Trpa1

Summary

Gene Symbol: Trpa1
Description: transient receptor potential cation channel, subfamily A, member 1
Alias: Anktm1, transient receptor potential cation channel subfamily A member 1, ankyrin-like with transmembrane domains protein 1
Species: rat

Top Publications

  1. pmc HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
    Samer R Eid
    Department of Pain Research, Neuroscience Drug Discovery, Merck Research Laboratories, West Point, Philadelphia, USA
    Mol Pain 4:48. 2008
  2. pmc TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1
    Margaux M Salas
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Eur J Neurosci 29:1568-78. 2009
  3. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
  4. pmc TRPA1 contributes to cold hypersensitivity
    Donato Del Camino
    Hydra Biosciences, Inc, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:15165-74. 2010
  5. pmc TRPA1 is a component of the nociceptive response to CO2
    Yuanyuan Y Wang
    Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 30:12958-63. 2010
  6. pmc Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception
    Manish Raisinghani
    Dept of Pharmacology, Southern Illinois Univ School of Medicine, Springfield, IL 62702, USA
    Am J Physiol Cell Physiol 301:C587-600. 2011
  7. doi Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels
    Bruce R Bianchi
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, R4DJ, AP9 1, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 341:360-8. 2012
  8. pmc TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats
    Steve McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Mol Pain 6:14. 2010
  9. doi Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn
    Yun Sook Kim
    Department of Oral Anatomy and Neurobiology, Kyungpook National University, Daegu, Korea
    J Comp Neurol 518:687-98. 2010
  10. pmc The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain
    Ombretta Caspani
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 4:e7383. 2009

Research Grants

Scientific Experts

  • Donato Del Camino
  • K Weller
  • Francois Rugiero
  • Satoshi Koba
  • Paul J Wrigley
  • Bruce R Bianchi
  • S McGaraughty
  • Samer R Eid
  • Katsura Nozawa
  • Qihai Gu
  • ARMEN AKOPIAN
  • Scott Earley
  • JIN RO
  • Hirokazu Katsura
  • Xu Feng Zhang
  • Jun Chen
  • J Frederick
  • Koichi Noguchi
  • Hong Wei
  • Yi Dai
  • Takashi Kondo
  • Kimiko Kobayashi
  • Koichi Obata
  • Antti Pertovaara
  • Claudia H Tambeli
  • Luana Fischer
  • Ivan J M Bonet
  • Carlos Amilcar Parada
  • Romina Nassini
  • Serena Materazzi
  • Ryosuke Kojima
  • Ari Koivisto
  • Chun Chun Hsu
  • De Shou Cao
  • You Shuei Lin
  • Hitoshi Doihara
  • Igor B Philyppov
  • Ivliane Nozadze
  • Jianghui Meng
  • Krisztina Pohoczky
  • Maria Dux
  • Dustin Green
  • J Asgar
  • Ken Yamamoto
  • Ayako Ujike
  • Zsuzsanna Helyes
  • Marcelo C Dall'Acqua
  • Gabriela Trevisan
  • Milos R Filipović
  • Hiroki Yamanaka
  • Tetsuo Fukuoka
  • Maki Tsumura
  • Pierangelo Geppetti
  • Wim Vermeulen
  • Shenhui Wang
  • Bi Yu Liu
  • Suzy Krimon
  • N Nishio
  • Xun Qian
  • Peter Thornton
  • Andressa Perin-Martins
  • Sen Wang
  • Gabor Pozsgai
  • Mirjam J Eberhardt
  • Izumi Kaji
  • Rebecca M Edelmayer
  • Marie E Barabas
  • Liana Merrill
  • Hiroto Miwa
  • Louis S Premkumar
  • Toshihide Yokoyama
  • Jun Sakurai
  • Yu Ru Kou
  • Mahendra Bishnoi
  • Linlin Zhong
  • Myung Jin Choi
  • Manish Raisinghani
  • Edinéia Lemos Andrade
  • Naoki Yoshida
  • Yan Bo Yu
  • Yun Sook Kim
  • Alexander Staruschenko
  • J P Dunham
  • Yuanyuan Y Wang
  • Daisuke Uta
  • Young Ho Jin
  • Yang Dong
  • Boram Sun
  • Shenglan Wang
  • F Aura Kullmann

Detail Information

Publications84

  1. pmc HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
    Samer R Eid
    Department of Pain Research, Neuroscience Drug Discovery, Merck Research Laboratories, West Point, Philadelphia, USA
    Mol Pain 4:48. 2008
    ..The recent discovery and description of the transient receptor potential family of receptors including TRPV1 and TRPA1 has provided a number of potential new therapeutic targets for treating chronic pain...
