Gene Symbol: MAMU-A
Description: major histocompatibility complex, class I, A
Alias: MAMU-A1, MAMU-A2, major histocompatibility complex, class I, A, MHC class 1 protein, MHC class I protein
Species: Rhesus monkey
- The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primatesJ E Boyson
University of Wisconsin, Madison, WI 53715, USA
J Immunol 156:4656-65. 1996..Although MHC class II allelic lineages are shared between humans and Old World primates, no such trans-species sharing of allelic lineages is seen at the MHC class I loci...
- Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeysG Voss
Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA
J Virol 70:7335-40. 1996..The characterization of the two HIV-1 Env CTL epitopes and their restricting MHC class I alleles will provide a basis for studying vaccine- and virus-elicited cytotoxic effector cell responses in rhesus monkeys...
- Unparalleled complexity of the MHC class I region in rhesus macaquesNel Otting
Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands
Proc Natl Acad Sci U S A 102:1626-31. 2005....
- MHC class I A region diversity and polymorphism in macaque speciesNel Otting
Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P O Box 3306, 2280 GH, Rijswijk, The Netherlands
Immunogenetics 59:367-75. 2007..The latter situation contrasts the observations of the major histocompatibility complex class II genes in rhesus and cynomolgus macaques, which share a high number of identical alleles (>30%) as defined by exon 2 sequencing...
- Identification of MHC class I sequences in Chinese-origin rhesus macaquesJulie A Karl
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
Immunogenetics 60:37-46. 2008..The discovery of 27 novel MHC class I sequences in this analysis underscores the genetic diversity of Chinese rhesus macaques and contributes reagents that will be valuable for studying cellular immunology in this population...
- Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaquesX Ma
Center for Vaccines and Biotherapeutics, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Tissue Antigens 73:184-7. 2009..As the set of Mamu-A alleles in Chinese rhesus macaques differs from the alleles of Indian animals, more work still needs to be carried out to identify these new allele-restricted immune responses with regard to vaccine studies...
- The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertypeChristopher Solomon
Department of Biological Sciences, California State University San Marcos, San Marcos, CA 92096, USA
Immunogenetics 62:451-64. 2010..These studies provide the first functional characterization of an MHC class I molecule in the context of Chinese rhesus macaques and the first instance of HLA-B7 analogy for rhesus macaques...
- Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus PeptidesJamie L Schafer
Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
PLoS Pathog 11:e1005145. 2015....
- TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysChrista E Osuna
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Pathog 10:e1004069. 2014..These findings advance our understanding of the regulation of T cell immunodominance and will aid HIV vaccine design. ..
- Full-length novel MHC class I allele discovery by next-generation sequencing: two platforms are better than oneDawn M Dudley
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI, 53705, USA
Immunogenetics 66:15-24. 2014..We anticipate that this method will facilitate rapid expansion and near completion of sequence libraries of polymorphic loci, such as MHC class I, within a few years...
- Mamu-B genes and their allelic repertoires in different populations of Chinese-origin rhesus macaquesYi Liu
Laboratory Animal Center of the Academy of Military Medical Science, Beijing, 100071, China
Immunogenetics 65:273-80. 2013..Our results are an important addition to the limited MHC immunogenetic information available for rhesus macaques of Chinese origin...
- Preliminary observations of MHC class I A region polymorphism in three populations of Chinese-origin rhesus macaquesAixue Li
Laboratory Animal Center of the Academy of Military Medical Science, Beijing, 100071, China
Immunogenetics 64:887-94. 2012..Further immunogenetic work is needed to investigate the MHC polymorphism among different populations of Chinese rhesus macaques and to reveal the functional implication of such polymorphism and disease outcome correlations...
- Diversity of MHC class I genes in Burmese-origin rhesus macaquesTaeko K Naruse
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
Immunogenetics 62:601-11. 2010..These findings further revealed the diversity and complexity of MHC locus in the rhesus macaques...
- KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaquesIna Hellmann
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
J Virol 87:5305-10. 2013..These findings underscore the crucial role of activating killer-cell immunoglobulin-like receptors (KIRs) in NK cell-mediated SIV responses during early SIV infection...
- Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeysSo yon Lim
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 6:e1000997. 2010..34 or 0.36, respectively. These findings call into question the premise that CCL3L CNV is important in HIV/SIV pathogenesis...
- Allelic diversity within the high frequency Mamu-A2*05/Mane-A2*05 (Mane-A*06)/Mafa-A2*05 family of macaque MHC-A lociJ Wu
Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA
Tissue Antigens 72:29-38. 2008....
- Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificitiesScott Southwood
Department of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Immunogenetics 63:275-90. 2011....
- Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeysEun Young Kim
Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Suite 200, Chicago, IL 60611, USA
J Virol 82:5631-5. 2008..These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation...
- First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escapeFuliang Chu
Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, 13 Beiyitiao, Zhongguancun, Beijing 100080, People s Republic of China
J Immunol 178:944-52. 2007..The results we present in this study are most relevant for the rational design of Mamu-A*01-restricted CTL epitopes with improved binding, as a step toward development of AIDS vaccines...
- A high incidence of Shigella-induced arthritis in a primate species: major histocompatibility complex class I molecules associated with resistance and susceptibility, and their relationship to HLA-B27J A Urvater
Wisconsin Regional Primate Research Center, University of Wisconsin Madison 53715, USA
Immunogenetics 51:314-25. 2000..Surprisingly, there was a statistically significant association between the rhesus macaque MHC A locus allele, Mamu-A*12, and the absence of reactive arthritis following Shigella infection...
- A simian immunodeficiency virus envelope V3 cytotoxic T-lymphocyte epitope in rhesus monkeys and its restricting major histocompatibility complex class I molecule Mamu-A*02N Watanabe
Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
J Virol 68:6690-6. 1994..This viral CTL epitope and its restricting MHC class I molecule will facilitate the use of the SIVmac rhesus monkey model for studies of envelope-based vaccine strategies and for exploring AIDS immunopathogenesis...
- Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeysM D Miller
Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772
J Immunol 147:320-9. 1991..These studies illustrate that AIDS virus-specific CTL can be characterized in detail in the rhesus monkey and lay the foundation for exploring novel approaches to AIDS virus vaccination in this species...