durand, UMR CNRS 5504, UR INRA 792, 31077 Toulouse, France
Curr Genet 41:323-32. 2002..The evidence that KNR4 is a member of the PKC1 pathway and genetically interacts with BCK2, a gene involved together with Cln3-Cdc28 in the G1 to S transition phase of the cell cycle, was as follows...
- Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiaeH Wijnen
Graduate Program in Genetics State University of New York, Stony Brook, New York 11792, USA
Genetics 153:1131-43. 1999..Activation of SBF and MBF depends on the G(1) cyclin Cln3 and a largely uncharacterized protein called Bck2. We show here that the induction of SBF/MBF target genes by Bck2 depends partly, but not wholly, on SBF and MBF...
- Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2C J Di Como
Cold Spring Harbor Laboratory, New York 11724 2212
Mol Cell Biol 15:1835-46. 1995..The members of one of these complementation groups have mutations in the BCK2 gene...
- Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiaeP D Andrews
Department of Biochemistry, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
J Cell Sci 113:507-20. 2000..Dephosphorylation by PP1 therefore functions positively to promote cell integrity, bud morphology and polarization of the actin cytoskeleton and glc7-10 cells require higher levels of Pkc1p activity to sustain these functions...
- Experimental testing of a new integrated model of the budding yeast Start transitionNeil R Adames
Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061
Mol Biol Cell 26:3966-84. 2015..Our study demonstrates the advantages of combining model design, simulation, and testing in a coordinated effort to better understand a complex biological network. ..
- Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeastNazareth Bastajian
The Donnelly Centre and the Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
PLoS Genet 9:e1003507. 2013The Bck2 protein is a potent genetic regulator of cell-cycle-dependent gene expression in budding yeast...
- A network of yeast basic helix-loop-helix interactionsK A Robinson
Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA
Nucleic Acids Res 28:4460-6. 2000..Ino2p is the only protein in common with the data presented here. Our finding that Ino4p interacts with five bHLH proteins suggests that Ino4p is likely to be a central player in the coordination of multiple biological processes...
- Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiaeRitu Pathak
Department of Biochemistry and Biophysics, Texas A and M University, 2128 TAMU, College Station, TX 77843, USA
Eukaryot Cell 3:1627-38. 2004..Our findings identify two gene products with a probable regulatory role in the timing of initiation of cell division...
- Multiple pathways for suppression of mutants affecting G1-specific transcription in Saccharomyces cerevisiaeKarin Flick
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Genetics 169:37-49. 2005..Together with additional characterization these findings indicate that multiple independent pathways are sufficient for proliferation in the absence of G(1)-specific transcriptional activators...
- The 'interactome' of the Knr4/Smi1, a protein implicated in coordinating cell wall synthesis with bud emergence in Saccharomyces cerevisiaeFadi Basmaji
Laboratoire de Biotechnologie et Bioprocédés, UMR CNRS 5504 and INRA 792, 135, Avenue de Rangueil, 31077 Toulouse Cedex 04, France
Mol Genet Genomics 275:217-30. 2006....
- Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profilesMartin Valachovic
Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, 40536
Genetics 173:1893-908. 2006..We show that deletion of YND1, like deletion of GDA1, alters the sphingolipid profiles, suggesting that changes in sphingolipids compensate for lethality produced by changes in sterol composition and abundance...
- Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targetsHongyin Wang
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
PLoS Biol 7:e1000189. 2009..The cell may titrate Cln3 molecules against the number of SBF binding sites, and this could be the underlying basis of the size-control mechanism for Start...
- The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell sizeKaren Artiles
Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
PLoS Genet 5:e1000727. 2009..Together, these observations demonstrate that Rts1 is a key player in pathways that link nutrient availability, cell size, and G1 cyclin transcription. Since Rts1 is highly conserved, it may function in similar pathways in vertebrates...
- Saccharomyces cerevisiae YCRO17c/CWH43 encodes a putative sensor/transporter protein upstream of the BCK2 branch of the PKC1-dependent cell wall integrity pathwayH Martin-Yken
Centre de Bioingenierie Gilbert Durand, UMR CNRS 5504, UMR INRA 792, F 31077 Toulouse Cedex 04, France
Yeast 18:827-40. 2001..Genetic analysis places CWH43 upstream of the BCK2 branch of the PKC1 signalling pathway, since cwh43 mutations were synthetic lethal with pkc1 deletion, whereas the ..