tumor necrosis factor alpha

Summary

Gene Symbol: tumor necrosis factor alpha
Description: tumor necrosis factor
Alias: RATTNF, TNF-alpha, Tnfa, tumor necrosis factor, cachectin, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2
Species: rat

Top Publications

  1. doi Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells
    Sukanya Phalitakul
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Pharmacol Res 64:493-500. 2011
  2. pmc Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes
    Monika A Niewczas
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 23:507-15. 2012
  3. doi Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    J Cyst Fibros 11:63-7. 2012
  4. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
  5. ncbi Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults
    Marcelo Addas-Carvalho
    Haematology and Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil
    Ann Hematol 84:709-14. 2005
  6. pmc LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner
    Aedin M Minogue
    Trinity College Institute for Neuroscience, Lloyd Building, University of Dublin, Trinity College, College Green, Dublin 2, Ireland
    J Neuroinflammation 9:126. 2012
  7. doi Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: initiated by hypoxia inducible factor 1α, presented by exosomes
    Xian Yu
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China
    J Mol Cell Cardiol 53:848-57. 2012
  8. ncbi Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle
    Stephan Clavel
    Laboratoire de Physiologie Cellulaire et Moleculaire, CNRS UMR 6548, Faculte des Sciences, Universite de Nice Sophia Antipolis, 28 Avenue Valrose, 06108 Nice Cedex 2, France
    Mech Ageing Dev 127:794-801. 2006
  9. ncbi Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 19:538-46. 2003
  10. ncbi The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy
    T S Fröde
    Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianopolis, SC, 88015 420, Brazil
    Cytokine 13:162-8. 2001

Detail Information

Publications177 found, 100 shown here

  1. doi Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells
    Sukanya Phalitakul
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    Pharmacol Res 64:493-500. 2011
    ..Consequently, vaspin could play inhibitory roles on inflammatory states of vascular SMCs...
  2. pmc Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes
    Monika A Niewczas
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 23:507-15. 2012
    ..In conclusion, elevated concentrations of circulating TNFRs in patients with type 2 diabetes at baseline are very strong predictors of the subsequent progression to ESRD in subjects with and without proteinuria...
  3. doi Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    J Cyst Fibros 11:63-7. 2012
    ..As inflammation is a key component inducing CF lung damage, we investigated whether the 8.1AH represents a lung function modifier in CF...
  4. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
    ..The cell specificity, metabolite stereospecificity, and the dependence on PKC argue for the participation of membrane receptors for 1alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in the regulation of ERK1/2 in the growth plate...
  5. ncbi Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults
    Marcelo Addas-Carvalho
    Haematology and Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil
    Ann Hematol 84:709-14. 2005
    ..These results suggest that cytokine polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of CINA and were not responsible for the increased cytokine in CINA patients...
  6. pmc LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner
    Aedin M Minogue
    Trinity College Institute for Neuroscience, Lloyd Building, University of Dublin, Trinity College, College Green, Dublin 2, Ireland
    J Neuroinflammation 9:126. 2012
    ..We sought to identify signaling kinases responsible for cytokine production and to delineate the complex interactions which govern time-related responses to lipopolysaccharide (LPS)...
  7. doi Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: initiated by hypoxia inducible factor 1α, presented by exosomes
    Xian Yu
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China
    J Mol Cell Cardiol 53:848-57. 2012
    Excessive tumor necrosis factor-α (TNF-α) expression is increasingly thought to be detrimental to cardiomyocytes in acute myocardial infarction...
  8. ncbi Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle
    Stephan Clavel
    Laboratoire de Physiologie Cellulaire et Moleculaire, CNRS UMR 6548, Faculte des Sciences, Universite de Nice Sophia Antipolis, 28 Avenue Valrose, 06108 Nice Cedex 2, France
    Mech Ageing Dev 127:794-801. 2006
    ..Therefore, IGF-1/Akt and TNFalpha represent potential mediators implicated in the regulation of MuRF1 and atrogin-1 genes during aging...
  9. ncbi Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 19:538-46. 2003
    ..of a nonlethal dose of LPS (1,000 microg/kg Escherichia coli) into male rats increased the mRNA content of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta in gastrocnemius muscle as early as 1 h; IL-6 mRNA was not ..
  10. ncbi The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy
    T S Fröde
    Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianopolis, SC, 88015 420, Brazil
    Cytokine 13:162-8. 2001
    ..Together, these findings may be relevant to the understanding of the mechanisms involved in airway inflammatory responses...
  11. ncbi Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B
    Pierre Olivier Esteve
    INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec H7V 1B7, Canada
    J Biol Chem 277:35150-5. 2002
    ..atypical PKC-zeta isoform participates in the induction of MMP-9 expression by interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in rat C6 glioma cells...
