Ubc

Summary

Gene Symbol: Ubc
Description: ubiquitin C
Alias: polyubiquitin-C
Species: rat

Top Publications

  1. pmc Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells
    Chrystelle V Garat
    Cardiovascular Pulmonary Research, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Campus Box B 133, Denver, CO 80262, USA
    Mol Cell Biol 26:4934-48. 2006
  2. ncbi Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43
    Edward Leithe
    Institute for Cancer Research at The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Cell Sci 117:1211-20. 2004
  3. ncbi Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment
    Edward Leithe
    Institute for Cancer Research at The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Biol Chem 279:50089-96. 2004
  4. doi Regulation of intracellular decorin via proteasome degradation in rat mesangial cells
    Huijuan Wu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China
    J Cell Biochem 111:1010-9. 2010
  5. ncbi Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors
    B D Butts
    Pharmacology, University of Colorado Health Science Center at Fitzsimons, Aurora, CO 80045, USA
    Mol Cell Neurosci 30:279-89. 2005
  6. pmc Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6)
    Michaeline L Hebron
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 288:4103-15. 2013
  7. ncbi The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
  8. doi A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1)
    Kieran J Clarke
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochim Biophys Acta 1817:1759-67. 2012
  9. pmc Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Neuron 73:962-77. 2012
  10. doi AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase
    Non Miyata
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
    Traffic 13:168-83. 2012

Research Grants

  1. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 2002
  2. Bioinformatics for Protein Microarrays
    Richard Zangar; Fiscal Year: 2009
  3. Crosstalk between oncoprotein Ski and TGF-B signaling
    Yin Sun; Fiscal Year: 2008
  4. Functions of BPAG1n
    BRIAN PIERCHALA; Fiscal Year: 2007

Scientific Experts

  • Richard Zangar
  • Reng Fei Shi
  • S P Bhattacharyya
  • V D Nair
  • Guangping Chen
  • Yin Sun
  • Marie W Wooten
  • Naunchan Chutabhakdikul
  • E Skarpen
  • Edward Leithe
  • Shinichi Kondo
  • Brian A Pierchala
  • Nazira Ozgen
  • Michaeline L Hebron
  • Irina Lonskaya
  • Yan Zhang
  • Quan Guang Zhang
  • Huijuan Wu
  • Thangiah Geetha
  • Sudha K Shenoy
  • Maire Beeken
  • Elena Lonati
  • Tsun Jui Liu
  • Charbel E H Moussa
  • Julien Bertrand
  • Akashi Togawa
  • Sang oh Han
  • Vijayalaxmi C Nalavadi
  • Non Miyata
  • Hyunjin Noh
  • Julia Mössinger
  • Kieran J Clarke
  • Eunice Y Yuen
  • Stephane Dalle
  • Dong Han
  • Simon Thompson
  • Limor Raz
  • Kyoung Ja Kwon
  • Zhigang Zhang
  • Danielle A Sliter
  • Nadia Litterman
  • Zhonghua Zhao
  • Kunhong Xiao
  • Darrell W Brann
  • Yan Dong
  • Steven P Gygi
  • Wei Zhang
  • Weina Jiang
  • Jihee Kim
  • Christophe Altier
  • Sung Mi Kim
  • Chang Hoon Woo
  • Moran Golan
  • Rodrigo Alzamora
  • Huali Zhang
  • Márcio S Baptista
  • Diego F Calvisi
  • Sonja Bareiss
  • Young Don Kwak
  • Mun Kit Choy
  • Arun K Shukla
  • Safia Costes
  • Da Fu
  • Yun Bian
  • Richard J H Wojcikiewicz
  • Gina D Visser Smit
  • Taro Misaki
  • Ming Zhang
  • Xiang Li
  • Lakshmi Gopinathan
  • Semyon Melnikov
  • Alessia Ciarrocchi
  • Rohit Singhal
  • Jenny Ekberg
  • Robert J Lefkowitz
  • Andreia F Carvalho
  • Margaret M P Pearce
  • Tatsuo Yamamoto
  • Yun Sik Lee
  • Takayuki Hattori
  • Graeme S Cottrell
  • Akira Hishida
  • Yoshihide Fujigaki
  • Masatoshi Kitagawa
  • Hirotaka Fukasawa
  • Junetsu Ogasawara
  • Hiroyuki Suzuki
  • Chrystelle V Garat
  • Gregory D Salinas
  • Keiji Uchiyama

Detail Information

Publications94

  1. pmc Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells
    Chrystelle V Garat
    Cardiovascular Pulmonary Research, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Campus Box B 133, Denver, CO 80262, USA
    Mol Cell Biol 26:4934-48. 2006
    ..These results indicate that in addition to direct phosphorylation, proteolysis and intracellular localization are key mechanisms regulating CREB content and activity in SMCs...
