Xdh

Summary

Gene Symbol: Xdh
Description: xanthine dehydrogenase
Alias: XOR, xanthine dehydrogenase/oxidase, xanthine oxidoreductase
Species: rat

Top Publications

  1. pmc Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria
    K Ichida
    Second Department of Medicine, The Jikei University School of Medicine, Tokyo 105
    J Clin Invest 99:2391-7. 1997
  2. pmc Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules
    Toshio Ohtsubo
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Hypertension 54:868-76. 2009
  3. pmc Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway
    Ying qian Zhang
    Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, P R China
    Int J Mol Med 38:1055-62. 2016
  4. pmc Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats
    Takashi Shirakura
    Pharmaceutical Development Research Laboratories, Teijin Institute for Bio Medical Research, Teijin Pharma Ltd, 4 3 2, Asahigaoka, Hino, 191 852, Tokyo, Japan
    Naunyn Schmiedebergs Arch Pharmacol 389:831-8. 2016
  5. doi New 1,4-Dihydropyridines Down-regulate Nitric Oxide in Animals with Streptozotocin-induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action
    Elina Leonova
    Latvian Institute of Organic Synthesis, Riga, Latvia
    Basic Clin Pharmacol Toxicol 119:19-31. 2016
  6. doi Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen
    Jiro Ogura
    Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Biochem Pharmacol 97:89-98. 2015
  7. pmc HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase
    Jayasri Nanduri
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 10:e0119762. 2015
  8. doi Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo
    Luisa B Maia
    UCIBIO, REQUIMTE, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
    Biochemistry 54:685-710. 2015
  9. doi Xanthine crystals induced by topiroxostat, a xanthine oxidoreductase inhibitor, in rats, cause transitional cell tumors
    Takeo Shimo
    Research Laboratories 2, Fuji Yakuhin Co, Ltd, 636 1 Iidashinden, Nishi ku, Saitama shi, Saitama, 331 0068, Japan
    Arch Toxicol 88:1035-42. 2014
  10. pmc Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload
    James D Gladden
    University of Alabama at Birmingham UABComprehensive Cardiovascular Center, UAB Birmingham, Alabama
    Am J Physiol Heart Circ Physiol 305:H1440-50. 2013

Research Grants

  1. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
  2. Uric Acid in Childhood Hypertension
    Daniel Feig; Fiscal Year: 2007
  3. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
  4. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
  5. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications73

  1. pmc Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria
    K Ichida
    Second Department of Medicine, The Jikei University School of Medicine, Tokyo 105
    J Clin Invest 99:2391-7. 1997
    ..Thus, in three subjects with type I xanthinuria, the primary genetic defects were confirmed to be in the xanthine dehydrogenase gene...
  2. pmc Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules
    Toshio Ohtsubo
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Hypertension 54:868-76. 2009
    b>Xanthine oxidoreductase (XOR) is an enzyme responsible for purine degradation, reactive oxygen species production, and adipogenesis. XOR gene-disrupted (XOR(-/-)) mice demonstrate renal failure and early death within several months...
  3. pmc Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway
    Ying qian Zhang
    Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, P R China
    Int J Mol Med 38:1055-62. 2016
    ..Furthermore, HGF prevents XO activation following H/R primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Ca2+. ..
  4. pmc Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats
    Takashi Shirakura
    Pharmaceutical Development Research Laboratories, Teijin Institute for Bio Medical Research, Teijin Pharma Ltd, 4 3 2, Asahigaoka, Hino, 191 852, Tokyo, Japan
    Naunyn Schmiedebergs Arch Pharmacol 389:831-8. 2016
    ....
  5. doi New 1,4-Dihydropyridines Down-regulate Nitric Oxide in Animals with Streptozotocin-induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action
    Elina Leonova
    Latvian Institute of Organic Synthesis, Riga, Latvia
    Basic Clin Pharmacol Toxicol 119:19-31. 2016
    ..Furthermore, inhibitors of nitric oxide synthase (NOS) and an inhibitor of xanthine oxidoreductase (XOR) decreased NO production in kidneys of diabetic animals...
  6. doi Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen
    Jiro Ogura
    Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Biochem Pharmacol 97:89-98. 2015
    ..ROS derived from XO may cause the suppression of function of the ileum for the excretion of uric acid with aging. The results of our study provide a new insight into the causes of increasing hyperuricemia/gout prevalence with aging. ..