  12. ncbi Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction
    Hong Hua
    Institute of Medical Science, Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Am J Physiol Renal Physiol 284:F303-12. 2003
    ..Hence, ET-1 activates mesangial cell ERK1/2 predominantly through a pathway involving EGF-R transactivation, leading to a mechanism involving attachment to caveolin-1, presumably in caveolae...
  13. ncbi Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, 2600 1 Kitakanemaru, Otawara, Tochigi 324 8501, Japan
    Endocrinology 144:4868-75. 2003
    ..These results strongly suggest that IL-1 beta and TNF-alpha may represent the major proinflammatory cytokines mediating the LPS-induced suppression of GnRH and LH release, whereas the role of IL-6 seems to be insignificant...
  14. doi Interleukin-6, TNF-alpha and interleukin-1 beta levels in blood and tissue in severely burned rats
    Diane Agay
    Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, BP87, 38702 La Tronche Cedex, France
    Eur Cytokine Netw 19:1-7. 2008
    ....
  15. pmc Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}
    Lei Diao
    From the Department of Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton Laboratories, Pfizer Inc, Groton, Connecticut 06340
    J Biol Chem 285:31185-92. 2010
    ....
  16. ncbi [The expression of mucosal IL-1β, TNFα and serotonin transporter in chronic visceral hypersensitivity rats]
    Yan Chi
    Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China
    Zhonghua Nei Ke Za Zhi 49:781-4. 2010
    ....
  17. doi Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-α and its receptor 1
    Lianghu Huang
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine New York, New York, USA
    Kidney Int 79:613-23. 2011
    Endoplasmic reticulum (ER) stress is actively involved in acute organ injury. Since tumor necrosis factor α (TNFα) plays a role in acute kidney injury, and induces ER stress and cell death in vitro, we examined the contribution of TNFα..
  18. doi TNF-α and IL-1β mediate Japanese encephalitis virus-induced RANTES gene expression in astrocytes
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Neurochem Int 58:234-42. 2011
    ..Antibody neutralization studies suggested the potential involvement of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) in mediating additional RANTES production...
  19. doi Serum levels of IL-1β, IL-6 and TNF-α in rats fed with Kashin-Beck disease-affected diet
    Denglu Yan
    Orthopedic Department West China Hospital of Sichuan University, Chengdu, Sichuan, China
    Int J Rheum Dis 13:406-11. 2010
    To investigate the serum level of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in rats which have been fed with Kashin-Beck disease (KBD) epidemic district food.
  20. doi Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia
    Rodrigo Del Rio
    Laboratorio de Neurobiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Brain Res 1395:74-85. 2011
    ..Thus, present results suggest that the local expression of chemosensory modulators and pro-inflammatory cytokines in the CB may have different temporal contribution to the CB chemosensory potentiation induced by CIH...
  21. doi Oligomers of β-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1β, tumour necrosis factor-α, and a nuclear factor κ-B mechanism in the rat brain
    I Carrero
    Laboratory of Neuroanatomy, Institute of Neuroscience of Castilla and Leon, Valladolid University Campus of Soria, Spain
    Exp Neurol 236:215-27. 2012
    ....
  22. doi GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia
    Holly F Green
    Department of Anatomy and Neuroscience, University College Cork, Ireland
    Neurochem Int 61:666-71. 2012
    ..These results demonstrate a role for GSK-3 as a modulator of inflammatory cytokine levels in the brain, and contribute to a mechanistic insight into neurological disorders in which neuroinflammation is a characteristic feature...
  23. pmc Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia/hypoxia: role of tumor necrosis factor-α
    Sydney R Murphy
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 304:R130-5. 2013
    ..While our laboratory has shown tumor necrosis factor-α (TNF-α) and sFlt-1 to be elevated in pregnant rats in response to placental ischemia, the importance ..
  24. ncbi Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha
    Yosuke Osawa
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 280:27879-87. 2005
    b>Tumor necrosis factor (TNF)-alpha signals cell death and simultaneously induces the generation of ceramide, which is metabolized to sphingosine and sphingosine 1-phosphate (S1P) by ceramidase (CDase) and sphingosine kinase...
  25. ncbi TNFalpha and TNF receptor 1 expression in the mixed neuronal-glial cultures of hippocampal dentate gyrus exposed to glutamate or trimethyltin
    Izabela Figiel
    Laboratory of Mechanisms of Neurodegeneration and Neuroprotection, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, PAS, Pasteur 3 St, 02 093 Warsaw, Poland
    Brain Res 1131:17-28. 2007
    We examined the expression and cellular localization of tumor necrosis factor alpha (TNFalpha) and its type 1 receptor (TNFR1) in mixed neuronal-glial cultures of rat hippocampal dentate gyrus exposed to glutamate (GLU) or trimethyltin (..
