Tnfrsf1a

Summary

Gene Symbol: Tnfrsf1a
Description: TNF receptor superfamily member 1A
Alias: TNFR-1, Tnfr1, tumor necrosis factor receptor superfamily member 1A, TNF-R1, TNF-RI, TNFR-I, p55, p60, tumor necrosis factor receptor 1, tumor necrosis factor receptor superfamily, member 1a, tumor necrosis factor receptor type I
Species: rat

Top Publications

  1. ncbi Tumor necrosis factor signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
    Cell Death Differ 10:45-65. 2003
  2. ncbi Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Brain Res 996:202-12. 2004
  3. doi TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells
    Yongwei Qin
    Key Laboratory for Neuroregeneration of JiangSu Province, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PR China
    Neurochem Res 33:1077-84. 2008
  4. pmc Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model
    Cheryll Williams-Skipp
    University of Colorado Denver Health Sciences Center
    Arthritis Rheum 60:408-18. 2009
  5. pmc Imbalances in serum proinflammatory cytokines and their soluble receptors: a putative role in the progression of idiopathic IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis, and a potential target of immunoglobulin therapy?
    G Rostoker
    Service de Néphrologie et Laboratoire d Investigation Clinique, Hôpital Claude Galien, Quincy sous Sénart Unité Inserm U 139 France
    Clin Exp Immunol 114:468-76. 1998
  6. ncbi Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy
    G Guo
    Department of Internal Medicine and the Department of Cell Biology and Physiology, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110 1092, USA
    Am J Physiol 277:F766-72. 1999
  7. ncbi Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis
    Morag Robertson
    Department of Ophthalmology, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 44:3034-41. 2003
  8. pmc Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition
    Maria H Lind
    Department of Bioscience, Clinical Research Center, Karolinska Institutet, Novum, SE 141 57 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:4972-7. 2004
  9. ncbi In vivo transfer of soluble TNF-alpha receptor 1 gene improves cardiac function and reduces infarct size after myocardial infarction in rats
    Masahiro Sugano
    Department of Molecular and Cellular Biology, Division of Molecular and Clinical Gerontology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita, 874 0838, Japan
    FASEB J 18:911-3. 2004
  10. ncbi Tumor necrosis factor-alpha-induced apoptosis in murine cytomegalovirus retinitis
    Jun Zhou
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Invest Ophthalmol Vis Sci 48:1691-700. 2007

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi Tumor necrosis factor signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
    Cell Death Differ 10:45-65. 2003
    ..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed...
  2. ncbi Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Brain Res 996:202-12. 2004
    ..Since secondarily degenerating neurons are viable targets for neuroprotection, inhibition of TNF death receptor signaling may be an effective strategy to protect RGCs in several neurodegenerative injuries...
  3. doi TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells
    Yongwei Qin
    Key Laboratory for Neuroregeneration of JiangSu Province, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PR China
    Neurochem Res 33:1077-84. 2008
    ..TNF-alpha exhibits its biological effect through two distinct surface receptors, TNF receptor 1 (TNFR1) and TNFR2...
  4. pmc Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model
    Cheryll Williams-Skipp
    University of Colorado Denver Health Sciences Center
    Arthritis Rheum 60:408-18. 2009
    ..To examine the relative importance of tumor necrosis factor receptor I (TNFRI) signaling in the hematopoietic tissue compartment in the progression of collagen-induced arthritis (CIA), a model of rheumatoid arthritis (RA)...
  5. pmc Imbalances in serum proinflammatory cytokines and their soluble receptors: a putative role in the progression of idiopathic IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis, and a potential target of immunoglobulin therapy?
    G Rostoker
    Service de Néphrologie et Laboratoire d Investigation Clinique, Hôpital Claude Galien, Quincy sous Sénart Unité Inserm U 139 France
    Clin Exp Immunol 114:468-76. 1998
    ..This process may play a role in the progression of the disease and be one of the targets of immunoglobulin therapy...
  6. ncbi Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy
    G Guo
    Department of Internal Medicine and the Department of Cell Biology and Physiology, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110 1092, USA
    Am J Physiol 277:F766-72. 1999
    ..Mice in which individual TNF-alpha receptors TNFR1 or TNFR2 had been genetically knocked out were used, and results were compared with mice of C57Bl/6 background ..
  7. ncbi Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis
    Morag Robertson
    Department of Ophthalmology, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 44:3034-41. 2003
    ....
  8. pmc Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition
    Maria H Lind
    Department of Bioscience, Clinical Research Center, Karolinska Institutet, Novum, SE 141 57 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:4972-7. 2004
    ..We now show that by crossing K5-IkappaBalpha mice onto a tumor necrosis factor receptor 1(Tnfr1)-null background, both the inflammatory and the tumorigenic responses are blocked...