  2. ncbi Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43
    Edward Leithe
    Institute for Cancer Research at The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Cell Sci 117:1211-20. 2004
    ..Taken together, these data provide the first evidence that EGF-induced phosphorylation of Cx43 induces binding of ubiquitin and targets Cx43 for internalization and degradation in a proteasome-dependent manner...
  3. ncbi Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment
    Edward Leithe
    Institute for Cancer Research at The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Biol Chem 279:50089-96. 2004
    ..Moreover, the results suggest that the proteasome might play an indirect role in Cx43 degradation by affecting the level of monoubiquitin conjugation and trafficking of Cx43 to endosomal compartments...
  4. doi Regulation of intracellular decorin via proteasome degradation in rat mesangial cells
    Huijuan Wu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China
    J Cell Biochem 111:1010-9. 2010
    ....
  5. ncbi Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors
    B D Butts
    Pharmacology, University of Colorado Health Science Center at Fitzsimons, Aurora, CO 80045, USA
    Mol Cell Neurosci 30:279-89. 2005
    ..However, chronic proteasome inhibition causes a build-up of phosphorylated c-Jun and Bim, which eventually overwhelms the effects of MEF2 and triggers apoptosis...
  6. pmc Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6)
    Michaeline L Hebron
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 288:4103-15. 2013
    ..Parkin and TDP-43 formed a multiprotein complex with HDAC6, perhaps to mediate TDP-43 translocation. In conclusion, Parkin ubiquitinates TDP-43 and facilitates its cytosolic accumulation through a multiprotein complex with HDAC6...
  7. ncbi The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway...
  8. doi A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1)
    Kieran J Clarke
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochim Biophys Acta 1817:1759-67. 2012
    ..We conclude that there is a role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial UCP1. This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012)...
  9. pmc Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Neuron 73:962-77. 2012
    ..Our results suggest that repeated stress dampens PFC glutamatergic transmission by facilitating glutamate receptor turnover, which causes the detrimental effect on PFC-dependent cognitive processes...
  10. doi AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase
    Non Miyata
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan
    Traffic 13:168-83. 2012
    ..Taken together, these results identify AWP1 as a novel cofactor of Pex6 involved in the regulation of Pex5 export during peroxisome biogenesis...
  11. pmc C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection
    Quan Guang Zhang
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 108:E617-24. 2011
    ..As a whole, the study provides support for a "critical period" for E2 neuroprotection of the hippocampus and provides important insight into the mechanism underlying the critical period...
  12. pmc Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor
    Chang Hoon Woo
    Aab Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    FASEB J 24:4917-28. 2010
    ..We identified ICER as a novel CHIP substrate and that the ERK5-CHIP complex plays an obligatory role in inhibition of ICER expression, cardiomyocyte apoptosis, and cardiac dysfunction...
  13. pmc Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases
    Maire Beeken
    Departments of Internal Medicine, Nephrology
    J Am Soc Nephrol 25:2511-25. 2014
    ..This study identifies altered proteolysis as a feature of persistent podocyte injury. In the future, specific UPS proteins may serve as new biomarkers or therapeutic targets in persistent nephrotic syndrome. ..