  26. ncbi Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum level
    Weiyan Yao
    Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    J Gastroenterol Hepatol 22:1866-71. 2007
    ..The aim of this study was to investigate the effect of thymosin alpha 1 (TA1) on severe acute pancreatitis (SAP) in rats...
  27. ncbi [Effect of ginsenoside Rgl on the expression of TNF-alpha and MCP-1 in rats with diabetic nephropathy]
    Li Na Zhang
    Department of Nephrology, State Key Laboratory of Biotherapy of Human Disease, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:466-71. 2009
    To investigate the effects of Ginsenoside Rgl on proteinuria and the expression of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in rats with diabetic nephropathy (DN).
  28. ncbi Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis
    B Yucesoy
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 172:75-82. 2001
    ..These studies suggest that gene-environment interactions involving cytokine polymorphisms play a significant role in silicosis by modifying the extent of and susceptibility to disease...
  29. doi Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways
    Patrick T Ronaldson
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada
    Mol Pharmacol 77:644-59. 2010
    ..e., tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta, IL-6], which are secreted in response to HIV-1 envelope ..
  30. doi Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species
    Masao Takahashi
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 294:H2879-88. 2008
    ..These results also suggest that ANG II and TNF-alpha cooperatively stimulate vascular inflammation in vivo as well as in vitro...
  31. ncbi Myocardial expression of TNF-alpha, IL-1beta, IL-6, IL-8, IL-10 and MCP-1 after a single MDMA dose administered in a rat model
    Margherita Neri
    Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D Avanzo, 71100 Foggia, Italy
    Curr Pharm Biotechnol 11:413-20. 2010
    ..alterations related to the biological response between MDMA administration and inflammatory cytokines (tumor necrosis factor-alpha, IL-1beta, IL-6, 8, 10, and monocyte chemotactic protein-1). A total of 25 male rats were used...
  32. ncbi Vessel-specific stimulation of protein synthesis by nitric oxide synthase inhibition: role of extracellular signal-regulated kinases 1/2
    Fabrice M A C Martens
    Faculty of Pharmacy, Department of Pharmacology, Faculty of Medicine Université de Montréal, Montreal, Canada
    Hypertension 39:16-21. 2002
    ..This heterogeneous role of NO on vascular growth may explain the heterogeneity of vascular remodeling observed in essential hypertension, a condition associated with endothelial dysfunction...
  33. ncbi Insulin-like growth factor 1 prevents liver injury through the inhibition of TNF-alpha and iNOS induction in D-galactosamine and LPS-treated rats
    Takeshi Hijikawa
    The Department of Surgery, Kansai Medical University, Moriguchi, Osaka, Japan
    Shock 29:740-7. 2008
    ..Insulin-like growth factor 1 may inhibit the induction of proinflammatory cytokines and iNOS through an nuclear factor-kappa B-independent pathway and have a novel therapeutic potential in the prevention of liver injury...
  34. ncbi ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding
    Raj Kishore
    Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106 4906, USA
    Am J Physiol Gastrointest Liver Physiol 282:G6-15. 2002
    ..Kupffer cells isolated from rats fed ethanol in their diet for 4 wk accumulated 4.3-fold more tumor necrosis factor (TNF)-alpha in response to LPS compared with pair-fed rats...
  35. ncbi Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium
    Emiliano A Palmieri
    Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, L Califano Facoltà di Medcina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    Am J Physiol Heart Circ Physiol 282:H926-34. 2002
    ..and severe (35 mmHg) mechanical stretch on the time course (from 0 to 60 min) of myocardial expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and insulin-like growth factor (IGF)-1 and their cognate receptors...
  36. ncbi The interplay of collagen IV, tumor necrosis factor-alpha, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis
    Michelle K Y Siu
    Population Council, Center for Biomedical Research, New York, New York 10021, USA
    Endocrinology 144:371-87. 2003
    ..Taken collectively, these observations strengthen the notion that ECM is involved in the regulation of junction dynamics in addition to its structural role in the testis...
  37. ncbi Immunocytochemical localization of TNF type 1 and type 2 receptors in the rat spinal cord
    Gregory M Holmes
    Laboratory of Autonomic Neuroscience, Pennington Biomedical Research Center, 6400 Perkins Road, Louisiana State University, Baton Rouge, LA 70808, USA
    Brain Res 1025:210-9. 2004
    b>Tumor necrosis factor-alpha (TNF-alpha) is secreted in numerous pathophysiological situations by a variety of cell types...
  38. ncbi Inhibition of tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression in diabetic rats: role of insulin
    E A Anjos-Valotta
    Research Division, Institute of Heart InCor, LIM 11, University of Sao Paulo Medical School, Av Dr Eneas de Carvalho Aguiar 44, 05403 000 Sao Paulo, SP, Brazil
    Inflamm Res 55:16-22. 2006
    ..The effects of insulin on intercellular adhesion molecule (ICAM)-1-mediated leukocyte adhesion and migration were investigated...
