Wnt1

Summary

Gene Symbol: Wnt1
Description: wingless-type MMTV integration site family, member 1
Alias: Int1, proto-oncogene Wnt-1, Wingless-type MMTV integration site 1, homolog, wingless-related MMTV integration site 1
Species: rat

Top Publications

  1. ncbi Prevalence of disabled stereopsis in a class of optometry students
    W L Larson
    Ecole d Optometrie, Universite de Montreal, Quebec, Canada
    Optom Vis Sci 69:923-5. 1992
  2. ncbi Identification of connexin43 as a functional target for Wnt signalling
    M A van der Heyden
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, The Netherlands
    J Cell Sci 111:1741-9. 1998
  3. ncbi Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts
    J A Schroeder
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599 7260, USA
    Oncogene 19:3193-9. 2000
  4. ncbi Beta-catenin/Tcf activation partially mimics the transforming activity of Wnt-1 in Rat-1 fibroblasts
    C S Young
    Department of Pathology and OB GYN, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Differentiation 71:477-85. 2003
  5. ncbi Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms
    Won Bae Kim
    Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
    J Endocrinol 193:93-106. 2007
  6. ncbi Wnt1-overexpressing skeletal myoblasts as an improved cell therapy for cardiac repair following myocardial infarction
    G Q Du
    The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education
    Panminerva Med 57:153-66. 2015
  7. pmc Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth
    Liang Dong
    1 Institute of Basic Medicine Science, College of Life Science, Chinese PLA General Hospital, Beijing 100853, China 2
    Sci Rep 4:5432. 2014
  8. pmc WNT signaling underlies the pathogenesis of neuropathic pain in rodents
    Yan kai Zhang
    Department of Neurobiology, Parker University Research Institute, Dallas, Texas 75229, USA
    J Clin Invest 123:2268-86. 2013
  9. pmc Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein
    Maria V Barbolina
    Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois 60622, USA
    J Biol Chem 288:141-51. 2013
  10. pmc Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling
    Nanthakumar Subramaniam
    Storr Liver Unit, Westmead Millennium Institute and Sydney Medical School, University of Sydney, Westmead, New South Wales, Australia
    Cancer Prev Res (Phila) 5:553-61. 2012

Scientific Experts

  • Chun Liang Lin
  • Jesus Villar
  • Jin Ran Chen
  • G Q Du
  • Liang Dong
  • Maria V Barbolina
  • Yan kai Zhang
  • Nanthakumar Subramaniam
  • Zhao Zhong Chong
  • Ana Carolina Cuzzuol Fracalossi
  • David Ehrlich
  • Jennifer M Williams
  • Dejun Zhong
  • Renée van Amerongen
  • Lenka Doubravska
  • Paola Spinsanti
  • Won Bae Kim
  • Jan Kitajewski
  • C S Young
  • Goncalo Castelo-Branco
  • J J Liu
  • H G Nie
  • Y S Wang
  • B Yu
  • M M Zhang
  • W J Du
  • Haojie Hao
  • Lei Xia
  • Jiejie Liu
  • Chuan Tong
  • Weidong Han
  • Qingwang Han
  • Huiling Liu
  • Qian Hou
  • Yali Zhao
  • Dongdong Ti
  • Xiaobing Fu
  • Lisa Rooper
  • Hilal Gurler
  • M Sharon Stack
  • Xue Jun Song
  • Jaclyn Shepard
  • Angela A Song
  • Andre A Kajdacsy-Balla
  • Yiuying Liu
  • Zhi Jiang Huang
  • Lonnie D Shea
  • Su Liu
  • MiJung Kim
  • Peter Penzes
  • Matthew J Ravosa
  • Michael Weiss
  • Yue Peng Liu
  • Caroline Wilson
  • Ronald M Evans
  • Christopher Liddle
  • Annette R Atkins
  • Mara H Sherman
  • Sally Coulter
  • Renuka Rao
  • Michael Downes
  • Jinling Hou
  • Kenneth Maiese
  • Shaohui Wang
  • Yan Chen Shang
  • Bryon E Petersen
  • Seh Hoon Oh
  • Celina Tijuko Fujiyama Oshima
  • Nicole Steiger
  • Houda Darwiche
  • Marcelo de Souza Silva
  • Carsten N Gutt
  • J A Schroeder
  • Thomas Shupe
  • Daniel Araki Ribeiro
  • Martin A Thome
  • Robert Koesters
  • Alan O Perantoni
  • Magnus von Knebel Doeberitz
  • Marda Jorgensen
  • Felix Niggli
  • Elisabeth Bruder
  • Yueming Song
  • DeSheng Zhang
  • Qing Wang
  • Minm Kang
  • Roberta Misasi
  • Vladimir Korinek
  • Roel Nusse
  • Alessandra Caruso