  2. pmc TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1
    Margaux M Salas
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Eur J Neurosci 29:1568-78. 2009
    ..Previous studies have characterized the properties of TRPA1 in heterologous expression systems...
  3. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..Both allyl isothiocyanate and THC mediate their excitatory effects by activating ANKTM1, a member of the TRP ion channel family recently implicated in the detection of noxious cold...
  4. pmc TRPA1 contributes to cold hypersensitivity
    Donato Del Camino
    Hydra Biosciences, Inc, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:15165-74. 2010
    b>TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial...
  5. pmc TRPA1 is a component of the nociceptive response to CO2
    Yuanyuan Y Wang
    Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 30:12958-63. 2010
    ..Here we show that CO(2) specifically activates a subpopulation of trigeminal neurons that express TRPA1, a mustard oil- and cinnamaldehyde-sensitive channel, and that these responses are dependent on a functional TRPA1 ..
  6. pmc Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception
    Manish Raisinghani
    Dept of Pharmacology, Southern Illinois Univ School of Medicine, Springfield, IL 62702, USA
    Am J Physiol Cell Physiol 301:C587-600. 2011
    Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca(2+)-permeant, nonselective cationic channel...
  7. doi Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels
    Bruce R Bianchi
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, R4DJ, AP9 1, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 341:360-8. 2012
    The transient receptor potential ankyrin-1 (TRPA1) channel has emerged as an attractive target for development of analgesic and anti-inflammatory drugs...
  8. pmc TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats
    Steve McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Mol Pain 6:14. 2010
    There is growing evidence supporting a role for TRPA1 receptors in the neurotransmission of peripheral mechanical stimulation...
  9. doi Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn
    Yun Sook Kim
    Department of Oral Anatomy and Neurobiology, Kyungpook National University, Daegu, Korea
    J Comp Neurol 518:687-98. 2010
    Transient receptor potential ankyrin 1 (TRPA1), responding to noxious cold and pungent compounds, is implicated in the mediation of nociception, but little is known about the processing of the TRPA1-mediated nociceptive information ..
  10. pmc The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain
    Ombretta Caspani
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 4:e7383. 2009
    ..Recently the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been identified and proposed to be molecular sensors for cold...
  11. doi TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout
    Gabriela Trevisan
    Graduate Program in Biological Sciences Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil Laboratory of Cellular and Molecular Biology, Graduate Program in Health Science, University of Southern Santa Catarina, Criciuma, SC, Brazil
    Free Radic Biol Med 72:200-9. 2014
    ..The transient potential receptor ankyrin 1 (TRPA1) is expressed by a subpopulation of peptidergic nociceptors and, via its activation by endogenous reactive oxygen ..
  12. pmc Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat
    James P Dunham
    Department of Physiology and Pharmacology, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    Eur J Neurosci 27:3151-60. 2008
    ..The transient receptor potential channel A1 (TRPA1) is a receptor localized to putative nociceptive neurones and is implicated in mechanical and thermal nociception...
  13. pmc Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats
    G Ji
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Marine Biomedical Institute, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neuroscience 154:1054-66. 2008
    ..Recent data indicate both transient receptor potential (TRP) M8 and TRPA1 play a role. In relation to TRPA1, there are reported increases in mRNA...
  14. doi Molecular determinants of species-specific activation or blockade of TRPA1 channels
    Jun Chen
    Neuroscience, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    J Neurosci 28:5063-71. 2008
    b>TRPA1 is an excitatory, nonselective cation channel implicated in somatosensory function, pain, and neurogenic inflammation...
  15. pmc Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization
    Armen N Akopian
    Department of Endodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Physiol 583:175-93. 2007
    ..The TRPA1 channel plays a key role in the processing of noxious information and can undergo functional desensitization by ..