  14. pmc Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons
    Márcio S Baptista
    Center for Neuroscience and Cell Biology, Department of Life Sciences, University of Coimbra, Coimbra, Portugal
    PLoS ONE 5:e10139. 2010
    ..This is the first time that the UPS has been implicated in the events triggered during excitotoxicity and the first molecular target of the UPS affected in this cell death process...
  15. pmc Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets
    Safia Costes
    Institut National de la Sante et de la Recherche Medicale INSERM, U661, Equipe Avenir, Institut de Genomique Fonctionnelle, Montpellier, France
    Diabetes 58:1105-15. 2009
    ..The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. We investigated whether prolonged exposure of beta-cells to high glucose affects the functional integrity of CREB...
  16. pmc Tollip is a mediator of protein sumoylation
    Alessia Ciarrocchi
    Department of Biology, Bologna University, Bologna, Italy
    PLoS ONE 4:e4404. 2009
    ..We conclude that Tollip is involved in the control of both nuclear and cytoplasmic protein traffic, through two different and often contrasting processes: ubiquitylation and sumoylation...
  17. ncbi Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2
    Jenny Ekberg
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 282:12135-42. 2007
    ..Furthermore, Nedd4-2 could ubiquitinate KCNQ2/3 in transfected cells. Taken together, these data suggest that Nedd4-2 is potentially an important regulator of M-current activity in the nervous system...
  18. ncbi Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation
    Shinkou Kyo
    Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
    Genes Cells 8:825-36. 2003
    ..However, it was not clear whether Src family kinase Lyn is regulated by the Cbl family of ubiquitin-protein ligases...
  19. pmc Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer's disease risk factor
    Elena Lonati
    Department of Health Science, University of Milano Bicocca Monza MI, Italy
    Front Cell Neurosci 8:1. 2014
    ....
  20. pmc Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance
    Irina Lonskaya
    Department of Neuroscience, Laboratory for Dementia and Parkinsonism, Georgetown University Medical Center, Washington, DC, United States of America
    PLoS ONE 8:e83914. 2013
    ..These studies demonstrate that parkin ubiquitination affects its protein stability and E3 ligase activity, possibly leading to α-Synuclein sequestration and subsequent clearance. ..
  21. doi Lose dose genistein inhibits glucocorticoid receptor and ischemic brain injury in female rats
    Rengfei Shi
    School of Kinesiology, Shanghai University of Sport, 588 Qingyuan Huan Road, Shanghai 200438, China Electronic address
    Neurochem Int 65:14-22. 2014
    ....
  22. ncbi Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27
    C Liu
    Departments of Cell and Developmental Biology and Plastic and Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 275:18724-31. 2000
    ..Ectopic expression of PASS1 in two cultured cell lines was observed to inhibit the ability of hsp27 to protect cells against heat shock, indicating that PASS1 does interact with hsp27 in the live cell...
  23. doi Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation
    Julien Bertrand
    INSERM unit 1073, University of Rouen, Rouen, France Institute for Research and Innovation in Biomedicine, University of Rouen, Rouen, France
    Proteomics 13:3284-92. 2013
    ..Further studies should lead to the identification of ubiquitin ligases responsible for Grp75 and Grp78 ubiquitination. ..
  24. doi Prenatal stress increased Snk Polo-like kinase 2, SCF β-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood
    Naunchan Chutabhakdikul
    Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakornpathom 73170, Thailand Electronic address
    Int J Dev Neurosci 31:560-7. 2013
    ..In addition, an involvement of the UPS system in the prenatal stress model has led to a greater understanding of the effects of prenatal stress later on in life. ..
  25. pmc Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1
    Stephane Dalle
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
    Mol Cell Biol 22:6272-85. 2002
    ....
  26. pmc Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch
    Julia Mössinger
    Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Takustraße 6, 14195 Berlin, Germany
    EMBO Rep 13:1087-94. 2012
    ..These findings unravel a new molecular link between phosphoinositide-regulated endosomal membrane traffic, ubiquitin and the modulation of Wnt signalling...
