BCK2

Summary

Gene Symbol: BCK2
Description: Bck2p
Alias: CTR7
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:5843-53. 1993
  2. pmc Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START
    C B Epstein
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 14:2041-7. 1994
  3. pmc Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock
    Venkata K Kuravi
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 22:4892-907. 2011
  4. ncbi Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast
    Francisco Ferrezuelo
    Departament de Ciencies Mediques Basiques, Institut the Recerca Biomèdica de Lleida, Universitat de Lleida, Lleida, Spain
    Cell Cycle 8:239-52. 2009
  5. ncbi CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast
    Michael Costanzo
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, M5S 1A8, Canada
    Cell 117:899-913. 2004
  6. ncbi Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5
    Robertus A M de Bruin
    Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell 117:887-98. 2004
  7. pmc G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1
    Michael Costanzo
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Cell Biol 23:5064-77. 2003
  8. ncbi Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae
    Ivan Munoz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona
    Yeast 20:157-69. 2003
  9. ncbi KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2, a gene involved in cell cycle progression in Saccharomyces cerevisiae
    Helene Martin-Yken
    Centre de Bioingenierie Gilbert Durand, UMR CNRS 5504, UR INRA 792, 31077 Toulouse, France
    Curr Genet 41:323-32. 2002
  10. pmc Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiae
    H Wijnen
    Graduate Program in Genetics State University of New York, Stony Brook, New York 11792, USA
    Genetics 153:1131-43. 1999

Scientific Experts

  • Neil R Adames
  • Francisco Ferrezuelo
  • Michael Costanzo
  • Nazareth Bastajian
  • Venkata K Kuravi
  • Helene Martin-Yken
  • Hongyin Wang
  • Karen Artiles
  • Fadi Basmaji
  • Martin Valachovic
  • Karin Flick
  • Curt Wittenberg
  • Jean Francois
  • Ritu Pathak
  • Adilia Dagkessamanskaia
  • Robertus A M de Bruin
  • Oliver Schub
  • Brenda Andrews
  • Ivan Munoz
  • Helena Friesen
  • Brenda J Andrews
  • H Martin-Yken
  • Cornelia Kurischko
  • Manasi Puri
  • Francis C Luca
  • K A Robinson
  • P D Andrews
  • Herman Wijnen
  • Stephanie Anastasia
  • Ying Cai
  • Derek McCusker
  • Lucas B Carey
  • Bruce Futcher
  • Douglas R Kellogg
  • H Wijnen
  • Michel Rossignol
  • Fabien Durand
  • Lisa Wilcox
  • James Eckstein
  • Dina Balderes
  • Robert Barbuch
  • Stephen L Sturley
  • Bart M Bareither
  • Robert C Dickson
  • M Shah Alam Bhuiyan
  • Carole Pichereaux
  • Martin Bard
  • Lydia M Bogomolnaya
  • John Yates
  • Michael Polymenis
  • Ivan Rupes
  • Tatyana I Kalashnikova
  • Jinbai Guo
  • Danielle Dewar
  • Jonathan S Millman
  • Joy L Nishikawa
  • Xiaojing Tang
  • Mike Tyers
  • W Hayes McDonald
  • Kevin Breitkreuz
  • Ernesto Simon
  • Joaquin Arino
  • Nuria Casals
  • Josep Clotet
  • Driss Talibi
  • F Klis
  • J Francois
  • P de Groot
  • A Dagkessamanskaia
  • A Ram
  • M J Stark
  • M Kharodawala
  • C J Di Como
  • J M Lopes
  • J I Koepke
  • B Futcher
  • C B Epstein
  • K S Lee
  • K T Arndt
  • H Chang
  • F R Cross
  • D E Levin
  • L K Hines