  16. pmc Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
    Yi Dai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo, Japan
    J Clin Invest 117:1979-87. 2007
    ..Transient receptor potential A1 (TRPA1) is an excitatory ion channel on primary sensory nerves of pain pathway...
  17. pmc TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    J Clin Invest 115:2393-401. 2005
    ..Here we report that the pharmacological blockade of TRPA1 in primary sensory neurons reversed cold hyperalgesia caused by inflammation and nerve injury...
  18. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ..Recently, two other members of this superfamily, TRPA1 and TRPM8, have been cloned and characterized as possible candidates for cold transducers in primary afferent ..
  19. ncbi Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats
    Hirokazu Katsura
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Exp Neurol 200:112-23. 2006
    ..In the present study, we precisely examined the incidence of cold hyperalgesia and the changes of TRPA1 and TRPM8 expression in the L4 and L5 DRG following L5 spinal nerve ligation (SNL), because it is likely that the ..
  20. doi Transient receptor potential A1 mediates an osmotically activated ion channel
    Xu Feng Zhang
    Neuroscience Research, R4PM, AP9A, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Eur J Neurosci 27:605-11. 2008
    ..A recent study of TRPA1 knockout mice demonstrated deficits in sensing mechanical stimuli, suggesting a role for TRPA1 also in somatic ..
  21. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
    ..Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8...
  22. ncbi Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury
    J Frederick
    Western Connecticut State University, 181 White Street, Danbury, CT 06810, USA
    Biochem Biophys Res Commun 358:1058-64. 2007
    ..We developed a multiplex ribonuclease protection assay (RPA) to quantify rat TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 RNA levels in DRG...
  23. ncbi A painful trp can be a bonding experience
    Zita Peterlin
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 53:635-8. 2007
    The receptive field of the TRPA1 nociceptor is remarkably expansive when compared to other chemodetectors such as odorant receptors...
  24. pmc TRPA1-dependent regulation of bladder detrusor smooth muscle contractility in normal and type I diabetic rats
    Igor B Philyppov
    Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
    J Smooth Muscle Res 52:1-17. 2016
    b>TRPA1 is a Ca(2+)-permeable cation channel that is activated by painful low temperatures (<17°C), irritating chemicals, reactive metabolites and mediators of inflammation...
  25. doi Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain
    Ryosuke Kojima
    Pharmacology Research Labs, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan Electronic address
    Eur J Pharmacol 723:288-93. 2014
    ..We previously reported that transient receptor potential ankyrin 1 (TRPA1) is highly expressed in enterochromaffin (EC) cells, which are 5-hydroxytryptamine (5-HT)-releasing cells, and ..
  26. doi TRPA1 ion channels in vagal afferent nerves contribute to ventilator-induced lung injury in a rat model
    Shenhui Wang
    Department of Anesthesiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, 250012, China
    Gen Physiol Biophys 32:389-94. 2013
    In order to investigate the effects of transient receptor potential channel A1 (TRPA1)-mediated neurogenic inflammatory reaction on the process of ventilator-induced lung injury (VILI)...
  27. doi Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels
    N Nishio
    Pain Research Center, Kansai University of Health Sciences, Kumatori, Osaka 590 0482, Japan
    Neuroscience 247:201-12. 2013
    ..Furthermore, in the presence of a transient receptor potential ankyrin 1 (TRPA1) channel antagonist (HC-030031) or a transient receptor potential vanilloid 1 (TRPV1) channel antagonist (..
  28. doi Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity
    Peter Thornton
    MedImmune, Granta Park, Cambridge CB21 6GH, UK
    Neurosci Lett 545:23-8. 2013
    ..Anti-ARTN antibodies had no effect on hypersensitivity in response to partial nerve ligation in mice. These data suggest that ARTN-GFRα3 interactions partially mediate early stage nociceptive signalling following an inflammatory insult...
  29. doi Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats
    Wim Vermeulen
    Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Eur J Pharmacol 698:404-12. 2013
    The aim of the present study is to investigate the effects of TRPV1 and TRPA1 receptor antagonists and their synergism on the visceromotor responses during experimental colitis in rats...