  27. ncbi Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells
    Olga V Leontieva
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 279:5788-801. 2004
    ..Our findings highlight subcellular distribution and phosphorylation state as critical determinants of PKCalpha desensitization pathways...
  28. pmc Activation of OASIS family, ER stress transducers, is dependent on its stabilization
    S Kondo
    Department of Biochemistry, Institute of Biomedical and Health Sciences, University of Hiroshima, Hiroshima 734 8553, Japan
    Cell Death Differ 19:1939-49. 2012
    ..These findings suggest that ER stress stabilizes OASIS family members and this is a novel molecular mechanism for the activation of ER stress transducers...
  29. ncbi SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor
    Samir Ali
    Department of Medicine, Division of Hematology and Molecular Oncology Group, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 278:52021-31. 2003
    ..Together our results provide a novel function for SHP-2 as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways...
  30. pmc Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
    Yihong Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    J Cell Biol 162:71-84. 2003
    ....
  31. pmc Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
    Yun Bian
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, 736 Cambridge St CBR3, Boston, MA 02135, USA
    Am J Physiol Heart Circ Physiol 297:H1974-83. 2009
    ..NRG1 maintains cardiac troponins by the erbB2-PI3K pathway, which may lessen Dox-induced cardiac dysfunction...
  32. pmc Regulation of peroxisome proliferator-activated receptor-alpha by MDM2
    Lakshmi Gopinathan
    The Huck Institutes of the Life Sciences, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 108:48-58. 2009
    ..These studies identify a role for MDM2 in regulating PPARalpha-mediated pathways of lipid metabolism...
  33. ncbi Ubiquitination of mammalian Pex5p, the peroxisomal import receptor
    Andreia F Carvalho
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    J Biol Chem 282:31267-72. 2007
    ..Together with mechanistic data recently described for yeast Pex5p, these findings provide strong evidence for the existence of Pex4p- and Pex22p-like proteins in mammals...
  34. pmc MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation
    Guangping Chen
    Renal Division, Department of Medicine, Emory University School of Medicine, WMRB Rm 338, 1639 Pierce Dr, NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F1528-34. 2008
    ..The mechanism is likely to be physiologically important as UT-A1 ubiquitination was identified in kidney inner medullary tissue. The ubiquitin-proteasome degradation pathway provides an important novel mechanism for UT-A1 regulation...
  35. doi Cell-cycle-dependent PC-PLC regulation by APC/C(Cdc20)-mediated ubiquitin-proteasome pathway
    Da Fu
    Department of Biochemistry, Fudan University, Shanghai, PR China
    J Cell Biochem 107:686-96. 2009
    ..Taken together, our data indicate that PC-PLC regulation in cell cycles is controlled by APC/C(Cdc20)-mediated UPP...
  36. doi Down-regulating protein kinase C alpha: functional cooperation between the proteasome and the endocytic system
    Semyon Melnikov
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Cell Signal 21:1607-19. 2009
    ....
  37. doi Antidepressants increase β-arrestin 2 ubiquitinylation and degradation by the proteasomal pathway in C6 rat glioma cells
    Moran Golan
    Department of Pharmacology, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, Israel 84105
    J Pharmacol Exp Ther 332:970-6. 2010
    ....
  38. pmc Acetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogen
    Limor Raz
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 6:e27039. 2011
    ..However, it is not known whether acetylation of p53 is altered in the hippocampus following global cerebral ischemia (GCI) or is regulated by the hormone, 17β-estradiol (17β-E(2)), and thus, this study examined these issues...
  39. pmc Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity
    Wei Zhang
    Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, China
    PLoS ONE 6:e26297. 2011
    ..These results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses...
  40. doi Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor
    Hyunjin Noh
    Department of Internal Medicine, Soon Chun Hyang University, Seoul, Korea
    Lab Invest 92:1583-96. 2012
    ..These findings suggest that Hsp90 inhibitor prevents the development of renal fibrosis via a mechanism dependent on Smurf2-mediated degradation of TβRII...
  41. pmc MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors
    Sang oh Han
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 199:817-30. 2012
    ..In response to β blocker therapy with carvedilol, MARCH2 E3 ligase activity regulates cell surface β(2)AR expression and, consequently, its signaling...