  9. ncbi In vivo transfer of soluble TNF-alpha receptor 1 gene improves cardiac function and reduces infarct size after myocardial infarction in rats
    Masahiro Sugano
    Department of Molecular and Cellular Biology, Division of Molecular and Clinical Gerontology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita, 874 0838, Japan
    FASEB J 18:911-3. 2004
    ..Suppression of TNF-alpha bioactivity from the early stage of infarction with the sTNFR1 plasmid improved cardiac function and reduced infarct size...
  10. ncbi Tumor necrosis factor-alpha-induced apoptosis in murine cytomegalovirus retinitis
    Jun Zhou
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Invest Ophthalmol Vis Sci 48:1691-700. 2007
    ..To explore the mechanism underlying retinal apoptosis in MCMV retinitis, this study was initiated to determine whether the tumor necrosis factor receptor (TNFR)1-TNF pathway is involved in apoptosis during MCMV retinitis...
  11. doi Quantification of the mRNA encoding Tumor Necrosis Factor alpha (TNFalpha) and its receptors in human nasal polyps
    B Rostkowska-Nadolska
    Department of Otolaryngology, Wroclaw Medical University, Wroclaw, Poland
    Adv Med Sci 53:263-9. 2008
    ..The object of the study was to assess the expression of the genes encoding TNFalpha and its receptors (TNF-R1 and TNF-R2) in patients with nasal polyps (NP)...
  12. doi TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis
    Ben J E Raveney
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Immunol 183:2321-9. 2009
    ..depends on activation by T cell-produced IFN-gamma and autocrine TNF-alpha signaling in the myeloid cells via TNFR1. In the absence of TNFR1 signaling, relative T cell expansion in the retina is increased, indicating that ..
  13. doi Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain
    C Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neuroscience 169:463-74. 2010
    ..Mechanisms by which TNF, through its receptor subtypes, TNF receptor 1 (TNFR1) and -2 (TNFR2), elicits altered sensation and pain behavior, are still incompletely understood...
  14. pmc 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway
    D N Roy
    Cell Biology and Physiology Division, Indian Institute of Chemical Biology, A Unit of Council of Scientific and Industrial Research, Kolkata, India
    Br J Pharmacol 160:1823-43. 2010
    ....
  15. doi Enhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers
    Kalpa Patel
    Department of Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA
    Int J Cancer 129:133-42. 2011
    ..The inclusion of autoantibody biomarkers provided a dramatic improvement in the overall test performance characteristics, relative to the original test panel, including an 11% improvement in the classification efficiency...
  16. pmc TNF/TNFR1 signaling mediates doxorubicin-induced diaphragm weakness
    Laura A A Gilliam
    Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 300:L225-31. 2011
    ..TNF-induced diaphragm weakness is mediated through TNF type 1 receptor (TNFR1)...
  17. doi TNF-α enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury
    Xi Chen
    Pain Research Center and Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, 74 Zhongshan Rd 2, Guangzhou 510080, PR China
    Exp Neurol 227:279-86. 2011
    ..These data suggest that the increase in sodium currents in uninjured DRG neurons following nerve injury might be mediated by over-production of TNF-α...
  18. pmc TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α
    Leslie A Bruggeman
    Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    Lab Invest 91:413-25. 2011
    ....
  19. doi Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats
    Kazunori Kuwata
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu, Tokyo 183 8509, Japan
    Toxicology 283:8-17. 2011
    ..Furthermore, BNF increased HO-1-expressing Kupffer cells and liver cells expressing tumor necrosis factor receptor 1 (TNFR1) and the TNFR1-associated death domain...
  20. doi Blocking TNF-α by combination of TNF-α- and TNFR-binding cyclic peptide ameliorates the severity of TNBS-induced colitis in rats
    Bingjiao Yin
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Eur J Pharmacol 656:119-24. 2011
    ..In the present study we combined TNF-α binding cyclic peptide (TBCP) and TNFR1 binding cyclic peptide (TRBCP) to treat TNBS-induced colitis in rats for one week...
  21. doi Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn's disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2
    Yin Shi
    Shanghai Institute of Acupuncture Moxibustion and Meridians, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China
    Chin J Integr Med 17:212-7. 2011
    To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, ..
  22. doi Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina
    Viswanathan Sivakumar
    Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597
    J Pathol 224:245-60. 2011
    ..Our results suggest that activated microglial cells in hypoxic neonatal retina produce increased amounts of TNF-α and IL-1β that could induce RGC death...
  23. pmc Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-α-treated hepatocytes
    Hyun Ae Eum
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Pathol 179:1221-9. 2011
    b>Tumor necrosis factor receptor 1 (TNFR1) activation in hepatocytes can trigger apoptotic or inflammatory signaling...