  7. pmc HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase
    Jayasri Nanduri
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 10:e0119762. 2015
    ..More importantly, silencing XO blocked IH-induced upregulation of HIF-1α demonstrating that HIF-1α activation by IH requires Nox2 activation by XO. ..
  8. doi Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo
    Luisa B Maia
    UCIBIO, REQUIMTE, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
    Biochemistry 54:685-710. 2015
    ..Collectively, our results supported the possibility that XO/XD and AO can contribute to NO generation under hypoxia inside a living human cell. Furthermore, the molecular mechanism of XO/AO-catalyzed nitrite reduction was revised. ..
  9. doi Xanthine crystals induced by topiroxostat, a xanthine oxidoreductase inhibitor, in rats, cause transitional cell tumors
    Takeo Shimo
    Research Laboratories 2, Fuji Yakuhin Co, Ltd, 636 1 Iidashinden, Nishi ku, Saitama shi, Saitama, 331 0068, Japan
    Arch Toxicol 88:1035-42. 2014
    ..underlying mechanism of transitional cell tumors found in the carcinogenicity testing of topiroxostat, a xanthine oxidoreductase inhibitor, in which topiroxostat was orally given to F344 rats at 0.3, 1, and 3 mg/kg for 2 years...
  10. pmc Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload
    James D Gladden
    University of Alabama at Birmingham UABComprehensive Cardiovascular Center, UAB Birmingham, Alabama
    Am J Physiol Heart Circ Physiol 305:H1440-50. 2013
    ..However, LV remodeling and diastolic properties are not improved, which may explain the failure of XO inhibition to improve symptoms and hospitalizations in patients with severe heart failure...
  11. ncbi New developments in anthracycline-induced cardiotoxicity
    A Mordente
    Institute of Biochemistry and Clinical Biochemistry, Catholic University School of Medicine, 00168 Roma, Italy
    Curr Med Chem 16:1656-72. 2009
    ....
  12. doi Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene
    Jin Yang
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 31:931-40. 2008
    ..Xanthine dehydrogenase (XDH) produces urate and, in its oxidase isoform, reactive oxygen species...
  13. doi Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate
    Ken Okamoto
    Department of Biochemistry and Molecular Biology, Nippon Medical School, 1 1 5 Sendagi, Bunkyou ku, Tokyo 113 8602, Japan
    J Am Chem Soc 132:17080-3. 2010
    ..have been proposed for the binding mode of the substrate xanthine to and its activation mechanism by xanthine oxidoreductase. In an effort to distinguish between the two models, we determined the crystal structures of the urate ..
  14. pmc Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 297:F481-8. 2009
    ..In conclusion, hyperuricemia has a pathogenic role in the mild tubulointerstitial injury associated with diabetic nephropathy but not glomerular damage in db/db mice. Lowering uric acid may reduce tubulointerstitial injury in diabetes...
  15. doi Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion
    Wisam Khoury
    Division of Surgery B, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Surg Res 160:163-8. 2010
    ..It may be propagated by xanthine oxidase (XO)-generated oxidant stress. We investigated whether pancreas IR directly and acutely induces renal dysfunction and if this outcome could be prevented by mannitol...
  16. pmc Mobilization of xanthine oxidase from the gastrointestinal tract in acute pancreatitis
    Susana Granell
    Dept, of Experimental Pathology, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas IIBB CSIC, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    BMC Gastroenterol 4:1. 2004
    b>Xanthine oxidoreductase has been proposed to play a role in the development of local and systemic effects of acute pancreatitis...
  17. ncbi [The protective effects of carbachol on visceral ischemia-induced lipid peroxidation injury in rats with sepsis]
    Sen Hu
    Burns Institute, First Affiliated Hospital of PLA General Hospital, Beijing, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:552-4. 2009
    ..To investigate the effect of carbachol (CAR) on visceral perfusion and lipid oxidation injury in rats with sepsis...
  18. doi Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study
    Nihayet Bayraktar
    Department of Medical Biochemistry, School of Medicine, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
    J Clin Lab Anal 24:25-30. 2010
    ....
  19. doi Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress
    Hidetoshi Tsuda
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 427:266-72. 2012
    ..In conclusion; novel XO inhibitor, febuxostat, can protect kidney from renal I/R injury, and may contribute to preserve kidney function...
  20. doi Hypouricemic effect of the methanol extract from Prunus mume fruit in mice
    Li Tao Yi
    Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province, PR China
    Pharm Biol 50:1423-7. 2012
    ..The fruit of the Prunus mume Sieb. et Zucc (Rosaceae) is used as a health food or medicinal material in traditional herb medicine for a long time in Eastern Asian countries...