  42. doi Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection
    Kyoung Ja Kwon
    Departments of Neurology Pharmacology Rehabilitation, Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, School of Medicine, Konkuk University, Seoul, Korea
    J Pineal Res 50:110-23. 2011
    ....
  43. pmc An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning
    Nadia Litterman
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Biol 9:e1001060. 2011
    ....
  44. ncbi Bidirectional regulation of upstream IGF-I/insulin receptor signaling and downstream FOXO1 in cardiomyocytes
    Tsun Jui Liu
    Department of Medicine, Biological Chemistry, Physiology and Biophysics, Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697, USA
    J Endocrinol 192:149-58. 2007
    ..These findings indicate bidirectional regulation of insulin/IGF-I receptor signaling and FOXO1 in cardiomyocytes. FOXO1 may provide feedback control through upregulation of insulin and IGF-I receptor signaling...
  45. ncbi Downregulation of retinal GLUT1 in diabetes by ubiquitinylation
    Rosa Fernandes
    Biomedical Institute for Research in Light and Image, Center of Ophthalmology, University of Coimbra, Coimbra, Portugal
    Mol Vis 10:618-28. 2004
    ..To investigate the effect of chronic hyperglycemia on the levels of the glucose transporter GLUT1 in retina and its ubiquitinylation...
  46. pmc beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1
    Isao Usui
    Department of Medicine 0673, University of California, San Diego, Stein Bldg, Room 210, 9500 Gilman Dr, La Jolla, CA 92093 0673, USA
    Mol Cell Biol 24:8929-37. 2004
    ....
  47. ncbi Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    Mol Cell 20:301-12. 2005
    ..These findings reveal that polyubiquitination serves as a common platform for the control of receptor internalization and signaling...
  48. ncbi Monoubiquitination and cellular distribution of XIAP in neurons after traumatic brain injury
    George Lotocki
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Cereb Blood Flow Metab 23:1129-36. 2003
    ....
  49. pmc TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
    Thangiah Geetha
    Department of Biological Sciences and Program in Cell and Molecular Biosciences, Auburn University, Auburn, AL, USA
    EMBO J 24:3859-68. 2005
    ..Finally, unlike wild-type NRIF, the K19R NRIF failed to reconstitute p75-mediated apoptosis in nrif-/- neurons. These results reveal a unique mechanism of p75 signaling and a novel role for K63-linked ubiquitin chains...
  50. pmc Ubiquitin-dependent degradation of Smad2 is increased in the glomeruli of rats with anti-thymocyte serum nephritis
    Akashi Togawa
    First Department of Medicine and the Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Am J Pathol 163:1645-52. 2003
    ..These data suggest that the decrease in Smad2 resulted from enhanced ubiquitin-dependent degradation of Smad2 mediated by Smurf2, and is involved in the regulation of Smad2-mediated TGF-beta signaling in nephritic glomeruli...
  51. ncbi Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells
    Yue Xin Shan
    Department of Medicine, Biological Chemistry, Physiology and Biophysics, Center for Cardiovascular Hormone Research, University of California, Medical Science 1, Room C240, Irvine, CA 92697, USA
    J Mol Cell Cardiol 35:1135-43. 2003
    ..Antisense Hsp60 reduced the abundance of endogenous Hsp60 in cardiomyocytes and amplified the cytotoxicity of doxorubicin. These data provide a novel link between Hsp10/Hsp60 and cardiac protection in doxorubicin cardiomyopathy...
  52. ncbi Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors
    Phillip O Schnell
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Neurochem 85:483-91. 2003
    ..These results indicate that HIFs may play an important role in regulation of TH gene expression in oxygen-sensitive cells and also in the development of hypercatecholaminemia in pheochromocytoma tumors...
  53. pmc Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen
    Yun Sik Lee
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 9410, USA
    J Pharmacol Exp Ther 317:202-8. 2006
    ..Taken together, our results show that APAP or its reactive metabolite(s) can directly reduce the p53 content through mdm2-mediated ubiquitin conjugation, despite phosphorylation of p53 at its N terminus...