  39. ncbi Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury
    Martin Roderfeld
    Department of Gastroenterology Medical Clinic 11, University Hospital, Justus Liebig University, Giessen, Germany
    Liver Int 26:579-86. 2006
    ....
  40. doi SOCS-1 inhibits TNF-alpha-induced cardiomyocyte apoptosis via ERK1/2 pathway activation
    Ling Yan
    Department of Cardiology, Renmin Hospital of Wuhan University School of Medicine, 238 Jiefang Road, Wuchang, Wuhan 430060, People s Republic of China
    Inflammation 31:180-8. 2008
    b>Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine involved in mitogen-activated protein kinase (MAPK) signaling pathways, contributes to the pathogenesis of cardiovascular diseases...
  41. pmc Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis
    M Cabrera
    Department of Medicine, University of Cambridge Clinical School, Addenbrooke s Hospital, United Kingdom
    J Exp Med 182:1259-64. 1995
    ..ACL) caused by Leishmania braziliensis infection, is accompanied by high circulating levels of tumor necrosis factor (TNF)-alpha...
  42. ncbi Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma
    V M Keatings
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 153:530-4. 1996
    ..We found a significant increase in neutrophils and increased concentrations of tumor necrosis factor-alpha (TNF alpha) and interleukin-8 (IL-8) in the patients with COPD compared with the smoking and ..
  43. ncbi A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria
    J C Knight
    Molecular Infectious Diseases Group, Institute of Molecular Medicine, Oxford, UK
    Nat Genet 22:145-50. 1999
    ....
  44. ncbi Association of tumor necrosis factor alpha gene promoter polymorphism with the presence of chronic obstructive pulmonary disease
    S Sakao
    Department of Chest Medicine and Molecular Virology, Chiba University School of Medicine, Chiba, Japan
    Am J Respir Crit Care Med 163:420-2. 2001
    b>Tumor necrosis factor alpha (TNF-alpha), a potent proinflammatory cytokine, may be involved in the development of chronic obstructive pulmonary disease (COPD). The production of TNF-alpha is elevated in the airways of these patients...
  45. ncbi Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve
    Maria Schäfers
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 22:536-45. 2002
    b>Tumor necrosis factor-alpha (TNF) appears as a key player at both central and peripheral terminals in early degenerative pathology and pain behavior after peripheral nerve injury...
  46. ncbi Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium
    Brian D Shames
    Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
    Shock 17:114-9. 2002
    Over-production of tumor necrosis factor-alpha (TNF-alpha) following myocardial ischemia-reperfusion contributes to cardiac dysfunction, and anti-TNF-alpha has therapeutic potential for myocardial protection in cardiac surgery with ..
  47. ncbi Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Here, we show that a protein produced by glia, tumor necrosis factor alpha (TNFalpha), enhances synaptic efficacy by increasing surface expression of AMPA receptors...
  48. ncbi Role of tumor necrosis factor-alpha and the modulating effect of the caspases in rat corpus luteum apoptosis
    Michael Abdo
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia 6009, Australia
    Biol Reprod 68:1241-8. 2003
    b>Tumor necrosis factor-alpha (TNFalpha) is a pleiotropic cytokine that has been implicated in apoptosis of many cell systems...
  49. ncbi Tumor necrosis factor signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
    Cell Death Differ 10:45-65. 2003
    A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50,000 articles providing one or the other information about this pleiotropic cytokine or its relatives...
  50. ncbi Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:2517-21. 2003
    b>Tumor necrosis factor-alpha (TNF) is implicated in the initiation of neuropathic pain. In vitro, TNF activates p38 mitogen-activated kinase...
  51. ncbi Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:3028-38. 2003
    b>Tumor necrosis factor-alpha (TNF) is upregulated after nerve injury, causes pain on injection, and its blockade reduces pain behavior resulting from nerve injury; thus it is strongly implicated in neuropathic pain...
  52. ncbi Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
    Cristina de Alvaro
    Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 279:17070-8. 2004
    ..b>Tumor necrosis factor (TNF)-alpha caused insulin resistance on glucose uptake and GLUT4 translocation by impairing insulin ..
  53. ncbi TNF-857T, a genetic risk marker for acute anterior uveitis
    Ni Wen Kuo
    Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, United Kingdom
    Invest Ophthalmol Vis Sci 46:1565-71. 2005
    To determine the association between 17 single nucleotide polymorphisms (SNPs) of tumor necrosis factor-alpha, lymphotoxin-alpha, and the TNF-receptors genes (TNF, LTA, and TNFRSF1A and -B) and idiopathic acute anterior uveitis (IAU) and ..