  21. pmc Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats
    Ju Wang
    Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Evid Based Complement Alternat Med 2012:548430. 2012
    ..Cd exposure induced hyperuricemia with renal XOR hyperactivity and UA excretion dysfunction in rats...
  22. pmc Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide
    Jitendra D Vaghasiya
    Department of Pharmacology, Smt R B P M P C, Atkot 360 040, India
    Saudi J Gastroenterol 16:174-80. 2010
    ..This study was designed to investigate the possible effect of exenatide (Glucagon like Peptide-1 receptor agonist) on liver injury (distant organ) induced by renal ischemia reperfusion (IR) in diabetic rats...
  23. doi Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice
    Lvyi Chen
    School of Pharmacy, South Central University for Nationalities, Wuhan 430074, PR China
    Food Chem Toxicol 52:28-35. 2013
    ..These findings elucidated that polydatin exhibited prominent nephroprotective activities and low toxic effects...
  24. ncbi 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta
    Kenji Taki
    Department of Biochemical Toxicology, School of Pharmacy, Showa University, Tokyo, Japan
    J Toxicol Sci 37:607-15. 2012
    ..The 6-MP-treatment resulted in the increased xanthine oxidase (Xdh) expression in the placenta, which gene is related to the ischemic condition of tissues...
  25. pmc Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease
    Michelle P Kao
    Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Am Soc Nephrol 22:1382-9. 2011
    ..Because LVH and endothelial dysfunction associate with prognosis, these results call for further trials to examine whether allopurinol reduces cardiovascular events in patients with CKD and LVH...
  26. doi Aldehyde and xanthine oxidase activities in tissues of streptozotocin-induced diabetic rats: effects of vitamin E and selenium supplementation
    Tayyebeh Ghaffari
    Biochemistry Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
    Biol Trace Elem Res 147:217-25. 2012
    ..The results also indicate that administration of vitamin E and selenium has hypolipidemic, hypoglycemic, and antioxidative effects. It decreases tissue damages in diabetic rats, too...
  27. ncbi Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats
    Joydeep Das
    Division of Molecular Medicine, Bose Institute, P 1 12, CIT Scheme VII M, Kolkata 700054, India
    Amino Acids 43:1509-23. 2012
    ..Taurine supplementation in regular diet could, therefore, be beneficial to regulate diabetes-associated renal complications...
  28. doi Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy
    Hiroki Omori
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 16:549-56. 2012
    ..While some reports suggest a relationship between hyperuricemia and chronic kidney disease (CKD), the renoprotective mechanism of an XO inhibitor in CKD remains unknown. Recent reports have focused on XO as a source of oxidative stress...
  29. pmc The efficacy and safety of febuxostat for urate lowering in gout patients ≥65 years of age
    Robert L Jackson
    Takeda Global Research and Development Centers, Inc, One Takeda Parkway, Deerfield, Illinois 60015, USA
    BMC Geriatr 12:11. 2012
    ..The objective of this post hoc analysis was to examine the efficacy and safety of ULT with febuxostat or allopurinol in a subset of elderly subjects enrolled in the CONFIRMS trial...
  30. doi Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress
    Sarwat Sultana
    Molecular Carcinogenesis and Chemoprevention Division, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi, India
    J Pharm Pharmacol 64:872-81. 2012
    ..Chrysin possess antioxidant, anti-inflammatory and anti-cancer properties. The aim of this study was to investigate the protective efficacy of chrysin against cisplatin-induced nephrotoxicity...
  31. doi Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages
    Yoshifuru Tamura
    Division of Renal Diseases and Hypertension, Univ of Colorado Denver, C281, 12900E 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 303:F339-49. 2012
    ..In conclusion, nicorandil reduces albuminuria and ameliorates renal injury by blocking oxidative stress in chronic kidney disease...
  32. pmc Acrylonitrile-induced gastric toxicity in rats: the role of xanthine oxidase
    Fahad A Al-Abbasi
    Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
    Med Sci Monit 18:BR208-14. 2012
    ..The gastrointestinal tract is an important target organ for ACN toxicity. The objective of the present study was to investigate the role of xanthine oxidase (XO) in ACN-induced gastric toxicity in rats...
  33. pmc A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation
    Sian E Piret
    Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e45217. 2012
    ..8 Mbp region on chromosome 17E1.3. DNA sequencing of the xanthine dehydrogenase (Xdh) gene revealed a nonsense mutation at codon 26 that co-segregated with affected RENF mice...