Detail Information

Publications22

  1. pmc A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:5843-53. 1993
    ..The other suppressor gene, designated BCK2 (for bypass of C kinase), is predicted to encode a 92-kDa protein that is rich in serine and threonine residues...
  2. pmc Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START
    C B Epstein
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 14:2041-7. 1994
    ..at a low copy number; the gene responsible was distinct from BYC1 and was identical to the recently described BCK2 gene...
  3. pmc Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock
    Venkata K Kuravi
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 22:4892-907. 2011
    ..Here we establish that Cbk1 is critical for heat shock and cell wall stress signaling via Bck2, a protein associated with the Pkc1-Mpk1 cell integrity pathway...
  4. ncbi Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast
    Francisco Ferrezuelo
    Departament de Ciencies Mediques Basiques, Institut the Recerca Biomèdica de Lleida, Universitat de Lleida, Lleida, Spain
    Cell Cycle 8:239-52. 2009
    ..b>Bck2 becomes essential in the absence of Cln3, the most upstream activator of this transcriptional program...
  5. ncbi CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast
    Michael Costanzo
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, M5S 1A8, Canada
    Cell 117:899-913. 2004
    ..Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes...
  6. ncbi Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5
    Robertus A M de Bruin
    Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell 117:887-98. 2004
    ..Like mammalian Rb, Whi5 is a G1-specific transcriptional repressor antagonized by CDK...
  7. pmc G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1
    Michael Costanzo
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Cell Biol 23:5064-77. 2003
    ..Chromatin immunoprecipitation experiments confirm that Stb1 localizes to promoters of MBF-regulated genes. Our data indicate that, contrary to previous models, MBF and SBF have unique components and might be distinctly regulated...
  8. ncbi Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae
    Ivan Munoz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona
    Yeast 20:157-69. 2003
    ..The screening yielded several genes known to perform key roles in cell cycle events, such as CLN3, BCK2 or SWI4, thus proving its usefulness as a tool for this type of studies...
  9. ncbi KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2, a gene involved in cell cycle progression in Saccharomyces cerevisiae
    Helene Martin-Yken
    Centre de Bioingenierie Gilbert Durand, UMR CNRS 5504, UR INRA 792, 31077 Toulouse, France
    Curr Genet 41:323-32. 2002
    ..The evidence that KNR4 is a member of the PKC1 pathway and genetically interacts with BCK2, a gene involved together with Cln3-Cdc28 in the G1 to S transition phase of the cell cycle, was as follows...
  10. pmc Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiae
    H Wijnen
    Graduate Program in Genetics State University of New York, Stony Brook, New York 11792, USA
    Genetics 153:1131-43. 1999
    ..Activation of SBF and MBF depends on the G(1) cyclin Cln3 and a largely uncharacterized protein called Bck2. We show here that the induction of SBF/MBF target genes by Bck2 depends partly, but not wholly, on SBF and MBF...
  11. pmc Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2
    C J Di Como
    Cold Spring Harbor Laboratory, New York 11724 2212
    Mol Cell Biol 15:1835-46. 1995
    ..The members of one of these complementation groups have mutations in the BCK2 gene...
  12. ncbi Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae
    P D Andrews
    Department of Biochemistry, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
    J Cell Sci 113:507-20. 2000
    ..Dephosphorylation by PP1 therefore functions positively to promote cell integrity, bud morphology and polarization of the actin cytoskeleton and glc7-10 cells require higher levels of Pkc1p activity to sustain these functions...
  13. pmc Experimental testing of a new integrated model of the budding yeast Start transition
    Neil R Adames
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061
    Mol Biol Cell 26:3966-84. 2015
    ..Our study demonstrates the advantages of combining model design, simulation, and testing in a coordinated effort to better understand a complex biological network. ..
  14. pmc Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast
    Nazareth Bastajian
    The Donnelly Centre and the Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 9:e1003507. 2013
    The Bck2 protein is a potent genetic regulator of cell-cycle-dependent gene expression in budding yeast...
  15. pmc A network of yeast basic helix-loop-helix interactions
    K A Robinson
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA
    Nucleic Acids Res 28:4460-6. 2000
    ..Ino2p is the only protein in common with the data presented here. Our finding that Ino4p interacts with five bHLH proteins suggests that Ino4p is likely to be a central player in the coordination of multiple biological processes...
  16. pmc Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae
    Ritu Pathak
    Department of Biochemistry and Biophysics, Texas A and M University, 2128 TAMU, College Station, TX 77843, USA
    Eukaryot Cell 3:1627-38. 2004
    ..Our findings identify two gene products with a probable regulatory role in the timing of initiation of cell division...
  17. pmc Multiple pathways for suppression of mutants affecting G1-specific transcription in Saccharomyces cerevisiae
    Karin Flick
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Genetics 169:37-49. 2005
    ..Together with additional characterization these findings indicate that multiple independent pathways are sufficient for proliferation in the absence of G(1)-specific transcriptional activators...
  18. ncbi The 'interactome' of the Knr4/Smi1, a protein implicated in coordinating cell wall synthesis with bud emergence in Saccharomyces cerevisiae
    Fadi Basmaji
    Laboratoire de Biotechnologie et Bioprocédés, UMR CNRS 5504 and INRA 792, 135, Avenue de Rangueil, 31077 Toulouse Cedex 04, France
    Mol Genet Genomics 275:217-30. 2006
    ....
  19. pmc Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles
    Martin Valachovic
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, 40536
    Genetics 173:1893-908. 2006
    ..We show that deletion of YND1, like deletion of GDA1, alters the sphingolipid profiles, suggesting that changes in sphingolipids compensate for lethality produced by changes in sterol composition and abundance...
  20. pmc Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets
    Hongyin Wang
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA
    PLoS Biol 7:e1000189. 2009
    ..The cell may titrate Cln3 molecules against the number of SBF binding sites, and this could be the underlying basis of the size-control mechanism for Start...
  21. pmc The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell size
    Karen Artiles
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
    PLoS Genet 5:e1000727. 2009
    ..Together, these observations demonstrate that Rts1 is a key player in pathways that link nutrient availability, cell size, and G1 cyclin transcription. Since Rts1 is highly conserved, it may function in similar pathways in vertebrates...
  22. ncbi Saccharomyces cerevisiae YCRO17c/CWH43 encodes a putative sensor/transporter protein upstream of the BCK2 branch of the PKC1-dependent cell wall integrity pathway
    H Martin-Yken
    Centre de Bioingenierie Gilbert Durand, UMR CNRS 5504, UMR INRA 792, F 31077 Toulouse Cedex 04, France
    Yeast 18:827-40. 2001
    ..Genetic analysis places CWH43 upstream of the BCK2 branch of the PKC1 signalling pathway, since cwh43 mutations were synthetic lethal with pkc1 deletion, whereas the ..