Tnik

Summary

Gene Symbol: Tnik
Description: TRAF2 and NCK interacting kinase
Alias: RGD1561817, TRAF2 and NCK-interacting protein kinase
Species: rat

Top Publications

  1. doi Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade
    Tzer Bin Lin
    Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11049, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan, Department of Biotechnology, Asia University, Taichung 41354, Taiwan
    J Neurosci 35:16545-60. 2015
  2. pmc The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function
    Q Wang
    Pfizer Neuroscience Research Unit, Princeton, NJ, USA
    Mol Psychiatry 16:1006-23. 2011
  3. pmc Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
    Hiroshi Kawabe
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 65:358-72. 2010
  4. pmc MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function
    Natasha K Hussain
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:14786-94. 2010

Scientific Experts

  • Hiroshi Kawabe
  • Tzer Bin Lin
  • Q Wang
  • Natasha K Hussain
  • Gin Den Chen
  • Yat Pang Chau
  • Ting Ruan
  • Ming Chun Hsieh
  • Jen Kun Cheng
  • Cheng Yuan Lai
  • Hsien Yu Peng
  • R A Crozier
  • E I Charych
  • K Ishizuka
  • R J Weinberg
  • A Sawa
  • J B Lee
  • N M Graziane
  • H Murdoch
  • S J Moss
  • N J Brandon
  • B Bates
  • M P Kelly
  • K Kariya
  • A Hayashi-Takagi
  • Y Xie
  • A J Dunlop
  • S Seshadri
  • M D Houslay
  • R Revilla-Sanchez
  • V L Pulito
  • Z Yan
  • M Pausch
  • N Taylor
  • Morgan Sheng
  • Richard L Huganir
  • Honor Hsin

Detail Information

Publications4

  1. doi Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade
    Tzer Bin Lin
    Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11049, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan, Department of Biotechnology, Asia University, Taichung 41354, Taiwan
    J Neurosci 35:16545-60. 2015
    ..we report that the abundance of tumor necrosis factor receptor-associated factor 2 and NcK-interacting kinase (TNIK), a kinase that is presumed to regulate neural plasticity, was specifically enhanced in ipsilateral dorsal horn ..
  2. pmc The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function
    Q Wang
    Pfizer Neuroscience Research Unit, Princeton, NJ, USA
    Mol Psychiatry 16:1006-23. 2011
    ..We identify the Traf2 and Nck-interacting kinase (TNIK), an emerging risk factor itself for disease, as a key synaptic partner for DISC1, and provide evidence that the ..
  3. pmc Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
    Hiroshi Kawabe
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 65:358-72. 2010
    ..Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A...
  4. pmc MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function
    Natasha K Hussain
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:14786-94. 2010
    Misshapen/NIKs (Nck-interacting kinases)-related kinase (MINK) and closely related TRAF2/Nck-interacting kinase (TNIK) are proteins that specifically bind to activated Rap2 and are thus hypothesized to relay its downstream signal ..