AKR1

Summary

Gene Symbol: AKR1
Description: palmitoyltransferase AKR1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Interactions between the ankyrin repeat-containing protein Akr1p and the pheromone response pathway in Saccharomyces cerevisiae
    L R Kao
    Department of Biology, Indiana University, Bloomington 47405, USA
    Mol Cell Biol 16:168-78. 1996
  2. pmc AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction
    P M Pryciak
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Mol Cell Biol 16:2614-26. 1996
  3. pmc The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors
    S A Givan
    Institute of Molecular Biology, University of Oregon, Eugene 97403, USA
    Mol Biol Cell 8:1317-27. 1997
  4. pmc Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane
    Y Feng
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mol Cell Biol 20:5350-9. 2000
  5. pmc The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase
    Amy F Roth
    Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Biol 159:23-8. 2002
  6. ncbi Transmembrane topology of the protein palmitoyl transferase Akr1
    Eugenia G Politis
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 280:10156-63. 2005
  7. pmc Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1
    Akio Kihara
    Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 choume, Kita ku, Sapporo 060 0812, Japan
    Mol Cell Biol 25:9189-97. 2005
  8. pmc Global analysis of protein palmitoylation in yeast
    Amy F Roth
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cell 125:1003-13. 2006
  9. pmc Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation
    Sandra Holbein
    Institute of Molecular Biology, University of Zurich, CH 8057 Zurich, Switzerland
    RNA 15:837-49. 2009
  10. pmc The ankyrin repeats and DHHC S-acyl transferase domain of AKR1 act independently to regulate switching from vegetative to mating states in yeast
    Piers A Hemsley
    School of Biological Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e28799. 2011

Scientific Experts

  • P M Pryciak
  • Piers A Hemsley
  • L J Oehlen
  • Amy F Roth
  • Akio Kihara
  • Nicholas G Davis
  • Hao Wu
  • Sandra Holbein
  • Marissa J Nadolski
  • Yusuke Ohno
  • Yasuyuki Igarashi
  • Takamitsu Sano
  • Eugenia G Politis
  • Y Feng
  • Patrick Brennwald
  • Bernhard Dichtl
  • Agnieszka Wengi
  • Laurence Decourty
  • Maurine E Linder
  • Alain Jacquier
  • Florian M Freimoser
  • John R Yates
  • Beimeng Sun
  • Junmei Wan
  • William N Green
  • Aaron O Bailey
  • Brett S Phinney
  • M A Osman
  • Jason A Kuchar
  • Fumiko Kurotsu
  • Soichiro Iwaki
  • S A Givan
  • L R Kao
  • Ying Feng
  • Linyi Chen
  • N G Davis
  • R A Cerione
  • G F Sprague
  • R Ji
  • L Bender
  • J Peterson
  • A Bender

Detail Information

Publications15

  1. pmc Interactions between the ankyrin repeat-containing protein Akr1p and the pheromone response pathway in Saccharomyces cerevisiae
    L R Kao
    Department of Biology, Indiana University, Bloomington 47405, USA
    Mol Cell Biol 16:168-78. 1996
    ..Cells from which AKR1 had been deleted were alive but misshapen at 30 degrees C and inviable at 37 degrees C...
  2. pmc AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction
    P M Pryciak
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Mol Cell Biol 16:2614-26. 1996
    ....
  3. pmc The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors
    S A Givan
    Institute of Molecular Biology, University of Oregon, Eugene 97403, USA
    Mol Biol Cell 8:1317-27. 1997
    ..First, when receptor synthesis is shut off, akr1 delta cells retain the ability to mate longer than do AKR1 cells...
  4. pmc Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane
    Y Feng
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mol Cell Biol 20:5350-9. 2000
    ..While no obvious defect was seen for wild-type Ste3p phosphorylation in akr1 or yck mutant backgrounds, examination of the Delta320-413 Ste3p deletion mutant phosphorylation did reveal a clear ..
  5. pmc The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase
    Amy F Roth
    Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Biol 159:23-8. 2002
    ..Finally, our results indicate that palmitoylation within the yeast cell is controlled by multiple PTase specificities. The conserved DHHC-CRD sequence, we propose, is the signature feature of an evolutionarily widespread PTase family...
  6. ncbi Transmembrane topology of the protein palmitoyl transferase Akr1
    Eugenia G Politis
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 280:10156-63. 2005
    ..Portions of the yeast protein invertase (Suc2p) were inserted in-frame at 10 different hydrophilic sites within the Akr1 polypeptide...
  7. pmc Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1
    Akio Kihara
    Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 choume, Kita ku, Sapporo 060 0812, Japan
    Mol Cell Biol 25:9189-97. 2005
    ..Here, we demonstrate that Lcb4 is modified by palmitoylation. This modification was greatly reduced in mutants for AKR1, which was recently identified as encoding a protein acyltransferase...
  8. pmc Global analysis of protein palmitoylation in yeast
    Amy F Roth
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cell 125:1003-13. 2006
    ....
  9. pmc Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation
    Sandra Holbein
    Institute of Molecular Biology, University of Zurich, CH 8057 Zurich, Switzerland
    RNA 15:837-49. 2009
    ..Finally, chemical-genetic profiling revealed genome-wide pathways linked to cordycepin activity and identified novel genes involved in poly(A) homeostasis...
  10. pmc The ankyrin repeats and DHHC S-acyl transferase domain of AKR1 act independently to regulate switching from vegetative to mating states in yeast
    Piers A Hemsley
    School of Biological Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e28799. 2011
    ..One of the best-characterised examples is the yeast pheromone response pathway, which is negatively regulated by AKR1. AKR1-like proteins are present in all eukaryotes and contain a DHHC domain and six ankyrin repeats...
  11. pmc Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton
    M A Osman
    Department of Pharmacology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 142:443-55. 1998
    ..Mol. Cell. Biol. 15:723-730). We propose that Iqg1p acts as a scaffold to recruit and localize a protein complex involved in actin-based cellular functions and thus mediates the regulatory effects of Cdc42p on the actin cytoskeleton...
  12. ncbi Potential regulation of Ste20 function by the Cln1-Cdc28 and Cln2-Cdc28 cyclin-dependent protein kinases
    L J Oehlen
    Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:25089-97. 1998
    ....
  13. ncbi Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins
    Yusuke Ohno
    Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 choume, Kita ku, Sapporo 060 0812, Japan
    Biochim Biophys Acta 1761:474-83. 2006
    ..Human DHHC mRNAs also differ in their tissue-specific expression. These results may provide clues to aid in discovering the specific function(s) of each DHHC protein...
  14. pmc Molecular recognition of the palmitoylation substrate Vac8 by its palmitoyltransferase Pfa3
    Marissa J Nadolski
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:17720-30. 2009
    ..This demonstrates that regions distant from the palmitoylated cysteines are important for recognition by DHHC proteins...
  15. pmc The function of two Rho family GTPases is determined by distinct patterns of cell surface localization
    Hao Wu
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Mol Cell Biol 30:5207-17. 2010
    ..First, palmitoylation of a cysteine residue by the Akr1 palmitoyltransferase is required both for the switch of function and the switch of localization properties of this ..