  34. doi Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study
    Hiroyuki Terawaki
    Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine, Fukushima, Japan
    Clin Exp Nephrol 17:549-53. 2013
    ..The present study aimed to clarify the beneficial effect of allopurinol on cardiovascular morbidity and mortality in a cohort of hypertensive nephropathy patients with impaired kidney function...
  35. pmc Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    JAMA 300:924-32. 2008
    ..Experimentally increasing uric acid levels using a uricase inhibitor causes systemic hypertension in animal models...
  36. doi Renal oxidative stress following CO2 pneumoperitoneum-like conditions
    Wisam Khoury
    Division of General Surgery B, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Surg Endosc 23:776-82. 2009
    ..We investigated the possibility that PNP-associated renal damage is pressure dependent, and that oxidative stress is thereby involved...
  37. doi The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice
    Dur Zong Hsu
    Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng Li Road, Tainan, Taiwan
    Food Chem Toxicol 46:2736-41. 2008
    ..Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species...
  38. pmc Protective effect of endogenous hydrogen sulfide against oxidative stress in gastric ischemia-reperfusion injury
    Jie Cui
    Department of Physiology, Xuzhou Medical College, Xuzhou 221004, P R China
    Exp Ther Med 5:689-694. 2013
    ..05). Endogenous H(2)S has a protective effect against GI-R in rats by inhibiting oxygen free radical overproduction...
  39. doi Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats
    Yan Jun Cao
    School of Medicine, Xi an Jiaotong University, Xi an 710061, PR China
    Phytomedicine 20:1048-54. 2013
    ..IMP showed antihypertensive and antioxidant effects in the renal injury of renovascular hypertensive rats, suggesting that IMP could be of therapeutic use in preventing renal injury related hypertension...
  40. doi The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy
    Jochen Springer
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany Center for Cardiovascular Research, Charite Medical School, Berlin, Germany Norwich Medical School, University of East Anglia, Norwich, UK Electronic address
    Int J Cardiol 168:3527-31. 2013
    ..Xanthine oxidase (XO) metabolizes purines to uric acid and its inhibition has been shown to improve clinical outcome in patients with chronic heart failure...
  41. doi Hyperbaric oxygen therapy in rats attenuates ischemia-reperfusion testicular injury through blockade of oxidative stress, suppression of inflammation, and reduction of nitric oxide formation
    Yu Zhang
    Department of Hyperbaric Oxygen, PLA Navy General Hospital, Beijing, People s Republic of China
    Urology 82:489.e9-489.e15. 2013
    ....
  42. pmc Multiple antioxidants improve cardiac complications and inhibit cardiac cell death in streptozotocin-induced diabetic rats
    Santosh Kumar
    National Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune, India
    PLoS ONE 8:e67009. 2013
    ....
  43. ncbi Efficacy and safety of allopurinol in patients with hypoxanthine-guanine phosphoribosyltransferase deficiency
    Rosa J Torres
    Division of Clinical Biochemistry, La Paz University Hospital, Madrid, Spain
    Metabolism 56:1179-86. 2007
    ..Xanthine lithiasis, developing as a consequence of allopurinol therapy, should be preventable by adjustment of allopurinol dose...
  44. ncbi Role of xanthine oxidoreductase in experimental acute renal-allograft rejection
    Kai Sun
    Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    Transplantation 77:1683-92. 2004
    ..b>Xanthine oxidoreductase (XOR) may constitute a relevant reactive oxygen species (ROS) source. The study was conducted (1)...
  45. pmc Identification of the rat xanthine dehydrogenase/oxidase promoter
    C W Chow
    Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN 37232
    Nucleic Acids Res 22:1846-54. 1994
    ..processes with a wide spectrum of clinical presentations; the enzyme xanthine dehydrogenase/oxidase (XDH/XO) is thought to play a key role in ischemia--reperfusion injury...
  46. ncbi Aluminium increases xanthine oxidase activity and disturbs antioxidant status in the rat
    R Moumen
    Equipe d Université Hydrolases et Cytotoxicité, Centre Hospitalier Universitaire et Université, Caen, France
    J Trace Elem Med Biol 15:89-93. 2001
    ..Our data suggest that Al toxicity could be mediated by its action on both pro- and anti-oxidant enzymes. The biological significance of these findings remains to be established...