  24. ncbi [Fas and TNFR1 expressions after cerebral ischemia and reperfusion in rats: association with cell apoptosis and the effects of Bcl-2 overexpression]
    Gang Wu
    Department of Anesthesiology, Xi an Jiaotong University College of Medicine, Xi an 710004, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1298-303. 2011
    To investigate the effect of Bcl-2 overexpression on Fas and TNFR1-mediated apoptosis and its possible mechanism in rat hippocampus following global ischemia/reperfusion (IR).
  25. pmc ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor
    Zhongyu Liu
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 286:39654-62. 2011
    ..Herein we describe a novel apoptotic pathway involving α2-6 sialylation of the TNFR1 death receptor by the ST6Gal-I sialyltransferase...
  26. pmc Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes
    Monika A Niewczas
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 23:507-15. 2012
    ..Of the examined markers, only TNF receptors 1 and 2 (TNFR1 and TNFR2) associated with risk for ESRD...
  27. doi Moxibustion inhibits apoptosis and tumor necrosis factor-alpha/tumor necrosis factor receptor 1 in the colonic epithelium of Crohn's disease model rats
    Chun hui Bao
    Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    Dig Dis Sci 57:2286-95. 2012
    ..Previous studies have shown that moxibustion on Tianshu (ST25) and Qihai (CV6) is effective for treating Crohn's disease. However, the mechanism of moxibustion has not been clearly elucidated...
  28. doi Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model
    Tetsuhiro Ishikawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 38:11-6. 2013
    Immunohistological analysis of spinal glial cells and analysis of pain behavior in the rat neuropathic pain model were investigated to clarify the function of tumor necrosis factor (TNF)-α receptors p55 type 1 and p75 type 2.
  29. pmc TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    Adam P Gregory
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nature 488:508-11. 2012
    ..Here we have investigated a single nucleotide polymorphism (SNP) in the TNFRSF1A gene, that encodes tumour necrosis factor receptor 1 (TNFR1), which was discovered through GWAS to be associated ..
  30. pmc Predictive value of conjointly examined IL-1ra, TNF-R I, TNF-R II, and RANTES in patients with primary glomerulonephritis
    Rafał Zwiech
    Department of Kidney Transplantation, Medical University of Łódź, Łódź, Poland
    J Korean Med Sci 28:261-7. 2013
    ..In conclusion, the urinary excretion of IL-1ra, TNF-R I and R II, and RANTES examined conjointly are effective in predicting favorable response to immunosuppressive treatment in patients with GN...
  31. pmc Soluble TNF receptor 1-secreting ex vivo-derived dendritic cells reduce injury after stroke
    Melissa G Works
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    J Cereb Blood Flow Metab 33:1376-85. 2013
    ..These studies indicate that cell-mediated delivery of proteins may be a promising new approach to reduce brain damage after acute neurologic insult. ..
  32. pmc Amelioration of liver injury by continuously targeted intervention against TNFRp55 in rats with acute-on-chronic liver failure
    Yumin Xu
    Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS ONE 8:e68757. 2013
    ..TNF receptor: IgG Fc [sTNFR:IgG-Fc]) prevented/reduced development of acute liver failure by blocking the TNF/TNFR1 (TNFRp55) pathway...
  33. pmc Is there a role of TNFR1 in acute lung injury cases associated with extracorporeal circulation?
    Yu Zhao
    Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, China
    J Zhejiang Univ Sci B 15:281-8. 2014
    ..In this study, we evaluated the role of tumor necrosis factor receptor 1 (TNFR1) in ECC-induced ALI by blocking TNF-α binding to TNFR1 with CAY10500...
  34. ncbi Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus
    D Aderka
    Department of Medicine T, Ichilov Hospital, Tel Aviv, Israel
    Arthritis Rheum 36:1111-20. 1993
    ....
  35. ncbi Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock
    Jose Iglesias
    Department of Internal Medicine, Robert Wood Johnson School of Medicine, Neptune, NJ, USA
    Am J Kidney Dis 41:62-75. 2003
    ..Acute renal failure (ARF), a common and serious complication in patients with septic shock, has high mortality. Recent data suggest that proinflammatory cytokines may contribute to sepsis-associated ARF...
  36. pmc Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats
    Taro Misaki
    Department of Health and Nutritional Sciences, Faculty of Health Promotional Sciences, Hamamatsu University, Hamamatsu, Japan
    Am J Pathol 175:74-83. 2009
    ..Two TNFalpha receptors (TNFRs), TNFR1 and TNFR2, are known to exist...