  30. doi Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon
    Izumi Kaji
    Laboratory of Physiology, Institute for Environmental Science, Univ of Shizuoka, Shizuoka, Japan
    Am J Physiol Gastrointest Liver Physiol 302:G690-701. 2012
    ..The transient receptor potential A1 (TRPA1) channel is considered to be a chemosensor in several sensory tissues...
  31. pmc Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury
    Dustin Green
    University of Texas Health Science Center at San Antonio
    Mol Pain 12:. 2016
    ..The transient receptor potential channels, TRPV1 and TRPA1, are expressed by a subset of nociceptive sensory neurons and contribute to inflammatory hypersensitivity...
  32. doi P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors
    Suzy Krimon
    Department of Structural and Functional Biology, Institute of Biology, State University of Campinas UNICAMP, Brazil
    Pharmacol Biochem Behav 112:49-55. 2013
    ..In this study, we have evaluated whether TRPA1, 5-HT3 and 5-HT1A receptors, whose activation is essential to formalin-induced inflammatory nociception, are ..
  33. doi Potential role of spinal TRPA1 channels in antinociceptive tolerance to spinally administered morphine
    Hong Wei
    King s Lab, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
    Pharmacol Rep 68:472-5. 2016
    ..Since the astrocyte-DAAO pathway generates hydrogen peroxide, an agonist of the TRPA1 channel expressed spinally on nociceptive nerve terminals and astrocytes, we tested a hypothesis that the spinal ..
  34. pmc Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts
    Maki Tsumura
    Department of Physiology, Tokyo Dental College, Chiba, Japan
    PLoS ONE 8:e82233. 2013
    ..of transient receptor potential (TRP) melastatin subfamily member 8 (TRPM8) and ankyrin subfamily member 1 (TRPA1) channels in odontoblasts remain to be clarified...
  35. doi The contribution of transient receptor potential ankyrin 1 (TRPA1) to the in vivo nociceptive effects of prostaglandin E₂
    Marcelo C Dall'Acqua
    Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil
    Life Sci 105:7-13. 2014
    Although evidence suggest that TRPA1 mediates some effects of prostaglandins, it is not known whether TRPA1 contributes to the in vivo nociceptive effects of prostaglandin E2 (PGE2), a key mediator of inflammatory pain.
  36. pmc Meningeal blood flow is controlled by H2 S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway
    Maria Dux
    Department of Physiology, University of Szeged, Szeged, Hungary
    Br J Pharmacol 173:431-45. 2016
    ..The vasodilator effect of NO may be due to the NO-derived compound, nitroxyl (HNO), generated through reaction with endogenous H2 S. We investigated the involvement of HNO in CGRP release and meningeal blood flow...
  37. doi Bidirectional effects of hydrogen sulfide via ATP-sensitive K(+) channels and transient receptor potential A1 channels in RIN14B cells
    Ayako Ujike
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Eur J Pharmacol 764:463-70. 2015
    ..H2S can activate both KATP and TRPA1 channels at a similar concentration range...
  38. doi Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats
    Ivliane Nozadze
    Department of Neurophysiology, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia
    Behav Pharmacol 27:29-36. 2016
    ..Recent findings in the field of pain have established a family of six thermo-TRP channels (TRPA1, TRPM8, TRPV1, TRPV2, TRPV3, and TRPV4) that exhibit sensitivity to increases or decreases in temperature, as well ..
  39. pmc The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats
    J Asgar
    University of Maryland School of Dentistry, Department of Neural and Pain Sciences, 650 W Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 310:206-15. 2015
    Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is expressed in muscle afferents and direct activation of these receptors induces acute mechanical hypersensitivity...
  40. pmc Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration
    Ken Yamamoto
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo, 194 8543, Japan
    Mol Pain 11:69. 2015
    ..In the present study, we investigated the effects of oxaliplatin on transient receptor potential ankyrin 1 (TRPA1) in dorsal root ganglion (DRG) neurons of rats.