  54. ncbi Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-alpha
    Thomas Korn
    Department of Neurology, Universitat des Saarlandes, Homburg, Germany
    FASEB J 19:1878-80. 2005
    ..experiments using neutralizing antibodies and by incubation of astrocytes with recombinant cytokines, tumor necrosis factor-alpha (TNF-alpha) was identified as being responsible for the down-modulation of GLAST...
  55. ncbi Association between tumour necrosis factor-alpha G-308A polymorphism and risk of nephropathy in obese Chinese type 2 diabetic patients
    Ying Wang
    Divison of Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Nephrol Dial Transplant 20:2733-8. 2005
    The G-308A polymorphism in the promoter region of the tumor necrosis factor alpha (TNF-alpha) gene has been reported to be associated with insulin resistance and obesity, both of which may increase the risk of diabetic nephropathy...
  56. ncbi Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha
    B Babbette D LaMarca
    Department of Physiology and Obstetrics Gynecology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 46:1022-5. 2005
    Inflammatory cytokines such as tumor necrosis factor (TNF)-alpha are elevated in preeclamptic women and are thought to be an important link between placental ischemia and endothelial dysfunction...
  57. ncbi The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat
    Ji Tian Xu
    Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, 74 Zhongshan Rd 2, Guangzhou 510080, PR China
    Pain 123:306-21. 2006
    Accumulating evidence has demonstrated that tumor necrosis factor-alpha (TNF-alpha) plays an important role in neuropathic pain...
  58. ncbi Association of TNF haplotypes with asthma, serum IgE levels, and correlation with serum TNF-alpha levels
    Shilpy Sharma
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India
    Am J Respir Cell Mol Biol 35:488-95. 2006
    Both biochemical and genetic evidence have implicated the genes for TNF-alpha (TNFA) and lymphotoxin-alpha (LTA) in atopic asthma...
  59. ncbi Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma
    Toru Nakazawa
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:12633-41. 2006
    ..Previous studies suggest that the cytokine tumor necrosis factor-alpha (TNF-alpha) may contribute to the disease process, although its role in vivo and its mechanism of ..
  60. ncbi Effects of anti-tumor necrosis factor-alpha and anti-intercellular adhesion molecule-1 antibodies on ischemia/reperfusion lung injury
    Chi Huei Chiang
    Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University Taipei, Taiwan, ROC
    Chin J Physiol 49:266-74. 2006
    Inhibition of neutrophil activation and adherence to endothelium by antibodies to tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecules (ICAM-1), respectively, might attenuate ischemia-reperfusion injury (I/R)...
  61. ncbi Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administration
    Nobuhisa Sasaki
    Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Spine (Phila Pa 1976) 32:413-6. 2007
    ..An experimental animal study...
  62. doi Positive correlation of tumor necrosis factor-alpha early expression in myocardium and ventricular arrhythmias in rats with acute myocardial infarction
    Hua Xiao
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tong Ji Medical College, Hua Zhong University of Science and Technology, People s Republic of China
    Arch Med Res 39:285-91. 2008
    b>Tumor necrosis factor-alpha (TNF-alpha) is found to play important roles in acute myocardial infarction (AMI). Ventricular arrhythmias arising from AMI are leading causes of sudden cardiac death (SCD)...
  63. doi Transient early expression of TNF-alpha in sciatic nerve and dorsal root ganglia in a mouse model of painful peripheral neuropathy
    Paola Sacerdote
    Department of Pharmacology, University of Milano, Via Vanvitelli 32, 20129 Milano, Italy
    Neurosci Lett 436:210-3. 2008
    The proinflammatory cytokine tumor necrosis factor-alpha (TNF) is an important mediator in neuropathic pain...
  64. pmc Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy
    Yugal Behl
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    Am J Pathol 172:1411-8. 2008
    ..diabetic rats and type 2 Zucker diabetic fatty rats were treated by intravitreal injection of the tumor necrosis factor-specific inhibitor pegsunercept, and the impact was measured by analysis of retinal trypsin digests...
  65. doi Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells
    Nahuai Badiola
    Institut de Neurociencies, Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain
    Neurobiol Dis 35:438-47. 2009
    ..Altogether, these results show that apoptosis of cortical neurons after OGD is mediated by TNF-alpha/TNF-alpha receptor 1...
  66. doi Chronic expression of low levels of tumor necrosis factor-alpha in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation
    Ana Laura De Lella Ezcurra
    Institute Leloir Foundation and IIBBA CONICET, Patricias Argentinas 435, Buenos Aires, Argentina
    Neurobiol Dis 37:630-40. 2010
    ..For example, tumor necrosis factor-alpha (TNF-alpha), a key pro-inflammatory cytokine, has been shown to exert toxic or no effects on the ..
  67. pmc Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior
    Jeong Il Choi
    Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA
    Pain 149:243-53. 2010
    ..was reduced and biochemical changes blocked by spinal pretreatment, but not post-treatment, with a tumor necrosis factor (TNF) antagonist, Etanercept (100microg)...