  37. doi Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-α and its receptor 1
    Lianghu Huang
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine New York, New York, USA
    Kidney Int 79:613-23. 2011
    ..When TNFα-receptor-deficient mice were treated with tunicamycin, severe renal injury developed in TNFR1-/- but not TNFR2-/- mice, suggesting this aspect of TNFα action was through TNF receptor-1 (TNFR1)...
  38. ncbi [Effect of intra-articular ozone injection on serum and synovial TNF-α, TNFR I, and TNFR II contents in rats with rheumatoid arthritis]
    Bin Yu
    Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1055-8. 2011
    ..ozone injection at different concentrations on the contents of tumor necrosis factor-α (TNF-α), TNF receptor I (TNFR I), and TNFR II in the serum and synovium of rats with rheumatoid arthritis (RA) and explore the therapeutic ..
  39. doi Structural damage in diabetic nephropathy is associated with TNF-α system activity
    Jose Manuel Fernandez-Real
    Department of Diabetes, Endocrinology and Nutrition, and CIBEROBN Fisiopatología de la Obesidad y Nutrición, University Hospital of Girona Dr Josep Trueta, Carretera de França s n, 17007, Girona, Spain
    Acta Diabetol 49:301-5. 2012
    ..58, P = 0.005). After controlling for age, body mass index and blood pressure, the association of TNFR1 with mesangial expansion persisted significant...
  40. doi The effect of intra-articular injection of different concentrations of ozone on the level of TNF-α, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis
    Huiqiang Chen
    Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
    Rheumatol Int 33:1223-7. 2013
    ..and to investigate the role of O3 in regulating the level of TNF-α (tumor necrosis factor), TNF-R1 (tumor necrosis factor receptor 1), and TNF-R2. Forty-eight Wistar rats were randomly divided into eight groups...
  41. ncbi Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis
    J Aten
    Department of Pathology, University of Amsterdam, The Netherlands
    J Am Soc Nephrol 11:1426-38. 2000
    ..for several other TNF(R) family members revealed in proliferative lupus nephritis a similar distribution for TNFR1 as was observed for CD134L. In contrast, glomerular expression of TNFR2 was similar in all cases examined...
  42. pmc Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway
    Noam Jacob
    Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Immunol 182:2532-41. 2009
    ..We generated SLE-prone New Zealand Mixed 2328 mice genetically deficient in TNFR1, in TNFR2, or in both receptors...
  43. doi Urinary excretion of soluble tumour necrosis factor receptor 1 as a marker of increased risk of progressive kidney function deterioration in patients with primary chronic glomerulonephritis
    Ilona Idasiak-Piechocka
    Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland
    Nephrol Dial Transplant 25:3948-56. 2010
    ..TNF α), a potent proinflammatory cytokine, in the kidneys are mediated by two membrane receptors (TNFR), TNFR1 and TNFR2...
  44. pmc Opposing actions of hippocampus TNFα receptors on limbic seizure susceptibility
    Marc S Weinberg
    Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Exp Neurol 247:429-37. 2013
    ..Twenty four hours after acute limbic seizures the rat hippocampus exhibited a rapid upregulation of TNFR1, but a simultaneous downregulation of TNFR2...
  45. pmc Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes
    Monika A Niewczas
    Research Division of Joslin Diabetes Center, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 4:62-70. 2009
    ..The aim of our study was to examine serum markers of the TNF and Fas pathways for association with cystatin-C based estimated glomerular filtration rate (cC-GFR) in subjects with type 1 diabetes (T1DM) and no proteinuria...
  46. pmc Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves
    Yongjun Wang
    Key Laboratory of Neuroregeneration, Nantong University, Nantong, PR China
    PLoS ONE 7:e43436. 2012
    ..TNFRI family member Tnfrsf1a, Birc2 and Birc3 were mined out integrating as master regulators to mediate inflammatory responses...
  47. ncbi Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients
    D Aderka
    Department of Medicine, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Israel
    Cancer Res 51:5602-7. 1991
    ..The mean +/- SD concentrations of both the soluble type I (p55) and type II (p75) receptors were significantly higher in the cancer patients than in the healthy controls: 1...
  48. ncbi Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein
    A Himmler
    Ernst Boehringer Institut, Bender Co GesmbH, Vienna, Austria
    DNA Cell Biol 9:705-15. 1990
    ..for TNF-alpha and increased reactivity with a monoclonal antibody directed against the human TNF receptor chain p60. When a stop codon was introduced into the cDNA at the site corresponding to the carboxyl terminus of TNF-BP, ..
  49. ncbi Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer
    A Gadducci
    Department of Gynecology and Obstetrics, University of Pisa, Italy
    Anticancer Res 16:3125-8. 1996
    The pretreatment serum levels of the soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) were retrospectively measured in 38 patients with endometrial cancer and 55 patients with benign uterine diseases as controls...