  47. ncbi Xanthine oxidase and aldehyde oxidase: a simple procedure for the simultaneous purification from rat liver
    Luisa Maia
    Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade de Lisboa, Edificio C8, Campo Grande, 1749 016 Lisboa, Portugal
    Arch Biochem Biophys 400:48-53. 2002
    ..The purified enzymes gave single bands of approximately 300 kDa on a polyacrylamide gel gradient electrophoresis and displayed the characteristic absorption spectra of highly purified enzymes...
  48. ncbi Xanthine oxidase mediates cytokine-induced, but not hormone-induced bone resorption
    Janos M Kanczler
    Department of Medical Sciences, Bone and Joint Research Group, University of Bath, Bath, BA2 7AY, UK
    Free Radic Res 37:179-87. 2003
    ..Therefore, XO may play a pivotal role in cytokine-induced bone resorption and, if manipulated appropriately, could show a therapeutic benefit in inflammatory bone disorders such as RA...
  49. ncbi Xanthine oxidase and activated neutrophils cause oxidative damage to skeletal muscle after contractile claudication
    A R Judge
    PO Box 118205, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 286:H252-6. 2004
    ....
  50. ncbi Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats
    Yakup Aliciguzel
    Department of Biochemistry, Akdeniz University Medical School, Antalya, Turkey
    J Lab Clin Med 142:172-7. 2003
    ..The aim of this study was to investigate whether an increase in oxidative stress related to xanthine oxidoreductase occurs in diabetes...
  51. ncbi Estrogen modulates xanthine dehydrogenase/xanthine oxidase activity by a receptor-independent mechanism
    Rohit Budhiraja
    Pulmonary and Critical Care Division, Tupper Research Institute, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Antioxid Redox Signal 5:705-11. 2003
    Hypoxia causes up-regulation and activation of xanthine dehydrogenase/xanthine oxidase (XDH/XO) in vitro and in the lungs in vivo...
  52. ncbi Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by
    Y Amaya
    Department of Biochemistry, Yokohama City University School of Medicine, Japan
    J Biol Chem 265:14170-5. 1990
    ..Hydropathy analysis around the cysteine residues suggests that the 2Fe/2S sites are associated with the 20-kDa fragment portion of the enzyme...
  53. pmc Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells
    Guansong Wang
    Institute of Respiratory Diseases, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, PR China
    Int J Biochem Cell Biol 40:461-70. 2008
    Xanthine dehydrogenase/oxidase (XDH/XO) is associated with various pathological conditions related to the endothelial injury. However, the molecular mechanism underlying the activation of XDH/XO by hypoxia remains largely unknown...
  54. ncbi Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant
    Tomoko Nishino
    Department of Biochemistry and Molecular Biology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Biol Chem 280:24888-94. 2005
    ..The crystal structure of the C535A/C992R/C1324S mutant was determined in its demolybdo form, confirming its dehydrogenase conformation...
  55. pmc Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats
    Mari Carmen Gomez-Cabrera
    Catholic University of Valencia, Spain
    J Physiol 567:113-20. 2005
    ....
  56. ncbi Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury
    Ping Lu
    Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Hepatobiliary Pancreat Dis Int 4:350-5. 2005
    It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ..
  57. ncbi Pivotal role of xanthine oxidase in the initiation of tubulointerstitial renal injury in rats with hyperlipidemia
    W Gwinner
    Department of Nephrology, Medical School of Hannover, Hannover, Germany
    Kidney Int 69:481-7. 2006
    ..These results point to an important role for XO in the early stage of hyperlipidemia-associated renal injury, mediating macrophage infiltration by a putatively redox-dependent upregulation of MCP-1 and VCAM-1...
  58. ncbi Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent
    Mohammad A Newaz
    Center for Cardiovascular Diseases, Texas Southern University, Houston, TX 77004, USA
    J Cardiovasc Pharmacol 48:88-94. 2006
    ..05) as well as XO expression in the aorta of aging rats. These results suggest that increased free radical generation-associated increase in SBP in aging rats is XO but not NAD(P)H oxidase-dependent...
  59. ncbi Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase
    Ryosuke Asai
    Department of Biochemistry and Department of Molecular Biology, Nippon Medical School, 1 1 5 Sendagi, Tokyo, Japan
    J Biochem 141:525-34. 2007
    Reactive oxygen species are generated by various systems, including NADPH oxidases, xanthine oxidoreductase (XOR) and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena...
  60. ncbi PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor
    Laura E Roberts
    Department of Biochemistry, University of Bath, Bath, UK
    J Cell Biochem 101:1567-87. 2007
    ..In the present work, promoter activation analyses of xanthine oxidoreductase (XOR) in epithelial cells uncovered the unexpected opposite effect of these inhibitors on activation of ..