Detail Information

Publications25

  1. ncbi Prevalence of disabled stereopsis in a class of optometry students
    W L Larson
    Ecole d Optometrie, Universite de Montreal, Quebec, Canada
    Optom Vis Sci 69:923-5. 1992
    ..Stereoacuity had the worst predictive value (43%) and stereolatency the best (100%). The prevalence of disabled stereopsis in this group was no less than 34% and might have been as great as 95%...
  2. ncbi Identification of connexin43 as a functional target for Wnt signalling
    M A van der Heyden
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, The Netherlands
    J Cell Sci 111:1741-9. 1998
    Wnt mediated signal transduction is considered to regulate activity of target genes. In Xenopus embryos, ectopic Wnt1 and Wnt8 expression induces gap-junctional communication...
  3. ncbi Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts
    J A Schroeder
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599 7260, USA
    Oncogene 19:3193-9. 2000
    ..Collectively, these results reveal cooperative induction of mammary gland tumorigenesis by simultaneous deregulation of EGF-like (TGFalpha) and Wnt growth factors...
  4. ncbi Beta-catenin/Tcf activation partially mimics the transforming activity of Wnt-1 in Rat-1 fibroblasts
    C S Young
    Department of Pathology and OB GYN, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Differentiation 71:477-85. 2003
    ..As ectopic expression of beta-cateninS37A only partially mimics Wnt-1 effects on Rat-1 cells, we conclude that Wnt-1 signaling elicits biochemical events that act in addition to beta-catenin/Tcf signaling to promote cell growth...
  5. ncbi Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms
    Won Bae Kim
    Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
    J Endocrinol 193:93-106. 2007
    ..We hypothesize that Wnt signaling contributes to the ability of TSH to simultaneously increase cell growth and functional, thyroid-specific, gene expression...
  6. ncbi Wnt1-overexpressing skeletal myoblasts as an improved cell therapy for cardiac repair following myocardial infarction
    G Q Du
    The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education
    Panminerva Med 57:153-66. 2015
    ..In this study, we evaluate the therapeutic potential of SkMs genetically modified with Wnt1gene (Wnt1 SkMs) in a rat model with myocardial infarction (MI).
  7. pmc Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth
    Liang Dong
    1 Institute of Basic Medicine Science, College of Life Science, Chinese PLA General Hospital, Beijing 100853, China 2
    Sci Rep 4:5432. 2014
    ..Our study reveals that BM-MSC-generated Wnt1a promotes the DP's ability to induce hair cycling and regeneration. ..
  8. pmc WNT signaling underlies the pathogenesis of neuropathic pain in rodents
    Yan kai Zhang
    Department of Neurobiology, Parker University Research Institute, Dallas, Texas 75229, USA
    J Clin Invest 123:2268-86. 2013
    ..These findings indicate a critical mechanism underlying the pathogenesis of neuropathic pain and suggest that targeting the WNT signaling pathway may be an effective approach for treating neuropathic pain, including bone cancer pain...
  9. pmc Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein
    Maria V Barbolina
    Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois 60622, USA
    J Biol Chem 288:141-51. 2013
    ..Similar results were obtained in other tissue-invasive cells such as vascular endothelial cells, suggesting a novel mechanism for functional coupling of matrix adhesion with Wnt signaling...
  10. pmc Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling
    Nanthakumar Subramaniam
    Storr Liver Unit, Westmead Millennium Institute and Sydney Medical School, University of Sydney, Westmead, New South Wales, Australia
    Cancer Prev Res (Phila) 5:553-61. 2012
    ..These results suggest that AICAR and metformin may confer disease-specific therapeutic benefits...
  11. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
    ..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles...
  12. pmc Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 6:e23914. 2011
    ..Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI...
  13. pmc EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes
    Zhao Zhong Chong
    Department of Neurology and Neurosciences, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07101, USA
    Curr Neurovasc Res 8:103-20. 2011
    ..Erythropoietin (EPO) represents one of these novel strategies but the dependence of EPO upon Wnt1 and its downstream signaling in a clinically relevant model of DM with elevated D-glucose has not been elucidated...