  50. ncbi Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1
    C Sommer
    Neurologische Klinik, Universitat Wurzburg, Josef Schneider Strasse 11, Wurzburg, 97080, Germany
    Exp Neurol 151:138-42. 1998
    ..Neutralizing antibodies to TNF, to the TNF receptor 1 (TNFR1), and to the TNF receptor 2 (TNFR2) were administered by epineurial injection once daily to mice with CCI...
  51. ncbi Soluble tumor necrosis factor receptor type I enhances tumor development and persistence in vivo
    C L Selinsky
    Department of Microbiology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado 80523, USA
    Cell Immunol 200:81-7. 2000
    Secretion of human soluble tumor necrosis factor receptor type I (sTNFRI) by the mouse fibrosarcoma cell line, L929, previously has been demonstrated to confer resistance to in vitro lysis by TNF and to LAK- and CTL-mediated cytolysis...
  52. ncbi A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family
    C Dode
    Universite Paris V, Institut Cochin de Genetique Moleculaire, and Hôpital Cochin, France
    Arthritis Rheum 43:1535-42. 2000
    ..tumor necrosis factor receptor (TNFR)-associated periodic syndrome (TRAPS), in a French family and to investigate the role of the mutated 55-kd tumor necrosis factor alpha (TNFalpha) receptor (TNFR1) in the pathogenesis of the disease.
  53. ncbi Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis
    L A Ortiz
    Section of Pulmonary Diseases, Critical Care, and Environmental Medicine, Department of Pathology, and the Lung Biology Program, Tulane University Medical Center, New Orleans, Louisiana 70112 2699, USA
    Am J Respir Crit Care Med 163:244-52. 2001
    ..factors AP-1 and NF-kappaB in the lungs of C57BL/6 mice, and of mice deficient in one of the two types of TNFR (p55(-/-) or p75(-/-)), exposed to silica (0.2 g/kg) or saline by intratracheal instillation...
  54. ncbi Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors
    V I Shubayev
    Department of Anesthesiology, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0629, USA
    J Neuroimmunol 114:48-56. 2001
    ..These findings highlight a dynamic process of TNF-alpha protein and receptor regulation throughout the peripheral neural axis that bears on both the normal function of DRG neurons and the pathogenesis of painful neuropathies...
  55. ncbi Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases
    Y Amrani
    Department of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 60:646-55. 2001
    ..We also found that agonistic antibodies specific for either TNFR1 or TNFR2 stimulated IL-6 and RANTES secretion and activated p38 and p42/44 MAPKs...
  56. ncbi Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
    ..00001). The TNF-alpha receptor 1 (TNFR1) density in peripheral blood monocytes was similar in DM-2 patients and in nondiabetic subjects...
  57. ncbi Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat
    Carlos A Parada
    Department of Medicine, Division of Neuroscience and Sciences Program, NIH Pain Center UCSF, C522 Box 0440, 521 Parnassus Ave, University of California at San Francisco, San Francisco, CA 94143 0440, USA
    Eur J Neurosci 17:1847-52. 2003
    ..Intrathecal administration of antisense to tumour necrosis factor receptor type-1 (TNFR1) reduced the level of TNFR1 transported toward the peripheral terminals of sensory neurons, and attenuated both ..
  58. ncbi Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death
    Sachiko Shinoda
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA
    Eur J Neurosci 17:2065-76. 2003
    The consequences of activation of tumour necrosis factor receptor 1 (TNFR1) during neuronal injury remain controversial...
  59. ncbi In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue
    M Ermert
    Department of Pathology, Justus Liebig University Giessen, Langhansstr 10, 35385 Giessen, Germany
    Cytokine 22:89-100. 2003
    ....
  60. ncbi Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia
    Maria G Catalano
    Laboratorio di Endocrinologia Oncologica, Dipartimenti di Fisiopatologia Clinica and Oncologia, Universita di Torino, I 10126 Turin, Italy
    Int J Oncol 23:429-36. 2003
    ..This is the first demonstration of a selective up-regulation of TNF-RI in cancer cachexia and suggests that local production of TNF-alpha and IL-6 is a corner-stone in the induction/maintenance of this syndrome...
  61. ncbi Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats
    Ping Yan
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Exp Neurol 183:286-97. 2003
    ..The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whether these two receptors are expressed after SCI has not been demonstrated...
  62. ncbi Effect of low-protein diet and protein supplementation on the expressions of TNF-alpha, TNFR-I, and TNFR-II in organs and muscle of LPS-injected rats
    Nilima Raina
    Department of Nutrition, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Am J Physiol Endocrinol Metab 286:E481-7. 2004
    ..This increase is suppressed by refeeding protein. A differential pattern between translation and transcription of TNF-alpha and its receptors is present. Our data suggest that protein restriction may be deleterious in sepsis...