  54. ncbi Suppression of cytochrome P450 3A protein levels by proteasome inhibitors
    Richard C Zangar
    Pacific Northwest National Laboratory, 902 Battelle Blvd, MS P7 56, Richland, WA 99352, USA
    J Pharmacol Exp Ther 305:872-9. 2003
    ....
  55. ncbi SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells
    Margaret M P Pearce
    Departments of Pharmacology and Medicine, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Biol Chem 282:20104-15. 2007
    ..Overall, these studies identify SPFH2 as a key ERAD pathway component and suggest that it may act as a substrate recognition factor...
  56. ncbi p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:39550-60. 2006
    ..These results suggest that abnormalities in p53 signaling play a role in dopaminergic cell death induced by proteasome inhibition and may be relevant to neurodegeneration in PD...
  57. pmc Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression
    Marcie Colledge
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Neuron 40:595-607. 2003
    ..These data suggest that ubiquitination of PSD-95 through an Mdm2-mediated pathway is critical in regulating AMPA receptor surface expression during synaptic plasticity...
  58. pmc OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level
    Yan Zhang
    Key Laboratory of Molecular Medicine of Chinese Education Ministry, Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, People s Republic of China
    PLoS ONE 7:e29654. 2012
    ..The aim of this study is to investigate the role of OTUB1 expression in MC and its relationship with DCN during glomerulonephritis...
  59. ncbi A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
    Elizabeth Yeh
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Cell Biol 6:308-18. 2004
    ..Thus, Ras-dependent signalling cascades ensure transient and self-limiting accumulation of c-Myc, disruption of which contributes to human cell oncogenesis...
  60. ncbi Altered regulation of EGF receptor signaling following a partial hepatectomy
    E Skarpen
    Laboratory for Toxicopathology, Institute of Pathology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Cell Physiol 202:707-16. 2005
    ..This may be a pre-replicative competence event that increases growth factor effects during G1 progression...
  61. ncbi cAMP perturbs inter-Sertoli tight junction permeability barrier in vitro via its effect on proteasome-sensitive ubiquitination of occludin
    Wing Yee Lui
    Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong
    J Cell Physiol 203:564-72. 2005
    ....
  62. pmc Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection
    Simon Thompson
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Biol Chem 286:19331-9. 2011
    ..Taken together, these data support a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance...
  63. doi The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels
    Christophe Altier
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Neurosci 14:173-80. 2011
    ..Thus, Cavββ regulates the ubiquitination and stability of the calcium channel complex...
  64. pmc The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton
    Gianluca Cestra
    Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:1731-6. 2005
    ..Thus, ArgBP2/nArgBP2 is a scaffold protein that control the balance between adhesion and motility by coordinating the function of multiple signaling pathways converging on the actin cytoskeleton...
  65. pmc Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation
    Vijayalaxmi C Nalavadi
    Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurosci 32:2582-7. 2012
    ..Thus, control of FMRP levels at the synapse by dephosphorylation-induced and UPS-mediated degradation provides a mode to regulate protein synthesis...
  66. pmc Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways
    Huali Zhang
    Center for Cardiovascular Translational Biomedicine, Division of Cardiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Mol Cell Cardiol 49:918-30. 2010
    ..We conclude that such selective interactions between CryAB mutants and HSPB1 overexpression might have important implications for the clinical manifestations and potential treatment...
  67. pmc Rapid Ca2+-dependent decrease of protein ubiquitination at synapses
    Hong Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:14908-13. 2003
    ..In nerve terminals, protein ubiquitination may play a role both in the regulation of synaptic function, including vesicle traffic, and in the coordination of protein turnover with synaptic use...
  68. pmc ROMK1 channel activity is regulated by monoubiquitination
    Dao Hong Lin
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:4306-11. 2005
    ..This finding implicates the linking of a single ubiquitin molecule to channels as an important posttranslational regulatory signal...