  61. ncbi NADH oxidase activity of rat and human liver xanthine oxidoreductase: potential role in superoxide production
    Luisa Maia
    Centro de Quimica e Bioquimica, Faculdade de Ciencias da Universidade de Lisboa, 1749 016 Lisbon, Portugal
    J Biol Inorg Chem 12:777-87. 2007
    ..NADH oxidase activity of both xanthine dehydrogenase (XD) and xanthine oxidase (XO) forms of rat liver xanthine oxidoreductase (XOR) and to evaluate the potential role of this mammalian enzyme as an O2*- source, kinetics and ..
  62. pmc Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels
    John E Baker
    Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 43:437-44. 2007
    ..protection against myocardial infarction in two rat models of ischemia/reperfusion injury and the role of xanthine oxidoreductase, NADPH oxidase, nitric oxide synthase and K(ATP) channels in mediating nitrite-induced cardioprotection...
  63. doi Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Chi Mei Medical Center, Tainan, Taiwan
    Free Radic Biol Med 50:1461-70. 2011
    ..Xanthine oxidase inhibition ameliorates sympathetic innervation and arrhythmias possibly via inhibition of the peroxynitrite-mediated nerve growth factor pathway...
  64. ncbi Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats
    Robert P Jankov
    Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Center, 76 Grenville Street, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L233-45. 2008
    ..Due to the potential for adverse effects on normal growth, targeting XO may represent a superior "antioxidant" strategy to ROS scavengers for neonates with pulmonary hypertension...
  65. pmc Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase
    Haitao Li
    Center for Biomedical EPR Spectroscopy and Imaging, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    J Biol Chem 283:17855-63. 2008
    ....
  66. pmc Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats
    Emilie C Viel
    Lady Davis Institute for Medical Research, Montreal, QC, Canada H3T 1E2
    Am J Physiol Heart Circ Physiol 295:H281-8. 2008
    ..Our findings demonstrate the involvement of ET(A) receptor-modulated O(2)(*-) derived from XO and from mitochondrial oxidative enzymes in arteries from DOCA-salt rats...
  67. pmc Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase
    Andrew J Webb
    William Harvey Research Institute, Centre for Clinical Pharmacology, Barts and The London, Charterhouse Square, London, UK
    Circ Res 103:957-64. 2008
    ..Our previous studies suggest that xanthine oxidoreductase (XOR) is an important nitrite reductase in the heart and kidney...
  68. pmc Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction
    Melissa A Whidden
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol (1985) 106:385-94. 2009
    ..Nonetheless, the failure of XO inhibition to completely prevent MV-induced diaphragmatic oxidative damage suggests that other sources of oxidant production are active in the diaphragm during prolonged MV...
  69. ncbi Renal xanthine oxidoreductase activity during development of hypertension in spontaneously hypertensive rats
    Juha T Laakso
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Hypertens 22:1333-40. 2004
    Hyperuricaemia and reactive oxygen species have recently been associated with essential hypertension. Xanthine oxidoreductase (XOR) produces urate and, in its oxidase isoform, reactive oxygen species also...
  70. doi Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta
    Kevin G Soucy
    Department of Biomedical Engineering, Johns Hopkins Medical Institutions, 600 N Wolfe St, Tower 711, Baltimore, MD 21287, USA
    J Appl Physiol (1985) 108:1250-8. 2010
    ..These findings demonstrate that XO inhibition can offer protection from radiation-induced endothelial dysfunction and cardiovascular complications...
  71. doi Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase
    Meital Portugal-Cohen
    School of Pharmacy, Institute of Drug Research, The Hebrew University of Jerusalem, Israel
    J Dermatol Sci 58:105-12. 2010
    ..Heavy cocaine abusers are known to develop adverse skin manifestations, however, a possible mechanism for such damages has not yet been proposed...
  72. doi Differential effects of xanthine oxidase inhibition and exercise on albumin concentration in rat tissues
    Aristidis S Veskoukis
    Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
    Appl Physiol Nutr Metab 35:244-50. 2010
    ..Our findings suggest that the increase in albumin concentration in skeletal muscles may be an antioxidant mechanism response, but may depend on the type of oxidative stress and be stimulation- and tissue-specific...

Research Grants5

  1. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
    ....
  2. Uric Acid in Childhood Hypertension
    Daniel Feig; Fiscal Year: 2007
    ..abstract_text> ..
  3. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ....
  4. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  5. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
    ..1 ..