  63. ncbi Intramuscular gene transfer of soluble tumor necrosis factor-alpha receptor 1 activates vascular endothelial growth factor receptor and accelerates angiogenesis in a rat model of hindlimb ischemia
    Masahiro Sugano
    Department of Molecular and Cellular Biology, Division of Molecular and Clinical Gerontology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita, 874 0838, Japan
    Circulation 109:797-802. 2004
    ..Soluble TNF-alpha receptor 1 (sTNFR1) is an extracellular domain of TNFR1 and an antagonist to TNF-alpha...
  64. ncbi TNF alpha-p55 receptors: medullary brainstem immunocytochemical localization in normal and vagus nerve-transected rats
    Gerlinda E Hermann
    Laboratory of Autonomic Neuroscience, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Brain Res 1004:156-66. 2004
    ..The aim of this study was to determine the location of the TNFR1 receptor (p55) in the medulla using immunocytochemical methods...
  65. ncbi Immunocytochemical localization of TNF type 1 and type 2 receptors in the rat spinal cord
    Gregory M Holmes
    Laboratory of Autonomic Neuroscience, Pennington Biomedical Research Center, 6400 Perkins Road, Louisiana State University, Baton Rouge, LA 70808, USA
    Brain Res 1025:210-9. 2004
    ..These studies identify the locus of type-1 TNF (TNFR1 or p55) and type-2 TNF (TNFR2 or p75) receptors within the spinal cord...
  66. ncbi Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion
    Yanzhang Li
    Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University Marburg, 35033 Marburg, Germany
    J Neurosci 24:9623-31. 2004
    ..Therefore, we differentiated the neuronal and non-neuronal sites of TNFalpha, TNFR1, and TNFR2 mRNA synthesis in dorsal root ganglion (DRG) of control rats and evaluated how their expression is ..
  67. ncbi Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis
    B Chen
    Ruhrlandklinik, Tuschener Weg 40, 45239 Essen, Germany
    Eur Respir J 25:1039-43. 2005
    ..In conclusion, this study shows evidence of altered expression of tumour necrosis factor superfamily receptors in hypersensitivity pneumonitis...
  68. ncbi Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue
    Maite Figueras
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Int J Oncol 27:855-60. 2005
    The mRNA content of both TNF-alpha and its receptors (TNFR1 and TNFR2) in skeletal muscle and adipose tissue from cachectic rats has been assessed...
  69. ncbi Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury
    J Frederick Harrington
    Department of Neurosurgery, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Neurotrauma 22:919-28. 2005
    ..These CSF samples were analyzed by ELISA for the presence of TNF-alpha and soluble TNFR1 and TNFR2 (sTNFR1 and sTNFR2, respectively)...
  70. ncbi The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat
    Ji Tian Xu
    Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, 74 Zhongshan Rd 2, Guangzhou 510080, PR China
    Pain 123:306-21. 2006
    ..We found that immunoreactivity (IR) of TNF-alpha and TNF receptor 1 (TNFR1) in ipsilateral (but not in contralateral) L4 and L5 dorsal root ganglion (DRG) was increased following L5 VRT, ..
  71. ncbi Intra- and extraneuronal changes of immunofluorescence staining for TNF-alpha and TNFR1 in the dorsal root ganglia of rat peripheral neuropathic pain models
    P Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Kamenice 3, CZ 625 00, Brno, Czech Republic
    Cell Mol Neurobiol 26:1205-17. 2006
    ..the goal of present study was to investigate immunohistochemical distribution of TNF-alpha and TNF receptor-1 (TNFR1) proteins in the rat DRG following three types of nerve injury. 2...
  72. pmc Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors
    P Baier
    Department of General and Visceral Surgery, Albert Ludwigs University, Freiburg, Germany
    World J Gastroenterol 12:3835-40. 2006
    ..This is relevant due to the potential therapeutic use of growth factors in stimulating liver regeneration...
  73. pmc Biomechanical strain regulates TNFR2 but not TNFR1 in TMJ cells
    James Deschner
    Department of Oral Biology, The Ohio State University, 305 W 12th Avenue, 4010 Postle Hall, Columbus, OH 43210, USA
    J Biomech 40:1541-9. 2007
    ..cyclic tensile strain (CTS) regulates the gene expression of tumor necrosis factor (TNF)-alpha, its receptors TNFR1 and TNFR2, and inducible nitric oxide synthase (iNOS) under inflammatory conditions, and whether these effects of ..
  74. ncbi Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage
    George Lotocki
    Department of Neurological Surgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Eur J Neurosci 24:2283-90. 2006
    ..Here, TNFR1 signaling pathways were investigated in the cerebral cortex of adult male Sprague-Dawley rats subjected to ..