  41. doi Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium
    Krisztina Pohoczky
    Department of Pharmacology and PharmacotherapyUniversity of Pécs Medical School, Szigeti Street 12, H 7624 Pecs, HungaryJanos Szentagothai Research CentreUniversity of Pécs, Ifjúság Street 20, H 7624 Pecs, HungaryDepartments of PathologyUniversity of Pécs Medical School, Szigeti Street 12, H 7624 Pecs, HungaryDepartment of PhysiologyUniversity of Pécs Medical School, Szigeti Street 12, H 7624 Pecs, HungaryDepartment of Pathophysiology and GerontologyUniversity of Pécs Medical School, Szigeti Street 12, H 7624 Pecs, HungaryMTA PTE NAP B Chronic Pain Research GroupHungary, Szigeti Street 12, H 7624 Pecs, HungaryInstitute of Animal ScienceCentre for Agricultural and Applied Economic Sciences, University of Debrecen, PO Box 36, H 4015 Debrecen, Hungary Department of Pharmacology and PharmacotherapyUniversity of Pécs Medical School, Szigeti Street 12, H 7624 Pecs, HungaryJanos Szentagothai Research CentreUniversity of Pécs, Ifjúság Street 20, H 7624 Pecs, HungaryDepartments of PathologyUniversity of Pécs Medical School, Szigeti Street 12, H 7624 Pecs, HungaryDepartment of PhysiologyUniversity of Pécs Medical School, Materials and Manufacturing Engineering
    J Mol Endocrinol 56:135-49. 2016
    Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors expressed predominantly in sensory nerves are activated by inflammatory stimuli and mediate inflammation and pain...
  42. pmc TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion
    Jianghui Meng
    International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin 9, Ireland
    Sci Rep 6:21226. 2016
    ..Herein, TRPA1 and TRPV1 were found on vesicles containing calcitonin gene-related peptide (CGRP), accumulated at sites of exo- ..
  43. doi Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats
    Bi Yu Liu
    Department of Physiology, National Yang Ming University, Taipei 112, Taiwan
    Pulm Pharmacol Ther 26:364-72. 2013
    Laryngeal exposure to cigarette smoke (CS) evokes sensory irritation, but the mechanisms are largely unclear. The TRPA1 and TRPV1 receptors are two types of Ca(2+)-permeant channels located at the terminals of airway capsaicin-sensitive ..
  44. doi The role of transient receptor potential A 1 (TRPA1) in the development and maintenance of carrageenan-induced hyperalgesia
    Ivan J M Bonet
    Department of Functional and Structural Biology, Institute of Biology, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Neuropharmacology 65:206-12. 2013
    Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel important in setting nociceptive threshold. It is expressed in nociceptive C-fibers and in non-neuronal cells involved in pro-inflammatory mediators' release...
  45. pmc Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors
    Chun Chun Hsu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Am J Physiol Regul Integr Comp Physiol 305:R769-79. 2013
    ..sulfide (H2S) is an endogenous mediator inducing hyperalgesia through transient receptor potential ankyrin 1 (TRPA1) receptors located on nociceptors...
  46. doi The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation
    Gabor Pozsgai
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624, Pecs, Szigeti u 12, Hungary
    Eur J Pharmacol 689:56-64. 2012
    Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP)...
  47. doi Mechanisms underlying transient receptor potential ankyrin 1 (TRPA1)-mediated hyperalgesia and edema
    Andressa Perin-Martins
    Department of Physiology, Laboratory of Pain Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil
    J Peripher Nerv Syst 18:62-74. 2013
    The aim of this study was to investigate the mechanisms that contribute to hyperalgesia and edema induced by TRPA1 activation...
  48. pmc TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons
    Marie E Barabas
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e47988. 2012
    ..CGRP expression and IB4-binding are commonly used to define peptidergic and non-peptidergic subpopulations. TRPA1 is a polymodal, plasma membrane ion channel that contributes to mechanical and cold hypersensitivity during tissue ..
  49. pmc Recruitment of dynamic endothelial Ca2+ signals by the TRPA1 channel activator AITC in rat cerebral arteries
    Xun Qian
    Department of Physiology, University of South Alabama College of Medicine, Mobile, Alabama, USA
    Microcirculation 20:138-48. 2013
    Stimulation of endothelial TRP channels, specifically TRPA1, promotes vasodilation of cerebral arteries through activation of Ca2+ -dependent effectors along the myoendothelial interface...