  68. pmc In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death
    Yujing Bai
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 51:6639-51. 2010
    ..Risk factors for glaucomatous RGC death are elevated intraocular pressure and glial production of tumor necrosis factor-alpha (TNF-α)...
  69. pmc Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures
    Andrew J Steelman
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    J Neuroinflammation 8:89. 2011
    ..However, the effects of virus-induced glial activation on oligodendrocytes are not fully understood...
  70. doi Inhibition of TNF-α protects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent pathway
    Mona F Mahmoud
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
    Naunyn Schmiedebergs Arch Pharmacol 385:465-71. 2012
    ..In the present investigation, the effect of inhibition of tumor necrosis factor-alpha (TNF-α) using pentoxifylline or infliximab against hepatic I/R injury induced in rats by 45-min ..
  71. pmc Analysis of the local kinetics and localization of interleukin-1 alpha, tumour necrosis factor-alpha and transforming growth factor-beta, during the course of experimental pulmonary tuberculosis
    R Hernandez-Pando
    Department of Pathology, National Institute of Nutrition Salvador Zubiran, Mexico City, Mexico
    Immunology 90:607-17. 1997
    ....
  72. ncbi TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition
    Jian Y Zou
    Bowles Center for Alcohol Studies, CB 7178 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1034:11-24. 2005
    Glutamate and the proinflammatory cytokine, tumor necrosis factor alpha (TNF alpha), have been suggested to contribute to neurodegenerative diseases...
  73. ncbi Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart
    S O Kim
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    J Cell Biochem 71:286-301. 1998
    ....
  74. pmc Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway
    R Bi
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    Proc Natl Acad Sci U S A 98:13391-5. 2001
    ..Thus, cyclic changes in female sexual hormones result in marked variations in the state of activation of a major cellular signaling pathway critical for learning and memory and in a cellular model of learning and memory...
  75. ncbi Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha
    Laura Fernández-Celemín
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 283:E1279-90. 2002
    ..Taken together, our data suggest that TNF-alpha induced in muscle after LPS injection can locally inhibit IGF-I expression. The inhibition of muscle IGF-I production could contribute to the catabolic effect of TNF-alpha...
  76. ncbi Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation
    Sabine Beck
    Center of Pharmacology, University Hospital Frankfurt, 60590 Frankfurt, Germany
    J Biol Chem 278:29799-812. 2003
    ..A2 (sPLA2s) potentiate the expression of pro-inflammatory sPLA2-IIA first induced by cytokines like tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta...
  77. ncbi Nitric oxide synthase expressions in rat dorsal root ganglion after a hind limb tourniquet
    Sumiko Abe
    Department of Legal Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan
    Neuroreport 14:2267-70. 2003
    ..the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to ..
  78. ncbi PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes
    Guoliang Ding
    Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Mol Cell Cardiol 40:821-8. 2006
    ..b>Tumor necrosis factor alpha (TNFalpha) is one of the important pathological factors in inflammatory responses during the ..
  79. ncbi Modulation of HSP25 and TNF-alpha during the early stages of functional overload of a rat slow and fast muscle
    Kimberly A Huey
    Department of Kinesiology, University of Illinois, Urbana Champaign, 120 Freer Hall, 906 S Goodwin Ave, Urbana, IL 61801, USA
    J Appl Physiol (1985) 102:2307-14. 2007
    ..The purpose of this study was to investigate the responses of HSP25, phosphorylated HSP25 (pHSP25), and tumor necrosis factor-alpha (TNF-alpha) during FO of the slow soleus and fast plantaris...
  80. ncbi The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats
    H Zivna
    Department of Physiology, Institute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Czech Republic
    Adv Clin Path 5:147-53. 2001
    ..Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats...
  81. ncbi Intracellular application of TNF-alpha impairs cell to cell communication via gap junctions in glioma cells
    Aiden Haghikia
    Department of Neurology, St Josef Hospital Bochum, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    J Neurooncol 86:143-52. 2008
    ..In order to better characterize their response to inflammation, we evaluated the influence of tumor necrosis factor alpha (TNF-alpha) on the coupling behaviour and the membrane resting potential (MRP) of glioma cells (F98 ..
  82. ncbi Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release
    Mian Zhou
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Am J Physiol Regul Integr Comp Physiol 294:R84-92. 2008
    ..We, therefore, conclude that LPS downregulates PPAR-gamma expression during sepsis via an increase in TNF-alpha release...
  83. doi Association of single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer risk in Indian population
    Indu Kohaar
    Division of Molecular Genetics and Biochemistry, Institute of Cytology and Preventive Oncology ICMR, Noida, India
    Breast Cancer Res Treat 114:347-55. 2009
    ..The aim of the present study was to investigate the potential association of functional single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer...