  75. ncbi Exercise preconditioning reduces brain damage and inhibits TNF-alpha receptor expression after hypoxia/reoxygenation: an in vivo and in vitro study
    Yun Hong Ding
    Department of Neurosurgery, The University of Texas Health Science Center at San Antonio, Mail Code 7843, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Curr Neurovasc Res 3:263-71. 2006
    ..Chronically increased TNF-alpha expression was also found to reduce TNFI and II responding to acute ischemia/reperfusion insult...
  76. pmc Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice
    Kristy J Szretter
    Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Virol 81:2736-44. 2007
    ..interleukin-6 (IL-6), macrophage inflammatory protein 1 alpha (MIP-1alpha), IL-1 receptor (IL-1R), or tumor necrosis factor receptor 1 (TNFR1) by the use of two avian influenza A viruses isolated from humans, A/Hong Kong/483/97 (HK/483) ..
  77. ncbi Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women
    Alenka Mavri
    Inserm UMR 626 and Université de la Méditerranée, Marseille, France
    Thromb Haemost 97:62-6. 2007
    ..The aim of this study was to investigate the influence of polymorphism A36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, ..
  78. pmc Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis
    Lisheng Zhang
    Departments of Medicine Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Arterioscler Thromb Vasc Biol 27:1087-94. 2007
    Mechanisms by which tumor necrosis factor-alpha (TNF) contributes to atherosclerosis remain largely obscure. We therefore sought to determine the role of the arterial wall TNF receptor-1 (TNFR1) in atherogenesis.
  79. pmc Up-regulation of p55 TNF alpha-receptor in dorsal root ganglia neurons following lumbar facet joint injury in rats
    Yoshihiro Sakuma
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Eur Spine J 16:1273-8. 2007
    ..In the current study, changes in TNF receptor (p55) expression in DRG neurons innervating the L5/6 facet joint following facet joint injury were investigated in rats ..
  80. ncbi Lipopolysaccharide-induced upregulation of tumor necrosis factor-alpha (TNF-alpha) and TNF receptors in rat sciatic nerve
    Youhua Wang
    The Jiangsu Province Key Lab of Neuroregeneration, Nantong University, Nantong, 226001, People s Republic of China
    J Mol Neurosci 32:207-16. 2007
    ..Therefore, we focused our study on TNF-alpha, TNFR1, and TNFR2 protein synthesis and expression patterns in sciatic nerve of controls and rats under systemic ..
  81. doi Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung
    Ming Zhang
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 5582, USA
    Clin Cancer Res 14:1868-76. 2008
    ..Radiation-induced lung toxicity limits the delivery of high-dose radiation to thoracic tumors. Here, we investigated the potential of inhibiting the tumor necrosis factor-alpha (TNF-alpha) pathway as a novel radioprotection strategy...
  82. doi Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model
    Cristina E Constantin
    Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Neurosci 28:5072-81. 2008
    ..type 2 (TNFR2) gene attenuated heat hyperalgesia and prevented TRPV1 upregulation in tumor-bearing mice, whereas TNFR1 gene deletion played a minor role...
  83. doi TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 44:298-303. 2008
    ..pneumophila. In the case of TNFR1-knock-out mice and TNFR2-knock-out mice, a high mortality rate was observed after inoculation of 1x10(7)CFU/head ..
  84. pmc The roles of TNF-alpha and the soluble TNF receptor I on sleep architecture in OSA
    Herbert J Yue
    Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Sleep Breath 13:263-9. 2009
    ..We hypothesized that the TNF receptor might play an important role in the inflammation as well as sleep architecture changes in patients with OSA...
  85. doi Differences in serum cytokine levels between influenza virus A and B infections in children
    Masatoki Sato
    Department of Pediatrics, Fukushima South Aizu Hospital, Tajima 967 0006, Japan
    Cytokine 47:65-8. 2009
    ..To investigate differences in cytokine production between influenza A and B...
  86. doi Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study
    T M L Eagan
    Dept of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    Eur Respir J 35:540-8. 2010
    ..05). The present study confirms that certain circulating inflammatory mediators are an important phenotypic feature of COPD...
  87. ncbi Lack of soluble tumor necrosis factor alpha receptor 1 and 2 and interleukin-1beta compartmentalization in lungs of mice after a single intratracheal inoculation with live Porphyromonas gingivalis
    Ana Nemec
    Veterinary Faculty, Small Animal Clinic, University of Ljubljana, Ljubljana, Slovenia
    Exp Lung Res 35:605-20. 2009
    ..Development of pneumonia is dependent on the P. gingivalis dose; however, part of the cytokine response is unique to the systemic compartment, even in animals that do not develop pneumonia...