  14. doi Alternative wnt signaling is initiated by distinct receptors
    Renée van Amerongen
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Sci Signal 1:re9. 2008
    ..Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example...
  15. doi Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
    Jin Ran Chen
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Bone Miner Res 25:2399-411. 2010
    ....
  16. pmc The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation
    Jennifer M Williams
    University of Florida College of Medicine, Department of Pathology, PO Box 100275, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    Am J Pathol 176:2732-42. 2010
    ..This study elucidates novel findings implicating Wnt1 in directing oval cell differentiation during the rat 2-acetylaminofluorene (2AAF) and 2/3 partial hepatectomy (PHx)..
  17. doi Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide
    Ana Carolina Cuzzuol Fracalossi
    Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP, SP, Brazil
    Exp Mol Pathol 88:176-83. 2010
    ..purpose of this study was to characterize the Wnt/beta-catenin signaling pathway as depicted by the expression of Wnt1, Frizzled-1, Wnt5a, Frizzled-5 and beta-catenin during 4NQO-induced rat tongue carcinogenesis by ..
  18. ncbi [Effect of Wnt-1 on the process of inducing neural stem cells into neurons by all-trans-retinoic acid in vitro]
    Dejun Zhong
    Department of Spinal Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou Sichuan, 646000, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:742-6. 2009
    ..To explore the expression of Wnt-1 during the process of inducing neural stem cells (NSCs) into neurons by using all-trans-retinoic acid (ATRA) in vitro and the effect of Wnt-1 on NSCs differentiation...
  19. pmc Nuclear accumulation of beta-catenin protein indicates activation of wnt signaling in chemically induced rat nephroblastomas
    David Ehrlich
    Division of Applied Tumor Biology, Institute of Pathology, University Hospital of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Pediatr Dev Pathol 13:1-8. 2010
    ..Nuclear expression of beta-catenin in the absence of Ctnnb1 mutations implies, however, alternate mutational targets in rat nephroblastomas...
  20. doi Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells
    Lenka Doubravska
    Laboratory of Cell and Developmental Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 14220, Praha 4, Czech Republic
    Apoptosis 13:573-87. 2008
    ..We observed that co-culture of human pre-B leukemia cells KM3 and REH with Wnt1- or Wnt3a-producing rat embryonic fibroblasts efficiently suppressed Apo2L/TRAIL-induced apoptosis of the lymphoid ..
  21. ncbi Simvastatin reverses high glucose-induced apoptosis of mesangial cells via modulation of Wnt signaling pathway
    Chun Liang Lin
    Division of Nephrology, Chiayi Chang Gung Memorial Hospital and Graduate Institute of Clinical Medicine, Chang Gung University, Chiayi, Taiwan
    Am J Nephrol 28:290-7. 2008
    ..We examined the role of simvastatin (SIM) in modulation of Wnt/beta-catenin signaling in the apoptosis of high glucose (HG)-stressed mesangial cells in vitro and in vivo...
  22. ncbi Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells
    Paola Spinsanti
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 104:1588-98. 2008
    We examined the effect of Wnt1 and Wnt7a on cell proliferation using undifferentiated PC12 cells, which originate from the neural crest and are widely employed as a neuronal cell model...
  23. ncbi Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression
    A Erdreich-Epstein
    Division of Hematology Oncology, Childrens Hospital Los Angeles, California 90027 6016, USA
    Growth Factors 15:149-58. 1998
    ..Ectopic expression of Wnt1 converts the PC12 neural crest-derived rat pheochromocytoma cell line from a round phenotype that express ..
  24. ncbi Transformation by Wnt family proteins correlates with regulation of beta-catenin
    H Shimizu
    Strang Cornell Cancer Research Laboratory, Cornell University Medical College, New York, New York 10021, USA
    Cell Growth Differ 8:1349-58. 1997
    ..These data also imply the existence of receptors that respond to certain Wnt proteins but not to others...
  25. pmc Differential transformation of mammary epithelial cells by Wnt genes
    G T Wong
    Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Mol Cell Biol 14:6278-86. 1994
    ..These data demonstrate that the Wnt genes have distinct effects on cell growth and should not be regarded as functionally equivalent...