CCR5

Summary

Gene Symbol: CCR5
Description: C-C motif chemokine receptor 5
Alias: C-C chemokine receptor type 5, C-C CKR-5, C-C chemokine receptor 5, CC chemokine receptor 5, CC-CKR-5, CCR-5
Species: Rhesus monkey

Top Publications

  1. pmc A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, California, USA
    J Virol 88:2011-24. 2014
  2. pmc CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV
    Kathleen M Kelly
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD
    J Am Heart Assoc 3:e000874. 2014
  3. pmc Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239
    L Marcon
    Division of Human Retrovirology, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 71:2522-7. 1997
  4. pmc Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry
    Z Chen
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 71:2705-14. 1997
  5. pmc Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains
    A L Edinger
    Department of Pathology, University of Pennsylvania, Philadelphia 19104, USA
    Proc Natl Acad Sci U S A 94:4005-10. 1997
  6. pmc Identification and comparison of eleven rhesus macaque chemokine receptors
    B J Margulies
    Retrovirus Biology Laboratory, Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS Res Hum Retroviruses 17:981-6. 2001
  7. pmc Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea
    Kevin J Kunstman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:12310-8. 2003
  8. ncbi Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques
    Andrea Weiler
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
    Immunogenetics 58:1003-9. 2006
  9. pmc Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut
    David P Wilson
    Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, New South Wales, Australia
    J Virol 81:8025-9. 2007
  10. pmc Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana 70433, USA
    J Virol 82:5618-30. 2008

Scientific Experts

  • Andrea Weiler
  • Koen K A Van Rompay
  • Kathleen M Kelly
  • Jacob T Minang
  • Yusuke Matsumoto
  • Michael Piatak
  • Siu hong Ho
  • Ronald S Veazey
  • David P Wilson
  • Steven M Wolinsky
  • Kevin J Kunstman
  • Zoe Hunter
  • Carlo G Tocchetti
  • Brandon F Keele
  • Kristina Abel
  • Julianne Peabody
  • David R Graham
  • David Montefiori
  • Kartika Jayashankar
  • Bryce Chackerian
  • Robert J Adams
  • Celia C LaBranche
  • Kelly A Metcalf Pate
  • Kara Jensen
  • Joseph L Mankowski
  • Alexey Lyashkov
  • Patrick M Tarwater
  • Sarah E Beck
  • Djahida Bedja
  • Nazareno Paolocci
  • Suzanne E Queen
  • B J Margulies
  • Matthew T Trivett
  • Robert J Gorelick
  • Gregory Q Del Prete
  • Eugene V Barsov
  • David E Ott
  • Charles M Trubey
  • Claes Ohlen
  • James A Thomas
  • Tomoyuki Miura
  • Hirofumi Akari
  • Yoshitaka Goto
  • Takeshi Haga
  • Agegnehu Gettie
  • Jeffrey D Lifson
  • Jörn E Schmitz
  • Paula M Acierno
  • Vanessa M Hirsch
  • Kenneth Williams
  • Gabriel J Foster
  • Cecilia Cheng-Mayer
  • Marcelo J Kuroda
  • Kimberly J McEvers
  • Charles R Brown
  • Melisa D Rett
  • Michael H Newberg
  • David C Montefiori
  • Eun Young Kim
  • E Peter Rieber
  • J E Clements
  • James Blanchard
  • Nataliya Trunova
  • Susanne H C Baumeister
  • Lei Zhang
  • Miles P Davenport
  • Matthew D H Lay
  • Mario Roederer
  • Joseph J Mattapallil
  • L Marcon
  • A L Edinger
  • Z Chen
  • Anne D Yoder
  • Robert W Doms
  • Carla Kuiken
  • Jennifer Kunstman
  • Riri Shibata
  • Una R Smith
  • Preston Marx
  • Michael Agy
  • Bridget Puffer
  • Satish Pillai
  • Jennifer Stanton
  • Bette T Korber
  • D A Hauer
  • K A Martin
  • K Miller
  • R W Doms
  • C Gerard
  • P D Ponath

Detail Information

Publications13

  1. pmc A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, California, USA
    J Virol 88:2011-24. 2014
    As an alternative to targeting human immunodeficiency virus (HIV), we have developed vaccines targeting CCR5, a self-protein critically involved in HIV replication and pathogenesis...
  2. pmc CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV
    Kathleen M Kelly
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD
    J Am Heart Assoc 3:e000874. 2014
    ..As cardiomyocytes are not productively infected, damage may be an indirect process attributable to a combination of pro-inflammatory mediators and viral proteins...
  3. pmc Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239
    L Marcon
    Division of Human Retrovirology, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 71:2522-7. 1997
    ..Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIVmac239 envelope glycoproteins to mediate virus entry and cell-to-cell fusion...
  4. pmc Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry
    Z Chen
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 71:2705-14. 1997
    ..Macrophage-tropic HIV-1 isolates are generally specific for CCR5, a receptor for the CC chemokines RANTES, MIP-1alpha, and MIP-1beta, while T-cell line-tropic viruses tend to use ..
  5. pmc Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains
    A L Edinger
    Department of Pathology, University of Pennsylvania, Philadelphia 19104, USA
    Proc Natl Acad Sci U S A 94:4005-10. 1997
    ..Macrophage tropic (M-tropic) HIV-1 isolates use CCR5, and T cell tropic (T-tropic) strains use CXCR4...
  6. pmc Identification and comparison of eleven rhesus macaque chemokine receptors
    B J Margulies
    Retrovirus Biology Laboratory, Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS Res Hum Retroviruses 17:981-6. 2001
    ..the cloning and comparison of 11 rhesus macaque chemokine receptors and receptor-like proteins (CCR1, CCR2b, CCR3, CCR5, CCR8, CXCR4, STRL33, GPR1, GPR15, APJ, and CRAM-A/B), the human counterparts of which have been previously shown ..
  7. pmc Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea
    Kevin J Kunstman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:12310-8. 2003
    ..To investigate nonhuman primate CC-chemokine receptor 5 (CCR5) homologue structure and function, we amplified CCR5 DNA sequences from peripheral blood cells obtained from 24 ..
  8. ncbi Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques
    Andrea Weiler
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
    Immunogenetics 58:1003-9. 2006
    ..We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-alpha, and TSG101 and looked for associations with decreased viral ..
  9. pmc Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut
    David P Wilson
    Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, New South Wales, Australia
    J Virol 81:8025-9. 2007
    ..6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.
  10. pmc Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana 70433, USA
    J Virol 82:5618-30. 2008
    ..In intestinal tissues and lymph nodes, we observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls, suggesting that these SIV-..
  11. pmc Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus
    Siu hong Ho
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 82:5653-6. 2008
    ..Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively...
  12. ncbi Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5
    Yusuke Matsumoto
    Department of Veterinary Microbiology, University of Miyazaki, Miyazaki, Japan
    J Vet Med Sci 72:1057-61. 2010
    ..Here we found that peripheral DP T cells were readily induced to express CCR5, a secondary receptor for SIV, by in vitro stimulation with either concanavalin A or anti-CD3/CD28 monoclonal ..
  13. pmc TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection
    Jacob T Minang
    AIDS and Cancer Virus Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Virology 409:132-40. 2011
    Studies using transformed human cell lines suggest that most SIV strains use CCR5 as co-receptor. Our analysis of primary rhesus macaque CD4(+) T-cell clones revealed marked differences in susceptibility to SIV(mac)239 infection...