  88. doi Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease
    K Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Tissue Antigens 74:386-92. 2009
    ..Metabolic syndrome and diabetes are associated with higher plasma concentrations of TNF-alpha and its receptors...
  89. pmc CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection
    Deepti R Nagarkar
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 5688, USA
    J Immunol 183:6698-707. 2009
    ..The requirement of TNF-alpha for RV1B-induced airway responses was tested using TNFR1(-/-) mice...
  90. ncbi [Experimentation and investigation of the effects of TNF and the acceptor expression in renal early trauma with extraneous adrenomedullin]
    Xiao peng Han
    Department of Surgery, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou 730050, China
    Zhonghua Wai Ke Za Zhi 47:1415-8. 2009
    ..To investigate the effects of TNF-alpha, TNF-beta and the acceptor expression about mechanical renal trauma with extraneous ADM...
  91. doi Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer
    Eung Bae Lee
    Department of Thoracic Surgery, Kyungpook National University Hospital, Daegu, Korea
    Ann Surg Oncol 17:2608-18. 2010
    ..This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC)...
  92. pmc The association between BMI and plasma cytokine levels in patients with acute lung injury
    Renee D Stapleton
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, HSRF 222, Burlington, VT 05405, USA
    Chest 138:568-77. 2010
    ..We hypothesized that cytokine response might be attenuated in patients who are obese and critically ill or that obesity might modify the relationship between plasma cytokines and clinical outcomes in ALI...
  93. pmc Deficiency in the serum-derived hyaluronan-associated protein-hyaluronan complex enhances airway hyperresponsiveness in a murine model of asthma
    Long Zhu
    Institute for Molecular Science of Medicine, Aichi Medical University School of Medicine, Yazako, Nagakute, Japan
    Int Arch Allergy Immunol 153:223-33. 2010
    ..The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is also involved in airway allergy...
  94. pmc Upregulation of TNF-alpha and Receptors Contribute to Endothelial Dysfunction in Zucker Diabetic Rats
    Xue Gao
    Departments of Internal Medicine, Medical Pharmacology and Physiology and Nutritional Sciences, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, MO 65211
    Am J Biomed Sci 2:1-12. 2010
    ..The mRNA expression of TNF receptor 1 (TNFR1, but not TNFR2) significantly increased in coronary arteries in ZDF rats...
  95. ncbi TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis
    J Sainz
    Experimental Research Unit, Virgen de las Nieves University Hospital, Granada, Spain
    Int J Immunopathol Pharmacol 23:423-36. 2010
    ..TNF acts through TNF receptor 1 (TNFR1) triggering a pro-inflammatory response, and therefore plays a pivotal role in immune regulation and host immune ..
  96. doi An atherogenic lipid profile with low serum paraoxonase-1 activity during nematode infection in rats
    Ayman Samir Farid
    Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalioubeya, Egypt
    Eur J Clin Invest 40:984-93. 2010
    ..Therefore, we aimed to explore the effects of Nippostrongylus brasiliensis infection in male Wistar rats, a model of human gastrointestinal nematode infections, on hepatic PON1 synthesis and the levels of lipid parameters...
  97. pmc Tumor necrosis factor α primes cerebral endothelial cells for erythropoietin-induced angiogenesis
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Cereb Blood Flow Metab 31:640-7. 2011
    ..Blockage of TNF receptor 1 (TNFR1) suppressed TNF-α-upregulated EPOR expression and abolished EPO-induced tube formation...
  98. doi Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats
    Yanfei Li
    Department of Pharmacology, Zunyi Medical College, Zunyi, PR China
    Planta Med 77:117-21. 2011
    ..The spatial behavior was tested by the Morris water maze; the level of tumor necrosis factor receptor 1 (TNFR1) mRNA was detected by real time RT-PCR, and the protein level of TNFR1, nuclear factor kappa-B ..
  99. doi S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-κB pathway in rats
    Qi Hai Gong
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China
    Brain Behav Immun 25:110-9. 2011
    ..Furthermore, SPRC afforded beneficial actions in inhibitions tumor necrosis factor (TNF)-α, TNF-α receptor 1 (TNFR1) and Aβ generation, as well as IκB-α degradation and phospho-transcription factors of the nuclear factor κB ..
  100. pmc Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 250:245-55. 2011
    ..These responses were attenuated in mice lacking the p55 receptor for TNFα (TNFR1-/-), demonstrating that signaling via TNFR1 is key to CEES-induced injury, oxidative stress, and inflammation...

Research Grants4

  1. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
  2. Pathogenesis of Endotoxin-Induced Acute Renal Failure
    Patrick Cunningham; Fiscal Year: 2006
    ..abstract_text> ..
  3. Transcriptional regulation in chronic renal disease pathogenesis
    LESLIE BRUGGEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..