Genomes and Genes
Gene Symbol: CCR5
Description: C-C motif chemokine receptor 5
Alias: C-C chemokine receptor type 5, C-C CKR-5, C-C chemokine receptor 5, CC chemokine receptor 5, CC-CKR-5, CCR-5
Species: Rhesus monkey
- A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251Koen K A Van Rompay
California National Primate Research Center, University of California, Davis, California, USA
J Virol 88:2011-24. 2014As an alternative to targeting human immunodeficiency virus (HIV), we have developed vaccines targeting CCR5, a self-protein critically involved in HIV replication and pathogenesis...
- CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIVKathleen M Kelly
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD
J Am Heart Assoc 3:e000874. 2014..As cardiomyocytes are not productively infected, damage may be an indirect process attributable to a combination of pro-inflammatory mediators and viral proteins...
- Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239L Marcon
Division of Human Retrovirology, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 71:2522-7. 1997..Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIVmac239 envelope glycoproteins to mediate virus entry and cell-to-cell fusion...
- Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entryZ Chen
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
J Virol 71:2705-14. 1997..Macrophage-tropic HIV-1 isolates are generally specific for CCR5, a receptor for the CC chemokines RANTES, MIP-1alpha, and MIP-1beta, while T-cell line-tropic viruses tend to use ..
- Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strainsA L Edinger
Department of Pathology, University of Pennsylvania, Philadelphia 19104, USA
Proc Natl Acad Sci U S A 94:4005-10. 1997..Macrophage tropic (M-tropic) HIV-1 isolates use CCR5, and T cell tropic (T-tropic) strains use CXCR4...
- Identification and comparison of eleven rhesus macaque chemokine receptorsB J Margulies
Retrovirus Biology Laboratory, Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
AIDS Res Hum Retroviruses 17:981-6. 2001..the cloning and comparison of 11 rhesus macaque chemokine receptors and receptor-like proteins (CCR1, CCR2b, CCR3, CCR5, CCR8, CXCR4, STRL33, GPR1, GPR15, APJ, and CRAM-A/B), the human counterparts of which have been previously shown ..
- Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and AnthropoideaKevin J Kunstman
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Virol 77:12310-8. 2003..To investigate nonhuman primate CC-chemokine receptor 5 (CCR5) homologue structure and function, we amplified CCR5 DNA sequences from peripheral blood cells obtained from 24 ..
- Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaquesAndrea Weiler
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
Immunogenetics 58:1003-9. 2006..We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-alpha, and TSG101 and looked for associations with decreased viral ..
- Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gutDavid P Wilson
Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, New South Wales, Australia
J Virol 81:8025-9. 2007..6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.
- Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeysRonald S Veazey
Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana 70433, USA
J Virol 82:5618-30. 2008..In intestinal tissues and lymph nodes, we observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls, suggesting that these SIV-..
- Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virusSiu hong Ho
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
J Virol 82:5653-6. 2008..Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively...
- Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5Yusuke Matsumoto
Department of Veterinary Microbiology, University of Miyazaki, Miyazaki, Japan
J Vet Med Sci 72:1057-61. 2010..Here we found that peripheral DP T cells were readily induced to express CCR5, a secondary receptor for SIV, by in vitro stimulation with either concanavalin A or anti-CD3/CD28 monoclonal ..
- TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infectionJacob T Minang
AIDS and Cancer Virus Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Virology 409:132-40. 2011Studies using transformed human cell lines suggest that most SIV strains use CCR5 as co-receptor. Our analysis of primary rhesus macaque CD4(+) T-cell clones revealed marked differences in susceptibility to SIV(mac)239 infection...