  69. pmc Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons
    Sonja Bareiss
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    J Neurosci Res 88:2350-63. 2010
    ....
  70. ncbi Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway
    Gregory D Salinas
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 281:40164-73. 2006
    ..Together our data demonstrate that actinfilin acts as a scaffold, linking GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation...
  71. pmc PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation
    Ming Zhang
    Medical College of Nankai University, Tianjin 300071, PR China
    J Cell Sci 122:1382-9. 2009
    ..These results suggest that PTHrP might prevent premature hypertrophy in chondrocytes, at least in part by inducing degradation of Runx2 and Runx3 in a cyclin-D1-dependent manner...
  72. pmc Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5
    Xiang Li
    Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 284:16170-82. 2009
    ....
  73. doi PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2
    Mun Kit Choy
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 20QQ, UK
    J Cell Physiol 222:635-9. 2010
    ..In summary, we propose that p53-induced HIF1A degradation is not exclusively MDM2-mediated, but reversible by PKB/Akt phosphorylation...
  74. ncbi Beta-adrenergic receptor trafficking by exercise in rat adipocytes: roles of G-protein-coupled receptor kinase-2, beta-arrestin-2, and the ubiquitin-proteasome pathway
    Junetsu Ogasawara
    Department of Kinesiology, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
    FASEB J 20:350-2. 2006
    ..However, the decreased protein expression of beta2-AR at 24 h might be due to some change occurring at the translational levels...
  75. ncbi Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway
    R C Zangar
    Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Mol Pharmacol 61:892-904. 2002
    ..This conjugation reaction, however, seems to be distinct from the classical ubiquitination pathway but may be related to the substrate-dependent stabilization of CYP3A observed in vivo...
  76. ncbi Angiotensin II-induced down-regulation of inositol trisphosphate receptors in WB rat liver epithelial cells. Evidence for involvement of the proteasome pathway
    S Bokkala
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:12454-61. 1997
    ..We conclude that Ang II-stimulated IP3R degradation involves enhanced ubiquitination of the protein and degradation by the proteasome pathway...
  77. pmc Activation of protein kinase C triggers its ubiquitination and degradation
    Z Lu
    Department of Biological Sciences, Hunter College and the Graduate School of the City University of New York, New York 10021, USA
    Mol Cell Biol 18:839-45. 1998
    ..Moreover, a kinase-dead ATP-binding mutant of PKC alpha could not be depleted by TPA treatment. These data are consistent with a suicide model whereby activation of PKC triggers its own degradation via the ubiquitin-proteasome pathway...
  78. pmc Down-regulation of types I, II and III inositol 1,4,5-trisphosphate receptors is mediated by the ubiquitin/proteasome pathway
    J Oberdorf
    Department of Pharmacology, SUNY Health Science Center at Syracuse, 750 East Adams Street, Syracuse, NY 13210 2339, USA
    Biochem J 339:453-61. 1999
    ..In total these data indicate that the ubiquitin/proteasome pathway mediates Ins(1,4, 5)P3-receptor down-regulation and suggest that ubiquitination is stimulated by the binding of Ins(1,4,5)P3 to its receptor...
  79. ncbi Polyubiquitin is a new phenotypic marker of contractile vascular smooth muscle cells
    P J Adam
    Department of Medicine, Addenbrookes Hospital, University of Cambridge, UK
    Cardiovasc Res 33:416-21. 1997
    ..The aim of this study was to identify and characterise a 2.8 kb transcript, 2E10, which was highly expressed in freshly dispersed rat aortic VSMCs and downregulated in multiply passaged cultured VSMCs...
  80. ncbi Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1
    Anne C Marinovic
    Renal Division, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 277:16673-81. 2002
    ..The mechanisms that increase ubiquitin (UbC) expression have not been identified...
  81. pmc Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradation
    Danielle A Sliter
    Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 286:1074-82. 2011
    ....
  82. pmc AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells
    Rodrigo Alzamora
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 299:F1308-19. 2010
    ..These results indicate that AMPK inhibits KCNQ1 activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane...