  50. pmc Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation
    Liana Merrill
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:744-56. 2012
    ..examined the transcriptional and translational plasticity of three transient receptor potential (TRP) channels (TRPA1, TRPV1, TRPV4) with established neuronal and non-neuronal expression and functional roles in the lower urinary ..
  51. pmc Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies
    Mirjam J Eberhardt
    Institute of Physiology and Pathophysiology Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 287:28291-306. 2012
    ..The electrophilic structure of this cytotoxic ketoaldehyde suggests TRPA1, a receptor channel deeply involved in inflammatory and neuropathic pain, as a molecular target...
  52. pmc Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells
    De Shou Cao
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 7:e38005. 2012
    ..Here, we demonstrate the expression of the transient receptor potential ankyrin 1 (TRPA1) ion channel in the pancreatic beta cells and its role in insulin release...
  53. doi Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain
    Hong Wei
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    Anesthesiology 117:137-48. 2012
    The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed on nociceptive primary afferent nerve fibers...
  54. ncbi Transient receptor potential A1 is involved in cold-induced contraction in the isolated rat colon smooth muscle
    Yang Dong
    Institute of Chinese Materia Medica, Shanghai Key Laboratory of Complex Prescription Experimental Teaching Centre, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Sheng Li Xue Bao 62:349-56. 2010
    ..The aims of this study were to determine if TRPA1 contributed to cold-induced contractions in the isolated rat colon preparations and explore the potential ..
  55. doi TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release
    K Weller
    Institute of Physiology and Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
    Neuropeptides 45:391-400. 2011
    Vagal sensory afferents innervating airways and abdominal tissues express TRPV1 and TRPA1, two depolarizing calcium permeable ion channels playing a major role in sensing environmental irritants and endogenous metabolites which cause ..
  56. doi Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain
    Takashi Kondo
    Department of Anatomy and Neuroscience, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Neuroreport 24:68-72. 2013
    ..On the basis of these results, the aim of this study was to investigate the involvement of p38 and TRPA1 in acute visceral pain. Male Sprague-Dawley rats were used...
  57. pmc Warmth suppresses and desensitizes damage-sensing ion channel TRPA1
    Sen Wang
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 8:22. 2012
    ..Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of substances that are released following tissue damage to evoke ..
  58. pmc Activation of TRPA1 on dural afferents: a potential mechanism of headache pain
    Rebecca M Edelmayer
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA
    Pain 153:1949-58. 2012
    Activation of transient receptor potential ankyrin-1 (TRPA1) on meningeal nerve endings has been suggested to contribute to environmental irritant-induced headache, but this channel may also contribute to other forms of headache, such as ..
  59. doi Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy
    Ari Koivisto
    Orion Corporation, OrionPharma, Finland
    Pharmacol Res 65:149-58. 2012
    ..Here we test the hypothesis that the transient receptor potential ankyrin 1 (TRPA1) ion channel on primary afferent nerve fibers is involved in the pathogenesis of PDN, due to sustained activation ..
  60. pmc Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia
    Jin Y Ro
    University of Maryland Baltimore School of Dentistry, Program in Neuroscience, Department of Neural and Pain Sciences, 650 W Baltimore Street, Baltimore, MD 21201, USA
    Pain 144:270-7. 2009
    The involvement of TRPV1 and TRPA1 in mediating craniofacial muscle nociception and mechanical hyperalgesia was investigated in male Sprague-Dawley rats...
  61. doi The mechanosensitive cell line ND-C does not express functional thermoTRP channels
    Francois Rugiero
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, London, UK
    Neuropharmacology 56:1138-46. 2009
    ..Furthermore, transfecting ND-C cells with the candidate mechanotransducer channel TRPA1 does not increase MA current amplitudes, despite TRPA1 being functionally expressed at the plasma membrane...
  62. pmc Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca2+-Activated K+ channels
    Scott Earley
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1680, USA
    Circ Res 104:987-94. 2009
    ..The sole member of the ankyrin (A) transient receptor potential (TRP) subfamily, TRPA1, is a Ca(2+)-permeable nonselective cation channel activated by electrophilic compounds such as acrolein (tear gas)..