  84. doi Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells
    F Ortis
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles ULB, Route de Lennik, 808 CP 618, 1070, Brussels, Belgium
    Diabetologia 51:1213-25. 2008
    ..The aim of the present study was to compare the effects of IL-1beta and TNF-alpha on cell death and the pattern of NF-kappaB activation and global gene expression in beta cells...
  85. ncbi Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia
    Cancer Biol Ther 7:1139-45. 2008
    ..The aims of this study were to determine whether changes in serum levels of NFkappaB, TNF, IL-1beta and IL-6 following administration of different drugs predicted histological evidence of tissue damage...
  86. doi Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma
    Beena Puthothu
    Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Pediatr Allergy Immunol 20:157-63. 2009
    b>Tumor necrosis factor (TNF-)alpha is a proinflammatory cytokine that is important in the innate host defence and thus in the defence of infectious agents. However, in excess it provokes the development of chronic inflammatory diseases...
  87. pmc Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
    J Cortijo
    Department of Pharmacology, University of Valencia, Spain
    Br J Pharmacol 156:534-44. 2009
    ..The effects of a phosphodiesterase 4 (PDE4) inhibitor, roflumilast, on bleomycin-induced lung injury were explored in 'preventive' and 'therapeutic' protocols and compared with glucocorticoids...
  88. pmc Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis
    Jessica Carmen
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Res 1263:143-54. 2009
    ..These findings have implications for disease intervention and therapeutic development for the prevention of CNS damage associated with inflammatory responses...
  89. ncbi [Protective effects of continue insulin infusion on liver mitochondrion in the early stage of septic rats]
    Qi Yi Zeng
    Department of Neonate, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:525-8. 2009
    ..To investigate the protective effects of continue insulin infusion on liver mitochondrion and its mechanism in the early stage of lipopolysaccharide-induced septic rats...
  90. pmc (Pro)renin receptor contributes to diabetic nephropathy by enhancing renal inflammation
    Luis C Matavelli
    Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Clin Exp Pharmacol Physiol 37:277-82. 2010
    ..4. In conclusion, the PRR is involved in the development and progression of kidney disease in diabetes by enhancing renal production of the inflammatory cytokines TNF-alpha and IL-1beta, independent of renal AngII effects...
  91. pmc Cell-cell interaction promotes rat marrow stromal cell differentiation into endothelial cell via activation of TACE/TNF-alpha signaling
    Jian Xu
    Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Cell Transplant 19:43-53. 2010
    ..Microenvironment is important in cell fate determination. Tumor necrosis factor-alpha converting enzyme (TACE), a well-characterized "sheddase," participates in the differentiation ..
  92. pmc Reactive astrocytes in glial scar attract olfactory ensheathing cells migration by secreted TNF-alpha in spinal cord lesion of rat
    Zhida Su
    Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Minister of Education, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, China
    PLoS ONE 4:e8141. 2009
    ..However, little is known about the mechanisms of OECs migrating from injection site to glial scar/lesion site...
  93. pmc Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation
    Martine Liberge
    Universite Aix Marseille, UMR 6149 Université de Provence CNRS, Neurobiologie Intégrative et Adaptative, Pole 3C, Comportement, Cerveau, Cognition, Centre de St Charles, Case B, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    J Neuroinflammation 7:91. 2010
    ..The expressions of inflammatory and neuroprotective factors after chemical or mechanical UL were also compared to verify that the inflammatory response was not due to the toxicity of sodium arsanilate...
  94. ncbi [Effects of xiongshao capsule combined with ischemic postconditioning on monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in rat myocardium with ischemic reperfusion injury]
    Da Wu Zhang
    Department of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091
    Zhongguo Zhong Xi Yi Jie He Za Zhi 30:1279-83. 2010
    To investigate effect of Xiongshao Capsule (XSC) combined with ischemic postconditioning (IPoC) on tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) contents as well as inflammatory cell infiltration (..
  95. doi Capability of nondegenerated and degenerated discs in producing inflammatory agents with or without macrophage interaction
    Hideki Hamamoto
    Kobe University Graduate School of Medicine, Kobe, Japan
    Spine (Phila Pa 1976) 37:161-7. 2012
    ..Molecular biological and immunohistological examinations...
  96. pmc Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-α-mediated chondrocyte death through apoptosis and autophagy
    Sung Won Lee
    Department of Rheumatology, Dong A University College of Medicine, Busan, Korea
    PLoS ONE 6:e19163. 2011
    ..To build an in vitro experimental system for simulating tumor necrosis factor (TNF)-α-induced cell death in aged chondrocytes with decreased CK2 activity, chondrocytes were co-treated ..
  97. pmc Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats
    Diana M Sama
    Graduate Center for Gerontology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e38170. 2012
    The role of tumor necrosis factor α (TNF) in neural function has been investigated extensively in several neurodegenerative conditions, but rarely in brain aging, where cognitive and physiologic changes are milder and more variable...