  83. pmc Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance
    Sung Mi Kim
    Department of Cellular and Molecular Pharmacology, Bioengineering and Therapeutic Sciences and the Liver Center, University of California, San Francisco, California 94158 2517, USA
    J Biol Chem 285:35866-77. 2010
    ....
  84. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
    ..Thus, our data provide the first evidence of a functional link between β-arrestins and TRPV4 and uncovers an entirely novel mechanism to maintain appropriate intracellular Ca(2+) concentration to avoid excessive Ca(2+) signaling...
  85. pmc Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory
    Nazira Ozgen
    Department of Pharmacology, Columbia University, New York, New York 10032, USA
    Heart Rhythm 7:964-70. 2010
    ..The KChIP2 decrease is attributed to a decrease in its transcription factor, cyclic adenosine monophosphate response element binding protein (CREB)...
  86. pmc Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc
    Young Don Kwak
    Neurodegenerative Disease Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 285:9847-57. 2010
    ..This study demonstrates that NEDD4-1-mediated PTEN ubiquitination is crucial in the regulation of PI3K/Akt signaling by PTEN during the neuronal response to zinc, which may represent a common mechanism in neurodegeneration...
  87. pmc Cbl controls EGFR fate by regulating early endosome fusion
    Gina D Visser Smit
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    Sci Signal 2:ra86. 2009
    ..This study provides the first evidence that Cbl regulates receptor fate by controlling the fusion of sorting endosomes. We postulate that it does so by modulating the abundance of tyrosine-phosphorylated Hrs...
  88. ncbi Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation
    Brian A Pierchala
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Neurosci 26:2777-87. 2006
    ..Therefore, lipid rafts sequester Ret away from the degradation machinery located in nonraft membrane domains, such as Cbl family E3 ligases, thereby sustaining Ret signaling...
  89. pmc Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats
    Taro Misaki
    Department of Health and Nutritional Sciences, Faculty of Health Promotional Sciences, Hamamatsu University, Hamamatsu, Japan
    Am J Pathol 175:74-83. 2009
    ....
  90. doi The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Int J Cancer 126:1275-81. 2010
    ....
  91. ncbi Ubiquitin-dependent down-regulation of the neurokinin-1 receptor
    Graeme S Cottrell
    Departments of Surgery and Physiology, University of California, San Francisco, 94143 0660, USA
    J Biol Chem 281:27773-83. 2006
    ..Thus, chronic stimulation with SP induces ubiquitination of the NK(1)R, which mediates its degradation and down-regulation...
  92. ncbi Nucleotide sequence and expression of the rat polyubiquitin mRNA
    T Hayashi
    Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan
    Biochim Biophys Acta 1218:232-4. 1994
    ..These clones were rat homologues for human UbB and UbC gene families, respectively. 1.2 kb UbB transcript, as well as 2.8 kb and 3...
  93. ncbi p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis
    Keiji Uchiyama
    Mitsubishi Kagaku Institute of Life Sciences, Tokyo 194 8511, Japan
    Dev Cell 11:803-16. 2006
    ..Interestingly, although VCIP135 is also required, its deubiquitinating activity is unnecessary for p97/p37-mediated activities...
  94. ncbi Rats fed soy protein isolate (SPI) have impaired hepatic CYP1A1 induction by polycyclic aromatic hydrocarbons as a result of interference with aryl hydrocarbon receptor signaling
    Rohit Singhal
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Toxicol Appl Pharmacol 227:275-83. 2008
    ..These data suggest that feeding SPI-containing diets antagonizes AhR signaling by a novel mechanism which differs from those established for known AhR antagonists...

Research Grants4

  1. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 2002
    ....
  2. Bioinformatics for Protein Microarrays
    Richard Zangar; Fiscal Year: 2009
    ....
  3. Crosstalk between oncoprotein Ski and TGF-B signaling
    Yin Sun; Fiscal Year: 2008
    ..abstract_text> ..
  4. Functions of BPAG1n
    BRIAN PIERCHALA; Fiscal Year: 2007
    ..abstract_text> ..