  63. pmc Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones
    Paul J Wrigley
    Pain Management Research Institute, Kolling Institute, Level 13, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Br J Pharmacol 157:371-80. 2009
    ..TRP) channels, transient receptor potential melastatin-1 (TRPM8) and transient receptor potential ankyrin-1 (TRPA1), are expressed in subpopulations of sensory neurones and have been proposed to mediate innocuous and noxious cold ..
  64. ncbi Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain
    Chul Kyu Park
    Department of Physiology and Molecular and Cellular Neuroscience Program, College of Dentistry and Dental Research Institute, Seoul National University, 28 2 Yeongeon Dong Chongno Ku, Seoul 110 749
    J Biol Chem 281:17304-11. 2006
    ..Single cell reverse transcription-PCR and immunohistochemistry revealed expression of TRPV1, TRPM8, and TRPA1 in subsets of such neurons...
  65. pmc TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
    Katsura Nozawa
    Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
    Proc Natl Acad Sci U S A 106:3408-13. 2009
    ..Here, we demonstrate that the transient receptor potential (TRP) cation channel TRPA1, which is activated by pungent compounds or cold temperature, is highly expressed in EC cells...
  66. pmc Functional TRP and ASIC-like channels in cultured urothelial cells from the rat
    F Aura Kullmann
    Dept of Pharmacology and Chemical Biology, Univ of Pittsburgh School of Medicine, E 1340 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 296:F892-901. 2009
    ..The TRPV4 agonist 4alpha-phorbol-12,13 didecanoate (4alpha-PDD; 1-5 microM) and the TRPA1/TRPM8 agonist icilin (50-100 microM) elicited transient currents in a high percentage of cells (>70%)...
  67. ncbi Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer
    S Hayashi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    Inflammopharmacology 15:218-22. 2007
    We examined the influence of TRPA1 on the epithelial restitution using a rat gastric epithelial cell line RGM1 monolayer...
  68. ncbi Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons
    Hirokazu Katsura
    Department of Otolaryngology, Hyogo College of Medicine, 1 1 Mukogawa, Nishinomiya, Hyogo 663 8501, Japan
    Chem Senses 31:681-8. 2006
    ..Capsaicin-, menthol-, and mustard oil-sensitive receptors are TRPV1, TRPM8, and TRPA1, respectively...
  69. ncbi Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons
    T Mizushima
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Neuroscience 140:1337-48. 2006
    Two cold-sensitive transient receptor potential (TRP) channels, TRPA1 and TRPM8, have been identified and considered interesting because of their possible roles in thermosensation, nociception and other functions...
  70. doi Transient receptor potential A1 channel contributes to activation of the muscle reflex
    Satoshi Koba
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Heart Circ Physiol 300:H201-13. 2011
    This study was undertaken to elucidate the role played by transient receptor potential A1 channels (TRPA1) in activating the muscle reflex, a sympathoexcitatory drive originating in contracting muscle...
  71. doi Transient receptor potential A1 increase glutamate release on brain stem neurons
    Boram Sun
    Department of Physiology and Medical Research Center, School of Medicine, Graduate School, Kyung Hee University, Seoul, Korea
    Neuroreport 20:1002-6. 2009
    ..b>TRPA1 ligands are found as common ingredients of pungent spices and can trigger autonomic reflexes and alter blood ..
  72. doi TRPA1 agonists delay gastric emptying in rats through serotonergic pathways
    Hitoshi Doihara
    Pharmacology Laboratories, Drug Discovery Research, Astellas Pharma, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Naunyn Schmiedebergs Arch Pharmacol 380:353-7. 2009
    Our recent study found that TRPA1 is highly expressed in enterochromaffin cells and that stimulation of these cells with TRPA1 agonists enhances 5-hydroxytryptamine (5-HT) secretion in vitro...
  73. pmc Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors
    J P Dunham
    Department of Physiology and Pharmacology, University of Bristol, School of Medical Sciences, University Walk, Bristol, UK
    Neuroscience 165:1412-9. 2010
    The role of transient receptor potential channel A1 (TRPA1) in noxious cold sensation remains unclear. Some data support the hypothesis that TRPA1 is a transducer of noxious cold whilst other data contest it...