  98. doi Tumor necrosis factor-α plays an initiating role in extracorporeal circulation-induced acute lung injury
    Tao Li
    Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, 610041, China
    Lung 191:207-14. 2013
    ..The aim of this study was to test the hypothesis that tumor necrosis factor-α (TNF-α) plays an initiating role in the onset of extracorporeal circulation (ECC)-induced ALI.
  99. pmc Transcription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell lines
    Susan J Burke
    Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States
    Mol Immunol 62:54-62. 2014
    ....
  100. pmc Experimental Disc Herniation in the Rat Causes Downregulation of Serotonin Receptor 2c in a TNF-dependent Manner
    Daniel Jönsson
    Musculoskeletal Research, Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30, Gothenburg, Sweden
    Clin Orthop Relat Res 473:1913-9. 2015
    ..An inflammatory reaction, with tumor necrosis factor (TNF) playing an essential role, has been demonstrated...
  101. pmc Intermittent reductions in respiratory neural activity elicit spinal TNF-α-independent, atypical PKC-dependent inactivity-induced phrenic motor facilitation
    Nathan A Baertsch
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, Wisconsin
    Am J Physiol Regul Integr Comp Physiol 308:R700-7. 2015
    ....

Research Grants22

  1. Chronic Alcohol Consumption Induces Tumor Angiogenesis
    Jian Wei Gu; Fiscal Year: 2006
    ..The new information will promote cancer prevention and treatment. ..
  2. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  3. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  4. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2010
    ..from a peroxynitrite- dependent mechanism to a mechanism dependent upon the proinflammatory cytokine, tumor necrosis factor 1 (TNF1)...
  5. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  6. Transcriptional regulation in chronic renal disease pathogenesis
    LESLIE BRUGGEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. SELF-DETERMINANTS & INDIRECTION OF ANTI-SELF IMMUNITY
    KAMAL MOUDGIL; Fiscal Year: 2001
    ..They believe that such predetermined, experimentally programmed control of the display hierarchy of cryptic self determinants would pave the way for novel immunotherapeutic strategies for prevention and treatment of cancer. ..
  8. Cytokines on Olfactory Receptor Neuron Function
    Andrew Lane; Fiscal Year: 2006
    ..Additional bench research will be performed in the laboratory of Dr. Schleimer, an established scientist with expertise in airway inflammation and cytokine modulation of cell function. ..
  9. PROFILING SYNOVIAL VASCULATURE IN ARTHRITIS-PRONE RATS
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..abstract_text> ..
  10. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2005
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  11. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  12. BRAIN ISCHEMIA AND MAP KINASE ACTIVATION
    Clifton Callaway; Fiscal Year: 2003
    ..The conduct of this project will provide extensive opportunities for collaboration with other basic scientists at the University of Pittsburgh, and promote the candidate's growth as an independent researcher. ..
  13. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..The results of this study are essential to understand the molecular basis of deranged metabolism in sepsis. Understanding the mechanism might be useful for developing appropriate therapeutic intervention during sepsis. ..
  14. REGULATION OF AUTOIMMUNITY THROUGH EPITOPE SPREADING
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..This in turn would contribute to developing novel therapeutic approaches for RA and other autoimmune diseases. [unreadable] [unreadable]..
  15. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  16. Modulation of Autoimmunity by Green Tea Polyphenols
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..The results of this study would help in establishing a reliable scientific basis for the use of PGT in autoimmune arthritis, and in developing better therapeutic approaches for RA. ..
  17. Cytokine Regulation of Periradicular Pain in Humans
    Asma Khan; Fiscal Year: 2007
    ..Dr Kenneth Kornman of IL Genetics will serve as a consultant on this project and will oversee the genotyping and genetic analysis. Statistical consultation will be provided by Dr. Brad Pollock. ..
  18. Brainstem Esophageal-Gastric Reflexes
    Richard Rogers; Fiscal Year: 2009
    ....
  19. Focal Brain Ischemia in the TNF-alpha-Transgenic Rat
    L Pettigrew; Fiscal Year: 2007
    b>Tumor necrosis factor-alpha (TNFalpha) is a pleotrophic cytokine secreted by astroglia, macrophages, and other cells participating in the inflammatory reaction initiated by cerebral infarction...
  20. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..both peptide-chain initiation and elongation, and that these changes are mediated by the overproduction of tumor necrosis factor (TNF)a which alters the responsiveness of the heart to insulin-like growth (IGF)-l and growth hormone (GH),..
  21. TNF Mediates Obstruction-Induced Renal Injury
    KIRSTAN MELDRUM; Fiscal Year: 2008
    ..of inflammatory mediators have been implicated in the pathophysiology of renal obstruction, including tumor necrosis factor (TNF)...
  22. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..