  74. pmc Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1
    Qihai Gu
    Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Appl Physiol (1985) 108:891-7. 2010
    ..Transient receptor potential A1 (TRPA1) is selectively expressed in a subpopulation of pulmonary C-fiber afferents and has been considered as a major ..
  75. doi Activations of TRPA1 and P2X receptors are important in ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats
    You Shuei Lin
    Graduate Institute of Medical Sciences, Department of Physiology, School of Respiratory Therapy, College of Medicine, Taipei Medical University, and Neuroscience Research Center, Department of Respiratory Therapy, Taipei Medical University Hospital, Taipei, Taiwan
    J Appl Physiol (1985) 108:1293-303. 2010
    ..was prevented by N-acetyl-L-cysteine (NAC; an antioxidant), HC-030031 [a transient receptor potential ankyrin 1 (TRPA1) receptor antagonist], and iso-pyridoxalphosphate-6-azophenyl-2',5'-disulfonate (iso-PPADS; a P2X receptor ..
  76. doi Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model
    Yan Bo Yu
    Department of Gastroenterology, Qilu Hospital, Shandong University, 250012, Jinan, People s Republic of China
    Neurochem Res 35:797-803. 2010
    ..In the present study, we aimed to examine the involvement of TRPV1 and TRPA1 in the stress-induced visceral hyperalgesia...
  77. pmc Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel
    Alexander Staruschenko
    Department of Physiology and Kidney Disease Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    J Biol Chem 285:15167-77. 2010
    Several lines of evidence suggest that TRPA1 and TRPV1 mutually control the transduction of inflammation-induced noxious stimuli in sensory neurons. It was recently shown that certain TRPA1 properties are modulated by TRPV1...
  78. pmc TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord
    Daisuke Uta
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Neurosci 31:1960-73. 2010
    The TRPA1 channel has been proposed to be a molecular transducer of cold and inflammatory nociceptive signals...
  79. doi Role of transient receptor potential A1 in gastric nociception
    Takashi Kondo
    Division of Upper Gastroenterology, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Digestion 82:150-5. 2010
    ..b>TRPA1 was coexpressed with ERK1/2 in gastric primary afferent neurons, and attenuation of TRPA1 activation using ..
  80. pmc Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin
    Naoki Yoshida
    Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo 650 8530, Japan
    Mol Pain 7:41. 2011
    The transient receptor potential (TRP) channel subtype A1 (TRPA1) is known to be expressed on sensory neurons and respond to changes in temperature, pH and local application of certain noxious chemicals such as allyl isothiocyanate (AITC)..
  81. doi TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury
    Edinéia Lemos Andrade
    Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, Santa Catarina SC, Brazil
    Am J Physiol Renal Physiol 300:F1223-34. 2011
    The ankyrin-repeat transient receptor potential 1 (TRPA1) has been implicated in pathological conditions of the bladder, but its role in overactive bladder (OAB) following spinal cord injury (SCI) remains unknown...
  82. doi Transient receptor potential (TRP) A1 activated currents in TRPV1 and cholecystokinin-sensitive cranial visceral afferent neurons
    Myung Jin Choi
    Department of Physiology, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Brain Res 1383:36-42. 2011
    ..b>TRPA1 channel have also been identified on cranial visceral afferent neurons but their distribution and functional ..

Research Grants4

  1. Mechanisms of Nociceptive Neuronal Plasticity
    ARMEN AKOPIAN; Fiscal Year: 2004
    ..abstract_text> ..
  2. INTERACTIONS OF TRPV1 AND TRPA1 AND INFLAMMATORY PAIN
    Armen N Akopian; Fiscal Year: 2010
    ..In this application, we propose to test the primary hypothesis that a functional interaction between TRPA1 and TRPV1 channels plays a key role in the integration of inflammation-induced stimuli by sensory neurons...
  3. TRPM4 Channels in the Control of Cerebral Artery Tone
    Scott Earley; Fiscal Year: 2005
    ..It is anticipated that these studies will generate significant new information regarding the role of mechanosensitive cation channels in the regulation of VSM membrane potential and the regulation of cerebral blood flow. ..
  4. Brainstem Mechanisms of Craniofacial Muscle Pain
    JIN RO; Fiscal Year: 2006
    ..abstract_text> ..